Oryctolagus cuniculus (rabbit): 100339981 Help Entry 100339981         CDS       T03373                                  Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu04022   cGMP-PKG signaling pathway ocu04068   FoxO signaling pathway ocu04081   Hormone signaling ocu04140   Autophagy - animal ocu04150   mTOR signaling pathway ocu04151   PI3K-Akt signaling pathway ocu04152   AMPK signaling pathway ocu04211   Longevity regulating pathway ocu04213   Longevity regulating pathway - multiple species ocu04722   Neurotrophin signaling pathway ocu04910   Insulin signaling pathway ocu04920   Adipocytokine signaling pathway ocu04923   Regulation of lipolysis in adipocytes ocu04930   Type II diabetes mellitus ocu04931   Insulin resistance ocu04932   Non-alcoholic fatty liver disease ocu04935   Growth hormone synthesis, secretion and action ocu04960   Aldosterone-regulated sodium reabsorption ocu05010   Alzheimer disease ocu05206   MicroRNAs in cancer ocu05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     100339981    04022 cGMP-PKG signaling pathway     100339981    04151 PI3K-Akt signaling pathway     100339981    04152 AMPK signaling pathway     100339981    04150 mTOR signaling pathway     100339981   09133 Signaling molecules and interaction    04081 Hormone signaling     100339981  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     100339981  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100339981    04923 Regulation of lipolysis in adipocytes     100339981    04920 Adipocytokine signaling pathway     100339981    04935 Growth hormone synthesis, secretion and action     100339981   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100339981   09156 Nervous system    04722 Neurotrophin signaling pathway     100339981   09149 Aging    04211 Longevity regulating pathway     100339981    04213 Longevity regulating pathway - multiple species     100339981  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     100339981   09164 Neurodegenerative disease    05010 Alzheimer disease     100339981   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     100339981   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100339981    04932 Non-alcoholic fatty liver disease     100339981    04931 Insulin resistance     100339981 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  100339981 NCBI-ProteinID:  XP_002712555 LinkDB All DBs Position 7:5126214..5184722 Genome browser AA seq 1241 aa AA seqDB search MASPPETEGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGASATGAGGAGGSCSGSSGLGEAGEDLSYGDMPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPN GHYILARGGNGHRYIPGAGLGVSPALAAEDAASAADLENRFRKRTHSAGTSPTISHQKTP SQSSVEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLERRGGHHRPDSS TLHTDDGYMPMSPGVAPVPGSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYM MMSPSGSCSPDIGGGPSSSSGSSGVSAAPSGSSYGKLWTNGVGGHHSHALPHPKPPAESS GGKLLPCTGEYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELE EGARHQHLRLSSSSGRLLYAATAEDSSSSTSSDSLGGGYCGARPEPGLPHPHHHVLQPHL PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSLPHPPEPKSPGEYVNIEF GSDQPGYLSGPVASHSSPSIRCPPQLQPAPREEETGTEEYMNMDLGPGRRATWQENTGAD LGRVGPAPPGAASVCRPTRAVPSSRGDYMTMQMGCSRQSYVDTSPVAPVCYADMRAGIAA EEASLPRATAAAPSSSSAASSSPTEPQGAAELATRSSLLGGPQGPGGMSAFTRVTLSPNR NQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNTVSFGGGASGGGSGGSGSEDVKRHSS ASFENVWLRPGELVGAPKETAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQPQPPQ PVPPHPHQPLGSGESSSTSRSSEDLSAYASISFQKQPEDRQ NT seq 3726 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgaaggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaagcgctttttcgtgctgcgggccgccagcgaggcggggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgggacgaacactttgccattgcggcagacagcgag gccgagcaggacagctggtaccaggctctcctgcagctgcacaaccgcgccaagggccac cacgatggggcctcggccaccggggcgggaggcgctgggggcagctgcagcggcagctct ggcctgggcgaggctggagaggacttgagctacggggacatgcccccaggacccgccttc aaggaggtctggcaggtgatcttgaaacccaaaggcctggggcagacaaagaatttgatc ggcatctaccgcctgtgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gccgcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactccgagaacttc ttcttcatcgaggtgggccgctccgccgtgacgggccccggcgagttctggatgcaggtg gatgactccgtggtggcccagaacatgcacgagaccatcttggaggccatgcgggccatg agcgacgagttccgccctcgcagcaagagccagtcctcctccaactgctccaaccccatc agcgtccccctgcgccggcaccatctcaacaacccgccgcccagccaggtggggctgacg cgccgctcgcgcaccgagagcatcaccgccacctccccggccagcatggtgggcgggaag ccaggttccttccgggtccgcgcctccagcgacggcgaaggcaccatgtcgcgcccagcc tcggtggacggcagcccggtgagccccagcaccaacaggacccacgcccaccggcatcgg ggcagctcccggctgcacccgccgctcaaccacagccgctccatacccatgccttcttct cgctgctcgccgtcggccaccagccccgtcagtttgtcgtccagcagcaccagtggccac ggctccacctcggactgtctcttcccgcggcggtcgagcgcctctgtgtccggctccccc agcgatggtggcttcatctcctccgacgagtatggctcgagtccttgcgactttcgaagt tccttccgcagtgtcactcccgattccctgggccacaccccgccagcccgcggtgaggag gagctcagtaactacatctgcatgggcggcaaaggggcctccaccctggccgcccccaac ggtcactacattttggctcgcggaggcaatggccaccgctacatccccggggcgggcctg ggcgtgagccccgccctggctgcggaggatgcagccagcgccgccgacctggaaaatcgc ttccggaagcgaactcactcggcgggcacctcccctaccatttcgcaccagaagacccca tcgcagtcctcggtggagtacacagagatgatgcctgcctacccaccgggaggtggcagt ggaggccgactgcccggctacaggcactccgccttcgtgcccacccactcttaccccgag gagggtctggagatgcaccccttggagcgccgcgggggccaccaccggccagactcctcc actctccacactgacgatggctacatgcccatgtccccgggggtggccccggtgccaggg agcagccgcaagggcagtggggactacatgcccatgagccccaagagtgtatctgcccct caacagatcatcaaccccatcagacgccacccccagagagtggaccccaatggctacatg atgatgtcccccagtggcagctgctcccctgacattggcggtgggcccagcagcagcagt ggcagcagcggcgtcagcgccgccccttccgggagcagctacggcaagctgtggaccaat ggggtagggggccaccactctcatgccctgcctcaccccaaaccccctgcggagagcagt ggtggcaagctcttgccttgcacaggtgaatacatgaacatgtcgccagtgggggactcc aacaccagcagcccctcagactgctactatggccctgaggacccccagcacaagccagtc ctctcctactactcactgccaaggtcctttaagcacacccagcggccgggggagctggag gaaggtgcccggcaccagcacctccgcctctcctctagctctggtcgccttctctatgct gcgacagctgaagattcttcttcttccaccagcagcgacagcctgggtggtggatactgt ggggctaggccagagcctggcctcccgcatccccaccatcatgtcctacagccccacctg cctcgaaaggtggacacagctgctcagaccaacagccgcctggctcggcccacgaggctg tccctgggggatcccaaggccagtaccttgcctcgggttcgagagcagcagcagcagcag cagtccctgccgcaccctccggagcccaagagcccaggggagtatgtgaatattgaattt gggagtgatcaacctggctacctgtctggccctgtggcttcccacagctctccctctatc aggtgtccaccccagctccagccagctccccgagaggaagagactggcaccgaggagtac atgaacatggacctgggacctggccggagggcaacctggcaggagaacacaggggctgac ttgggcagagtgggccctgcacctcctggggcagctagcgtttgcaggcccacccgggca gtgcccagcagccgaggcgactacatgaccatgcagatgggttgttcccgccagagctac gtggatacctccccagtggcccctgtctgctatgctgacatgcgggcaggcattgctgcc gaggaggccagcctgccccgggccacagcggctgctccttcctcatcctcagcagcctcc tcttcccccactgagcctcaaggtgcagctgaactggctactcgctcctccctgctggga gggccacaaggccccgggggcatgagtgccttcacccgggtgaccctcagtccgaaccgc aaccagagtgccaaagtgatccgtgcagacccacaagggtgccggaggaggcatagctca gagaccttctcctctacacccagtgccacccgggcgggcaacacggtgtctttcggaggg ggcgcttcaggagggggcagcggtggcagcggcagtgaggatgtgaaacgccacagctct gcttcctttgagaatgtgtggctgaggcccggggagctggtgggagcccccaaggagaca gcccaagtgtgtggggctgctgggggtttggagaatggtcttaactacatagacctggat ttggtcaaggacttcaaacagcgccctcaggagcgcccccctcagccgcagcctccccag cctgtgccccctcatcctcatcagcccctgggcagcggtgagagcagctccaccagccgc tccagtgaggatttaagcgcctatgccagcatcagtttccagaagcaaccagaggaccgc cagtag

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