KEGG   Oryctolagus cuniculus (rabbit): 100346986
Entry
100346986         CDS       T03373                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00140  Steroid hormone biosynthesis
ocu01100  Metabolic pathways
ocu04913  Ovarian steroidogenesis
ocu04925  Aldosterone synthesis and secretion
ocu04927  Cortisol synthesis and secretion
ocu04934  Cushing syndrome
Module
ocu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
ocu_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ocu_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100346986
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100346986
   04925 Aldosterone synthesis and secretion
    100346986
   04927 Cortisol synthesis and secretion
    100346986
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100346986
Enzymes [BR:ocu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     100346986
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     100346986
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR Ldh_1_N Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 100346986
NCBI-ProteinID: XP_002715728
Ensembl: ENSOCUG00000004132
UniProt: G1SL49
LinkDB
Position
13:complement(45113463..45128498)
AA seq 375 aa
MAMSGWSCLVTGAGGFLGQRIVHLLVQEQELQEIRILDKVFQPGVKEEFSKLQNKTKLTM
LEGDILDEQCLNTACQGVSVVIHTACVIDVTGVIHRDTIIDVNLRGTQLLLQACVQASVP
IFIYTSSLEVAGPNSYKEIIRNGHEAEHHESAWSAPYPYSKKLAEKSVLAANGYTLKNGG
TLYTCALRPMYIYGEGSKFLARMINNSLKNKGILISNGKFSIANPVYVGNVAWAHILATR
ALRDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSQKWGLCLDPRPSLPLPLQYWLSFLL
EVVSFLLTPIYKYRPPFNRHLVTLSNSVFTFSYKKAQQDLGYEPLFSWEEAKQRTMEWIG
SLVEQHRETLKTKTQ
NT seq 1128 nt   +upstreamnt  +downstreamnt
atggccatgtctgggtggagctgcctggtgacaggagcaggagggtttctgggtcagagg
atcgtccacctgctggtccaggagcaggagctgcaggagatcaggatcctggacaaggtc
ttccaaccaggagtgaaggaggaattttcaaagctccagaacaagaccaagctgaccatg
ctggaaggagacattctggatgaacagtgcctcaacacagcctgccagggagtctctgtt
gtcatccacactgcctgtgtcattgacgtcacaggtgtcattcaccgagacaccattata
gatgtcaatctgagaggtacccagctcctgttgcaggcctgtgtccaagccagtgtgccg
atcttcatctacaccagctcattggaagtagctggaccaaactcgtacaaggagatcatc
aggaatggccacgaggcagaacaccacgaaagtgcatggtctgctccatacccatacagc
aaaaagttggctgagaagtcagtgctggcagccaatgggtacactcttaaaaatggcggc
accttgtacacttgtgccttaaggcccatgtacatctatggggaaggaagcaaatttctt
gctcgaatgataaataactccctgaagaacaaagggatcctgataagtaacggcaagttc
tccatagccaacccagtctatgtgggcaacgtggcatgggctcacattctggccacgagg
gcactacgggaccccaagaaggccccgagcatccgaggacagttctactacatctcagat
gacacccctcaccagagctatgacaacctcaactacaccctgagccaaaagtggggcctc
tgcctggatcccagaccgagcctcccgctacctctgcagtactggctcagcttcctactg
gaagtagtgagcttcctgttgaccccaatttacaaatatcgaccccccttcaaccgccac
ttggtgacattatccaacagtgtgttcaccttctcctacaagaaagctcagcaagatctg
gggtatgagcccctcttcagttgggaggaagccaaacagaggaccatggagtggattggt
tccctggtggaacagcacagggagaccctgaagaccaagacccagtga

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