KEGG   Oryctolagus cuniculus (rabbit): 100349958
Entry
100349958         CDS       T03373                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04020  Calcium signaling pathway
ocu04062  Chemokine signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04072  Phospholipase D signaling pathway
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04613  Neutrophil extracellular trap formation
ocu04650  Natural killer cell mediated cytotoxicity
ocu04658  Th1 and Th2 cell differentiation
ocu04659  Th17 cell differentiation
ocu04660  T cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04670  Leukocyte transendothelial migration
ocu04722  Neurotrophin signaling pathway
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04919  Thyroid hormone signaling pathway
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu05012  Parkinson disease
ocu05022  Pathways of neurodegeneration - multiple diseases
ocu05135  Yersinia infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05171  Coronavirus disease - COVID-19
ocu05200  Pathways in cancer
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05214  Glioma
ocu05223  Non-small cell lung cancer
ocu05225  Hepatocellular carcinoma
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05417  Lipid and atherosclerosis
Module
ocu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100349958
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100349958
   04014 Ras signaling pathway
    100349958
   04015 Rap1 signaling pathway
    100349958
   04370 VEGF signaling pathway
    100349958
   04064 NF-kappa B signaling pathway
    100349958
   04066 HIF-1 signaling pathway
    100349958
   04020 Calcium signaling pathway
    100349958
   04070 Phosphatidylinositol signaling system
    100349958
   04072 Phospholipase D signaling pathway
    100349958
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100349958
   04650 Natural killer cell mediated cytotoxicity
    100349958
   04660 T cell receptor signaling pathway
    100349958
   04658 Th1 and Th2 cell differentiation
    100349958
   04659 Th17 cell differentiation
    100349958
   04664 Fc epsilon RI signaling pathway
    100349958
   04666 Fc gamma R-mediated phagocytosis
    100349958
   04670 Leukocyte transendothelial migration
    100349958
   04062 Chemokine signaling pathway
    100349958
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    100349958
   04919 Thyroid hormone signaling pathway
    100349958
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100349958
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100349958
  09158 Development and regeneration
   04360 Axon guidance
    100349958
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100349958
   05206 MicroRNAs in cancer
    100349958
   05205 Proteoglycans in cancer
    100349958
   05231 Choline metabolism in cancer
    100349958
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100349958
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100349958
   05214 Glioma
    100349958
   05223 Non-small cell lung cancer
    100349958
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100349958
   05171 Coronavirus disease - COVID-19
    100349958
   05167 Kaposi sarcoma-associated herpesvirus infection
    100349958
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100349958
  09164 Neurodegenerative disease
   05012 Parkinson disease
    100349958
   05022 Pathways of neurodegeneration - multiple diseases
    100349958
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100349958
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100349958
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100349958
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100349958
Enzymes [BR:ocu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100349958
Membrane trafficking [BR:ocu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100349958
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100349958
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7 PH_9
Other DBs
NCBI-GeneID: 100349958
NCBI-ProteinID: XP_051702059
Ensembl: ENSOCUG00000008231
LinkDB
Position
4:complement(7089824..7124319)
AA seq 1293 aa
MAGAASPCANGCAPGAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLKERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRT
GERPDLCRVTLPEFQQFLLEYQGELWAIDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRSEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASLAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPNTMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPMW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKVAQENGDLSPFGSTSLRERGSDASGQLFHGRAREGSFEARYQQPF
EDFRISQEHLADHFDGRERRAPRRTRVNGDSRL
NT seq 3882 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccttgcgccaatggctgcgctcccggcgcgccctcggaagcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaaactggagacgcgccagatc
acgtggagccgcggcgccgacaagatcgagggggccattgacattcgtgaaatcaaggag
atccgcccaggaaagacctcacgggacttcgatcgctatcaagaggaccccgctttccgc
ccagaccagtcacactgctttgtcatcctctatgggatggaattccgcctgaagaccctg
agcttacaagcaacgtctgaggatgaagtgaatatgtggatcaagggcttaacttggctg
atggaggacacattgcaggcagctacacctctgcagattgagaggtggcttcggaaacag
ttttactcagtggatcggaatcgggaggatcgtatttcagccaaagacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctcaaggagcggctgacggac
ctggagcagcgcagtggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggatctccccttcttggaagccagcgccctgaggaca
ggggagcgaccagatctttgccgagtgacccttcctgagttccagcagttcctccttgag
taccagggggagctatgggccattgaccggctccaggtacaggaattcatgctcagcttt
ctccgggaccccttgcgagagattgaggaaccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcccagctggatgcagtgtgcccagac
accatgaacaaccctctctcccactattggatctcatcctcacacaacacgtacctgact
ggggaccagttctccagcgagtcctccctggaagcctatgctcggtgtctgcggatgggc
tgtcgctgcattgaattggactgctgggatggcccagatgggatgccagtcatttaccat
ggacacacccttaccaccaagatcaagttctcagatgtcctgcataccatcaaggaacat
gcctttgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcc
cagcagaggaacatggcccagtactttaagaaggtgctgggggacacgctcctcaccaag
cctgtggacattgctgccgatgggctgccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctatgaggaagtgcccacctcggtgatg
tactctgagaatgacatcagcaactccatcaagaatggcatcctgtacttggaggatcct
gtgaaccacgagtggtatccccactactttgttctgaccagcagtaagatctattactct
gaagagaccagcagtgaccagggcaatgaagatgaggaggagcccaaggaggccagtggc
agcacagagctgcactccaatgagaagtggttccacgggaagcttggggcaggacgggac
gggcggcacatcgccgagcgcctgctcacggaatactgcatcgagactggcgcccccgac
ggctccttcctagttcgggagagcgagacctttgtgggcgactacacattgtctttctgg
cggaatgggaaagtccagcactgccgtatccactcccggcaggatgctgggacccccaag
ttcttcctgacagacaatctggtctttgactccctctatgatctcatcacacactaccag
caagtgcctctgcgctgcaatgagtttgagatgcgtctgtcagagcctgttccacagacc
aatgcccatgagagcaaagagtggtaccatgcaagcctgaccagagcacaggctgagcat
atgctgatgcgtgttccccgtgatggggccttcctggtgcgaaaacggagtgagcccaac
tcatatgccatctccttccgggctgagggcaagatcaagcattgccgtgtccagcaggag
ggccagacagtgatgctggggaactcggagtttgacagcctcgttgacctcatcagctac
tatgagaagcacccactgtaccgcaagatgaagctccgctatcctatcaatgaagaggcg
ttggagaagattggcacagctgaacctgactatggggccctgtatgagggccgaaaccct
ggcttttacgtggaggcaaaccctatgccgactttcaagtgtgcagtcaaagccctcttt
gactacaaggcgcagagagaggatgagctgaccttcaccaagagcgctatcatccagaat
gtagagaagcaagaaggaggctggtggcgaggagactatggcggaaaaaagcagctgtgg
ttcccttcaaactatgtggaagagatggtcagtccagcggccctggagcctgaaagggag
cacttggacgagaacagccccctgggggacttgctgcggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtgttctccatcagc
atggcctcgctggcccactggtccctggatgttgctgccgactcacaggaggagctacag
gactgggtgaaaaagatccgtgaggtggcccagactgcagatgccaggctcaccgagggg
aagatgatggaacggaggaagaagatcgcgctggaactgtctgagcttgtcgtctactgc
cggcctgttcccttcgatgaagagaaaatcggcacagagcgagcttgctatcgggacatg
tcatccttcccggaaaccaaggctgagaaatatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccgtctgcaactctcccgcatctaccccaagggccagagactagactcc
tctaattatgaccctttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagaccccagataagcctatgcagatgaaccaggccctcttcatggctggtgggcactgt
ggctacgtgctgcagcccaacaccatgcgggatgaggccttcgatccattcgacaagagc
agcctccgggggctagagccgtgtgccatctgcattgaggtgctgggggctcggcatctg
ccgaagaatggccgaggcattgtgtgtcctttcgtggagattgaggtggctggagcagag
tatgacagtaccaagcagaagacagaatttgtggtggacaatggactgaacccgatgtgg
cccgccaagcccttccacttccagatcagcaaccctgaatttgccttcctgcgctttgtg
gtatatgaagaagacatgttcagtgaccagaacttcctggctcaggctactttcccagtg
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctg
gagttggcctctctgctcatcaagatcgacattttccctgccaaggtagcacaggagaat
ggtgacctcagtccctttggtagcacgtctctgcgggaacggggttcagatgcctcaggc
cagctgtttcacggcagagcccgagaaggttcttttgaagcccgctaccagcagccgttt
gaggacttccgcatttcccaggagcatcttgcagaccattttgatggtcgagaacgaagg
gccccaaggaggactcgggtcaatggagacagccgcctctag

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