Oryctolagus cuniculus (rabbit): 127486194 Help Entry 127486194         CDS       T03373                                  Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu04062   Chemokine signaling pathway ocu04151   PI3K-Akt signaling pathway ocu04217   Necroptosis ocu04550   Signaling pathways regulating pluripotency of stem cells ocu04630   JAK-STAT signaling pathway ocu04658   Th1 and Th2 cell differentiation ocu04659   Th17 cell differentiation ocu05161   Hepatitis B ocu05162   Measles ocu05166   Human T-cell leukemia virus 1 infection ocu05169   Epstein-Barr virus infection ocu05200   Pathways in cancer ocu05203   Viral carcinogenesis ocu05223   Non-small cell lung cancer ocu05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     127486194    04151 PI3K-Akt signaling pathway     127486194  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     127486194   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     127486194  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     127486194    04659 Th17 cell differentiation     127486194    04062 Chemokine signaling pathway     127486194  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     127486194    05203 Viral carcinogenesis     127486194   09162 Cancer: specific types    05223 Non-small cell lung cancer     127486194   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     127486194    05161 Hepatitis B     127486194    05162 Measles     127486194    05169 Epstein-Barr virus infection     127486194   09163 Immune disease    05340 Primary immunodeficiency     127486194  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ocu01001]     127486194 Enzymes [BR:ocu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      127486194 Protein kinases [BR:ocu01001]  Non-receptor tyrosine kinases   JAK family [OT]    127486194 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo SH2 ABC1 FERM_C_FAK1 pKID Haspin_kinase Motif Other DBs NCBI-GeneID:  127486194 NCBI-ProteinID:  XP_051685925 LinkDB All DBs Position Unknown AA seq 1102 aa AA seqDB search MAPPSEETPLIPPRSCSLSSAEAGALHVLLPHPGPGRPPRLSFSFGDHSAEALCVRAAKA SGVLPVYHSLFALATEDLSCWFPPSHVFSVEDGATQVLVYRLRFYFPEWFGLDKCHRFGL HKELASAILDFPVLEHLFAQRRSDLVSGRLPVGLSFREQSECLSLAVLDLARMAREQARR PAELLKAVSYKACLPPRLRDLIQGLSFVTRGRIRRTVRRALRRVAACQADRHALMVKYIM DLERLDPAGAAETFCVGLPGADGADTQGLLQVAGGSGVAWSPGGQEALQPFCDFPEIVDI SITQAPRAGPAREHRVVTVTRTDTQILEAEFPGLPHALSFVALVDGYFRLTTDSGHYFCK EVAPPRLLEEAAEQCHGPITLDFAVHKLKAQGSLPGSYVLRRSPQDFDSFLLTVCVQTPL GPDYKGCLVRRDPTGAFSLAGLGRPHSSLGELLAAYRSGGLHVDGAMLTLSSCCAPRPRE KSNLIVVRRGCGPATPADPPQGLHPLSQLTFHKVPADSLEWHENLGRGSFTSIFRGSRRE AVDGEARRSEVLLKVVDARHRHCLESFLEAASLMSQVSFPHLVLLHGVCMAGDSTMVQEF VPLGAVDTYLRRHGHRVPASWKLQVAKQLAYALNYLEDRGLTHGNVSARKVLLAREGADG SPPFIKLSDPGVSPAVLSREMLADRIPWVAPECLQDPQALGLEADKWGFGATVWEVFSGA PMPVSALEPAEKLDFYEQRSRLPAPPWAELALLIEQCMAYAPGRRPSFRAIIRDLNSLST SDYELLSDPAPGAPGPRAGLWGGAQLHACQDPTVFEERHLKFISQLGKGHFGSVELCRYD PLGDDTGALVAVKRLQHSGPDQERSFAREIQILKALHSDFIVKYRGVSYGPGRQSLRLVM EYLPRGCLRDFLQRHRARLGAGHLLLYASQICKGMEYLGSRRCVHRDLAARNILVESETH VKIADFGLAKLLPLDKDYYVVREPGQSPIFWFAPESLADNVFSLQSDVWSFGVVLYELFT YSDKSCSPSAEFLRMMGGERDAPGLCRLLELLAEGQRLPAPPACPAEVHELMQLCWAASP QDRPPFSALGPRLDALWSGSPG NT seq 3309 nt NT seq  +upstreamnt  +downstreamnt atggcgccccccagcgaggagacgccgctgatccccccgcgctcctgcagcctgtcctcg gcggaggcgggggccctgcacgtgctgctcccgcacccgggccccgggcgccccccgcgc ctgtccttttccttcggcgaccactcggccgaggccttgtgtgtgcgggccgccaaggcc agcggcgtgctgcccgtgtaccactcgctgttcgccctggccacggaggacctgtcctgc tggttcccgcccagccacgtcttctccgtggaggacggggccacccaggtcctggtctac aggctccgcttctacttccccgagtggttcgggctggacaaatgccaccgcttcgggctc cacaaagagttggccagcgccatcctggacttcccggtcctggagcacctgtttgcccag cgccgcagtgacctggtcagcgggcgcctccccgtgggcctgagcttccgggagcagagc gagtgcctgagcctggccgtgctggacctggcgcggatggcccgcgagcaggcgcggcgg ccggcggagctgctcaaggccgtcagctacaaggcctgcctgcctccgcgcctgcgcgac ctcatccagggcctgagcttcgtgacccgcggccgcatccgccggaccgtgcgccgcgcc ctgcgccgcgtggccgcgtgccaggccgaccggcacgcgctcatggtcaagtacatcatg gacctggagcggctggaccccgccggggcggccgagaccttctgcgtgggcctcccgggg gccgacggcgcagacacgcaggggctgctgcaggtggccggcggcagcggcgtagcctgg agccccggcggacaggaggccctgcagcccttctgtgacttccccgagatcgtggacatc agcatcacgcaggcgccgcgcgcgggcccggcccgggagcaccgcgtggtcaccgtgacc aggacggacacacagatcctggaggccgagttcccggggctgccccacgcgctgtccttc gtggcgctggtggacggctacttccggctgaccaccgactccgggcactacttctgcaag gaggtggccccgccgcggctgctggaggaggcggccgagcagtgccacggccccatcacc ctggacttcgcggtccacaagctgaaggcccagggctcgctccccggctcctacgtcctc cgccgcagcccccaggatttcgacagcttcctgctcaccgtctgtgttcagacgcccctg ggccccgactataaaggctgcctcgtccgccgcgaccccacgggcgccttctcactggcc ggcctcgggcggcctcacagcagcctgggggagctgctggcggcctaccggagtgggggg ctgcacgtggacggggccatgctgaccctcagctcctgctgcgcccccagacccagagag aagtccaacctgatcgtggtgcggaggggctgcgggcccgcgacccccgccgatccgccc cagggcctgcacccgctcagccagctcaccttccacaaggtcccggccgacagcctcgag tggcacgagaacctgggccgcggctccttcaccagcatcttccgcggctccaggcgcgag gcggtggacggggaggcgcggcggagcgaggtgctgctcaaagtggtggacgcgcggcac cgccactgcctggagtccttcctggaagccgccagcctgatgagccaggtctccttcccg catctcgtgctgctgcacggcgtgtgcatggccggagacagcaccatggtccaggagttc gtgccgctgggagccgtggacacgtacctgcgcaggcacggccaccgggtgccggccagc tggaagctgcaggtggccaagcagctggcctacgccctcaactacctggaggacaggggc ctcacccacggcaacgtgtcggcgcgcaaggtgctcctggcccgggagggggccgacggg agccccccgttcattaagctcagcgaccctggggtcagccccgccgtgctgagccgggag atgcttgcggacaggatcccctgggtggctcccgagtgtctgcaggacccgcaggccctc ggcctggaggcggacaagtggggcttcggggccaccgtctgggaggtgttcagcggcgcc ccgatgcccgtcagcgccctggagccggccgagaagctggacttctacgagcagcggagc cgcctgcccgccccgccgtgggccgagttggccctgctcattgagcagtgcatggcctac gcgccgggccggcggccgtccttccgagccatcatccgggacctcaacagcctcagcacg tccgactacgagctgctctcggaccccgcgccaggcgccccagggccccgcgccgggctg tggggcggcgcccagctccacgcctgccaggaccccacggtgtttgaggagaggcacctc aagttcatctcgcagctgggcaagggccacttcggcagcgtggagctgtgccgctacgac ccgctgggcgacgacacgggcgcgctggtggcggtgaagcggctgcagcacagcggcccc gaccaggagcgcagcttcgcacgcgagatccagatcctcaaggcgctgcacagcgacttc atcgtcaagtaccgcggcgtcagctacggcccgggtcgccagagcctgaggctggtcatg gagtacctgccccgcggctgcctgcgtgacttcctacagcgccaccgcgcgcgcctgggc gccggccacctgctgctgtacgcctcccagatctgcaagggcatggagtacctgggctcc cgccgctgcgtgcaccgcgacctggccgcgcgcaacatcttggtggagagcgagacgcac gtgaagatcgcggacttcggcctggccaagctgctgccgctggacaaggactactacgtg gtccgcgagcccggccagagccccatcttctggttcgcccccgagtcgctggcggacaac gtcttctcgctccagtcggacgtctggagcttcggcgtcgtcctatacgagctgttcact tacagcgacaagagctgcagcccctcggccgagttcctgcggatgatggggggagagcga gacgcccccggcctctgccgcctcctggagctgctggctgagggccagaggctgccggcg ccgcccgcctgcccggccgaggtccacgagctcatgcagctgtgctgggccgccagcccc caggaccggccgcccttcagcgccctggggccccggctggacgcgctgtggagcgggagc ccggggtag

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