KEGG   Ochotona curzoniae (black-lipped pika): 121166475
Entry
121166475         CDS       T11174                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like isoform X1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
ocz  Ochotona curzoniae (black-lipped pika)
Pathway
ocz00140  Steroid hormone biosynthesis
ocz01100  Metabolic pathways
ocz04913  Ovarian steroidogenesis
ocz04925  Aldosterone synthesis and secretion
ocz04927  Cortisol synthesis and secretion
ocz04934  Cushing syndrome
Module
ocz_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
ocz_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ocz_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ocz00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    121166475
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    121166475
   04925 Aldosterone synthesis and secretion
    121166475
   04927 Cortisol synthesis and secretion
    121166475
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    121166475
Enzymes [BR:ocz01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     121166475
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     121166475
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 KR RmlD_sub_bind NmrA Sacchrp_dh_NADP Ldh_1_N Pox_I1
Other DBs
NCBI-GeneID: 121166475
NCBI-ProteinID: XP_040851535
LinkDB
Position
Unknown
AA seq 373 aa
MTEWSCLVTGAGGFLGRRIVHLLVQEKGLQELRILDKVFEPEVKEEFSKLKNKIKLTMLE
EDILDEQCLVTACQGISVVIHTACLIDVRGVIPRDVIMDVNLKGTQLLLQACVRSSVPFF
IYTSSMEVAGPNSYKEIVRNGHEGEHRESTWSAPYPHSKKLAEKAVLAANGDTLKNGGTL
YTCALRPTYIYGEGSQNTASIINASLKNNGIIVRSGKFSIANPVYVGNVAWAHILASRVL
RDPQKAPNIQGKFYYIADNTPHQSYDNLNYTLSRKWGLCLDSTPSLPLSLQYWLAFLLEL
VSFLLAPIYNYQPPFNRHLVTLCNSVFTFSYQKARRDLGYEPLFSWEEAKQKTTEWIGSL
VEQHRQTLKTKTQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgactgagtggagctgcctcgtgacaggagcaggagggtttctgggtcggaggatcgtc
cacttgctcgtccaggagaaggggcttcaggagctcaggatcctggacaaggtctttgaa
ccagaagtgaaggaggaattttcaaagctcaagaacaagatcaagctgaccatgctggaa
gaagacattctggatgagcagtgcctcgtcacagcctgccagggcatctccgttgtcatc
cacactgcctgtctcattgatgtcagaggtgtcattcccagagacgtcatcatggatgtc
aatctgaaaggtacccagctgctgctgcaagcctgtgttcgatccagtgtgcccttcttc
atctacaccagctcaatggaagtggctggacccaactcatacaaggaaatcgtcaggaat
ggccatgagggagagcatcgcgaaagcacatggtctgctccatacccacacagcaagaag
ctggctgagaaggcagtgttggcagccaatggagacactctcaaaaatggtggcacattg
tacacttgtgctttgaggcccacgtacatctatggggaaggaagccaaaacactgcttct
attataaatgcgtccttgaaaaacaatgggatcatagtacgtagtggtaagttctccata
gccaacccggtctatgtaggcaacgtagcctgggctcacattctggcctcaagggtccta
cgggacccccaaaaggctccaaacatccagggaaagttctactacattgcagacaacact
cctcaccagagctatgacaacctcaattacacgctgagccgaaagtggggcctctgcctc
gattccacacccagcctgcctctgtctctgcagtactggcttgccttcctgctggagtta
gtgagcttcctgctggctccaatttacaactatcaaccccccttcaatcgccacttggtg
acactgtgcaatagcgtgttcaccttctcctaccagaaagctcggcgagatctgggctat
gagccactcttcagttgggaggaagccaagcagaagaccacagagtggattggctccctg
gtggaacagcacaggcagaccctgaagacaaagacgcagtga

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