KEGG   Otolemur garnettii (small-eared galago): 100949858
Entry
100949858         CDS       T07855                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
oga  Otolemur garnettii (small-eared galago)
Pathway
oga01521  EGFR tyrosine kinase inhibitor resistance
oga01522  Endocrine resistance
oga01524  Platinum drug resistance
oga04012  ErbB signaling pathway
oga04014  Ras signaling pathway
oga04015  Rap1 signaling pathway
oga04024  cAMP signaling pathway
oga04062  Chemokine signaling pathway
oga04066  HIF-1 signaling pathway
oga04068  FoxO signaling pathway
oga04070  Phosphatidylinositol signaling system
oga04071  Sphingolipid signaling pathway
oga04072  Phospholipase D signaling pathway
oga04081  Hormone signaling
oga04140  Autophagy - animal
oga04150  mTOR signaling pathway
oga04151  PI3K-Akt signaling pathway
oga04152  AMPK signaling pathway
oga04210  Apoptosis
oga04211  Longevity regulating pathway
oga04213  Longevity regulating pathway - multiple species
oga04218  Cellular senescence
oga04360  Axon guidance
oga04370  VEGF signaling pathway
oga04380  Osteoclast differentiation
oga04510  Focal adhesion
oga04550  Signaling pathways regulating pluripotency of stem cells
oga04611  Platelet activation
oga04613  Neutrophil extracellular trap formation
oga04620  Toll-like receptor signaling pathway
oga04625  C-type lectin receptor signaling pathway
oga04630  JAK-STAT signaling pathway
oga04650  Natural killer cell mediated cytotoxicity
oga04660  T cell receptor signaling pathway
oga04662  B cell receptor signaling pathway
oga04664  Fc epsilon RI signaling pathway
oga04666  Fc gamma R-mediated phagocytosis
oga04668  TNF signaling pathway
oga04670  Leukocyte transendothelial migration
oga04722  Neurotrophin signaling pathway
oga04725  Cholinergic synapse
oga04750  Inflammatory mediator regulation of TRP channels
oga04810  Regulation of actin cytoskeleton
oga04910  Insulin signaling pathway
oga04914  Progesterone-mediated oocyte maturation
oga04915  Estrogen signaling pathway
oga04917  Prolactin signaling pathway
oga04919  Thyroid hormone signaling pathway
oga04923  Regulation of lipolysis in adipocytes
oga04926  Relaxin signaling pathway
oga04929  GnRH secretion
oga04930  Type II diabetes mellitus
oga04931  Insulin resistance
oga04932  Non-alcoholic fatty liver disease
oga04933  AGE-RAGE signaling pathway in diabetic complications
oga04935  Growth hormone synthesis, secretion and action
oga04960  Aldosterone-regulated sodium reabsorption
oga04973  Carbohydrate digestion and absorption
oga05010  Alzheimer disease
oga05017  Spinocerebellar ataxia
oga05020  Prion disease
oga05100  Bacterial invasion of epithelial cells
oga05135  Yersinia infection
oga05142  Chagas disease
oga05146  Amoebiasis
oga05160  Hepatitis C
oga05161  Hepatitis B
oga05162  Measles
oga05163  Human cytomegalovirus infection
oga05164  Influenza A
oga05165  Human papillomavirus infection
oga05166  Human T-cell leukemia virus 1 infection
oga05167  Kaposi sarcoma-associated herpesvirus infection
oga05168  Herpes simplex virus 1 infection
oga05169  Epstein-Barr virus infection
oga05170  Human immunodeficiency virus 1 infection
oga05171  Coronavirus disease - COVID-19
oga05200  Pathways in cancer
oga05203  Viral carcinogenesis
oga05205  Proteoglycans in cancer
oga05206  MicroRNAs in cancer
oga05207  Chemical carcinogenesis - receptor activation
oga05208  Chemical carcinogenesis - reactive oxygen species
oga05210  Colorectal cancer
oga05211  Renal cell carcinoma
oga05212  Pancreatic cancer
oga05213  Endometrial cancer
oga05214  Glioma
oga05215  Prostate cancer
oga05218  Melanoma
oga05220  Chronic myeloid leukemia
oga05221  Acute myeloid leukemia
oga05222  Small cell lung cancer
oga05223  Non-small cell lung cancer
oga05224  Breast cancer
oga05225  Hepatocellular carcinoma
oga05226  Gastric cancer
oga05230  Central carbon metabolism in cancer
oga05231  Choline metabolism in cancer
oga05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oga05415  Diabetic cardiomyopathy
oga05417  Lipid and atherosclerosis
oga05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oga00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100949858 (PIK3R1)
   04014 Ras signaling pathway
    100949858 (PIK3R1)
   04015 Rap1 signaling pathway
    100949858 (PIK3R1)
   04370 VEGF signaling pathway
    100949858 (PIK3R1)
   04630 JAK-STAT signaling pathway
    100949858 (PIK3R1)
   04668 TNF signaling pathway
    100949858 (PIK3R1)
   04066 HIF-1 signaling pathway
    100949858 (PIK3R1)
   04068 FoxO signaling pathway
    100949858 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    100949858 (PIK3R1)
   04072 Phospholipase D signaling pathway
    100949858 (PIK3R1)
   04071 Sphingolipid signaling pathway
    100949858 (PIK3R1)
   04024 cAMP signaling pathway
    100949858 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    100949858 (PIK3R1)
   04152 AMPK signaling pathway
    100949858 (PIK3R1)
   04150 mTOR signaling pathway
    100949858 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100949858 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100949858 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    100949858 (PIK3R1)
   04218 Cellular senescence
    100949858 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100949858 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100949858 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100949858 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100949858 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    100949858 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    100949858 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    100949858 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    100949858 (PIK3R1)
   04660 T cell receptor signaling pathway
    100949858 (PIK3R1)
   04662 B cell receptor signaling pathway
    100949858 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    100949858 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    100949858 (PIK3R1)
   04670 Leukocyte transendothelial migration
    100949858 (PIK3R1)
   04062 Chemokine signaling pathway
    100949858 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100949858 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    100949858 (PIK3R1)
   04929 GnRH secretion
    100949858 (PIK3R1)
   04915 Estrogen signaling pathway
    100949858 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    100949858 (PIK3R1)
   04917 Prolactin signaling pathway
    100949858 (PIK3R1)
   04926 Relaxin signaling pathway
    100949858 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    100949858 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    100949858 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100949858 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100949858 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    100949858 (PIK3R1)
   04722 Neurotrophin signaling pathway
    100949858 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100949858 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    100949858 (PIK3R1)
   04380 Osteoclast differentiation
    100949858 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    100949858 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    100949858 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100949858 (PIK3R1)
   05206 MicroRNAs in cancer
    100949858 (PIK3R1)
   05205 Proteoglycans in cancer
    100949858 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    100949858 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100949858 (PIK3R1)
   05203 Viral carcinogenesis
    100949858 (PIK3R1)
   05230 Central carbon metabolism in cancer
    100949858 (PIK3R1)
   05231 Choline metabolism in cancer
    100949858 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100949858 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100949858 (PIK3R1)
   05212 Pancreatic cancer
    100949858 (PIK3R1)
   05225 Hepatocellular carcinoma
    100949858 (PIK3R1)
   05226 Gastric cancer
    100949858 (PIK3R1)
   05214 Glioma
    100949858 (PIK3R1)
   05221 Acute myeloid leukemia
    100949858 (PIK3R1)
   05220 Chronic myeloid leukemia
    100949858 (PIK3R1)
   05218 Melanoma
    100949858 (PIK3R1)
   05211 Renal cell carcinoma
    100949858 (PIK3R1)
   05215 Prostate cancer
    100949858 (PIK3R1)
   05213 Endometrial cancer
    100949858 (PIK3R1)
   05224 Breast cancer
    100949858 (PIK3R1)
   05222 Small cell lung cancer
    100949858 (PIK3R1)
   05223 Non-small cell lung cancer
    100949858 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100949858 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    100949858 (PIK3R1)
   05161 Hepatitis B
    100949858 (PIK3R1)
   05160 Hepatitis C
    100949858 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    100949858 (PIK3R1)
   05164 Influenza A
    100949858 (PIK3R1)
   05162 Measles
    100949858 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    100949858 (PIK3R1)
   05163 Human cytomegalovirus infection
    100949858 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100949858 (PIK3R1)
   05169 Epstein-Barr virus infection
    100949858 (PIK3R1)
   05165 Human papillomavirus infection
    100949858 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100949858 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    100949858 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100949858 (PIK3R1)
   05142 Chagas disease
    100949858 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100949858 (PIK3R1)
   05017 Spinocerebellar ataxia
    100949858 (PIK3R1)
   05020 Prion disease
    100949858 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100949858 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    100949858 (PIK3R1)
   05415 Diabetic cardiomyopathy
    100949858 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100949858 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    100949858 (PIK3R1)
   04931 Insulin resistance
    100949858 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100949858 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100949858 (PIK3R1)
   01524 Platinum drug resistance
    100949858 (PIK3R1)
   01522 Endocrine resistance
    100949858 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oga04131]
    100949858 (PIK3R1)
Membrane trafficking [BR:oga04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100949858 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 SH3_9 Laminin_I Exonuc_VII_L
Other DBs
NCBI-GeneID: 100949858
NCBI-ProteinID: XP_003785930
LinkDB
Position
Unknown
AA seq 727 aa
MANMSAEGYQYRALYDYKKEREEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLN
GYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADIEHQALTLPD
LAEQFAPPDVAPLLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDTTSVDLEMI
DVHILADAFKRYLLDLPNPVIPVAIYSEMISLAPEIQSSEEYIQLLKKLIRSPNIPHQYW
LTLQYLLKHFFKLSQAASKNLLTARALSEIFSPMLFRFPALSSDNTEHLIKVIEILISTE
WNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLV
RDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYN
PKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEI
QMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISE
IIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEW
LGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCY
ACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP
VYAQQRR
NT seq 2184 nt   +upstreamnt  +downstreamnt
atggcaaacatgagtgccgaggggtaccagtacagagcgctgtatgactataaaaaggag
agagaagaagatattgacttgcacctgggggatgtattgactgtgaataaagggtcctta
gtagctcttggattcagtgacggacaggaagccaggcctgaagaaattggctggctaaat
ggctataatgaaaccacaggggagaggggagactttccaggaacttatgtagaatatatt
ggaaggaagaaaatctcgcctcccacaccaaagccccggccacctcggccccttcctgtt
gcaccaggttcttcgaaaactgaagcagacattgagcatcaagctttgacgctcccggac
cttgccgagcagtttgcccctcctgacgttgccccccttcttcttatcaagctcctggaa
gccatcgaaaagaaaggtctggagtgttcaactctatacaggacacagagctctagcaac
cctgcagaattacgacagcttcttgattgtgatacaacctctgtggacttggaaatgatc
gacgtgcacattttagcagacgctttcaaacgctatctcctggacttgccgaaccctgtc
atcccggtagccatttacagtgaaatgatttctttagccccagaaatacaaagctctgaa
gaatatatccagctattgaagaagctcattaggtcgcccaacatacctcatcagtattgg
ctcacacttcagtatttgttaaaacattttttcaagctctctcaagctgccagcaaaaac
cttctgactgcaagagcgctctcagaaatatttagccctatgcttttccgattcccagca
ctcagctctgataatactgaacacctcataaaagttatagaaattttaatctcaactgaa
tggaatgaacgacaacctgcaccagcattgcctcctaaaccaccaaaacccactactgta
gccaacaacggtatgaataacaatatgtccttacaagatgcagaatggtactggggagat
atctcgagggaagaagtgaatgaaaaacttcgagatacagcagacgggacctttttggta
cgagatgcatctacgaaaatgcatggtgattatactcttacactaaggaaaggaggaaat
aacaaattaatcaaaatatttcaccgagatggaaaatatggcttctctgaccctttaacc
ttcaattctgtggttgaactaataaaccactacaggaatgaatctctggctcagtataat
cccaaattggatgtgaaattactttatccagtatccaaataccaacaggatcaagtcgtc
aaagaagataatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaa
gaaaaaagtcgggaatatgatagattatatgaagaatatacccgtacttcccaggaaatc
caaatgaaaagaacagctattgaagcatttaacgaaaccataaaaatatttgaagaacag
tgccaaacccaggagcggtacagcaaagaatatatagaaaagtttaaacgtgaaggcaat
gagaaagaaatccaaaggatcatgcataattatgataagttaaagtctcgaatcagcgaa
attattgacagcagaagacggctagaggaagatttgaagaagcaggcagctgagtaccga
gagattgacaaacgtatgaacagcatcaaacctgacctcattcagctgagaaagacgaga
gaccaatacctgatgtggttgactcaaaaaggtgttcgacagaagaagttgaacgagtgg
ctgggcaacgaaaacactgaggaccaatattcactggtggaagatgatgaggatttgccc
caccatgacgagaagacatggaacgttgggagcagcaaccgaaacaaagccgaaaacctg
ttgcgagggaaacgggacggcacttttcttgtccgggagagcagtaaacagggttgctac
gcctgctctgtcgtggtggatggtgaagtgaagcattgtgtcataaacaagacagcaact
ggctacgggtttgctgagccctataacctgtacagctctctgaaggaactggtgctacat
taccaacacacctccctcgtgcagcacaacgactccctcaacgtcacactagcctacccg
gtatatgcacagcagaggcgatga

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