Otolemur garnettii (small-eared galago): 100958778 Help Entry 100958778         CDS       T07855                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism oga  Otolemur garnettii (small-eared galago) Pathway oga04022   cGMP-PKG signaling pathway oga04068   FoxO signaling pathway oga04081   Hormone signaling oga04140   Autophagy - animal oga04150   mTOR signaling pathway oga04151   PI3K-Akt signaling pathway oga04152   AMPK signaling pathway oga04211   Longevity regulating pathway oga04213   Longevity regulating pathway - multiple species oga04722   Neurotrophin signaling pathway oga04910   Insulin signaling pathway oga04920   Adipocytokine signaling pathway oga04923   Regulation of lipolysis in adipocytes oga04930   Type II diabetes mellitus oga04931   Insulin resistance oga04932   Non-alcoholic fatty liver disease oga04935   Growth hormone synthesis, secretion and action oga04960   Aldosterone-regulated sodium reabsorption oga05010   Alzheimer disease oga05206   MicroRNAs in cancer oga05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:oga00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     100958778 (IRS1)    04022 cGMP-PKG signaling pathway     100958778 (IRS1)    04151 PI3K-Akt signaling pathway     100958778 (IRS1)    04152 AMPK signaling pathway     100958778 (IRS1)    04150 mTOR signaling pathway     100958778 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     100958778 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     100958778 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     100958778 (IRS1)    04935 Growth hormone synthesis, secretion and action     100958778 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100958778 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     100958778 (IRS1)   09149 Aging    04211 Longevity regulating pathway     100958778 (IRS1)    04213 Longevity regulating pathway - multiple species     100958778 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     100958778 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     100958778 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     100958778 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100958778 (IRS1)    04932 Non-alcoholic fatty liver disease     100958778 (IRS1)    04931 Insulin resistance     100958778 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  100958778 NCBI-ProteinID:  XP_003784942 Ensembl:  ENSOGAG00000031700 UniProt:  H0XJ14 LinkDB All DBs Position Unknown AA seq 1233 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDAAAAPGVGGGGGSCSSSSALGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASIVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSARLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGTSTLTAPN GHYILSRGGNGHRCIPGAGLGTSPALAGDEAACAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERQGGHHR PDTSSLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDLGGGPSSSSSSSAAPSGSSYGKLWTNGVGGHHSQALPHPKPPGESS SGKLLPCTGDYMNMSPVGDSNTSSPSSCYYGPEYPQHKPVLSYYSLPRSFKHTQRPGELE EGARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARQEPGLPHAHHQVLQPHL PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQPLLHPEPKSPGEYVNIEFGSDQ PGYLSGPVASHSSPSVRCPSQLQPIPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRV GPAPPGAASVCRPTRAVPSSRGDYMTMQMGCPRQNYVDTSPVAPVSYADMRTGIAAEVSP PRATTAAPSSSAASASPAAPQGTAELAARSSLLGGPQGPGGMSAFTRVNLSPSCNQSAKV IRADPQGCRRRHSSETFSSKPSATRAANTVPFGGGAVVGSSGGSSSEDVKRHSSASFENV WLKPGELGGAPKEPTQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQAQPPPPPSPHQ PLGSGESSSTRRSSEDLSAYASISFQKQPEARQ NT seq 3702 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggttggctacctgcgc aaacccaagagcatgcacaagcgctttttcgtgctgcgagcggccagcgaggctgggggc ccggcgcgcctggagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgggacgaacacttcgccatcgcagccgacagtgag gccgagcaagacagctggtaccaggctctcctgcagctgcacaaccgtgccaagggccac cacgatgcggctgcagctccaggagtgggaggcggtgggggcagctgcagcagcagctca gccctgggcgaggctggggaggacttgagctatggggatgtgcccccaggacctgccttc aaagaggtctggcaggtgatcctgaagcccaagggcctgggtcagacaaagaacctaatt ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gccgctgccgtggtgctgcagctgatgaacatcaggcgctgcggccactcggagaacttc ttcttcatcgaggtgggccgttccgctgtgacagggcctggggaattctggatgcaggtg gatgactcggtggtggcccagaatatgcatgagaccatcctggaggccatgcgggctatg agtgatgagttccgccctcgcagcaagagccagtcctcatccaactgctccaaccccatc agcgtccccctgcgcaggcaccatctcaacaaccccccacccagccaggtggggctgacc cgccggtcacgcacagagagcatcaccgccacttcccctgccagcatagtgggtgggaag ccaggttcctttcgtgtccgcgcctctagcgacggagaaggcacgatgtcccgcccggcc tctgtggatggtagccctgtgagcccgagcaccaacaggacacatgcccaccggcatcgg ggcagcgcccggctgcaccccccactcaaccacagtcgctccatccccatgccttcctct cgatgctcgccttcagccaccagcccggtcagtctgtcgtccagcagcaccagtggccat ggctccacctcggactgtctcttcccgcggcggtctagcgcttctgtgtctggttccccc agtgatggcggtttcatctcctcggatgagtatgggtctagtccctgcgatttccgaagt tccttccgcagtgtcactccagattccctaggccacaccccaccagcccgtggtgaggag gagctgagcaactatatctgcatgggtggcaaggggacctccaccctgactgcccccaat ggccactacattttgtcccggggtggcaatggccaccgctgcattccgggagctggcttg ggcaccagtccagccttggctggggatgaagcagcctgcgctgcagatctggataatcgg ttccgaaagagaactcactcggcaggcacatcccccaccatttcccaccagaagaccccg tcccagtcatcggtggcttccattgaggagtatacggagatgatgcccgcctacccacca ggaggtggcagtggaggccgcctgccgggccaccggcactccgcctttgtgcccacccac tcttaccctgaggagggtctggaaatgcaccccttggagcgtcaagggggccatcaccgc cccgacacctccagcctccacactgacgatggctatatgcccatgtctccaggggtggcc ccagtgcctggcagcagaaagggcagtggggactatatgcccatgagccccaagagcgtg tctgccccccagcagatcatcaaccccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtcacccagtggcagctgctcccctgaccttggaggtgggcccagc agcagcagcagcagcagtgctgccccctctgggagcagctatgggaagctttggacaaat ggtgttggaggccaccactctcaagccctgccccaccccaaaccccctggggaaagcagc agtggcaagcttttgccttgcacaggggactacatgaacatgtcgccagtgggggactcc aacaccagcagcccctccagctgctactatggccctgagtacccccagcacaagccagtc ctctcctactactcattgccaaggtcatttaagcacacccagcgccctggggagttagag gagggtgcccggcaccagcacctccgcctttcctccagctctggccgccttctctacgct gcagcagcagaagattcttcttcttccaccagcagcgacagcctgggtgggggatactgt ggggctaggcaggagccaggactcccacatgcccaccatcaagtcttgcagccccatctg cctcgaaaagtggacacagctgcacagaccaacagtcgcctggctcggcccacgaggctg tccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcccctg ttacaccctgagcccaagagcccaggagaatatgtgaatattgaatttgggagtgatcag cctggctatttgtctggcccggtggcttcccacagctcaccttcagtcaggtgtccatcc cagctccaaccaattcccagggaggaagagactggcactgaggagtacatgaaaatggac ctggggccaggccgaagggcagcgtggcaggagagcactggtgttgagatgggcagagtg ggcccagcgcctcctggggctgctagtgtttgcaggcccacccgagcagtacccagcagt cgaggtgactacatgaccatgcagatgggttgtcctcgtcagaactacgtggacacctcc ccagttgcccctgtcagctatgctgacatgcggacaggcattgctgcagaggtgagccca ccccgggctaccacagctgctccctcgtcctcagctgcctctgcttcccctgctgcacct caagggacagctgaactggctgctcgctcatccctgctagggggcccccagggacccggg ggtatgagcgccttcacccgggtaaacctcagtcccagctgcaaccagagtgccaaagtg atccgtgcagacccacaagggtgccggaggaggcatagctcggagaccttctcctctaaa cctagtgccacccgggcggccaacaccgtgccctttggaggaggggctgtagtagggagt agtggtggcagcagcagtgaggatgtgaaacgccacagttctgcttcctttgagaatgtg tggctgaagcctggggagcttgggggagcccccaaagaaccaacccaagtgtgtggggct gctgggggtttggagaatggtcttaactatatagacctggatttggtcaaggacttcaag cagcgccctcaggagcgcccccctcaagcgcagcctcccccacccccatcccctcatcag cccctgggcagcggtgagagcagctccacccgccgctccagtgaggatttaagcgcctat gccagcatcagtttccagaagcagccagaggcccgccagtag

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