Oncorhynchus gorbuscha (pink salmon): 124006510 Help Entry 124006510         CDS       T07892                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b   KO K04961   ryanodine receptor 1 Organism ogo  Oncorhynchus gorbuscha (pink salmon) Pathway ogo04020   Calcium signaling pathway ogo04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ogo00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     124006510 (ryr1b)    04020 Calcium signaling pathway     124006510 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ogo01009]     124006510 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ogo04147]     124006510 (ryr1b)    04040 Ion channels [BR:ogo04040]     124006510 (ryr1b) Protein phosphatases and associated proteins [BR:ogo01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      124006510 (ryr1b) Exosome [BR:ogo04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    124006510 (ryr1b) Ion channels [BR:ogo04040]  Voltage-gated cation channels   Ryanodine receptor    124006510 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  124006510 NCBI-ProteinID:  XP_046172523 LinkDB All DBs Position LG19:complement(75265250..75495157) Genome browser AA seq 5081 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVVLQCTASVLKEQIKLCLACEGFGNRLCYLETTSNAQNCPP DLAICAFVLEQSLSVRALQEMLANTVDMSESSQGGGHRTLLYGHAILLRHYHSSMYLSCL TTSRSLTDKLSFDVGLQEDCVGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYASGDLMVDASFMQTLWNMNPVCSGCELAEGFLAGGQVLRLFHGHMDECLAISMPDDG DDKRSTAHYEGGAVCSQARSLWRLEPLRISWSGSHMKCGQSFRVRHITTGRYLCLDEEKG LMVLDPERANTKLSAFSFRVSKEKVEQARKRDVEGMGIPEIKYGESMCFVQHVSTSLWLT YASLDAKAARLGTMKRKAILHQEGHMDDALTVARSQTEESQAARMIFSTTGLFRQFIKGL DSLQGKNKSPVPVPLPLDGVVLSLQDLIFYFRPPEDELEHEEKQTKLRSLRNRQNLFQEE GMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFC DNLDWLVSKLDRLEASSGILEVLHCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLRSLCVCNGVAVRSNQNLITENLFPGRDLLLQTNIVNYVTSVRPNIFLGTCEGSTQYKK WYFEMMVDYVEPFVTATPSHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGHVPRQVASPNQHALAADDVVSCCLDLSVPSISFRVNGHPVQGMFENFNVDGLFFPVI SFSAGVKARLLLGGRHGDFKFLPPPGYAPCYEALLPKDRMRIEPIKEYKHDFDGVRNLLG PTQSLTHTSFTPNPVDTAQIVLPPHLEKIREKLAENIHSLWAITRIEQGWTYGIFRDDNK KLHPCLVDFQTLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKIIKMPKTYIM SNGFKPAPLDLNHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIMNKRNPRL VPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESTGLGLDDVRGDKVRIFRAEKS YAVTSGKWYFEFEAVTTEEMRVGWARPNVRADNELGADELAWVFNGKTAQRWHVGNDPFG RQWQSGDVVGCMIDLTEQNIMFTLNGEMLISDSGSDMAFKDIEIGEGFIPVCTLGLSQVG RINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFAPVPTNHQHIEVSRV DGTVDSAPCLKLTHKTFGSQNANTDMLFLRLSMPVEFDEVFKITAGTTPLTRTMTIHEDE VLEVEPDSEFEVLKKSASKKEQEEKEKEPSVAKETPEIEKDAMSEKGKKRGLFARAKKAA TINPPPTPPLVPRLQQDVVPDDRDDVEIIQNTTTYYYSVRIFAGQEPTGVWIGWVTPDYH MYDPNFDLSKVRNVTLTVGDDKGNIHDSMKHSNCYMVWGGDIGNSSQQARFSQEDTVVGC LVDLATGLMTFTANGKEINTFYQVEPNTKLFPAVFVQPSSQNMVQLELGKLRNIMPISAA MFRSERKNPVPQCPPRLDIQMLTPVIWSRMPNHFLDPEVGRVSERLGWMVECTEPLTMMA LHIPEENRCIDILELSERLDLLKFHFHTLMLYCAVCALGNNRVAHALCSHVDESQLFYAM ENTYLPGPLRSGFYDLLISIHLESAKRARLGTNREFIVPMSAETLSITLYPDAEKASDLP GVGLTTCLRPKLHFSTINFVGTDPDLYTLSPVFPLQELKTKAISMLTEAVLDGSQAMRDP VGGSVEFHFVPILKLISTLLIMGIFNDEDVKHILKMIDPNVFAGKKEEVEEGDEAEDATA KEEGEEVKEKEEEEADDEGVGEEEEEDEELKHLEKEEEGEAEEEEGEKEHEEEEKEKEED GEENVMTEEEVAAIELELEKEEAALEEGLLQMKLPESVKLQMCTLLQYFCDCELRHRVEA IVAYSDQFVNAIQTNQRVRYNLLMQAFSMSAAETARKTREFRSPPQDQVILLTNFKHGPE EEECPVPEETRDTLTEFHTDILIHCGVHIEAEEEEEEVDTSLRGRLGRLMGKVNNLRKKK EVVEEPEEEEEVKPSTLQELISHTMIHWAQEAFIQNPELVRLMFSLLHRQYDGLGELTRA LPKAYAINAISVQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTNCCRFLCYFCRISRQNQRSMFDHLSY LLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEKVVTYLAGCGLQSCPMLLSK GYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGAGL LAAIEEAIKISEDPARDGPTVKKDRRFPMFGGEEQQEENRVHLGNAIMSFYSALIDLLGR CAPEMHLIQACKGEALRIRAILRSLVPIEDLVGVISLSVQIPDYGKDGHTIEPKMSASFV PDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTLAFSTTEMALALNRYLC SAVLPLITKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEECLMSLVKYLR PSMLQHLLRKLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPNGWANFGVSSEEELHLS RKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYSSNTEKKASVDAEGNF DPKPVETTNTIIPEKLDAFINKYAEHTHDKWAFEKIQNNWSYGEVLDENAKTHPMLRPYK TFSEKDKEIYRWPIKESVKAMLAWEWTMEKAQAGEGEKVELKTSTRKISQTAQATYDPSH GYSPSPVDITAMALSRELQSMAEQLAENYHNTWGRKKKMELMGKGGGSHPLLVPYDTLTA KEKARDREKAQDLLKFLQLNGYAVTRGPKDMEQDISSIEKRFAYGFLQKLLKWMDIAQEF IAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKLLGSGGHSSN KEKEMIASIFCKLAALVRHRVSLFGTDAGAVVNCLHILSRSLDARTVMKSGPEIVKAGLR QFFESAADDIEKMVENLKLGKVSSRNQVKGVSQNINYTTIALLPVLTTLFDHIAQHQFGD DVILDDLQISCYRIMCSIYSLGTVKTPHAEKQRPALGECLANLAAAMPVAYLEPGLNEYN AYSVYTTKTPRERGILGLPSQVEELCTDIPELDVLMKEIGDLAESGARYTEMPHVIEITL PMLCNYLPRWWERGLENYPDLDGQLCTDVTSEQLNQLLGNIMKIVVNNLGIDEASWMKRL AVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEEQLRLEGKSEVDSEEGTIRDEF AVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSKSHNFKREEQNF VVMNEINNMSFLTADSKSKMSKAGGEEAGGSDVERTKKKRRGDRYSVQTSLIVAALKKML PIGLNMCSPADQELINLAKIRYSLKDTDEEVREFLQNNMHLQGKVEDPSMRWQMALYKET SGKAEDAEDPEKVVKRVQEVSAVLYHIEVTEHPYKSKKMVWHKLLSKQRRKAVVACFRMS PLYNIPRHRGSNMFLNGYKRNWLQTEGYQFEDRMIDDLSKAMEEEELGEEGEEEAETKPD PLHQLILHFSRTALTEKSKLEVDYLYMAYADIMAKSCHIGEEEEGEEEEAFEVTQTEMEK EMEKQRLLYQQSRLHNRGAAEMVLQMISACRGTGLRPSSTLKLGISILNTGNCDVQQRML DYLKDKKDVGFFLSIQALMQTCSVLDLNAFERQNKAEGLGMVSEEGSNMKLERDEKVMAD DEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFYWYY SGKDIIDEPGKRNFSKAMIVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA HMMMKLAQSCKDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSN VEMILKFFDMFLKLKDITGSDAFRDYVTDPRGLISKKDFYKAMDSQKQYSPSEIQFLLSC SEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVLNYF RPFLGRIEIMGASRKIERIYFEISEANRNQWEMPQVRESKRQFIFDVVNEGGESEKMELF VNFCEDTIFEMNIASQISEEEEEEVVDSEDEEEEGGGGGGELDENGEEIAPESSSAFSDF LTSVANFFNMFTFRNLRRRYRKLRKMTLKDMVVGVATFIYTILFGILSFIYSVCKGFFML IWSTLFGGELVEGAKKITVTELLASMPDPTQDEVHDELPPEPGADEGQEGIDGGEERDVG GGEEGEEGGDGEEKEGGRMPGFDTPGGLGDFGETTTVEPPTPEGTPLLKRKLLEATSGGE GEEIQEPEPEEETPPEEEKADNENGEKAEKEAEPVVKEEEAEVKEETLKTKAKKEKKPAE EGYELWNELEIQRIKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVGYDVEEGSEDIEG SALFEGSAAFEGSGLFEGSGAVDEGGSGIDPFDDGGDDDGGDDDDEEEGPFFFYLEESTG YMQPCLSMLAIIHTVIAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYVTEQPEDDDI KGQWDRLVLNTPSFPNNYWDKFVKTKVLAKYGDIYGRERIAELLGMDLASLDVSAMTQEK KPEPESGMLSWIISIDIKYQIWKFGVVFTDNTFLYLVWYMVMSLLGHFNNFFFACHLMDI AVGVKDLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNMSEDEDEPDMKC DDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLI IDAFGELRDQQEQVRENMETQCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLI NKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKTYEDQLA NT seq 15246 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggaggagaaggagaggaggagattcagttccttcgcacggatgaccaggtg gtgctacagtgcactgcttctgtcctgaaggagcagatcaaactgtgtctggcctgtgaa ggcttcgggaatcgactatgttacctggagaccacgtccaacgctcagaactgtccacca gatctggccatctgtgccttcgtcctggaacagtccctgtctgtacgtgcgctgcaggag atgctggctaacaccgtggacatgagtgagtcatcccaaggaggaggccaccgcacgctg ctgtacggccatgctatcctgctcagacactaccactctagcatgtatctgagctgcctg acgacgtctcggtcactaacagataagctgtccttcgatgtgggcctgcaagaagactgc gtaggcgaggcgtgttggtggacgattcacccagcgtccaaacagaggtcagagggagag aaggtcagggtaggagatgacctcatcctggtcagcgtctcctcagagagataccttcat ctgtcctatgccagtggtgatctgatggtagatgcgtccttcatgcagactctatggaac atgaaccctgtgtgttcaggctgcgagctggctgagggcttcctggccggaggtcaagtc ctcagactgttccacggtcacatggacgagtgtctggccatctccatgcctgacgacggg gacgacaaacgcagcaccgcccactatgaaggaggagccgtgtgtagccaggcccgttct ttatggagactggagcctctgagaatcagctggagcggcagccacatgaagtgtggccag tcgttccgtgtgcgccacatcaccacgggccgttacctctgtctggacgaggagaagggc ctgatggtcctcgaccctgagagggccaacaccaaactgtctgccttcagcttccgcgtg tcaaaggagaaggtggaacaggctcgtaagcgagacgtggagggaatgggcatcccagag atcaagtatggagagtccatgtgttttgtccagcacgtgtccaccagcctgtggcttacc tacgcctccctggatgctaaggctgctcgcctggggaccatgaagaggaaggccattctg caccaagagggtcacatggacgatgccctgactgtggcccggtcccagacagaggagtct caggctgctaggatgatctttagcaccacaggactcttcaggcagttcatcaagggtctg gactccctgcaggggaagaataagtcccctgtccccgtgcctctacccctggacggggtc gtcctctccctgcaggaccttatcttctacttccgtccccccgaagacgagctggaacac gaggagaaacagacaaagctgcgctccctccgaaaccgacagaacctcttccaagaggag ggtatgatcaccatcgtgctagagtgtatcgaccgtctgaacgtttacaacactgctgct cacttctctgagttcgccggagaggaggccgctgagtcctggaaggagattgtcaacttg ctctatgagctgctggcctctctgatcagggggaaccgttctaactgtgcgctgttctgt gataacctggactggctggtcagcaaactggaccggttggaggcgtcttcaggtatcttg gaggtgttgcactgtgttctgattgagagtccagaggttctgaacatcattcaggagaac cacatcaaatctatcatctctttgctggacaaacatggcagaaaccacaaggtgttggac gtgctccggtctctttgtgtgtgtaacggtgtggctgtaaggtccaatcagaacctcatc acagagaatctatttccaggtcgcgatctcctattgcagaccaacatcgtcaactacgta accagtgtgaggcccaacatcttcctgggaacctgcgaaggctctactcagtataagaag tggtactttgaaatgatggtagactatgtggagccttttgtgacagccacaccctctcac ctgcgtgtgggctgggccctgacggaggggtactccccctatcctgggggcggagagggc tggggtggcaacggagtgggggatgacctctactcgtacggcttcgatggactgcacctg tggtcaggtcacgtcccccgccaggtggcgtctcccaatcagcatgccctagcagctgat gatgtggtgtcgtgctgtctggatctgagcgtgcccagtatctcgttccgggtcaacggt cacccggtccagggcatgttcgagaacttcaacgtggatggactgttcttccccgtcatc agtttctctgctggagtcaaagctcgtttactgttgggtggtcgccatggagactttaag ttcctgccccccccgggctatgctccgtgctacgaggctctgctacccaaggacaggatg aggatcgaacccatcaaggagtacaaacacgactttgacggagtccgaaacttgctgggg ccaacccagtccctcacacacacatcctttaccccaaatcccgtagacactgctcagatc gtgttgccgccccacctggagaagatcagggagaagctggcagagaacatccactcgctg tgggccatcacgcgcatcgagcagggctggacttatggaatattcagagacgacaacaag aagctgcatccctgtctggtcgacttccagacccttcctgaacctgagaggaactacaat ctgcagatgtctggggaaacacttaagactctgctggccctgggctgccatgtgggcatg ggggatgagaaggcagaggagaacctgaagatcatcaagatgccaaagacctatataatg agcaatggatttaagcccgcccccctggatctgaaccacgtcaagctgacgcccaatcaa aaccagctggtggagaagctggcggagaacggtcacaacgtgtgggcacgggaccgcgtg cgccagggctggacgtacagcatcgtgcaggacatcatgaacaagcgtaacccccgtctg gttccttataacctgctggatgagagaaccaagaagaccaaccgagacagcgtcaacaac gctgtgcgcactctcattggctacggatacaacatcgagcctccagaccaggagagcact ggcctcggcctggatgacgtgcggggggataaggtacgtatcttccgtgctgagaagtcc tacgcggtcacgtctgggaagtggtactttgagtttgaggcggtgacgaccgaagagatg agagtgggctgggcccgacccaacgtcagggctgacaatgagctgggagcagacgagctg gcctgggtcttcaacggaaaaacggcccagcgctggcacgtgggcaatgacccgtttggt cgccagtggcagtcgggtgacgtggtggggtgcatgatcgacctgaccgaacaaaatatc atgttcaccctgaacggagagatgctcatcagcgactctggctcagacatggctttcaag gacatcgagataggggaaggcttcatcccagtgtgcaccctgggcctgtcccaggtgggc aggatcaacctgggtcagaacgtcagcagtctgcgctacttcgccatctgtggtctccag gagggcttcgaaccatttgccatcaacatgaagagagacattaccatgtggttcagcaag agcctgccacagttcgcccctgtgccaactaaccaccaacacattgaggtgtcccgcgtg gacgggacagtggacagcgctccctgcctgaagctgacccacaagacgttcggctcccag aatgccaacactgacatgctgttcctccgcctgagcatgcccgtggagtttgacgaggtc ttcaagatcacagccgggaccacgccgctgacccgcactatgaccatccacgaggacgag gttctggaggtggagccggactctgagtttgaggttctgaagaagtcggccagtaagaag gagcaggaagagaaggaaaaggaaccatctgtcgccaaggagacgcccgagatagagaag gacgcgatgtcagagaagggcaagaagagagggttgtttgctagggctaagaaggcagct accatcaaccctcccccaacccctcccttggtgccacggttacagcaggacgtggtccca gatgacagagatgatgtggagattatccagaataccaccacgtactactactcggtgaga atcttcgctggccaggagcccactggggtgtggatcggctgggtaacccccgactaccac atgtacgaccccaactttgacctctccaaggtccggaacgtcaccttgaccgttggagac gacaagggcaacatccacgacagtatgaagcatagtaactgctacatggtgtggggagga gacatcggcaacagctcccagcaggccaggttcagccaggaggacactgtggttggctgc ctggtcgacctggcaacaggcctcatgacattcacagccaatgggaaggagataaacacc ttctaccaggtggagcccaacacaaagctgtttcctgctgtgttcgtccagccctccagt cagaacatggtacagctggagctggggaaactcaggaacatcatgccaatctcagcagcc atgttccgcagtgagcgtaagaacccagtgccccagtgtcctcctcggctggacattcag atgctgacccccgtcatctggtcccgcatgcccaaccacttcctggacccagaggtcggc agggtcagcgagaggctgggctggatggtggagtgtaccgaacccctcaccatgatggcc ctgcacatacctgaggagaacaggtgtatagacatcctggagttgtctgagcgcctggat ctgctgaagttccacttccatactctgatgttgtactgtgctgtctgcgctctgggcaac aaccgtgtagcacacgccctctgctcgcacgttgacgaatcacagctcttctacgccatg gagaacacctacctgcccggtccccttcgcagcgggttctacgacctgctgatctccatc cacctggagtcagctaaacgggcacggctgggtaccaaccgggagttcattgtgcccatg tccgccgagaccctcagcatcaccctgtaccctgacgctgagaaggcctctgaccttcct ggggtggggttaactacctgtcttagacccaagctgcacttctcaaccatcaactttgtt gggacggatcctgacctgtacactctcagccccgtcttccctcttcaggaactgaagacg aaagccatcagcatgttgacagaggcggttctggatggtagccaggctatgagagaccca gtagggggcagcgtagagttccacttcgtcccaatcctgaagctcatcagcactctcctc atcatgggcatcttcaacgatgaagacgtcaaacacatcctcaagatgatcgaccccaat gtgttcgctgggaagaaagaggaggtggaggagggagacgaggcagaggatgctaccgcc aaggaagagggtgaagaagtgaaggagaaagaagaggaggaggcagatgatgaaggagta ggggaggaggaagaagaggatgaggaactgaaacacctcgagaaagaagaggagggggag gcggaggaggaggaaggggagaaggaacacgaggaggaggagaaggagaaagaggaagac ggggaggaaaatgtgatgacagaagaggaggtagcggcgatcgagttggagctggagaag gaagaggcggctttggaggagggactactgcagatgaaactaccagagtctgtcaaactg cagatgtgtacgctgctgcagtacttctgtgactgtgaactgaggcacagagtggaggct atcgtggcgtactcggatcagtttgtcaacgccattcagaccaatcagagagttcgctat aacctgctgatgcaggccttctccatgagcgctgccgagaccgcacgcaagacacgagag ttccgctccccacctcaagaccaggtgattctgctgactaacttcaagcatggtccagag gaggaggagtgcccagtaccggaggagaccagagacacactgaccgaattccacactgac atccttatacattgtggcgtgcacatcgaggcggaagaggaggaggaggaggtggacacc tctctgagagggcgccttggccggctgatgggcaaggtgaataacttgaggaagaaaaag gaggtggtggaggagccagaagaggaggaggaggtcaaacccagcactctccaggagttg atctcccataccatgatccactgggcccaagaggccttcattcagaaccctgagctggtg cgtctgatgttcagcctgctccacaggcagtatgatgggctgggagagctgaccagagcc ctgccgaaagcctacgccatcaacgccatatctgtccaggacacaatggacttgttggag tgcttgggccagatcagatctctgctcatcgttcagatgggccccgaggaggagaggctc atgatccagagcatcgggaacataatgaacaacaaggtgttctaccagcaccctaacctg atgagggctctggggatgcatgagactgtcatggaggtgatggttaacgtgctgggagga ggtggggattccaaggagatccggttcccccagatggtgaccaactgctgtcggttcctg tgttacttctgtcgcatcagccgtcagaaccagaggtccatgtttgatcacctcagctac ctgctgcagaacagcggcatcggtctaggtatgcgtggctccacccctctggatgtggct gcagcttcctgcatcgacaacaacgagctggccttagctctacaggagcaggacttggag aaggtggtgacctatctggcgggctgtggactacagagctgtcccatgctcctatctaag ggctaccctgacatcggctggaatccctgtgggggagagaaatacctcgacttcctgcgc tttgccgtctttgtcaacggagagagtgtggaggagaatgccaacgtggtggtgcgtcta ctgattcgtcggccagagtgttttggccccgccctgagaggagaggggggtgctggtctg ctggcggcaatagaggaggccatcaagatctcagaggacccggccagggacggacctact gtcaagaaggacaggcggttccccatgtttggtggtgaggagcagcaagaggagaaccgc gtccatcttggaaacgccatcatgtccttctactctgccctcatcgatctgctgggacgc tgtgcacctgagatgcacttgatccaggcgtgtaaaggtgaggctctgaggatccgggcc atcctgagatctctggttcctatagaagacctggttggagtcatcagtctgtctgtacag atacctgactacgggaaagatggtcacaccatagagcctaagatgtctgcgagctttgtc ccggaccacaaggcgtccatggtgctgttcctggaccgtgtgtatggtatcgacaaccag gacttcctgcttcatgttctggaggtgggcttcctgccagacatgagagctgccgcatcc ctggacacgctggcattcagcaccacagagatggctctggctctgaaccgctacctgtgt tccgctgtgctgcccctcatcaccaagtgtgcccctctgttcgcgggcaccgaccaccgc gccatcatgattgactccatgttgcacaccatctataggctgtcccgcgggcgagccctc accaaggctcagagagacgtcatcgaggagtgcctcatgtccctcgtcaagtaccttcga ccttccatgctgcagcatctgctgaggaagctggtgtttgacgtgccaatactcaacgag tttgctaagatgcctctgaagctcctgaccaatcactatgagcgttgttggaagtactac tgcctgcctaacggttgggccaactttggggtgtcgtcagaggaggagctgcacctgtcg cggaaactcttctggggaatcttcgagtctctggcgcacaagaaattcgatgccgagctg tttaagatcgccatgccatgtatctgtgccatcgctggcgccatcccccctgactatgtg gacgccagctactcctccaacacggagaagaaggcttcggtggacgccgaggggaacttt gaccccaaacccgtggagaccaccaacaccattatcccagagaagctggatgccttcatc aacaagtatgcagaacacactcacgacaagtgggccttcgaaaagatccagaacaactgg tcgtacggagaggtgctggatgaaaacgccaagacacaccccatgctgcgtccctacaag actttttccgagaaggacaaggagatctaccgttggcctatcaaggagtccgttaaggcc atgctggcctgggagtggacgatggagaaggctcaagcaggggagggagagaaggtggag ctgaagacctccacacggaagatctcccagactgctcaggcgacctatgaccccagccat ggctacagcccttcgcctgtggacatcactgccatggcgctgtccagggagctgcagtcc atggctgagcagctggctgaaaactaccacaacacctggggtaggaagaagaagatggag ctgatgggaaaaggtggcggttcccatcccctgctggtaccctatgacaccttgacggct aaggagaaggccagagacagagagaaagcccaggaccttctcaagttcctgcagctcaac ggatacgccgtcactaggggcccgaaggacatggaacaggacatctcctccatagagaag aggtttgcctatggtttcctccagaagctactgaagtggatggatattgcccaggagttc attgcccatctggaggctgtggttagcagtggcagagtggagaagtctccacacgaacag gagatcaagttctttgccaaaattctcctgccgctggttaaccaatactttaagaaccac tgcctctacttcctctccacacctgccaagttgctgggcagtggaggccactcctccaac aaggagaaggaaatgatcgccagtatcttctgtaagttggcagctctggtgagacacaga gtatctctctttggaacggatgctggcgcggtggtgaattgtctgcacatcctgtcacga tcactggacgccaggacggtaatgaagtcaggtcctgagattgtgaaggcaggactgcgt cagttctttgagagcgctgcagacgacatagagaagatggtggagaatctgaagctgggc aaggtttctagcaggaaccaggtgaagggtgtgtcccagaacatcaactacaccaccatc gccctgctccctgtcctgaccaccctgttcgaccacatcgcccagcaccagtttggggac gacgtcatcttggatgaccttcagatctcgtgttacaggatcatgtgttccatctactcg ctgggcaccgtgaagacgcctcacgctgagaagcagaggccggctctgggggagtgtctg gctaatcttgccgctgccatgcctgtggcctacctggagcctgggctcaacgagtacaac gcctactctgtgtacaccacgaagacacccagagagagaggcatcctgggcctgcccagc caagtagaggagctgtgtacggacatcccagagctagatgtcctgatgaaggagatcggg gacctggcagagtcaggggctcgctacactgagatgccccacgttatcgagatcaccctg cccatgctgtgtaactaccttccccgttggtgggagagaggtctggagaactaccccgac ctggacggacagctctgtactgacgtcacctcagagcaactcaaccagttgctgggcaac atcatgaagatagtggtgaataatctggggatagacgaagcctcctggatgaaacgcctg gcagtgtttgcccagcccatcgttagcagggccaagcctgagatgttgaagtctcatttc atcccgaccatggagaaactgaagaaacggagtgggaaggtggtggccgaggaggagcag ctgagactggaggggaagtctgaggtggacagtgaggaaggaaccattagggatgagttt gctgttctctgcagagacctctacgctctgtaccctctactgatcagatatgtggataac aacagggctcgatggttgacctgtccagacccagatgctgaggaactcttcaggatggtt ggagaggtgttcatcttctggtccaagtctcataacttcaagcgtgaggagcagaacttt gtggtaatgaatgagatcaacaacatgtctttcctgaccgctgacagcaagagtaagatg agcaaggccggcggggaagaggctggaggttctgatgtggagcgtaccaagaagaagcga aggggggaccgctattcggtgcagacatctctgatcgtagcggcgctgaagaagatgctt cctattggcctcaacatgtgttcccctgctgaccaggaactgattaacctggccaagata cgctacagcctgaaagacacagatgaggaggtgagagagtttctacagaacaacatgcat ctacagggcaaggtggaggacccgtcaatgcgctggcagatggcgctctataaggagacg tcagggaaggctgaggatgctgaggaccccgagaaggtggtcaagagagtccaggaggtg tccgctgtcctctaccacatagaggtgacggagcacccgtacaagtctaagaagatggtt tggcacaagctgctttctaaacaacggcgcaaagctgttgtggcctgcttcaggatgtca cccctctacaacatccccaggcaccgggggtccaacatgttcctgaatgggtacaagagg aattggctgcagactgaaggataccagtttgaagaccgtatgatcgatgacttgtctaaa gccatggaggaggaggagctgggagaagagggagaggaagaggcagaaactaaacctgac cctctgcatcagctcatcctacacttcagccggaccgctctcacggagaagagcaaactg gaagtagactacttatacatggcttatgctgacattatggccaagagttgccacatcggt gaggaggaggaaggggaagaggaggaggcctttgaagtgacccagactgagatggagaag gagatggagaagcagaggctcctgtatcagcagtcacgtctccacaacagaggagctgca gagatggtgctgcagatgatcagtgcctgcagaggtacagggctcagacccagctccacc ctgaagctggggatctcaatcctcaacacaggcaactgtgacgtacaacagaggatgctg gactacctgaaggacaaaaaggatgttggcttcttcctgagtattcaggctctgatgcag acctgcagcgttctagacctgaatgcctttgagagacagaacaaggcagagggccttggt atggtgtcagaggagggatcaaatatgaagcttgaacgtgatgagaaggtcatggcggat gatgagttcacctgtgacctgttccgcttcctgcagctgctctgtgagggacacaacaac gatttccagaactatctgcgtacccagactggcagcaccaccaccatcaacatcatcatc tgcactgtggactacctgctccgtctgcaggagtctatcagtgatttctactggtactac tctgggaaggacatcatagacgagccaggaaagaggaacttctccaaggccatgattgtg gctaaacaggtgttcaacagtctgactgagtatatccagggtccatgtacggggaaccag cagtctttggcccacagcaggttgtgggacgctgtggttggcttcctgcacgtctttgct cacatgatgatgaagctggctcagagttgtaaagactccagtcagattggtctgctgaag gaactcctggacctgcagaaagacatggtggtcatgctgttgtctctactggaaggcaac gtggtgaacggcaccatcgcccgtcagatggtggacatgctggtggagtcctccagtaat gtggagatgatcctcaagttcttcgacatgttcctcaagctgaaggacatcaccgggtct gacgccttcagagactacgtgaccgacccccgaggcctcatctccaagaaggacttctac aaggccatggacagccagaagcagtactctccgtctgagatccagttccttctgtcttgt tccgaggccgacgagaacgagatgatcaactttgaggagtttgccgaccgcttccaggag ccggccaaggacatcggcttcaacattgccgtgctgctcaccaacctgtctgagcacgta ccccacgatacgcgactacagaactttctggagcaagccgagagcgtcctcaactacttt agacccttccttggccggatagagatcatgggagcgagcaggaagatcgagaggatctat tttgagatcagcgaggccaacaggaaccagtgggagatgccgcaggtcagagagtccaag agacagttcatcttcgacgtggtcaacgagggcggggagagcgagaagatggagttgttt gtcaacttctgcgaggacaccatctttgagatgaacatagcctcacagatttctgaggag gaggaagaggaggtggtagactcagaggatgaagaggaagaaggaggaggaggaggagga gagttggacgaaaatggagaagagattgctcccgagtcgagctcggcgttctctgacttc ctgacaagcgtggcgaacttcttcaacatgttcaccttcaggaatctacggcggcgctac cgcaagcttaggaagatgactctgaaggatatggtggtgggcgtggccacgttcatctac accatcctgtttggtatcctgtctttcatctacagtgtgtgtaagggcttcttcatgctg atctggagcaccctgtttggaggagaactggtagagggtgccaagaagatcacggtgact gagcttttggccagtatgccggacccaacgcaagatgaggtgcacgacgaactgccacct gagccaggtgccgatgagggtcaggaggggatagacggaggagaggaaagagacgtggga ggaggagaggaaggagaggagggaggggatggtgaggagaaggagggaggacggatgcct gggttcgacacccctggagggctgggagactttggggagaccacaactgtagagccccct actccagaaggaaccccactgctcaagaggaaactgctggaagcaacgtccggaggagag ggtgaagaaatacaagagccagaaccagaggaagagacacccccagaggaggagaaggct gacaatgagaatggagagaaggcagagaaggaggctgagcccgtggtaaaagaggaagaa gcggaagtgaaggaggaaacattgaagaccaaggcaaagaaggagaagaaacctgcagag gagggctatgagctttggaatgagctggagatccagaggatcaaattcatgaactatctg tctcgtaacttctacaacctgcgcttcctggctctcttcatcgcctttgccctcaacttc atcctgctcttctacaaggttggatatgatgtagaggaggggtcagaagacattgagggc tccgccctgtttgagggatccgccgcgttcgagggttctgggttgttcgagggttccgga gctgtggatgagggcggttctgggattgatccatttgacgatggtggtgatgatgacggt ggcgatgatgatgatgaggaggaaggaccattttttttctacttggaggagagtacaggc tacatgcagccctgtttgtccatgctggccatcatacacactgtcatcgctttcctctgt atcattggatacaactgcctcaaggttcctctggtcatctttaagagggaaaaggagctg gctaggaagctggagtttgatggtctctatgtcaccgagcaaccagaagacgatgacatc aagggacagtgggaccgactggtgctcaacaccccgtcattccctaacaactactgggac aagtttgtgaagacaaaggtgcttgctaagtacggagacatatacggtagggagaggatc gcagagctgcttgggatggacctggcctctctagatgtcagcgccatgacacaagagaag aaacccgaaccagaaagtggcatgttaagctggattatctccattgatatcaaataccag atttggaagttcggggtggtcttcactgacaacacgttcctctatctagtctggtacatg gtcatgtctctgctgggccacttcaacaacttcttcttcgcctgtcacttgatggacatc gccgtcggtgtcaaagatttgcgcaccatcctctcctccgtcacacacaacggcaaacag ctgatgatgacggtgggtctactggctgtggtggtgtatctttacaccgtcgtggcattc aacttcttcaggaagttctacaacatgagcgaggacgaggatgaaccggacatgaagtgt gatgacatgatgacctgttacctgttccacatgtacgtgggtgtgcgtgccggcgggggt ataggagacgagatcgaggacccggcgggcgatgagtacgagctctaccgtgtcgtcttc gacatcaccttcttcttcttcgtaatcgtcatcctgctggctatcatccagggtctgatc attgatgcatttggcgagctgagagaccaacaagagcaggtcagagagaacatggagacg cagtgcttcatctgtggtatcggtagcgactactttgatacaactcctcatggcttcgaa acgcacaccttggaagagcataacttagccaactatatgttcttcctgatgtacctaatc aataaagatgaaacggagcacacaggacaggagtcgtatgtgtggaagatgtatcaagag agatgctgggacttcttccctgctggagactgtttcaggaagacgtatgaggatcagctg gcctag

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