Oncorhynchus keta (chum salmon): 118399867 Help Entry 118399867         CDS       T09424                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b   KO K04961   ryanodine receptor 1 Organism oke  Oncorhynchus keta (chum salmon) Pathway oke04020   Calcium signaling pathway oke04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oke00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118399867 (ryr1b)    04020 Calcium signaling pathway     118399867 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:oke01009]     118399867 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:oke04147]     118399867 (ryr1b)    04040 Ion channels [BR:oke04040]     118399867 (ryr1b) Protein phosphatases and associated proteins [BR:oke01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      118399867 (ryr1b) Exosome [BR:oke04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    118399867 (ryr1b) Ion channels [BR:oke04040]  Voltage-gated cation channels   Ryanodine receptor    118399867 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  118399867 NCBI-ProteinID:  XP_052325230 LinkDB All DBs Position 1:6064372..6365930 Genome browser AA seq 5058 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVVLQCTASVLKEQIKLCLACEGFGNRLCYLETTSNAQNCPP DLAICAFVLEQSLSVRALQEMLANTVDMSESSQGGGHRTLLYGHAILLRHYHSSMYLSCL TTSRSLTDKLSFDVGLQEDCVGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYASGDLMVDASFMQTLWNMNPVCSGCELAEGFLAGGQVLRLFHGHMDECLAISMPDDG DDKRSTAHYEGGAVCSQARSLWRLEPLRISWSGSHMKCGQSFRVRHITTGRYLCLDEEKG LMVLDPERANTKLSAFSFRVSKEKVEQARKRDVEGMGIPEIKYGESMCFVQHVSTSLWLT YASLDAKAARLGTMKRKAILHQEGHMDDALTVARSQTEESQAARMIFSTTGLFRQFIKGL DSLQGKNKSPVPVPLPLDGVVLSLQDLIFYFRPPEDELEHEEKQTKLRSLRNRQNLFQEE GMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFC DNLDWLVSKLDRLEASSGILEVLHCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVSD VWQMFGCLYICRVWIGVSSVVVELPSYVRPNIFLGTCEGSTQYKKWYFEMMVDYVEPFVT ATPSHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGHVPRQVASPNQH ALAADDVVSCCLDLSVPSISFRVNGHPVQGMFENFNVDGLFFPVISFSAGVKARLLLGGR HGDFKFLPPPGYAPCYEALLPKDRMRIEPIKEYKHDFDGVRNLLGPTLSLTHTSFTPNPV DTAQIVLPPHLEKIREKLAENIHSLWAITRIEQGWTYGIFRDDNKKLHPCLVDFQTLPEP ERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKIIKMPKTYIMSNGFKPAPLDLNHVK LTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIMNKRNPRLVPYNLLDERTKKTNR DSVNNAVRTLIGYGYNIEPPDQESTGLGLDDVRGDKVRIFRAEKSYAVTSGKWYFEFEAV TTEEMRVGWARPNVRADNELGADELAWVFNGKTAQRWHVGNDPFGRQWQSGDVVGCMIDL TEQNIMFTLNGEMLISDSGSDMAFKDIEIGEGFIPVCTLGLSQVGRINLGQNVSSLRYFA ICGLQEGFEPFAINMKRDITMWFSKSLPQFAPVPTNHQHIEVSRVDGTVDSAPCLKLTHK TFGSQNANTDMLFLRLSMPVEFDEVFKITAGTTPLTRTLTIHEDEVLEVEPDSEFEVLKK SASKKEQEEKEKEPSVAKETPEIEKDAMSEKGKKRGLFARAKKAATINPPPTPPLVPRLQ QDVVPDDRDDVEIIQNTTTYYYSVRIFAGQEPTGVWIGWVTPDYHMYDPNFDLSKVRNVT LTVGDDKGNIHDSMKHSNCYMVWGGDFGNSSQQARFSQEDTVVGCLVDLATGLMTFTANG KEINTFYQVEPNTKLFPAVFVQPSSQNMVQLELGKLKNIMPISAAMFRSERKNPVPQCPP RLDIQMLTPVIWSRMPNHFLDPEVGRVSERLGWMVECTEPLTMMALHIPEENRCIDILEL SERLDLLKFHFHTLMLYCAVCALGNNRVAHALCSHVDESQLFYAMENTYLPGPLRSGFYD LLISIHLESAKRARLGTNREFIVPMSAETLSITLYPDAEKASDLPGVGLTTCLRPKLHFS TINFVGTDPDLYTLSPVFPLQELKTKAISMLTEAVLDGSQAMRDPVGGSVEFHFVPILKL ISTLLIMGIFNDEDVKHILKMIDPNVFAGKKEEVEEGDEAEDATAKEEGEEVKEKEEEEA DDEGVGEEEEEDEELKHLEKEEEGEAEEEEGEKEHEEEEKEKEEDGEENVMTEEEVAAIE LELEKEEAALEEGLLQMKLPESVKLQMCTLLQYFCDCELRHRVEAIVAYSDQFVNAIQTN QRVRYNLLMQAFSMSAAETTRKTRGFRSPPQDQVILLTNFKHGPEEEECPVPEETRDTLT EFHTDILIHCGVHIEAEEEEEEVDTSLRGRLGRLMGKVNNLRKKKEVVEEPEEEEEVKPS TLQELISHTMIHWAQEAFIQNPELVRLMFSLLHRQYDGLGELTRALPKAYAINAISVQDT MDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMV NVLGGGGDSKEIRFPQMVTNCCRFLCYFCRISRQNQRSMFDHLSYLLQNSGIGLGMRGST PLDVAAASCIDNNELALALQEQDLEKVVTYLAGCGLQSCPMLLSKGYPDIGWNPCGGEKY LDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGAGLLAAIEEAIKISEDPA RDGPTVKKDRRFPMFGGEEQQEENRVHLGNAIMSFYSALIDLLGRCAPEMHLIQACKGEA LRIRAILRSLVPIEDLVGVISLSVQIPDYGKDGHTIEPKMSASFVPDHKASMVLFLDRVY GIDNQDFLLHVLEVGFLPDMRAAASLDTLAFSTTEMALALNRYLCSAVLPLITKCAPLFA GTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEECLMSLVKYLRPSMLQHLLRKLVFDV PILNEFAKMPLKLLTNHYERCWKYYCLPNGWANFGVSSEEELHLSRKLFWGIFESLAHKK FDAELFKIAMPCICAIAGAIPPDYVDASYSSNTEKKASVDAEGNFDPKPVETTNTIIPEK LDAFINKYAEHTHDKWAFEKIQNNWSYGEVLDENAKTHPMLRPYKTFSEKDKEIYRWPIK ESVKAMLAWEWTMEKAQAGEGEKVELKTSTRKISQTAQATYDPSHGYSPSPVDITAMALS RELQSMAEQLAENYHNTWGRKKKMELMGKGGGSHPLLVPYDTLTAKEKARDREKAQDLLK FLQLNGYAVTRGPKDMEQDISSIEKRFAYGFLQKLLKWMDIAQEFIAHLEAVVSSGRVEK SPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKLLGSGGHSSNKEKEMIASIFCKLAA LVRHRVSLFGTDAGAVVNCLHILSRSLDARTVMKSGPEIVKAGLRQFFESAADDIEKMVE NLKLGKVSSRNQVKGVSQNINYTTIALLPVLTTLFDHIAQHQFGDDVILDDLQISCYRIM CSIYSLGTVKTPHAEKQRPALGECLANLAAAMPVAYLEPGLNEYNAYSVYTTKTPRERGI LGLPNQVEELCTDIPELDVLMKEIGDLAESGARYTEMPHVIEITLPMLCNYLPRWWERGL ENYPDLDGLLCTDVTSEQLNQLLGNIMKIVVNNLGIDEASWMKRLAVFAQPIVNRAKPEM LKSHFIPTMEKLKKRSGKVVAEEEQLRLEGKSEVDSEEGTIRDEFAVLCRDLYALYPLLI RYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSKSHNFKREEQNFVVMNEINNMSFLTAD SKSKMSKAGGEEAGGSDVERTKKKRRGDRYSVQTSLIVAALKKMLPIGLNMCSPADQELI NLAKIRYSLKDTDEEVREFLQNNMHLQGKVEDPSMRWQMALYKETSGKAEDAEDPEKVVK RVQEVSAVLYHIEVTEHPYKSKKMVWHKLLSKQRRKAVVACFRMSPLYNIPRHRGSNMFL NGYKRNWLQTEGYQFEDRMIDDLSKAMEEEELGEEGEEEAETKPDPLHQLILHFSRTALT EKSKLEVDYLYMAYADIMAKSCHIGEEEEGEEEEAFEVTQTEMEKEMEKQRLLYQQSRLH NRGAAEMVLQMISACRGETGAMVSSTLKLGISILNTGNCDVQQRMLDYLKDKKDVGFFLS IQALMQTCSVLDLNAFERQNKAEGLGMVSEEGSNEKVMADDEFTCDLFRFLQLLCEGHNN DFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFYWYYSGKDIIDEPGKRNFSKAMIV AKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIGLLKELL DLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDITGSDAF RDYVTDPRGLISKKDFYKAMDSQKQYSPSEIQFLLSCSEADENEMINFEEFADRFQEPAK DIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVLNYFRPFLGRIEIMGASRKIERIYFEI SEANRNQWEMPQVRESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMNIASQISEEEEE EVVDSEDEEEEGGGGGGELDENGEEIAPESSSAFSDFLTSVANFFNMFTFRNLRRRYRKL RKMTLKDMVVGLATFIYTILFGILSFIYSVCKGFFMLIWSTLFGGELVEGAKKITVTELL ASMPDPTQDEVHDELPPEPGADEGQEGIDGGEERDVGGGDEGEEGGDGEEKEGGRMPGFD TPGGLGDFGETTTVEPPTPEGTPLLKRKLLEATSGGEGEEIQEPEPEEETPPEEEKADNE NGEKAEKEAEPVVKEEEPEVKEETLKTKAKKEKKPAEEGYELWNELEIQRIKFMNYLSRN FYNLRFLALFIAFALNFILLFYKVGYDVEEGSEDIEGSALFEGSALFEGSGLFEGSGAVD EGGSGIDPFDDGGDDDGGDDDDEEEGPFFFYLEESTGYMQPCLSMLAIIHTVIAFLCIIG YNCLKVPLVIFKREKELARKLEFDGLYVTEQPEDDDIKGQWDRLVLNTPSFPNNYWDKFV KTKVLAKYGDIYGRERIAELLGMDLASLDVSAMTQEKKPEPESGMLSWIISIDIKYQIWK FGVVFTDNTFLYLVWYMVMSLLGHFNNFFFACHLMDIAVGVKDLRTILSSVTHNGKQLMM TVGLLAVVVYLYTVVAFNFFRKFYNMSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGD EIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVRENMETQCF ICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCW DFFPAGDCFRKTYEDQLA NT seq 15177 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggaggagaaggagaggaggagattcagttccttcgcacggatgaccaggtg gtgctacagtgcactgcttctgtcctgaaggagcagatcaaactgtgtctggcctgtgag ggcttcgggaatcgactatgttacctggagaccacgtccaacgctcagaactgtccacca gatctggccatctgtgccttcgtcctggaacagtccctgtctgtacgtgcgctgcaggag atgctggctaacaccgtggacatgagtgagtcatcccaaggaggaggccaccgcacgctg ctgtacggccatgctatcctgctcagacactaccactctagcatgtatctgagctgcctg acgacgtctcggtcactaacagataagctgtccttcgatgtgggcctgcaagaagactgc gtaggcgaggcgtgttggtggacgattcacccagcgtccaaacagaggtcagagggagag aaggtcagggtaggagatgacctcatcctggtcagcgtctcctcagagagataccttcat ctgtcctatgccagtggtgatctgatggtggatgcgtccttcatgcagactctatggaac atgaaccctgtgtgttcaggctgcgagctggctgagggcttcctggccggaggtcaagtc ctcagactgttccacggtcacatggacgagtgtctggccatctccatgcctgacgacggg gatgacaaacgcagcaccgcccactatgaaggaggagccgtgtgtagccaggcccgttct ttatggagactggagcctctgagaatcagctggagcggcagccacatgaagtgtggccag tcgttccgtgtgcgccacatcaccacgggccgttacctctgtctggacgaggagaagggc ctgatggtcctcgaccctgagagggccaacaccaaactgtctgccttcagcttccgcgtg tcaaaggagaaggtggaacaggctcgtaagcgagacgtggagggaatgggcatcccagag atcaagtatggagagtccatgtgttttgtccagcacgtgtccaccagcctgtggcttacc tacgcctccctggatgctaaggctgctcgcctggggaccatgaagaggaaggccattctg caccaagagggtcacatggacgatgccctgactgtggcccggtcccagacagaggagtct caggctgctaggatgatctttagcaccacaggactcttcaggcagtttatcaagggtctg gactccctgcaggggaagaacaagtcccctgtccccgtgcctctacccctggacggggtc gtcctctccctgcaggaccttatcttctacttccgtccccccgaagacgagctggaacac gaggagaaacagacaaagctgcgctccctccgaaaccgacagaacctcttccaagaggag ggtatgatcaccatcgtgctagagtgtatcgaccgtctgaacgtttacaacactgctgct cacttctctgagttcgccggagaggaggccgctgagtcctggaaggagattgtcaacttg ctctatgagctgctggcctctctgatcagggggaaccgttctaactgtgcgctgttctgt gataacctggactggctggtcagcaaactggaccggttggaggcctcttcaggtatcttg gaggtgttgcactgtgtcctgattgagagtccagaggttctgaacatcattcaggagaac cacatcaaatctatcatctctttgctggacaaacatggcagaaaccacaaggtcagtgat gtctggcagatgtttggatgtttgtacatctgtagggtctggataggtgttagcagtgta gtggtggaacttccatcatatgtgaggcccaacatcttcctgggaacctgcgaaggctct actcagtataagaagtggtactttgagatgatggtagactatgtggagcctttcgtgaca gccacaccctctcacctgcgtgtgggctgggccctgacggaggggtactccccctatcct gggggcggagagggctggggtggcaacggggtgggggatgacctctactcgtacggcttc gatggactgcacctgtggtcaggtcacgtcccccgccaggtggcgtcgcccaatcagcat gccctagcagctgatgatgtggtgtcgtgctgtctggatctgagcgtgcccagtatctcg ttccgggtcaacggccacccggtccagggcatgttcgagaacttcaacgtagatggactg ttcttccccgtcatcagtttctctgctggagtcaaagctcgtttactgttgggtggtcgc catggagactttaagttcctgccccccccgggctatgctccgtgctacgaggccctgcta cccaaggacaggatgaggatcgaacccatcaaggagtacaaacacgactttgacggagtc cgaaacttgctggggccaaccctgtccctcacacacacctcctttacccccaatcccgta gacactgctcagatcgtgttgccgccccacctggagaagatcagggagaagctggcagag aacatccactcgctgtgggccatcacgcgcatcgagcagggctggacttatggaatattc agagacgacaacaagaagctgcatccctgtctggtcgacttccagacccttcctgaacct gagaggaactacaatctgcagatgtctggggaaacacttaagactctgctggccctgggc tgccatgtgggcatgggggatgagaaggcagaggagaacctgaagatcatcaaaatgcca aagacctatataatgagcaatggatttaagcccgcccccctggatctgaaccacgtcaag ctgacgcccaatcaaaaccagctggtggagaagctggcggagaacggtcacaacgtgtgg gcacgggaccgcgtgcgccagggttggacgtacagcatcgtgcaggacatcatgaataag cgtaacccccgtctggttccttataacctgctggatgagagaaccaagaagaccaaccga gacagtgtcaacaacgctgtgcgcactctcattggctacggatacaacatcgagcctcca gaccaggagagcactggcctcggcctggatgacgtgcggggggataaggtccgtatcttc cgtgctgagaagtcctacgcggtcacgtctgggaagtggtactttgagtttgaggcggtg acgaccgaagagatgagagtgggctgggcccgacccaacgtcagggctgacaatgagctg ggagcagacgagctggcctgggtcttcaatggaaaaacggcccagcgctggcatgtgggc aatgacccgtttggtcgccagtggcagtcgggtgacgtggtggggtgtatgatcgacctg accgaacaaaatatcatgttcaccctgaacggagagatgctcatcagcgactctggctca gacatggctttcaaggacatcgagataggagaaggcttcatcccagtgtgcaccctgggc ctgtcccaggtgggcaggatcaacctgggtcagaacgtcagcagtctgcgctacttcgcc atctgtggtctccaggagggcttcgaaccatttgccatcaacatgaagagagacattacc atgtggttcagcaagagcctgccacagttcgcccctgtgccaactaaccaccaacacatt gaggtgtcccgcgtggacgggacagtggacagcgctccctgcctgaagctgacccacaag acgttcggctcccagaatgccaacactgacatgctgttcctccgcctgagcatgcctgtg gagtttgacgaggtcttcaagatcacagccgggaccacgccgctgacccgcactttgacc atccacgaggacgaggttctggaggtggagccggactctgagtttgaggttctgaagaag tcggccagtaagaaggagcaggaagagaaggaaaaggaaccatctgtcgccaaggagacg cccgagatagagaaggacgcgatgtcagagaagggcaagaagagagggttgtttgctagg gctaagaaggcagctaccatcaaccctcccccaacccctcccttggtgccgcggttacag caggacgtggtcccagatgacagagatgatgtggagattatccagaataccaccacgtac tactactcggtgagaatcttcgctggccaggagcccactggggtgtggatcggctgggta acccccgactaccacatgtacgaccccaactttgacctctccaaggtccggaacgtcacc ttaaccgttggagacgacaagggcaacatccacgacagtatgaagcatagtaactgctac atggtgtggggaggagacttcggcaacagctcccagcaggccaggttcagccaggaggac actgtggttggctgcctggtcgacctggcaacaggcctcatgacattcacagccaatggg aaggagataaacaccttctaccaggtggagcccaacacaaagctgtttcctgctgtgttc gtccagccctccagtcagaacatggtacagctggagctggggaaactcaagaacatcatg ccaatctcagcagccatgttccgcagtgagcgtaagaacccagtgccccagtgcccaccc cggctggacatccagatgctgacccccgtcatctggtcccgcatgcccaaccacttcctg gacccagaggtcggcagggtcagcgagagactgggctggatggtggagtgtaccgagccc ctcaccatgatggccctgcacatacctgaggagaacaggtgtatagacatcctggagttg tctgagcgcctggatctgctgaagttccacttccatactctgatgttgtactgtgctgtc tgcgctctgggcaacaaccgtgtagcacacgccctctgctcgcacgttgacgaatcacag ctcttctacgccatggagaacacctacctgcccggtccccttcgcagcgggttctacgac ctgctgatctccatccacttggagtcagctaaacgggcacggctgggcaccaaccgggag ttcattgtgcccatgtccgccgagaccctcagcatcaccctgtaccctgacgctgagaag gcctctgaccttcctggggtggggttaactacctgtcttagacccaagctgcacttctca accatcaactttgttgggacggatcctgacctgtacactctcagccctgtcttccctctt caggaactgaagacgaaagccatcagcatgttgacagaggcggttctggatggtagccag gctatgagagacccagtagggggcagcgtagagttccacttcgtgcccatcctgaagctc atcagcactctcctcatcatgggcatcttcaacgacgaagacgtcaaacacatcctcaag atgatcgaccccaacgtgttcgctgggaagaaagaggaggtggaggagggagacgaggca gaggatgctaccgccaaggaagagggtgaagaagtgaaggagaaagaagaggaggaggca gatgatgaaggagtaggggaggaggaagaagaggatgaggaactgaaacacctagagaaa gaagaggagggggaggcggaggaggaggaaggggagaaggaacacgaggaggaggagaag gagaaagaggaagacggggaggaaaatgtgatgacagaagaggaggtagcggcgatcgag ttggagctggagaaggaagaggcggctttggaggagggactactgcagatgaaactacca gagtctgtcaaactgcagatgtgtacgctgctgcagtacttctgtgactgtgaactgagg cacagagtggaggctatcgtggcgtactcggatcagtttgtcaacgccattcagaccaat cagagagttcgctataatctgctgatgcaagccttctccatgagcgctgccgagaccaca cgcaagacacgagggttccgttccccacctcaggaccaggtgatcctgctgactaacttc aagcatggtccagaggaggaggagtgcccagtaccggaggagaccagagacacactgacc gaattccacactgacatccttatacattgtggcgtgcacatcgaggcggaagaggaggag gaggaggtggacacctctctgagagggcgccttggccggctgatgggcaaggtgaataac ttgaggaagaaaaaggaggtggtggaggagccagaagaggaggaggaggtcaaacccagc actctccaggagttgatctcccataccatgatccactgggcccaagaggcctttattcag aaccctgagctggtgcgcctgatgttcagcctgctccacaggcagtatgatgggctggga gagctgaccagagccctgcctaaagcctacgccatcaacgctatctctgtccaggacaca atggacttgttggagtgcttgggccagatcagatctctgctcatcgttcagatgggcccc gaggaggagaggctcatgatccagagcatcgggaacatcatgaacaacaaggtgttctac cagcaccctaacctgatgagggctctggggatgcacgagactgtcatggaggtgatggtt aatgtgctgggaggaggtggggattccaaggagatccggttcccccagatggtgaccaac tgctgtcggttcctgtgttacttctgtcgcatcagccgtcagaaccagaggtccatgttt gatcacctcagctacctgctgcagaacagtggcatcggccttggtatgcgtggctccacc cctctggatgtggctgcagcttcctgcattgacaacaacgagctggccttagctctacag gagcaggacttggagaaggtggtgacttatctggcgggctgtggactacagagctgtccc atgctcctgtctaagggttaccctgacatcggctggaatccctgtgggggagagaaatac ctcgacttcctgcgctttgccgtctttgtcaacggagagagtgtggaggagaatgccaac gtggtggtgcgtctactgattcgtcggccagagtgttttggccccgccctgagaggagag gggggtgctggtctgctggcggcaatagaggaggccatcaagatctcagaggacccggcc agggacggacctactgtcaagaaggacaggcggttccccatgtttggtggtgaggagcag caagaggagaaccgcgtccatcttggaaacgccatcatgtccttctactctgccctcatc gacctgctgggacgctgtgcacctgagatgcacttgatccaggcgtgtaaaggtgaggct ctgaggatccgggccatcctgagatctcttgttcctatagaagacctggtgggagtcatc agtctgtctgtacagatacctgactacgggaaagatggtcacaccatagagcctaagatg tctgcgagcttcgtcccggaccacaaggcgtccatggtgctgttcctggaccgtgtgtat ggtatcgacaaccaggacttcctgcttcatgttctggaggtgggcttcctgccagacatg agagctgccgcatccctggacacgctggcattcagcaccacagagatggctctggctctg aaccgctacctgtgttccgctgtgctgcccctcatcaccaagtgtgcccctctgttcgcg ggcaccgaccaccgcgccatcatgattgactccatgttgcacaccatctataggctgtcc cgcgggcgagccctcaccaaggctcagagagacgtcatcgaggagtgcctcatgtccctc gtcaagtaccttcgaccttccatgctgcagcatctgctgaggaagctggtgtttgacgtg ccaatactcaacgagtttgctaagatgcctctgaagctcctgaccaatcactatgagcgt tgttggaagtactactgcctgcctaacggttgggccaacttcggggtgtcgtcagaggag gagctgcacctgtcgcggaaactcttctggggaatcttcgagtctctggcgcacaagaaa ttcgatgccgagctgtttaagatcgccatgccgtgtatctgtgccatcgctggcgccatc ccccctgactatgtggacgccagctactcctccaacacggagaagaaggcttcggtggac gccgaggggaactttgaccccaaacccgtggagaccaccaacaccattatcccagagaag ctagatgccttcatcaacaagtatgcagaacacactcacgacaagtgggctttcgaaaag atccagaacaactggtcgtacggagaggtgctggatgaaaacgccaagacacaccccatg ctgcgtccctacaagaccttctccgagaaggacaaggagatctaccgctggcccatcaag gagtccgttaaggccatgctggcctgggagtggacgatggagaaggctcaagcaggggag ggagagaaggtggagctgaagacctccacacggaagatctcccagactgctcaggcgacc tatgaccccagccatggctacagcccttcgcctgtggacatcactgccatggcgctgtcc agagagctgcagtccatggctgagcagctggctgaaaactaccacaacacctggggtagg aagaagaagatggagctgatgggaaaaggtggcggttcccatcccctgctggtaccctat gacaccttgacggctaaggagaaggccagagacagagagaaagcccaggaccttctcaag ttcctgcagctcaacggatacgccgtcactaggggcccgaaggacatggaacaggacatc tcctccatagagaagaggtttgcctatggtttcctccagaagctactgaagtggatggat attgcccaggagttcatcgcccatctggaggctgtggttagcagtggcagagtggagaag tctccacacgaacaggagatcaagttctttgccaaaattctcctgccgctggttaaccag tactttaagaaccactgcctctacttcctctctacacctgccaagttgctgggcagtgga ggccactcctccaacaaggagaaggaaatgatcgccagtatcttctgtaagttggcagct ctggtgagacacagagtatctctctttggaacggatgctggcgcggtggtgaattgtctg cacatcctgtcacgatcactggacgccaggacggtaatgaagtcaggtcctgagattgtg aaggcaggactgcgtcagttctttgagagcgctgcagacgacatagagaagatggtggag aatctgaagctggggaaggtttctagcaggaaccaggtgaagggtgtgtcccagaacatc aactacaccaccatcgccctgctccctgttctgaccaccctgttcgaccacatcgcccag caccagtttggggacgacgtcatcttggacgaccttcagatctcgtgttacaggatcatg tgttccatctactcgctgggcaccgtcaagacgcctcacgctgagaaacagaggccggct ctgggggagtgtctggctaatcttgccgctgccatgcctgtggcctacctggagcctggc ctcaacgagtacaacgcctactctgtgtacaccacgaagacacccagagagagaggcatc ctgggcctgcccaaccaagtagaggagctgtgtacggacatcccagagctagatgtcctg atgaaggagatcggggacctggcagagtcaggggctcgctacactgagatgccccacgtt atcgagatcaccctgcccatgctgtgtaactaccttccccgttggtgggaaagaggtctg gagaactaccccgacctggacggactgctctgtactgacgtcacctcagaacagctcaac cagttgctgggcaacatcatgaagatagtggtgaataatctggggatagacgaagcctcc tggatgaaacgcctggcagtgtttgcccagcccatcgttaacagggccaagcctgagatg ttgaagtctcatttcatcccgaccatggagaaactgaagaaacgcagtgggaaggtggtg gctgaggaggagcagctgagactggaggggaagtctgaggtggacagtgaggaaggaacc attagggatgagtttgctgttctctgcagagacctctacgctctgtaccctctactgatc agatatgtggataacaacagggctcgatggttgacctgtccagacccagatgctgaggaa ctcttcaggatggttggagaggtgttcatcttctggtccaagtctcataacttcaagcgt gaggagcagaactttgtggtaatgaatgagatcaacaacatgtctttcctgaccgctgac agcaagagtaagatgagcaaggccggcggggaagaggctggaggttctgatgtggagcgt accaagaagaagcgaaggggggaccgctattcggtgcagacatctctgatcgtagcggcg ctgaagaagatgcttcctattggcctcaacatgtgttcccctgctgaccaggaactgatt aacctggccaagatacgctacagcctgaaagacacagatgaggaggtgagagagtttcta cagaacaacatgcatctacagggcaaggtggaggacccgtcaatgcgctggcagatggcg ctgtataaggagacgtcagggaaggctgaggatgctgaggaccccgagaaggtggtcaag agagtccaggaggtgtccgcggtcctctaccacatagaggtgacggagcacccatacaag tctaagaagatggtttggcacaagctgctttctaaacaacggcgcaaagctgttgtggcc tgcttcaggatgtcacccctctacaacatccccaggcaccgggggtccaacatgttcctg aatgggtacaagaggaattggctgcagactgaaggataccagtttgaagaccgtatgatc gatgacttgtctaaagccatggaggaggaggagctgggagaagagggagaggaagaggca gaaactaaacctgaccctctgcatcagctcatcctacacttcagccggaccgctctcacg gagaagagcaaactggaagtcgactacttatacatggcttatgctgacattatggccaag agttgccacatcggcgaggaggaggaaggggaagaggaggaggcctttgaagtgacccag actgagatggagaaggagatggagaagcagaggctcctgtatcagcagtcacgtctccac aacagaggagctgcagagatggtgctgcagatgatcagtgcctgcagaggtgagactggg gcgatggtgtcctccaccctcaagctggggatctcaatcctcaacacaggcaactgtgac gtacaacagaggatgctggactacctgaaggacaaaaaggatgttggcttcttcctgagt attcaggctctgatgcagacctgcagcgttctagacctgaatgcctttgagagacagaac aaggctgagggccttggtatggtgtcagaggagggatcaaatgagaaggtgatggcggat gatgagttcacctgtgacctgttccgcttcctgcagctgctctgtgagggacacaacaac gatttccagaactatctgcgtacccagactggcagcaccaccaccatcaacatcatcatc tgcactgtggactacctgctccgtctgcaggagtctatcagtgatttctactggtactac tctgggaaggacatcatagacgagccaggaaagaggaacttctccaaggccatgattgtg gctaaacaggtgttcaacagtctgactgagtatatccagggtccatgtacggggaaccag cagtctttggcccacagcaggttgtgggacgctgtggttggcttcctgcacgtctttgct cacatgatgatgaagctggctcaggactccagtcagattggtctgctgaaggaactcctg gacctacagaaagacatggtggtcatgctgttgtctctactggaaggcaacgtggtgaac ggcaccatcgcccgtcagatggtggacatgctggtggagtcctccagtaacgtggagatg atcctcaagttcttcgacatgttcctcaagctgaaggacatcaccgggtctgacgccttc agagactacgtgaccgacccccgaggcctcatctccaagaaggacttctacaaggccatg gacagccagaagcagtactctccgtctgagatccagttccttctgtcttgttccgaggcc gacgagaacgagatgatcaactttgaggagtttgccgaccgcttccaggagccggccaag gacatcggcttcaacatcgccgtactgctcaccaacctgtctgagcacgtgccccacgat acgcgactacagaactttcttgagcaagccgagagcgtcctcaactactttagacccttc cttggccggatagagatcatgggagcgagcaggaagatcgagaggatctattttgagatc agcgaggccaacaggaaccagtgggagatgccgcaggtcagagagtccaagagacagttc atcttcgacgtggtcaacgagggcggggagagcgagaagatggagttgtttgtcaacttc tgcgaggacaccatctttgagatgaacatcgcctcacagatttctgaggaggaggaagag gaggtggtagactcagaggatgaagaggaagaaggaggaggaggtggaggagagttggac gaaaatggagaagagattgctcccgagtcgagctcggcgttctctgacttcctgacaagc gtggcgaacttcttcaacatgttcaccttcaggaatcttcgacggcgctaccgcaagctt aggaagatgactctgaaggatatggtggtgggcttggccacgttcatctacaccatcctg tttggtatcctgtctttcatctacagtgtgtgtaagggcttcttcatgctgatctggagc accctgtttggaggagaactggtagagggtgccaagaagatcacggtgactgagcttttg gccagtatgccggacccaacgcaagatgaggtgcacgacgaactgccacctgagccaggt gccgatgagggtcaggaggggatagacggaggagaggaaagagacgtgggaggaggagat gaaggagaggagggaggggatggtgaggagaaggagggaggacggatgcctgggttcgac acccctggagggctgggagactttggggagaccacaactgtagagccccctactccagaa ggaaccccactgctcaagaggaaactgctggaagcaacgtccggaggagagggtgaagaa atacaagagccagaaccagaggaagagacacccccagaggaggagaaggctgacaatgag aatggagagaaggcagagaaggaggctgagcccgtggtaaaagaggaagaaccggaagtg aaggaggaaacattgaagaccaaggcgaagaaggagaagaaacctgcagaggagggctat gagctttggaatgagctggagatccagaggattaaattcatgaactatctgtctcgtaac ttctacaacctgcgcttcctggctctcttcatcgcctttgccctcaacttcatcctgctc ttctacaaggttggatatgatgtagaggaggggtcagaagacattgagggctccgccctg tttgagggctccgccctgttcgagggttctgggttgttcgagggttccggagctgtggat gagggtggttctgggattgatccatttgacgacggcggtgatgatgacggcggcgatgat gatgatgaggaggaaggaccattttttttctacttggaggagagtacaggctacatgcag ccctgtttgtccatgctggccatcatacacactgtcatcgctttcctctgtatcattgga tacaactgcctcaaggttcctctggtcatctttaagagggaaaaggagttggcgaggaag ctggagtttgatggtctgtatgtcaccgagcaaccagaagacgatgacatcaagggacag tgggaccgactggtgcttaacaccccgtcattccctaacaactactgggacaagtttgtg aagacaaaggtgcttgctaagtacggggacatatacggtagggagaggatcgcagagctg cttgggatggacctggcctctctggacgtcagcgccatgacacaagagaagaaacccgaa ccagaaagtggcatgttaagctggattatctccattgatatcaaatatcagatttggaag ttcggggtggtcttcactgacaacacgttcctctatctagtctggtacatggtcatgtct ctgctgggccacttcaacaacttcttcttcgcctgtcacttgatggacatcgccgttggt gtcaaagatttgcgcaccatcctctcctccgtcacacacaacggcaaacagctgatgatg actgtgggtctactggctgtggtggtgtatctttacaccgtcgtggcttttaacttcttc aggaagttctacaacatgagcgaggacgaggatgaaccggacatgaagtgtgatgacatg atgacctgttacctgttccacatgtacgtgggtgtgcgtgccggcgggggtataggagac gagatcgaggacccggcgggcgatgagtacgagctctaccgtgtcgtcttcgacatcacc ttcttcttcttcgtaatcgtcatcctgctggctatcatccagggtctgatcattgatgca tttggcgagctgagagaccaacaggagcaggtcagagagaacatggagacgcagtgcttc atctgtggtatcggtagcgactactttgatacaactcctcatggcttcgaaacgcacacc ttggaagagcataacttagccaactatatgttcttcctgatgtacctaatcaataaagat gaaacggagcacacaggacaggagtcgtatgtgtggaagatgtatcaagagagatgctgg gacttcttccctgctggagactgtttcaggaagacgtatgaggatcagctggcctag

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