Oryzias melastigma (Indian medaka): 112149715 Help Entry 112149715         CDS       T07439                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b isoform X4   KO K04961   ryanodine receptor 1 Organism oml  Oryzias melastigma (Indian medaka) Pathway oml04020   Calcium signaling pathway oml04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oml00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112149715 (ryr1b)    04020 Calcium signaling pathway     112149715 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:oml01009]     112149715 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:oml04147]     112149715 (ryr1b)    04040 Ion channels [BR:oml04040]     112149715 (ryr1b) Protein phosphatases and associated proteins [BR:oml01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      112149715 (ryr1b) Exosome [BR:oml04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    112149715 (ryr1b) Ion channels [BR:oml04040]  Voltage-gated cation channels   Ryanodine receptor    112149715 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  112149715 NCBI-ProteinID:  XP_024133364 LinkDB All DBs Position LG13:2967020..3072485 Genome browser AA seq 5059 aa AA seqDB search MAEGAEGEEEIQFLRTDDLVCLQCSASVQKETIKLCLSCEGFGDRLCFLETTSNAQSVPP DLAICSFILVQSLSVRALQEMLANTVEMTESSQGGGHRTLLYGHAILLRHHHSGMYLSCL TTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYASGDLMVDASFMQTLWSINPISSGCELAEGYLTGGHVLRLFHGHMDECLAIPTPEEG EEKRRMANYEGGAVCSQARSLWRLEPLRISWSGSHMKWGQSFRIRHITTGRYLCLDEEKG LMVVDPEKANTKLSAFCFRVSKEKVEVAQKRDVEGMGIPEIKYGESMCFVQHVSTGLWLT YAALDAKAARLGMMKRRVILHQEGHMDDALTVSRSQTEESQAARMIYSTTGLFRQFIKGL DSLSGKNKSPGTVSLPLAGVILSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQNLFQEE GMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFC DNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIVNYATSVRPNVFLGTCEGSTQYKK WYYEMMVDYVEPFMTAQATHLRVGWAMTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGTVARQVASPNAHTLAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNVDGLFFPVI SFSSGVKARFLLGGRHGEFKFMPPPGYAPCYEAVLPRERMRIEPIKEYKHDFEGVRNLLG PTLSLTHTSFTPCPVDTVQIVLPPHLERIREKLAENIHELWAITRIEQGWTYGQLRDDNK KLHPCLVDFQSLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKIKLPKTYVM TNGYKPAPLDLSHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIVNKRNPRL VPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQEGTGHGLENIRGDKVRIFRAEKS YAVTQGKWYFEFEAVTTGEMRVGWARPSVRSDTELGADELAYVFNGNKAQRWHIGNEPFG RQWLSGDVVGCMIDLTEMNIMFTLNGEMLMSDSGSEMAFKDIEVGEGFIPVCALGLSQVG RINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPTDHNHIEVSRV DGTVDSAPCLKLTHKTFGSQNANTDMMFLRLSMPVQFHETFKIPAGTTPLTRTLTIPEEE VVVVEPDSEFEVLKKSASRKEQEEDKKEPSVPKEVSVENEKDTASEKGKKKGFFSKAKKA AMTPLAPPPAPPTVPRLVEDVVPDDRDDPEIIMDTTTYYYSVRIFAGQEPSAVWVGWVTP DFHQYDQGFDLSKVRNVTVTVGDDRGNIHDSMKHSNCYMVWGGDLVSNQQTRFSQEDMVV GCLVDLATGLMTFTANGKEINTFYQVEPNTKLFPAVFIQPTNQNMAQLELGKLKNIMPIS AAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLNPEVGKISERLGWMVECTEPLIM MALHIPEENRCIDILELSERQDLMKFHYHTLMLYCAVCALGNNRVAHALCSHVDESQLFY AIENTYLPGPLRSGYYDLLISIHLESAKRARLGTNREFIVPMTEETLSIKLYPDTKKSHS LPGVGLTTCLRPKLHFSSINFVGTDPDLYTLSPIFPLQELKTRAISMLTEAVMDGSQAMR DPVGGSVEFHFVPILKLISTLLMIGIFNDEDTMHILKMIDPNVFSGKEEEEEGEKAEEEE AAKEGEAQVEEEEEELEDEGVSEEDEEELKDTEKEEQEGKEAKEEVEEGEKEKAEEPKEG KVDGEKAEEEKEAVEEEAKEEEEAPEEGLLQMKLPESVKLQMCTLLQYFCDCELRHRVET IVAYSDNFVQGVQSNQRVRYNLLMRAFTMSAAETARRTREFRSPPHDQVLLLTNFKNCPE EEDCPVPEEIRDTLTGFHNDILLHCGIHIEEEVEEEEVDTSLRGRLLSLVDKVKNLRKKK EEEEEKPEVEEEPKLSTLQELISHTMIHWAQESFIQNPELVRLMFSLLHRQYDGLGELIR ALPKAYAINAVSVQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGGDSKVIRFPQMVTNCCRFLCYFCRISRQNQRAMFDHLS YLLQNSGIGLGMSGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLAGCGLQMCPMLLS KGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAMEEAIKISEDPARDGPTVKKDRRFMFGGEEQHEENRVHLGNAIMSFYSALIDLLGR CAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPAYGKDGQIIEPKMSASFV PDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFSTTEMALALNRYLC SAVLPLLTKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEECLMSLCKYLR PSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVTSEEELHLS RKLFWGIFESLAHKKFDAELFKIAMPCLCAIAGAIPPDYVDASYSSHTEKKASVDAEGNF DPKPVETTNTIIPERLDAFINKYAEHTHDRWAFEKIQNNWTYGEVLDENAKTHPMLRPYK TFSEKDKEIYRWPIKESIKAMLAWEWTLEKAREGEGEVEKKATSQKMSQTAQATYDPSHG YNPQPIDITGMALSRELQSMAEQLAENYHNTWGRKKKLELQAKGGGTHPLLVPYDTLTAK EKARDREKAQDLLKFLQLNGYAVTRGLKDMEQDISSIEKRFAYGFLQKLLKWMDIAQEFI AHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKVLGSGGHSSNK EKEMIASIFCKLAALVRHRVSLFGTDAGAVVNCLHILSRSLDARTVMKSGPEIVKAGLRQ FFESAADDIEKMVENLKLGKVSSRNQVKGVSQNINYTTTALLPVLTSLFDHIAQHQFGDD VMLDDLQISCYRLMCSIYSLGTVKTPHVEKQRPALGECLAHLAAAMPVAFLEPTLNEFNT FSVYTTKTPRERSILGLPNQVEELCPDIPELEILIKEIHDLSESGARYTEMPHVIEITLP MMCNYLPRWWERGPENFPEQEGQLCTAVTSEHLNQLLGSIMKIVVNNLGIDEASWMKRLA VFAQPIVSRAKPEMLKSHFIPTMEKLKKRSSKVVAEEEHLRMEGKTEVDSENGTIRDEFA VLCRDLYALYPLLIRYVDNSRARWLTCPDPDAEELFRMVGEVFIFWSKSHNFKREEQNFV VMNEINNMSFLTADSKSKMSKAGDGESGGSEQERSKKKKRGDRYSVQTSLIVAALKKMLP IGLNMCSPADQELINLAKIRYSLKDTDEEVREFLHNNLHLQGKVEDPAMRWQMSLYKERS GNTEDAEDPEKVVKRVQEVSAVLYHIEVTEHPYKSKKMVWHKLLSKQRRRAVVACFRMTP LYNIPTHRAINMFLDAYKRNWLENEGYSFEDKMIDDLSKAMEEEEEEEEETERKPDPLHQ LILHFSRTALTEKTKLDVDHLYMSYADIMAKSCHIGEEDEGGDQEGEEPSFEVRQTEMEK EMEKQRLLYQQSRLHNRGAAEMVLQMISACKGEPGVMVSSTLKLGISILNGGNSDVQQKM LDYLKDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAEGLGMVSEEGTNEKVMADDEFTC DLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICTVDYLLRLQESISDFYWYYSGKDI IDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMK LAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFF DMFLKLKDIVASDAFRDYVTDPRGLISKKDFSKAMDSQKQYSPSEIQFLLSCSEADENEM INFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVLNYFRPFLGRIE IIGARRSIERIYFEISEANRNQWEMPQVRESKRQFIFDVVNEGGESEKMEMFVNFCEDTI FEMNIAASISEPEGEPEEEDDEEEEEEAGAVEESGEGEEGNGETHVPESTSAFADFIKSV MNFFHMFTFRNLRRRYRKLRKMTIKEMVIGLVTFIYTVLMGILIFVYNICKGFFTLIWKA LFGGGLVEGAKKMTVTEILASMPDPTQDEVHDELPPEPGAREVQDADGGAELLDAVVGEE EEEDGEEGEGGRLPGFNTPGGLGDFGETTTEEPPTPEGSPLLKRKLLAAATGGQGEEEKV EPEEVPQETEKADIENGEKAEKAEPEPEVKEEEPAKEEEEKEVKTKAKKEKKPAEGGFEL WNELEVQRIKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVSDSPPGEEEFEGSGLFEG SGLFEGSGAEEDGSGLEEGGEDEDEEGPLYYFLEESTGYMEPALAFLSIVHTIISFLCII GYNCLKVPLVIFKREKELARKLEFDGLYVTEQPEDDDIKGQWDRLVLNTPSFPNNYWDKF VKRKVLDKYGDIYGRERIAELLGMDLASLDVSAMTHGKKPEPDTSMFSWITSIDIKYQIW KFGVVFTDNTFLYLVWYMLMSMLGHYNNFFYACHLLDIAMGVKTLRTILSSVTHNGKQLV MTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIG DEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKC FICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERC WDFFPAGDCFRKQYEDQLG NT seq 15180 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggagcagaaggagaagaggagattcagttcctgcgaacggatgacctggtt tgtctccagtgctccgcctcggtccagaaggaaaccattaaactatgtttgtcctgtgaa ggcttcggggaccgtctctgcttcctggaaaccacgtccaacgctcagagcgttccgcca gatctagcaatatgttccttcatcctggtgcagtcgctgtcggtgcgagctctgcaggag atgctggccaacaccgtggagatgacggagtcgtctcaaggtggaggccatcgcacttta ctgtacggacacgccatccttctgaggcaccaccactcaggcatgtacctgagctgtttg accacatctcggtccctcaccgacaagctggcgtttgatgtgggcctgcaagaagactcc acaggtgaggcctgttggtggaccatccatcccgcctccaagcagagatcagaaggtgaa aaggtcagggtgggagacgacctcatcctggtcagcgtgtcgtctgagagatacctgcat ctgtcctacgccagcggagacctgatggtggacgcctccttcatgcagactttgtggagc attaaccccatcagttctggatgtgaactggctgaaggttatctgaccggaggtcacgtc ctccgtctttttcacggtcacatggacgagtgtctggctatcccgactccagaggaaggg gaagaaaaacgcaggatggccaactatgagggcggtgccgtgtgcagtcaggctcgatct ctgtggaggctggagccgctccggatcagctggagcgggagccacatgaagtggggacag tctttccgcattcgccacatcaccacaggtcggtacctgtgtctggacgaggaaaaaggc ctgatggtggttgatccagagaaggccaacaccaaactgtcagcattctgcttccgggtt tcaaaggagaaggtggaagtagctcagaagcgtgacgtggaggggatgggcatcccggag ataaagtatggagagtccatgtgctttgttcagcacgtgtcgacgggcctgtggcttacg tacgccgctctggatgctaaagctgctcgtttaggaatgatgaagaggcgggtcattctg catcaagagggtcacatggacgacgccctcaccgtgtcccgctcccaaactgaagagtct caagctgctcgaatgatctacagcacgacgggcctttttcggcagttcatcaaggggttg gactctctgagcgggaagaacaagtccccgggaaccgtgtctcttcctctggcgggggtc atcctctccctgcaggatctcatcttctactttcggccccccgaggaggagctggagcac gaggagaagcagaccaagctgcgctcgctccgcaaccggcagaacctcttccaggaggag gggatgatcaccatcgttctggagtgcatcgaccgtctcaacgtctacaacactgctgcc cacttctctgagtttgcaggcgaggaggcggcagagtcctggaaggagatcgtcaacctc ctctacgagctgctcgcgtctctgatccgaggaaaccgctccaactgcgctctgttctgt gataacctggactggctggtcagcaagctggaccgtctggaggcctcctcaggaattctg gaggtgctgtactgcgtcctcatcgagagtccagaggttctgaacatcatccaagagaac cacatcaagtccatcatctctctgttggacaagcatgggcggaaccacaaggttctggat gtcttgcgctctctttgtgtgtgtaacggcgtcgccgtgaggtccaaccagaacctcatc actgaaaacctgctgccgggtcgagacctcctgctgcagacaaacatagtgaactacgcc accagtgtgaggcccaacgtctttctgggaacatgtgagggctccacccagtacaagaag tggtactacgagatgatggtggactacgtggagcccttcatgaccgcgcaggcgacacac ctgcgggtgggctgggctatgaccgagggctacagcccctaccctggaggaggtgaaggc tggggaggcaacggcgtcggggacgacctctactcctatggcttcgacgggctgcatttg tggtcaggaaccgtggcgcggcaggtggcttctcccaacgctcacactctggctgcagac gatgtggtcagctgttgtctggatctgagcgtgcccagtatctccttccgaatcaatggc catccagttcagggcatgtttgaaaactttaacgtggacggcctcttctttccagtcatc agcttctcgtctggagtcaaagctcgcttcctgcttggaggtcgccatggagagttcaag ttcatgcccccaccaggctacgctccgtgctacgaggccgtgctgccgagagagaggatg cgcatcgagcccatcaaagagtacaagcatgactttgagggagtgcgcaacctcctgggt cccaccctgtccctcactcacacctccttcaccccctgccccgtagacaccgttcagatt gtgctgccgcctcatttggaacgtattcgagaaaaactggcggagaacattcatgaactg tgggccatcacccggattgagcagggatggacctacggccagttaagagatgacaacaaa aaactgcatccttgtttggtggatttccaaagtttgcctgaaccagaaagaaactacaac ctgcagatgtctggagaaactctcaagactctgctggctttgggttgccatgttggtatg ggagatgaaaaggccgaggagaatctcaagaagatcaagctgcccaaaacatacgtgatg accaacggttacaagccggcccccctcgacctcagccacgtcaaactgacaccaaaccag aatcagctggtggaaaaattggctgaaaatgggcataacgtttgggcgagggaccgagtt cgacaaggatggacctacagcatcgtgcaggacattgtgaataagcggaaccctcgtctt gttccctacaaccttctggacgagagaaccaagaagaccaaccgcgacagcgtcaacaac gcggtccgcaccctcatcggctacggctacaacatcgagcctccagatcaggagggcact ggccatggcctcgagaacatccgcggggacaaagtacgaatcttcagggcagagaagtcg tacgcggtgacccaaggaaagtggtactttgagtttgaggcggtgacgaccggagagatg agggtgggctgggcgcgccccagcgtccggtccgacactgagctgggagcagatgaactg gcctacgtcttcaacggcaataaggctcagaggtggcatattggaaacgagccgtttgga cgccagtggctgtccggggatgtggtcggttgcatgattgatctgacggagatgaacatc atgttcacgctcaacggagagatgctgatgagtgactcgggctctgagatggccttcaaa gatattgaagttggtgaaggtttcatcccagtgtgtgccctgggcctgtctcaggtcgga agaatcaatctgggtcagaacgtcagcagtctccgttattttgccatctgtgggctgcag gagggatttgaaccttttgcgatcaacatgaagcgagacatcaccatgtggttcagtaaa agcttacctcagtttgttcctgtccccacggaccacaatcatatcgaggtgtcccgtgtg gatgggacggtggatagcgccccctgtctgaagctgactcataaaacctttggctcgcag aacgccaacaccgacatgatgttcctcagactcagcatgcccgtccagttccacgagacc ttcaagatcccagccggcaccacgccgctcacgcgcacgctcaccatccctgaggaggag gtggtggtggtggagcccgactccgagtttgaagtcctgaagaaatctgccagccgtaag gagcaggaggaggacaagaaggagccatctgtgcccaaggaggtctccgtggagaacgag aaggacacggcttcagagaaggggaagaaaaaaggatttttctccaaggccaagaaagcc gccatgacacctcttgcccccccacctgcccctccaacggtccctcgtttggtggaagat gtggttcctgatgacagagatgaccctgagatcatcatggacaccaccacctattactac tctgtgaggatttttgctgggcaggagccgtctgccgtgtgggtcggttgggtcacgccc gactttcaccagtacgatcaaggctttgacctctccaaggtgcgaaacgtgacggtaact gtgggagacgacagaggaaacatccacgacagcatgaagcacagcaactgctacatggtt tggggaggagacctggtcagcaaccagcagactcgtttcagccaggaggacatggtggtc ggctgtctggttgacctggcaacgggcctcatgacctttacagccaacgggaaagagatc aacactttctaccaggtggagcccaacaccaagctgttccccgcagtcttcattcagccc accaaccagaacatggctcagctggagctgggaaaactcaagaacatcatgcccatctcg gcggccatgttccgcagcgaacgtaagaaccccgtccctcagtgcccccccaggctggac gtccagatgctcactccggtcatctggagccgcatgcccaaccacttcctcaacccggag gtgggcaagatcagtgaacgcctgggctggatggtggagtgtacagagccgctcatcatg atggcactccacatccccgaggagaacagatgcatcgacatcctggagctgtcggagcgt caggatctcatgaagttccactaccacactctgatgctctactgcgccgtgtgcgctctg gggaacaaccgcgtggcccacgccctgtgcagccacgtggacgagtcccagcttttctac gccatcgagaacacctacctacccggaccgctccgcagcggctactacgacctgctcatc agcattcatctggagtcggccaagcgggcgcggctgggcaccaacagggagttcattgtg cccatgactgaggagaccctcagtatcaagctctatcccgacacgaagaagtcccactct cttccgggcgtcggcctcaccacctgcttacggccaaagctgcatttctcatccatcaat tttgttgggacagatcctgatttgtacaccttgagtccaatatttccacttcaggagctg aaaaccagagctatcagcatgctgacggaggctgtgatggacggaagccaggccatgagg gatcctgtagggggcagcgttgagttccactttgtccccatcttgaagctcatcagcaca ctgttgatgattggtattttcaacgacgaagacaccatgcacatcctcaagatgattgat cccaacgtcttcagtggaaaggaggaggaggaggaaggagagaaagctgaggaggaggaa gccgccaaagagggtgaggcacaggtggaggaggaggaggaggagctcgaggatgagggt gtcagtgaggaggacgaagaagagctgaaagacacagagaaggaagagcaggaagggaaa gaggcgaaggaggaagtggaagaaggggagaaggagaaagcggaagagccaaaggaggga aaagtggatggtgaaaaagcagaggaagagaaggaggcagtggaggaggaagcaaaggag gaggaggaggctccagaggagggactgctccagatgaagcttccggagtccgtcaagctg cagatgtgcacgctcctgcagtacttctgcgactgcgagctccgccaccgcgtggaaacc atcgtggcgtattcggacaactttgtccagggcgttcagagcaaccagcgcgtgcgctac aacctgctgatgagggccttcaccatgtctgccgccgagaccgcccgcaggactcgcgag ttccgctcgccgccgcatgaccaggttctgttgctgaccaacttcaaaaactgtccagag gaagaggactgtcctgttcccgaggagattcgggacactttgacgggtttccataacgac atcctgcttcactgcggcatacatattgaagaggaggtagaggaggaggaggtggacacc tccctgcgaggaagacttctcagcctggtggacaaagtgaagaacttacgcaagaagaag gaggaggaggaggagaagccagaagtggaagaagaaccaaaactcagcactctgcaggag ctcatctcccacaccatgatccactgggcccaggagtccttcatccagaaccccgagctg gtccggctgatgttcagcctgctccacagacagtacgacggcctgggcgagctgatccgc gccctgcccaaagcctacgccatcaacgccgtgtccgtccaggacaccatggacctgctg gagtgtttgggtcagatccgctcgctgctcatcgtgcagatgggtccagaggaggagcgg ctcatgatccagagcatcgggaatatcatgaacaacaaagtgttttaccagcaccccaac ttgatgagagctctgggtatgcatgaaaccgtcatggaggtgatggtcaacgtgttagga ggaggaggagactcaaaggtgatccgattcccccaaatggtgaccaactgctgccgcttc ctgtgttacttctgccggatcagccgacagaaccagcgcgccatgtttgaccatctgagc tacctgctgcagaacagcggcatcggtttgggtatgagtggctccacccctctggacgtg gctgcagcctcctgcatcgataacaacgagctggcgttggctctacaggagcaggacctg gaaatggtggtgacgtacctggctggctgcgggctgcagatgtgtccaatgctcttgtct aaaggatatcctgacattggctggaacccctgtggaggagagagatatctggacttcctt cgctttgctgtctttgtcaacggagagagcgtggaggagaacgccaacgtggtggtgcgg ctgctcatccgtcgccccgagtgcttcggcccggccctgagaggagagggcggcaatggc ctcctggcagctatggaggaggccatcaagatctccgaggacccagcaagagacggtcca acggttaaaaaagacagacggttcatgtttggtggagaggaacagcatgaagagaaccgc gtgcacctgggaaacgccatcatgtccttctactcggctctcattgatctgctcggtcgc tgcgctccagagatgcatctaatccaagcaggaaaaggtgaagctctccgtatcagagcc atcctgaggtccctggtgcccatagaggacctggttggagtcatcagcctgcctgtgcag attcccgcctacggcaaagatggtcagatcattgagccaaagatgtctgccagctttgtg ccggaccacaaggcctccatggtgctgttcctggacagagtgtacggcatcgacaatcag gacttcttgctccacgtgctggaagtcggcttcctgcccgacatgagagctgctgcttct ctggataccgtagcattcagcaccactgagatggccttggcgctcaaccgctacctctgc tcagctgtgctgcctctcctcaccaagtgcgcccccctgtttgcgggaacggaccaccga gccatcatgatcgactccatgcttcacactatttaccgcctgtcccgcggccgcgccctg accaaggcgcagagggacgtcattgaagagtgcctcatgtcgctctgcaagtacctgaga ccctccatgctgcagcacctgctcagacggctggtgtttgatgttcccattctcaatgaa tatgcaaagatgcccctgaagctgctaactaatcactacgagcgctgttggaagtactac tgtctgccaaacggatgggccaacttcggtgtgacctccgaggaggagctgcatctttcc cggaaactcttctggggaatctttgagtcgctggcgcacaagaaatttgatgcagaactt ttcaaaatcgccatgccctgcctgtgcgccatcgccggagccattcctcctgactatgtg gacgccagctactcctctcacactgagaagaaagcctcggtggacgccgagggcaacttt gatcccaaaccagtggagaccaccaacaccatcatcccagagaggctggacgctttcatc aacaaatacgcagaacacactcatgatagatgggcttttgaaaagatccagaacaactgg acctacggagaggtgttagacgagaacgccaagactcaccccatgcttcggccgtacaag accttctctgagaaggacaaggagatctatcgctggcccattaaagagtccatcaaagcc atgctggcctgggagtggaccctggagaaagctagagaaggggaaggagaggtggagaag aaggccacctcacagaagatgtcccaaaccgctcaggcgacctatgaccccagtcatggc tacaaccctcagccaatagacatcacggggatggccctgtccagagagctgcagtctatg gcagagcagctggcagagaactatcacaacacctggggccggaagaagaagctggagctg caggccaaaggggggggcactcatcccctgctggtgccatatgacaccctgacggctaag gagaaggccagagacagggagaaggcccaggacctgctgaagttcctgcagctcaacgga tacgccgtgaccaggggtctgaaggacatggagcaggacatctcctccatcgagaagcgg ttcgcctacggattcctccagaagcttctcaagtggatggacatcgctcaggagtttatc gctcatctcgaggctgtggtcagcagcggtcgcgtggagaagtccccacacgaacaggaa atcaaattctttgccaagatcctcctgccgctggtgaaccagtacttcaagaaccactgc ttgtacttcctgtccacccccgccaaagtcctgggaagtggaggccactcctccaataag gagaaggagatgattgccagtatcttctgtaagttggctgccttggtgaggcacagggtt tctctttttgggacggatgcaggcgccgtggtcaactgtctgcacatcctgtcacgctcg ctggacgccaggactgtgatgaagtcgggacctgagatcgtgaaggctggcctgcgacag ttctttgagagcgcagcagacgacatcgagaagatggtggagaacctgaaactgggcaaa gtttccagccgaaaccaggtcaaaggcgtgtcccagaacatcaactacaccaccaccgct ctgctgcccgtcctcacctcgctgttcgaccacatcgcgcagcatcagtttggagatgac gtcatgctggatgacttgcaaatatcctgctatcggctgatgtgcagcatctactctctg ggaacggtgaagactcctcatgtggagaaacagcgtccagctctgggagagtgtctggcc cacctggccgccgccatgccggtcgccttcctggaaccgacgctgaacgagttcaacaca ttttctgtttacaccaccaagactccccgagagagatccattttgggtcttcccaaccaa gtggaggagctttgccccgacatccccgagctggagatcctcatcaaagagatccacgac ctttcagagtctggagctcggtacacggaaatgccacatgtgatcgagatcacgctcccc atgatgtgcaactacctgccgcgctggtgggagaggggcccggagaacttccccgagcag gagggccagctctgcaccgctgtcacctccgagcatctcaaccagctgctgggcagcatc atgaagatcgtggtcaacaacctgggcatcgacgaagcttcctggatgaagagattagcc gtttttgctcagccaattgtgagcagagcgaaaccagagatgcttaaatcccacttcatc cccaccatggagaagctgaagaagcgctcctcaaaggtagtggctgaggaggaacacctg cgcatggagggcaaaacggaggtggacagtgagaacgggaccattcgggacgagtttgcc gtgctttgccgggatctgtacgcgctctaccctttgctcatccgctacgtggacaacagc agggcaaggtggttgacctgtccagatcctgatgctgaggaacttttcaggatggttgga gaggttttcatcttctggtccaaatcacataacttcaaaagggaggagcagaactttgtg gtgatgaatgagatcaacaacatgtccttcctcactgctgacagcaaaagcaagatgagc aaggccggagacggagagtccggaggctcggagcaggaacgctccaagaagaagaagagg ggggaccgctactccgtgcagacctccctgattgtggcggccctgaagaagatgcttccc atcggcctcaatatgtgctctcctgcggaccaggagctcatcaatctggccaagatcaga tactcactgaaagacacagacgaggaagtgagggagttcctgcacaacaatctgcatctt caggggaaggttgaggacccggctatgcgctggcagatgtctctgtacaaggagcggtct ggaaacaccgaggatgcagaggacccagagaaggtggtgaagagggtgcaagaggtgtca gccgtcctctatcacatcgaggtgaccgagcatccctacaagtccaaaaagatggtttgg cacaagctgctgtccaagcagcgccgcagggcagtggtggcctgcttcaggatgacgcct ctctacaacatccccacgcatcgagccatcaacatgttcttggacgcctacaaacgcaac tggttggagaacgagggttactcgtttgaggacaagatgatcgacgacctgtcaaaagcc atggaggaagaggaggaagaggaagaggagacggagaggaagccggaccccctccaccag ctgattcttcatttcagccgcaccgccctcacggaaaagactaaactggacgtggatcat ctgtacatgtcctacgctgacattatggcaaagagctgccatattggtgaggaggacgaa gggggagatcaggagggggaggagccatcctttgaggtgcgacagacagagatggaaaag gagatggagaaacagaggcttctgtaccagcagtcccgtctgcacaaccgcggggctgca gagatggtgctgcagatgatcagcgcctgcaaaggtgaacctggagtcatggtttcttct actctcaaactgggaatctccatcctcaacggaggcaacagcgatgtgcagcagaaaatg ctggattatctgaaggataagaaggatgtgggcttcttcctgagcgttcaggctctgatg cagacctgcagcgttttggacttgaacgcctttgagaggcagaacaaggcagaaggtctg gggatggtttcagaggagggcaccaacgagaaggtgatggcagatgacgagttcacctgc gacctgttccgcttcctgcagctgctttgtgaaggacacaacaacgacttccagaactac ctgaggacgcagacgggcagcaccaccaccatcaacgtcatcatctgcactgtggactac ctgctgcgactgcaggaatccatcagtgacttttactggtattactctggaaaagacatc attgacgagcccgggaagaggaatttctccaaagcaatgacggtggccaaacaagtcttc aacagcctgacggagtacatccaggggccgtgcactgggaaccagcagtctctggctcac agcagactgtgggacgccgtcgtgggtttcctgcacgtcttcgctcacatgatgatgaaa ctggctcaggattccagtcaaattggacttttgaaggaactgctggatttgcagaaggac atggtggtcatgcttctgtccctactggaaggtaacgttgtgaacggcaccattgccagg cagatggttgacatgttggtggagtcctccagcaatgtggagatgatcctgaagttcttt gacatgttcctcaagcttaaggacatagtggcgtctgacgccttccgtgactatgtaact gacccgcgtgggctcatctccaagaaagacttctccaaagccatggacagccagaagcag tactctccatctgaaatccagttcctcctctcttgctcagaggcagatgagaacgagatg attaactttgaggagtttgcagatcgcttccaggagccggccaaagacattggcttcaac atcgccgttctcctcaccaatttatcggagcacgttcctcacgacactcgccttcagaac ttcctggaacaggccgaaagcgtgctcaactacttccgtcccttcctgggccgcatcgag atcatcggagccagaaggagtatcgagcgcatttactttgagatcagcgaggccaaccgc aaccagtgggagatgccgcaggtcagagagtccaagcggcagttcatcttcgacgtggtc aacgagggcggcgagagcgaaaagatggagatgtttgtgaacttctgcgaggacaccatt tttgagatgaacatcgcggcgtccatctctgagccagagggggaacctgaggaggaagat gatgaggaagaggaggaagaggcgggagcagtggaggagtctggagaaggagaagaagga aacggagagacccacgttcccgagtccacctctgcttttgcagacttcattaagagtgtg atgaacttctttcacatgttcaccttccgtaacctgcggcgccggtaccgcaagctgaga aaaatgaccataaaggagatggtgatcggcctggtgaccttcatctacacggttctgatg ggcatcttgatctttgtctataacatatgtaagggcttcttcacgctcatatggaaagca ctgtttggtggaggcctggtggagggggccaagaagatgacggtcacagagatcctagcc agcatgccagacccgacccaagacgaagtccacgatgagctgccaccggaaccaggagct cgagaggttcaagacgcagatggaggggcagaacttctggatgctgtggtgggagaggag gaggaagaggatggagaggagggcgaaggtggacgtctgccgggtttcaacactcctgga ggacttggagactttggagaaacgacaactgaagagccaccgactccagaggggtcccca ctgctgaagaggaagctgctggctgctgccactggaggacaaggagaggaagaaaaagtt gagcctgaagaagttcctcaggagacggagaaggctgacattgagaatggagagaaggcg gagaaagcagaacctgaaccagaggtgaaggaggaggagccagcgaaagaggaggaggag aaagaagtaaagacgaaggcaaagaaggagaagaaacctgcagaggggggctttgagctg tggaacgagctggaggttcagaggattaagttcatgaattatctttctcgcaatttctac aacctgcgtttcctggctctgttcatcgccttcgccctgaacttcatcctgctcttctac aaggtgtctgacagtcctccaggagaggaggagttcgaaggatctggtctgtttgagggc tctggcttgtttgaaggctctggcgcagaggaggacggctctggcctggaggaaggcggc gaggacgaggacgaagagggccctctgtactacttcttagaggagagcaccggctacatg gagccggccttggccttcctctctatcgtccacacaatcatctccttcctctgcatcatc ggctacaactgtctgaaggttcctctggtcatcttcaagcgagagaaggagctggcccgg aagctggagtttgatggtctgtacgtcacagagcagccggaggacgacgacatcaagggc cagtgggaccgactggtgctcaacactccgagcttccccaacaactactgggacaagttt gtcaagagaaaggttctggacaaatacggagacatttacggcagagagaggattgcagaa ctgctcggcatggacctggcgtctctggatgtcagcgccatgacccacgggaagaaacct gaacccgacacctcgatgttcagctggatcacttccattgacatcaagtaccagatctgg aagtttggtgtcgtcttcaccgacaacactttcctctacctggtctggtacatgctgatg tccatgctgggacactacaacaacttcttctacgcctgccaccttctggacatcgccatg ggggtcaaaacgctccgcaccatcctgtcctcggtcacccacaacggcaaacagctggtg atgacggtgggcctgctggccgtggtggtgtacctctacaccgtggtggccttcaacttc ttccggaagttctacaacaagagcgaggacgaggacgagccggacatgaagtgcgacgac atgatgacgtgctacctcttccacatgtacgtcggcgtccgcgccggtggcggcatcgga gacgagatcgaggacccggccggagacgagtacgagctgtaccgcgtggtctttgacatc accttcttcttcttcgtcatcgtcatcctgctggccatcatccagggtttgatcatcgac gccttcggagagctgagagaccagcaggagcaggtccgggaggacatggagacaaagtgc ttcatctgtgggataggaagcgactactttgacacaacgccgcatggctttgagacgcac accctggaggagcacaacttagccaactacatgttcttcctgatgtatctcatcaacaaa gatgaaaccgaacacaccggccaggagtcgtacgtgtggaagatgtaccaggagcgctgc tgggacttcttccccgccggagactgcttccggaagcagtatgaggaccagctgggataa

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