Oncorhynchus mykiss (rainbow trout): 110509422 Help Entry 110509422         CDS       T07259                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism omy  Oncorhynchus mykiss (rainbow trout) Pathway omy04020   Calcium signaling pathway omy04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:omy00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110509422    04020 Calcium signaling pathway     110509422  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:omy01009]     110509422   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:omy04147]     110509422    04040 Ion channels [BR:omy04040]     110509422 Protein phosphatases and associated proteins [BR:omy01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      110509422 Exosome [BR:omy04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    110509422 Ion channels [BR:omy04040]  Voltage-gated cation channels   Ryanodine receptor    110509422 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  110509422 NCBI-ProteinID:  XP_036824122 Ensembl:  ENSOMYG00000041322 LinkDB All DBs Position Y:31820484..31908546 Genome browser AA seq 5076 aa AA seqDB search MAEGGDGEEEIQFLRTDDQVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLANTTELNESSQGGGHRTLLYGHAILLKHTHSSMYLSCL TTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYASGELMVDASFMQTLWTMNPVMSGCELAEGFLTGGYVLRLFHGHMDECLAIPAAEQG DNQRRIAHYEGGAVCSHARSLWRLEPLRIGWSGGHMKWGQSFRVRHITTGRYLCLDEEKG LMVVDPEKANAKMSAFCFRISKEKVEVVKKRDVEGMGMPEIKYGESMCFVQHVSTGLWLT YASVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEEFQAARMIYNTAGLFTQFIKAL DSLSGKNKSSSGSPSLPMDSVVLSLQDLIFYFQPPEELEHEEKQTRLRSLKNRQNLFQEE GMITLVLDCIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRANCALFC DNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQSNIINYVTSVRPNIFLGTCGGSTQYKK WYFEVMVDHVKPFLTAQAFHLRVGWALTDGYSPYPGGGEGWGGNGVGDDLYSYAFDGLHL WSGRVPRHVATPNMHILAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDGLFFPVV SFSAGVKVRFLLGGRHGDFKFLPPPGYAPCYEAVLPKDRLHIEPIKEYKHDVNGVRNLLG PTQSLSHTAFTPCPVDTAQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGSFRDDNQ KLHPCLVGFQSLPEPERNYNLAMSVETLKTLLALGCHVGMGDEKAEENLKNIKMPKTYMM SSGYKPAPLDLNHVKLTPNQTNLVERLAENGHNVWARDRVHQGWTYSIVQDIMNKRNPRL VPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHGEGHSRGDKIRVFRAERS YAVTQGKWYFEFEAVTVGEMRVGWARPSVRADTELGADELAYVFNGFKAQRWHVGNEPFG RIWLPGDVVGCMIDLVEQNIFFTLNGKMLISDSGSEMAFKDIDIGDGFIPVCSLGLSQVG RLNLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPIPTEHPHVDVSRV DGTVDNAPCLKLTHKTFGSQNANTDLLFLRLSMPVEFHETFKIMAGTTPLTRTLTIPEDQ VLEVDPDSDFEVLKKSASRTEKEEEKEPSVPKDISVNGGENVKDASTEKSKKKGFLFKAK KAALTSPPVVPTMPRLTEEVVPDDRDDDDIILNTTTYYYSVRVIAGQEPSGVWVGWITPD YHQYDLHFDLSKVRNVTVTVGDDKGNIHDSMKRSNCYMVWGGEFSSSQQTRVSQEDFVIG CLIDLDTGLMTFTANGKEINTFYQVEPNTKLFPAVFVLPSSQNMLQVDLGKLKNIMPISA AMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLSPEMGRVNDRHGWMVECREPITMM ALHIPEENRCIDILELSERMDLLKFHYHTLKLYGSVCALGNNRVAHALCSHVDESQLFYA IENTYLPGPMRSGYYDLLISIHLESAKRNRLMTNKEFIVPMTEETLSINLNSDTDKSHAL PGVGLTTCLRPKLHFSPTGFVGADLDIYTLSPFIPLHVLKAKALTMLTEAVQDGGQAMRD PVGGSVEFHFVPILKLISTLLIMGVFDNEDVKHILKMIEPTVFSGEAEAAAQGEGDQTLA LKERGLKVKEEEEGAVESGHETEMEDEGMGEEDEEMEAELEELEPIEKEEDKGEDDGEKG AEETEKEVKHGEAEEQVGLEEGLLHMKLPESVKLQMCTLLQYFCDCELRHRVEAIIAFSD QFVSQLQANQRARYNELMLAYTMTAAETARKTLEFRSPPQEQVNMLMNLKNIAEDEDCPV PDEVRDALQAFHKNLLFHCSVHIEEEEVVEELDMSLKGRLLRMLDKLRHLRKKKVEEEKP EEENKPSTLQELITHTMVHWAQESFIQNPELVRLMFSLLHRQYDGLGELIRALPKAYTIN AISIKDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMSNKVFYQHPNLMRALGMHE TVMEVMVNVLGGGDSKEIRFPRMVTNCCRFLCYFCRISRQNQRSMFDHLSYLLQNSGIGL GMRGSTPLDVAAASCIDNNELALALQEQDLEKVVKYLAGCGLQSCPQLLAKGYPDIGWNP CGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAIEEAIK ISEDPARDGPTVKKDRRFPGMFPGGEGQHEENKVHLGNAIMSFYSALIDLLGRCAPEMHL IQAGKGEALRIRAILRSLVPIEDLVGVISLSVQIPDFGKDNSIIEPKMSSSFVPDHKAPM VLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAFCTTEMALALNRYLSLAVLPLI NKCAFLFAGTDHRAIMIDSMLHTIYRLSRGRAFTKAQRDVIEECLMALCKNLRPSMLQHL LRRLVFDVPILNEYAKMPLKLLNNHYERCWKYYCLPNGWGNFGVSSEEELHLTRKLFWGI FESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYSSKTEKKASVDAEGNFDPKPVET TNTIIPERLDGFINKYAEYTHDKWAFEKIQNNWTYGEMLDEDSKTHPMLRPYKTFSEKDK EIYRWPIKESVKAIIAWEWTLDQMREGEEAKTEQKKGARKISQTAQATYDPSHGYSPQPI EIPHMALSRELQSMAEQLAENYHNTWGRKKKMELQSKGGGSHPLLVPYDTLTAKEKARDR EKAQELLKFLQLNGFAVTRGIKDMESDISSIEKRFAYGFLQKLLKWMEMAQEFIAHLEAV VSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHSLYFLSTPAKVLGTGGHSSNKEKEMIA SIFCKMAALVRHRVSLFGNDAPAIVNCLHILARSLDARTVMKSGPEIVKAGLRSFFEGAA DDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSLFDHISQHQFGDDVLLDD LQMSCYRIMCAIYSLGTVKNPHVERQMPALGECLAHLAAAMPVAYLEPHLNEYNSFSVYT TKTPRERAILGLPNEVQELCQDIPELDVLLKEIGDLAESGARYTEMPHVIEITLPMLCNY LPRWWERGVEIFPELEGQICTDVTSEQLNQLLGSIMKIVVNNLGIDEASWMKRLAVFSQP IVSRAKPEMLKSHFIPTMEKLKKRTGKVVAEEDHLRMEGKAEGDEEEGTIREEFAVLCRD LYALYPLLIRYVDNNRARWLTCPDPDAEELFRMIGEVFIFWSKSHNFKREEQNFVVMNEI NNMSFLTADSKSKMSTAGGSDVERTKKKRDRYSVQTSLIVAALKKMLPIGLNMCSPADQE LINLAKIRYSLRDTDEEVREFLQNNLHLQGKVENPSMCWQMSLYKEMAGKAEDADAPEKV VKRVQEVSAVLYHIEVTEHPFKSKKIVWHKLLSKQRRKAVVACFRMTPLYNLPRHRASNM FLEGYKCNWIHTEGYSFEDRMIDDLSKAMEQEGEEEEETETKPDPLHQLILHFSRTALTE KSKLDTDYLYMAYADIMAKSCHIGEEDEGGEEVEEGAEDEMSFEVQQTELEKEMEKQRLL YQQSRLHNRGAAEMVLQMISACKGETGCMVSSTLKLGISILNGGNVEVQQKMLEYLKDKK DVGFFLSVQALMQTCSVLDLNAFERQNKAEGLGMLSEEGTSEKVMSDDEFTCDLFRVLQL LCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFYWYYSGKEIIDEPGKKN FSKAMTVAKQIFNSLTEYIQGPCTGNQQSLTHSRLWDAVVGFLHVFAHLMMKLAQDSSQI GLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKD IVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYSPSEIQFLLSCSEADENDMINFEEFAD RFQEPAKDIGFNIAVLLTNLSEHVPHDLRLKNFLEQAESVLNYFRPFLGRIEIMGASRKI ERIYFEISEVNRTQWEMPQVRESKRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMNIASQ ISEQEEEEEEEKDDDDPAGGGTDAGGGGGGDEGGNGEEGEPESISAFADFINSVLNFLSI FTFRNLRRQYRRVRKMTIKQIVVGLATFFWTILIGILHFIYSVCKGFFLLIWQTLFGGGL VEGAKNITVTEILASMPDPTQDELHGDLAGEPGVGKEQEAGGVTDQIDTGGGEEEEEEDN KDKEGGGTPRIDAPGGLGDMGIEATVEPPTPEGTPLTKRKQQPEEGDAAAADGQAADGQA ADGLAAEPASAPAIKEPPPEPEKADTENGEKAEKEAETKEEKQEEAIENKPKSKKDKKQH REQGFQLWTELDIQRNKFLNYLSRNFYNLRFLALFIAFALNFILLFYKVSDSPPGEGDEV EGSGMFEGSGLRVLFEGIGLFEGSAEEMEGSGGEEGGDEEEEGGPVYFFLEESTGYMQPT LTFLATLHTVIAFLCIIGYNCLKIPLVIFKREKELARKLEFDGLYITEQPEDDDIKGQWD RLVLNTLSFPSNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVSQQTDKKPEEPD NSTLARFTSIDFKYQIWKFGVVFTDGTFLYLCWYTIMSLLGHYNNFFYACHLLDIAIGVK DLRTILSSVTHNGKQLMMTLGLLAVVVYLYTVVAFIFFRKFYNKSEDEDEPDMKCDDMMT CYLFHMYVGVRAGGGIGDEIEDPAGDVYELYRVIFDITFFFFVIVILLAIIQGLIIDAFG ELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDET EHTGQESYVWKMYQERAWDFFPAGDCFRKQYEDQLA NT seq 15231 nt NT seq  +upstreamnt  +downstreamnt atggcagaagggggagatggagaggaggagattcagttcttgcgtacggatgaccaggtt gtgctacaatgcacagcctccattctgaaagaacagatcaaactgtgtctgtcatgcgaa ggctttgggaaccgcctctgcttcctggagaccacctctaacgctcagaatgtgccacct gatttggcaatctgctgcttcatcctggagcagtccctgtcggtacgagccttacaggag atgctggccaacaccacggaactcaatgagtcatctcaaggagggggccaccgtaccctg ctgtatggccacgctatccttctgaaacacactcactccagcatgtacctcagctgtttg actacctcaaggtcactcacagacaaactggcctttgatgtgggcttacaggaagattcc acaggggaggcgtgctggtggaccattcatcccgcgtccaagcagagatcagagggagag aaggtcagggtgggagatgacctcatcctggtcagcgtgtcctctgagagatacctgcat ctctcctatgccagtggtgaactcatggtggacgcctccttcatgcagactctgtggacc atgaaccctgtgatgtctggctgtgaacttgcggaaggctttctgactggaggctatgtt ctgagactgttccatggtcacatggatgagtgcttggctatccctgctgccgagcaagga gacaaccagcgcagaattgctcactatgaagggggtgctgtctgtagccatgcccggtca ctatggagactggaacccctccggattggatggagtggaggtcacatgaaatggggccag tcgttccgagtgcgtcatataaccacaggtcgctacctctgcttggatgaagagaaagga ctgatggtggtggaccctgaaaaagccaacgccaagatgtcagccttctgcttcagaatc tccaaggaaaaggtggaggtggttaagaagcgagatgtggagggcatgggcatgccagag atcaagtatggggagtccatgtgttttgtacagcacgtctccactggcctctggcttaca tacgcctctgtcgatgccaagtccgctcgcctgggacctcttaagaggaaggccatcctt cataaggagggccacatggacgatgccctgaccgtggcccgctcccagacagaggagttc caggctgctcgtatgatctacaacacagcaggcctcttcacccagttcattaaagcgctg gactctctgagtgggaagaacaagtcatcttcaggctccccgtctctgcccatggactct gtggtcctctccctgcaggacctcattttctacttccagcccccagaggagctggagcac gaggagaaacagaccagactacgctcccttaagaacagacagaacctcttccaagaggag ggcatgatcaccctggtgctggactgtatcgaccgactcaatgtctacaacacagcggcc cacttctccgagtttgcaggggaggaggctgccgagtcttggaaggagatagttaatctc ctctacgagctgctggcctcactgatcagggggaaccgggcgaactgtgcactgttctgt gataatctggactggctggtcagcaaactggaccgtctggaggcctcctcaggcatcctg gaggtgctgtactgtgttctgattgagagtccagaggttttgaacattatccaggagaac cacattaaatctataatttctttactggataagcatggacgcaatcacaaggtgttagat gtgctctgctctttgtgtgtgtgtaatggggtggctgtaaggtccaatcagaatctcatc acagagaatctgcttccgggtcgcgatctcctcctgcagtccaacatcatcaattatgtc accagtgtgaggcccaacatcttcctaggaacgtgtggaggatcaactcagtataagaag tggtattttgaggtgatggtggaccatgtaaagcccttcttgaccgcccaggccttccac ctgcgtgtgggctgggctctgactgatggctacagcccctaccctggaggtggtgagggc tggggtggtaacggggtgggggacgacctctactcatacgcctttgatggactccacctg tggtcaggacgagtcccacgtcatgtcgccacccccaacatgcacatcctagccgcagac gatgtcgtcagctgctgccttgatctgagtgtgcccagtatttctttccgtatcaacggg cacccggtgcagggcatgtttgagaacttcaacctggatggcttattcttccctgtcgtc agcttctctgcaggcgtcaaggttcgttttctcctgggagggcgtcatggagactttaaa ttcctcccacccccaggctatgctccgtgctatgaggctgtgctacccaaggatcgactg catattgagcccatcaaggagtataagcatgatgtcaatggtgtccgcaatctgttgggg cctacacagtccctctcgcacacagccttcaccccctgccctgtggacacagcacagatt gtgcttccgcctcacttggagcgcattcgggagaagctggcagaaaacagccatgagcta tgggctgtcactcgcattgaacaaggatggacctatgggtcgttccgagatgacaaccag aaactgcacccctgcctggtaggtttccagagcctgccagagccagagaggaattacaac cttgccatgtcagtagaaacactcaagactctactggcgctgggctgccatgtgggcatg ggagatgagaaagcagaggagaacctgaagaacatcaagatgcccaagacgtatatgatg agtagtggatataagcctgcccctctggacctcaaccatgtcaagctgacacccaaccag accaacctagtggagagactggcagagaatgggcacaacgtgtgggctcgtgacagggtt caccaggggtggacctacagcattgtacaggacataatgaacaaacgcaacccgcgcctg gtgccatacaacctgctggatgaaaagaccaagaagaccaacagagacactgtctgtgca gctgtccgcactctcatcggctacggttacaacattgagccacctgaccaggagagcagt ggtcatggggaaggtcattctcgtggagataagatccgggtgttccgggctgagaggtca tacgcggtgacccaggggaagtggtactttgagtttgaggctgtgactgtgggggagatg agagtgggttgggccagacccagtgtccgcgctgacacagagctgggagcagatgagctc gcctatgtcttcaatggtttcaaggctcagcgttggcatgtgggcaatgagccgtttggt cgtatctggttgccaggtgacgtggtgggctgtatgattgacctggtagagcagaacatc ttcttcaccctgaacggaaagatgctgatcagtgactctggatctgagatggccttcaag gacattgacataggagatggttttatccctgtgtgtagtctgggcctgtctcaggttggc cggctcaacctgggccagaacgtcagcagcctgcgctacttcaccatctgtggccttcag gagggctttgaacccttcgccatcaacatgaagagagacatcaccatgtggttcagcaag agcctgccccaattcatccctattcctacagaacaccctcacgttgatgtgtcccgtgtg gatgggacggtggacaacgctccctgtctgaaactgacccacaagaccttcggctctcag aatgccaacaccgatctgttgttcctgaggctcagtatgcccgtggagttccacgagacc tttaaaatcatggctgggaccacccccctgacacgaaccctgaccatccccgaggaccag gtcctggaggtggaccccgactctgactttgaggtgctgaagaagtctgccagccgcaca gagaaggaggaggagaaggagccctctgtgcctaaggatatctccgtcaacggaggagag aatgtgaaagatgcctctacagagaagagcaagaagaaggggttcctgttcaaggccaag aaggcagctttaacttcgccccctgttgttcccaccatgccccgtctgacggaggaagtg gtcccagacgacagagatgacgatgacatcatcctcaacaccaccacatactattattca gtgcgagtgattgcgggacaagagcccagcggggtgtgggtaggctggatcacccctgac taccaccaatacgacctgcactttgacctcagcaaagtaagaaatgtcacagtcaccgtg ggagatgacaaaggcaacatacatgacagtatgaagcgcagtaactgctacatggtgtgg ggaggggagttcagcagctcccagcagacccgtgtcagtcaggaggactttgtgattggc tgccttattgaccttgacacaggactcatgactttcacagccaatgggaaagagatcaac accttctaccaggtggagcccaacactaaattgttcccagctgtctttgtcctgccctcc agtcagaacatgctgcaagtggacctggggaagctcaagaacatcatgcctatttcagca gccatgttccgcagtgagcgtaagaacccggtccctcagtgtcctcccaggctggatgtc cagatgcttaccccagtcatttggagccgcatgccaaaccacttcctgtccccagagatg ggccgtgtgaacgacaggcacggctggatggtggagtgcagagagcctatcacaatgatg gccctgcacatccctgaggagaacagatgtattgacatcctggagttgtcggagcgtatg gacctgctgaagttccactaccacactctgaaactgtacggctcagtctgtgctctgggg aacaaccgcgtggctcatgccctgtgcagccatgttgacgaatcccagctattctacgcc atagagaacacctacctgcctggaccaatgaggagtggctactacgatctgctcatcagc attcacctggagtcggccaagcggaaccgcctcatgaccaataaggagttcattgtgccc atgactgaagagacgctcagcatcaacctcaactcagacactgacaaatcccatgcttta ccaggggtgggcctcactacctgtctgcgccccaaactccacttctcccccactgggttt gtaggggcagacctggatatctacaccctcagccccttcatccccctacatgtgctgaag gcaaaggccctgaccatgctgacagaagctgtccaggatggtggtcaagccatgcgggat cctgtaggaggcagcgttgagttccactttgtccccatcctcaagctcatcagcaccctg ctcatcatgggtgtgtttgataatgaagatgtcaagcacatcctgaagatgatagagcct acagtgttcagtggagaggcagaggctgctgcccagggagagggggaccaaacactggcc ctcaaagaacgggggttgaaggtgaaggaagaagaggagggagcagtagagagcggacat gaaacagaaatggaggatgaggggatgggtgaggaagatgaggaaatggaggcagagcta gaggagttggagcctatagaaaaagaggaagacaagggggaggatgacggagagaaaggt gctgaggagactgagaaggaggtgaagcatggagaggcagaagaacaagtaggtctggaa gagggattactgcacatgaagcttccagagtctgtcaaactacagatgtgcactctgctg cagtatttctgtgactgtgagttgcgccacagggtggaggccatcatagccttctcagac cagtttgtgagccagctgcaggccaaccagagagcccgctacaacgagctcatgctggcg tataccatgaccgctgctgagaccgctcgcaagacccttgagttccgctccccaccacag gagcaggtcaacatgctgatgaacttgaagaacattgcagaggatgaggattgtcctgtg cctgacgaggtccgcgatgccctgcaggcttttcacaagaacctgctgtttcactgcagt gtacatatcgaagaggaagaggtagtggaggagttggatatgtctctcaaagggcgactc ctccgaatgctggacaagttgaggcacctccgtaagaagaaggtagaggaggagaaacct gaggaggagaacaaacccagcaccctccaggagctgatcacccacaccatggtccactgg gcccaggagtcattcatccagaaccctgagctggtgcgtctgatgttcagcctgctgcac cgtcagtatgacgggctgggggagctgatccgggccctgcccaaggcctacaccatcaac gccatctccataaaggataccatggacctgctggagtgcctgggacagatccgctcactg ctcatcgtccagatgggccccgaggaggagaggctcatgatccagagcatcgggaacatc atgagcaacaaagtgttttatcagcaccccaacctgatgcgtgcgctgggcatgcacgag actgtcatggaggtgatggtcaacgtgctgggtggtggtgactccaaggagatcagattc cctcgtatggtcaccaactgctgtcgtttcctgtgctacttctgtcgtatcagtcgtcag aaccaacgctccatgttcgatcacctcagctacctgcttcagaacagcggcatcggcctt ggaatgcgtggctccacccctctagacgtagctgcagcatcctgtattgataacaatgag ctggctctggcgctacaggaacaagacctggagaaggtggtgaagtaccttgcaggctgt gggcttcagagctgtccccagctcctggctaagggttaccctgacattggctggaaccct tgtggcggagagaaatacctggacttcctccgcttcgctgtcttcgtcaacggagagagc gtagaggagaatgccaatgtggtggtgcgtcttctgatccgtcggccagagtgttttggc ccggccctgagaggagagggtgggaacggcctactggctgctatagaggaggccatcaag atctctgaagatcctgccagggacggccccactgtcaagaaagacaggcgcttccccggc atgttccctggtggagaggggcagcatgaggagaacaaggtgcatctggggaatgccatc atgtccttctactcagctctcattgacttgctgggacgctgcgctcctgagatgcatttg atccaggctgggaagggtgaggctcttaggatcagggccatcctgaggtccctggtgccc atagaggacctggtgggagtcatcagcctgtctgtccaaatcccagactttggaaaggat aacagcatcattgaacccaagatgtcttccagttttgtgccggaccacaaggctcccatg gtgctgttccttgacagagtgtatggtattgacaaccaggacttcctgctccatgtgctg gaggtgggcttcctgcctgacatgagggcagctgcttctctggacacagcagctttctgc accacagagatggccctggctctgaaccgctacctctctctggccgtgctgcccctcatc aacaagtgtgccttcctgtttgccggcacagaccaccgggccatcatgatcgactccatg ctgcacaccatctaccgtctgtcccgcggacgagccttcactaaggcccagagagatgtc attgaggaatgtctcatggctttgtgcaaaaatctacggccatccatgttacaacacctg ttgagaaggctggtatttgatgtaccaattctcaatgaatatgccaaaatgccacttaag cttttgaacaatcactatgagcgctgttggaagtactattgcctgcccaacggctggggc aactttggagtgtcatcagaggaggagctgcatctcacccgcaaactcttctggggcatc tttgagtccctggcccacaagaaatttgatgctgagctgttcaaaattgccatgccgtgc atatgtgccattgctggggccatccctccagattatgtagatgccagctactcctccaag actgagaagaaagcctcagtggatgcagagggaaactttgatcccaagccagtggagacc acaaatactatcatccctgagagattggatggtttcatcaacaaatatgctgaatacaca catgacaagtgggcttttgaaaagattcagaacaactggacgtatggagagatgttggat gaagattctaaaactcaccccatgctccgaccgtacaaaacattctcagagaaggacaaa gagatctaccgttggcccatcaaagagtccgtgaaggcgataattgcgtgggagtggact ctggatcaaatgagggaaggagaggaagccaagactgagcaaaagaagggtgctcggaaa atttctcagactgcacaggcaacgtacgaccccagccatggctacagtccccaaccgatt gagatcccccacatggcactgtcaagagagctgcagtccatggcagaacagcttgcagag aactatcacaatacctggggtcgcaagaagaagatggagctgcagtccaaaggaggaggc tcccaccctttgcttgtaccctatgacaccctgacagcaaaggaaaaggcacgagacagg gaaaaggctcaggagcttcttaaattccttcaactcaatggatttgcagtcaccaggggg ataaaagacatggagtcagacatctcatctatcgagaagcgctttgcttatggtttcctg cagaagctgttaaagtggatggagatggcccaggagttcatagctcatcttgaggctgtg gtgagcagtggcagagtggagaagtcgcctcatgagcaggagatcaaattctttgcaaag atcctgttgcccctgatcaatcagtactttaaaaaccactcgctgtacttcctgtccaca ccggccaaagtcctgggtactggaggacattcctctaacaaggagaaagagatgattgcc agcatcttctgtaaaatggctgctctggtgagacacagagtttctctctttggaaatgac gcccctgctattgtcaactgtcttcacatcctggcacgatctctcgacgcaaggacggtg atgaagtctgggcctgaaatcgtgaaggcagggctcaggtcattctttgagggtgcagct gatgatatagagaagatggtggagaacctcaaactgggaaaggtgtctaaaggcaaccag caggtgaaaggcgtgtcccagaacatcaactacaccaccattgctctgctcccagtcctc acctccctgttcgaccacatctctcagcaccagtttggagatgatgtccttttggatgat ctccagatgtcgtgttaccgcatcatgtgcgccatctactccctgggtactgtcaagaac cctcatgtggagaggcagatgccagccctaggggagtgtctggcccatctcgcggctgct atgccagtggcctacctggagccccatctcaatgagtacaactccttctctgtttacacc accaagacccccagagaaagagccatcctgggtctgcccaatgaggtccaggagttatgc caggacataccagagctagacgttctattgaaagagatcggggacttggcagagtcaggt gcccgttacacagagatgccccatgtgatcgagataactctgcccatgctgtgtaactac ctgccccgctggtgggaaagaggagtagagatcttccctgagctggagggccagatctgc accgacgtcacctctgagcagctcaaccagctgctgggcagcatcatgaagatcgtcgtc aataacctgggaattgacgaggcctcctggatgaagaggctggctgtcttctcccagcct attgtgagcagggccaagccagagatgctcaagtcccatttcatccccaccatggagaag ctgaagaagaggacagggaaggtggtggcagaggaggaccacctgcgtatggaggggaag gccgagggggatgaggaggagggcaccatcagggaggagtttgctgtgctctgcagggac ctgtacgccctctaccctctactcatccgctatgtggacaataacagggcaaggtggttg acatgcccagacccagatgcagaggagctcttcagaatgattggagaggtcttcatattc tggtccaaatctcataacttcaaacgagaggagcagaactttgtggtgatgaatgagatt aataacatgtctttcctcactgctgacagcaagagcaagatgagcacggctggtggctca gacgtggagcgtaccaagaagaaaagagatcgttactcagtgcagacgtcacttattgtg gctgccctgaaaaagatgctccccatcggcctcaacatgtgctcccctgctgatcaggag cttatcaacctggccaagatacgatactctttgagggacacggatgaggaagtaagagag tttttgcaaaacaacctgcatcttcaaggcaaggtggagaacccgtccatgtgctggcag atgtccctgtataaggagatggcagggaaggctgaggatgctgacgctccagagaaagtg gtgaagagggtgcaggaggtgtcagctgttctctatcacattgaggtgacggagcacccc ttcaaatccaaaaagattgtgtggcacaaactgctctccaagcagagacgcaaggctgtg gtagcctgctttaggatgactccactctacaacctacccaggcatagagcttccaatatg ttcctggaaggatacaaatgcaactggatccatactgaaggctactcctttgaggacaga atgatagacgacttgtctaaagccatggagcaggaaggagaggaagaggaagagactgag accaagccagatccccttcaccaactaattttgcatttcagccgtaccgctctcacagag aagagtaaacttgatacagattacctatatatggcatacgctgatattatggcaaagagc tgccacattggtgaggaggacgaagggggagaggaggtggaggaaggggctgaggatgag atgtcctttgaggtgcaacagacagaactggaaaaagagatggagaaacagagacttctg taccagcagtcccgtctccataaccgtggggcggctgagatggtgctgcagatgatcagt gcttgcaaaggtgagactggctgcatggtgtcctccacccttaaattgggcatctccatc ctaaacggtggtaatgttgaggttcaacagaaaatgcttgagtacttgaaggacaagaag gatgttggcttctttttgagtgtccaggctctaatgcagacatgcagtgtcctggacctg aatgcatttgagagacaaaacaaggcagagggtctgggcatgttgtcggaggagggaaca agtgagaaagtcatgtcggatgatgagtttacatgtgatctgttccgcgtgttgcagctg ctctgtgagggccacaataacgatttccagaactacttgaggacacagacaggcagcacc accactatcaacatcatcatctgcactgtggattacctcctccgactgcaggagtcaatc agtgatttctactggtattactctgggaaagagatcatcgatgagccaggcaagaagaac ttctccaaggccatgacagtggctaaacagatctttaacagtctgactgagtacatccag ggtccgtgtacaggcaaccagcagtccctgacccacagcaggttgtgggatgcagtagta ggcttcctccacgtctttgcccacttgatgatgaagctggcacaggactccagccagatt ggcctgctgaaggagctactggaccttcagaaagacatggtggttatgctgctctctcta ctagagggtaatgtggtgaacggcaccattgcccgtcagatggtggacatgctggtggag tcctccagcaacgtggagatgatcctcaagttctttgacatgttcctcaaactgaaggac attgtggcgtcagacgccttccgtgattacgtgaccgacccccgagggttaatctctaag aaagattttcagaaggccatggacagccagaaacagtactctccctccgagatccaattc ctgttgtcctgctcagaggctgatgagaacgacatgatcaactttgaggagtttgccgac cgcttccaggagccggctaaagacattggatttaacattgcagtgttgctgacaaacctg tctgaacatgtgcctcatgacctcaggctgaagaacttcttagagcaggcagagagtgta ctcaactacttccgccccttcctgggccgtattgagatcatgggagccagcaggaagata gagcgtatttattttgagatcagcgaggtcaaccgcacacagtgggagatgcctcaggtc agagagtccaaacgacagttcatctttgatgtggttaatgaggggggcgagtccgagaag atggagatgtttgtcaacttctgtgaggacactatctttgagatgaacattgcctcccag atctcagagcaggaggaggaggaggaggaggagaaggatgatgatgatccagctggagga ggaactgatgcaggaggaggaggaggtggagatgaaggcggcaatggagaggaaggagag ccagagtccatctctgcctttgcagacttcatcaacagcgtattgaacttcctgagtatc ttcacattccgtaacttgcgacggcaataccgcagggtaaggaagatgaccatcaagcag atagtggtgggtctggctaccttcttctggactatcctcatcggcatcctgcacttcatc tacagtgtatgtaagggcttcttcctgctcatctggcaaactctatttggcggaggcctg gtggagggagcaaagaacatcacagtgacagagatcctggccagtatgcctgaccccacc caggatgagctgcatggggacttggcaggggagcctggggttgggaaggagcaggaggca ggaggggtgactgaccaaatagatacaggcggtggagaggaggaggaggaggaggacaat aaagacaaggaaggtggggggacaccacgcatcgatgctcctggtggacttggtgacatg ggaattgaggccactgttgagcctcctactcccgagggtactcctttgaccaagagaaaa cagcaaccagaggagggtgatgctgcagcagctgatggccaagctgctgatggccaagca gctgatggcctagctgctgaaccggcttctgctcctgccataaaggagccacctccagag cctgagaaggcagacactgaaaatggagagaaggccgagaaagaagctgagaccaaagag gagaagcaggaggaagcgatagaaaataaacccaagtctaagaaagataagaagcaacac agggagcaagggttccaactctggactgagctggacatccaaagaaacaaattcttgaac tacctctctcggaacttttacaatctgcgttttctggcactgttcattgcatttgccctg aactttattctactcttctacaaggtgtcagacagcccccctggagaaggtgatgaggtg gagggctctggcatgtttgagggctcagggttgcgagtgctgtttgagggaattgggctg tttgagggctcagcagaggagatggagggatctggtggagaggaaggaggagacgaggaa gaggagggtggcccagtctacttcttcttggaggagagcactggctacatgcagcccacc ctcaccttcctggctaccctgcacaccgtcatcgccttcctctgcatcatcggttacaac tgtctaaagattcctcttgtgatctttaaaagagaaaaggagctggccaggaaactggag tttgatggtctttacatcacagagcagcctgaggatgatgacatcaaaggccaatgggac agactggtcctcaacacactctctttcccaagcaactactgggacaagtttgttaagcga aaggtcctggataagtatggagacatttatggcagagaaaggattgcagagctcctaggc atggatttagcctcgttggatgtcagtcaacaaactgataagaagccggaggaacccgac aattctacgttggccaggtttacgtctattgacttcaagtaccagatctggaaatttgga gttgtgttcacagacgggacttttctctacctgtgttggtacacgatcatgtccttgctt ggacattacaacaacttcttctatgcctgtcacttgctggacatagccatcggtgtgaag gatctgcgtactatcctgtcctctgtcacccacaatgggaaacaactcatgatgacattg ggcttgttggcagtggtggtgtatctctacactgtagtggcctttatcttcttccgcaag ttttacaacaagagtgaagatgaggatgagccggatatgaaatgtgacgacatgatgact tgctacctcttccatatgtatgtgggcgtgcgtgctggcggtggcataggggacgagatc gaggacccggcaggagacgtgtacgagctctaccgggtcatctttgacatcaccttcttc ttctttgtcattgtcatcctgttggccatcatccagggtctgatcattgacgccttcgga gagctcagagaccaacaggagcaggttaaggaagacatggagaccaagtgcttcatctgt ggaattggaagcgactactttgatacgacgccgcacggcttcgagacccacaccctagag gaacacaacttggccaactacatgttcttcttaatgtacctcatcaacaaagatgagacg gagcacactggccaggagtcgtatgtgtggaagatgtaccaggagcgagcgtgggacttc ttccctgctggcgactgtttcagaaagcaatatgaggatcagcttgcataa

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