Oncorhynchus mykiss (rainbow trout): 110533121 Help Entry 110533121         CDS       T07259                                  Name (RefSeq) ryanodine receptor 1 isoform X1   KO K04961   ryanodine receptor 1 Organism omy  Oncorhynchus mykiss (rainbow trout) Pathway omy04020   Calcium signaling pathway omy04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:omy00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110533121    04020 Calcium signaling pathway     110533121  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:omy01009]     110533121   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:omy04147]     110533121    04040 Ion channels [BR:omy04040]     110533121 Protein phosphatases and associated proteins [BR:omy01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      110533121 Exosome [BR:omy04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    110533121 Ion channels [BR:omy04040]  Voltage-gated cation channels   Ryanodine receptor    110533121 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  110533121 NCBI-ProteinID:  XP_036846351 Ensembl:  ENSOMYG00000016714 LinkDB All DBs Position 10:45813174..45885942 Genome browser AA seq 5105 aa AA seqDB search MAEGGDGEEEIQFLRTDDQVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLSNTMELNEAVDLDKWSSQGGGHRTLLYGHAILLKHTHS SMYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYASGDLMVDASFMQTLWTMSPVMSGCELAEGFLTGGYVLRLFHGHMDECLA IPAAEQGDDQRRIAHYEGGAVCSHARSLWRLEPLRIGWSGGHMKWGQSFRVRHITTGRYL CLDEEKGLLVVDPEKANAKMSAFCFRISKEKIEVAQKRDVEGMGTPEIKYGESMCFVQHV SSGLWLTYASVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEEFQAARMIYNTAGLF TQFIKALDSLSGKNKSSSGPPSLPMDSVALSLQDLIFYFRPPEEELEHEEKQTKLRSLKN RQNLFQEEGMITLVLDCIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGN RANCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKH GRNHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQSNIINYVTSVRPNIFLGTC EGSTQYKKWYFEVMVDYVEPFLTAQAFHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYS YAFDGLHLWSGRVLRHVASPNMHILAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNL DGLFFPVVSFSAGVRVRFLLGGRHGDFKFLPPPGYAPCYEAVLPKDRLRIEPIKEYKHDF NGVRNLLGPTQSLSHTAFTPCPVDTVQIVLPPHLERIREKLAENSHELWAATRIEQGWTY GSFRDDNKKLHPCLVDFQSLPEPEKNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKNI KMPKTYMMSSGYKPAPLDLNHVKLTPNQTNLVERLAENGHNVWARDRVHQGWTYSIVQDI MSKRNPRLVPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGNGEGHSRGNKI RVFRAEKSYAVTQGKWYFEFEAVTVGDMRVGWARPSVRADTELGADELAYVFNGFKAQRW HVGNEPFGRSWLPGDVVGCMIDLVEQNIFFTLNGEMLISDSGSEMAFKDIDTGDGFIPVC SLGLSQVGRLNLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPVPTEH PHIEVSRVDGTVDSAPCLKLTHKTFGSQNANTDLLFLRLSMPVEFHETFKVMAGTTPLTR ALTIPEDEVLEVDPDSDFEVLKKSASRTEKEEEKKEPSVPKEIPVNEGGENVKDASTEKS KKKGFLFKAKKAAFTPPPVVPTMPRLMEEVVPDDRDDDDIILNTTTYYYSVRVIAGQEPS GVWVGWITPDYHQYDLHFDLSKVRNVTVTVGDDKGNIHDSMKRSNCYMVWGGEFSSSQQT RVSQEDFVIGCLIDLDTGLMTFTANGKEINTFYQVEPNTKLFPAVFVLPSSQNMLQVELG KLKNIMPISAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLSPETGRVNERHGWM VECREPLTMMALHIPEENRCIDVLELSERMDLLKFHYHTLKLYGSVCALGNNRVAHALCS HVDESQLFYAIENTYLPGPMRSGYYDLLISMHLESAKRNRLMTNKEFIVPMTDETRSINL YSDTDNSHALPGVGLTTCLRPKLHFSPTGFVGTDLDIYTLSPFIPLQVLKAKALTMLTEA VQDGGQAMRDPVGGSVEFHFVPILKLISTLLIMGVFENEDVKHILKMIEPTVFSGEAEAA AEEAEATAKGAGSQTLALKEGGEEVKEEEEGAVESGHETEMEDEGMGEEDEELEAELEEL VEKEEEEDGEKVDGEKGAEETEKEATPGEADGEAEEQVGLEEGLLHMKLPESVKLQMCTL LQYFCDCELRHRVEAIIAFSDQFVSQVQANQRARYNELMLAFTMSAAETARKTREFRSPP QEQVNMLMNFKSIAEDEECPVPDEVRDALLSFHKNLLAHCGVHIEEEEVEEELDMSLKGR LFRILDKLRHLRKKKVEEAPEPVEETKPSTLQELISHTMIHWAQESFIQNPELVRLMFSL LHRQYDGLGELIRALPKAYTINAISIKDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIG NIMSNKVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRMVTNCCRFLCYFCRIS RQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEKVVKYLA GCGLQSCPQLLAKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPEC FGPALRGEGGNGLLAAIEEAIKISEDPARDGPTVKKDRRFPGMFPGGEEQHEENKVHLGN AIMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPMEDLVGVISLSVQIPDFG KDNSVIEPKMSSSFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAA FCTTEMALALNRYLSLAVLPLITKCAFLFAGTDHRAIMIDSMLHTIYRLSRGRAFTKAQR DVIEECLMALCKNLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNG WGNFGVSSEEELHLTRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYS SKTEKKALVDAEGNFDPKPVETTNTIIPERLDGFINRYAEYTHDKWAFEKIQNNWTYGEM LDENSKTHPMLRPYKTFSEKDKEIYRWPIKESMKAMIAWEWTLDQTREGDEAKTEQKKAA RKISQTAQATYDPSHGYSPQPIEISHTALSRELQSMAEQLAENYHNTWGRKKKMDLQSKG GGAHPLLVPYDTLTAKEKARDREKAHELLKFLQLNGFAVTRGMKDMESDISSIEKRFAYG FLQKLLKWMEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHCLYFL STPAKVLGSGGHSSNKEKEMIASIFCKMAALVRHRVSLFGNDAAAIVNCLHILARSLDAR TVMKSGPEIVKAGLRSFFEGAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLP VLTSLFDHISQHQFGDDVMLDDLQMSCYRIMCAIYSLGSVKNPHVERQRPALGECLAHLA AAMPVAYLEPHLNEYNAFSVYTTKSPRERAILGLPNEVQELCQDIPELDVLLKEIGDLAE SGARYTEMPHVIEITLPMLCNYLPRWWERGLENFPELEGQICTDVTSDQLNQLLGSIMKI VVNNLGIDEASWMKRLAVFSQPIVSRARPEMLKSHFIPTMEKLKKRTGKVVAEEDHLRME GKAEGDEEEGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVF IFWSKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKGSDSEAGGSDVERTKKKRRGDR YSVQTSLIVAALKKMLPIGLNMCSPADHELINLAKIRYSLRDTDEEVREFLQNNLHLQGK VENPSMRWQMSLYKEMAGKAEDADAPEKVVKRVQEVSAVLYHIEVTEHPFKSKKMVWHKL LSKQRRKAVVACFRMTPLYNLPRHRASNMFLEGYKRNWIHTEGYSFEDRMIDDLSKAMEQ EGEEEEETETKPDPLHQLILHFSRTALTEKSKLDTDYLYMAYADIMAKSCHIGEEDEGGE EVEEGAEDEMSFEVRQTELEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGCMVS STLKLGISILNGGNVEVQQKMLEYLKDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAEG LGMVSEEGTNMKSERGEKVMADDEFTCDLFRMLQLLCEGHNNDFQNYLRTQTGSTTTINI IICTVDYLLRLQESISDFYWYYSGKDIIDEPGKKNFSKAMTVAKQIFNSLTEYIQGPCTG NQQSLTHSRLWDAVVGFLHVFAHMMMKLAQGKDSSQIGLLKELLDLQKDMVVMLLSLLEG NVVNGTIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDF QKAMDSQKQYSPSEIQFLLSCSEADENDMINFEEFADRFQEPAKDIGFNIAVLLTNLSEH VPHDLRLKNFLEQAESVLNYFRPFLGRIEIMGASRKIERIYFEISEVNRTQWEMPQVRES KRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMNIASQISEQEEEKEEEDDDEPAEGGAEA GGGGGGDEEGNGEEGEPESSSAFADFINSLLNFLSIFTFRNLRRQYRRVRKMTIKQIVVG LATFFWTILIGILHFIYSVCKGFFLLIWQTLFGGGLVEGAKNITVTEILASMPDPTQDEV HGDLPGEPRTGEEQEAGGVTDQMDTGGGEEEEEDKQDKEGGGPPRIDAPGGLGDMGIEAT VEPPTPEGTPLTRRKQQPEEGAAAAADGQAAEPAPAPAPAIEEPPPEPEKADTENGEKAE KEAETKEEEKQEEPKEKKAKDKKTKKQHREQGFQLWTELDIQRNKFLNYLSRNFYNLRFL ALFIAFALNFILLFYKVSDSPPGEGDEVEGSGMFEGSGVGALFEGSGLFEGSAEEMEGSG GDEGGDEEEEEEGPVYFFLEESTGYMQPTLTFLAALHTVIAFLCIIGYNCLKIPLVIFKR EKELARKLEFDGLYITEQPEDDDIKGQWDRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYG RERIAELLGMDLASLDVSQQTDKKPEEPDNSTLAWCTSIDFKYQIWKCGVVFTDGTFLYL CWYTIMSLLGHYNNFFYACHLLDIAIGVKDLRTILSSVTHNGKQLMMTLGLLAVVVYLYT VVAFIFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDVYELY RVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTP HGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERAWDFFPAGDCFRKQY EDQLA NT seq 15318 nt NT seq  +upstreamnt  +downstreamnt atggcggaaggaggagatggagaggaggagattcagttcttacgtacggatgaccaggtt gtgctacaatgcactgcctccattctgaaagaacagatcaaactgtgtctttcatgtgag ggctttgggaaccgcctctgcttcctggagaccacctccaatgctcagaatgtgccacct gatttggcgatctgctgcttcatcctggagcagtccctgtcggtacgagccttacaggag atgctgtccaacaccatggagctcaacgaggcagtcgatttggacaaatggtcatctcaa ggagggggccaccgtaccctgctgtatggccatgccatcctactgaagcacactcactcc agcatgtacctcagctgtttgactacctcaaggtcactcacagacaaactggcctttgat gtgggcttacaggaagattccaccggggaggcgtgctggtggactattcaccctgcgtcc aagcagaggtcagagggagaaaaggtcagggtgggagatgacctcatcctggtcagcgtg tcctctgaaagatacctgcatctctcctacgccagtggtgacctcatggtggacgcctcc ttcatgcagacgctgtggaccatgagccctgtgatgtctggctgtgagcttgctgaaggc tttctgactggaggctatgttcttagactgttccatggtcacatggatgagtgcttggct atccctgctgccgaacaaggagacgaccagcgcagaattgctcattatgaagggggtgct gtctgtagccatgcccggtcactatggagactagaacccctccggattggatggagtgga ggtcacatgaaatggggccagtcgttccgagtgcgtcatataaccacaggccgctacctc tgcctggatgaagagaaaggactgctggtggtggaccctgaaaaagccaacgccaagatg tcagccttctgcttcagaatctccaaggaaaagatcgaggtggctcagaagcgagatgtg gagggcatgggcacaccagagattaagtatggggagtccatgtgttttgtacagcacgtc tcctctggcctctggcttacatacgcctctgtcgatgccaagtctgctcgcctgggacct cttaagaggaaggccatccttcataaggagggccacatggacgatgccctgaccgtggcc cgctcccagacagaggagttccaggctgctcgtatgatctacaacacagcaggcctcttc actcagttcattaaagcgctggactctctgagcggtaagaacaagtcttcttcaggcccc ccgtctctgcccatggactcagtggccctctccctgcaggacctcatcttctacttccgg ccccctgaggaggagctggagcacgaggagaagcagaccaaactacgctccctcaagaac agacagaacctcttccaagaggagggcatgatcaccctggtgctggactgtattgaccga ctcaatgtctacaacacggcggcccacttctccgagtttgcaggggaggaagctgccgag tcttggaaggaaatcgttaatctcctgtacgagctgctggcctctctcatcagaggtaac cgggccaactgtgctttgttctgtgataacctggattggctggtcagcaaactggaccgt ttagaggcctcctcaggcatcctggaggtgctgtactgcgttctgattgagagtccagag gtcctgaacatcatccaggagaaccacattaaatctatcatttctctactggataagcat ggacgcaatcacaaggtgttggatgtgctctgctctttgtgtgtgtgtaacggtgtggct gtaaggtccaatcagaatctcatcacagagaatctgcttccaggtcgcgacctcctcctg cagtccaacatcatcaattatgtcaccagtgtgagacccaacatcttcctcggaacctgt gagggatccacacagtataagaagtggtattttgaggtgatggtggattatgtggagcct ttcctgaccgcccaggccttccacctgcgtgtgggctgggctctgaccgagggctacagc ccctaccctgggggtggtgagggctggggcggcaacggggttggcgacgacctctactcc tacgcttttgatggactccacctgtggtcaggacgagtcctccggcatgtcgcctccccc aacatgcacatcctagcggcagacgatgtggtcagctgctgcctggatctgagcgtgccc agtatctcgttccgtatcaacgggcacccggtgcagggcatgtttgagaacttcaacctg gacggcctcttcttccctgtcgtcagcttctctgcaggtgtcagggttcgttttctcctg ggagggcggcatggggacttcaaattcctcccaccgccaggctatgccccgtgctatgag gctgtgctgcccaaggaccgactgcgtattgagcccatcaaggagtataagcatgatttc aatggtgtccgcaatctgttggggcctacacagtccctctcgcacactgccttcaccccc tgccctgtggacacagtacagattgtgcttccgcctcacttggagcgcattcgggagaag ctggcggaaaacagccatgagctatgggccgccactcgcattgaacaaggatggacctac gggtcgttccgagatgacaacaagaaactgcacccctgcctggtggatttccagagcctg ccagagccagagaagaattacaacctcgcaatgtctggagaaacactcaagactctgctg gcgctgggctgtcatgtgggcatgggggatgagaaagcagaggagaacctgaagaacatc aagatgcccaaaacgtatatgatgagtagtggatataagcctgcccctctggacctcaac catgtcaagctgacacccaaccagaccaacctagtggagagactggcagagaatgggcac aacgtgtgggctcgtgacagggtccaccagggatggacctacagcattgtacaggacatt atgagcaagcgcaacccgcgcctggtgccgtacaacctgctggacgaaaagaccaagaag accaacagagacactgtctgtgcagctgtccgcactctcatcggctacggttacaacatt gagccacctgaccaggagagcagtggtaatggagaaggtcattcccgtggaaataagatc cgtgtgttccgggctgagaagtcatatgcggtgactcaggggaagtggtactttgagttt gaggctgtcaccgtgggggatatgagagtgggttgggccagacccagtgtccgcgctgac acagagctgggggcggatgagctcgcctatgtcttcaatggtttcaaggctcagcgctgg catgtgggcaatgagccgtttggtcgtagctggttgccaggtgacgtggtaggctgtatg atcgacctggtagagcagaacatcttcttcaccctgaacggagagatgctgatcagcgac tctggctctgagatggccttcaaggacatagacacaggagatggctttatccctgtgtgt agtctgggcctgtctcaggttggccggctcaacctgggccagaacgtcagcagcctgcgc tacttcaccatctgtggcctgcaggagggctttgagcctttcgccatcaacatgaagaga gatatcaccatgtggttcagcaagagcctgccccagttcatccctgttcctacagaacac cctcacattgaggtgtcccgtgtggatgggacagtggacagcgctccgtgtctgaaactg acccacaagaccttcggctctcagaacgccaacacagacctgctgttcctgaggctcagc atgcccgtggagttccacgagacctttaaggttatggccgggaccacgcccctcacccga gctctgaccatccctgaggacgaggttctggaggttgaccccgactctgactttgaggtg ctgaaaaagtctgccagccgcacagagaaggaggaggagaagaaggagccctctgtgcct aaggagatccctgtcaacgaaggaggagagaacgtgaaagatgcctctacagagaagagc aagaagaaggggttcctgttcaaggccaagaaggcagctttcactccgccccctgttgtt cccaccatgccccgcctgatggaggaagttgtaccagacgatcgagatgacgacgacatc atcctcaacaccaccacatactattattcagtgcgagtgattgcgggacaagaacccagc ggtgtgtgggtgggctggatcaccccggactaccaccagtacgacctgcactttgacctc agcaaagtcagaaatgtcactgtcaccgtgggagatgacaaaggcaacatccatgacagt atgaagcgcagtaactgctacatggtgtggggaggggagttcagcagctcccagcagacc cgtgtcagccaggaggactttgtgattggctgccttattgacctggacactggcctcatg actttcacagccaacgggaaagagatcaacaccttctaccaggtggagcccaacactaaa ctgttcccagctgtctttgtcctgccctccagtcagaacatgctgcaagtggagctgggc aagctcaagaacatcatgcccatctcggcagccatgttccgcagtgagcgtaagaacccg gtcccccagtgtcctcccaggctggacgtccagatgctgaccccagtcatctggagccgt atgcccaaccacttcctgtccccagagacgggccgtgtgaacgagaggcacggctggatg gtggagtgtagagagcctctcaccatgatggccctgcacatccctgaagagaacagatgt attgacgtcctggagctgtcggagcgtatggacctgctgaagttccactaccacactctg aaattgtacggctcggtctgtgctctggggaacaaccgcgtggctcacgccctatgcagt catgttgatgagtcccagctgttctacgccatagagaacacctacctgcctggaccaatg aggagcggctactacgacctgctcataagcatgcacctggagtcggccaagaggaaccgc ctcatgaccaacaaggagttcatcgtgcccatgacagacgagacgcgcagcatcaacctc tactcagacactgacaactcccatgctttaccaggggtgggcctcactacctgcctgcgc cccaaactccacttctcccccactggctttgtggggacagacctggacatctacaccctc agcccattcatccccctacaggtgctgaaggcgaaggccctgaccatgctgacagaagct gtacaagacggtggtcaggccatgagggatcctgtaggaggcagtgttgagttccacttt gtccccatcctcaagctcatcagcaccctgctcatcatgggcgtgttcgagaatgaagat gtcaagcacatcctgaagatgatcgagcctacggtgttcagtggagaggcagaggctgct gcagaagaagcagaagccacagccaagggcgcggggagccaaacgctggcgctcaaagaa gggggggaggaggtgaaggaggaagaggagggagcagtggagagtggacatgaaacagaa atggaggacgaggggatgggtgaggaagatgaggaactggaggcagagctggaggagctg gtagaaaaagaggaagaggaggacggagagaaagtggatggagagaaaggtgctgaggag acagagaaggaggcgacgcctggagaggcagacggagaggcagaagaacaagtaggtctg gaagagggattactgcacatgaagctgccagagtctgtcaagctacagatgtgcactctg cttcagtatttctgtgactgtgagttgcgtcacagggtagaggccatcatagctttctca gaccagtttgtgagccaggtgcaggccaaccagagagcccgctacaacgagctcatgctg gcgttcaccatgagcgctgccgagacggcccgcaagacccgcgagttccgctccccaccg caggagcaggtcaacatgctgatgaactttaagagcattgcggaggatgaggagtgtcct gtgcctgatgaggtccgcgatgcccttctgtcttttcacaagaacctgcttgctcactgc ggagtacacattgaagaggaagaggtggaggaggagttggatatgtctctcaaaggacga ctcttcagaattttggacaagttgaggcaccttcgcaagaagaaggtagaggaggcgcca gaacctgtagaagagaccaaacccagcaccctccaggagctcatttcccacactatgatc cactgggcccaggagtcgttcatccagaaccctgagctggtgcgtctgatgttcagcctg ctgcaccgtcagtatgacgggctgggggagctgatccgggcattgcccaaggcctacacc atcaacgccatctccataaaggataccatggacctgctggagtgcctgggacagatccgc tcgctgctcatcgtccagatgggccccgaggaggagagactcatgatccagagcatcgga aacatcatgagcaacaaagtgttttatcagcaccccaacctgatgcgagcgctgggcatg cacgagactgtcatggaggtgatggtcaacgtgctgggtggtggcgactccaaggagatc agattccctcgcatggtcaccaactgctgtcgtttcctgtgctacttctgtcgtatcagt cgccagaaccagcgttccatgttcgaccacctcagctacctactacagaacagtggcatt ggccttggaatgcgtggctccacccctctagacgtggctgcagcatcctgcattgacaac aatgagctggctctggctctacaggaacaagacctggagaaggtggtgaagtacctcgca ggctgtgggctccagagttgtccccagctcctggctaagggttaccctgacattggctgg aacccgtgtggcggggagaaatacctggacttcctccgcttcgctgtcttcgtcaatgga gagagcgtagaggagaatgccaatgtggtggtgcgtcttctgatccgtcggccagagtgt tttggcccggctctgagaggagagggtgggaacggcctgctggctgctatagaggaggcc atcaagatctctgaagaccctgccagggacggccccactgtgaagaaagacaggcgcttc cccggcatgttccctggtggggaggagcagcatgaggagaacaaggttcacctggggaat gccatcatgtccttctactcagctctcattgacttgctgggacgctgcgctccagagatg catttgatccaggctgggaagggcgaggctctgaggatcagggccattctgaggtccctg gtgcctatggaggaccttgtcggagtcatcagcctctctgtccagataccagactttgga aaagataacagcgtcattgaacccaagatgtcttccagttttgtgccggaccacaaggct cccatggtgctgttccttgacagagtgtatggtattgacaaccaagacttcctgcttcat gtgctggaggtgggcttcctgcctgacatgagggcagctgcttctctggacacagcggct ttctgcaccacagagatggccctggccctgaaccgctacctctctctggccgtgctgccc ctcatcaccaagtgtgcctttttgttcgccggcactgaccaccgggccatcatgatcgac tctatgctgcacaccatctaccggctgtcccgcggacgagccttcactaaggcccagaga gatgtcatagaggagtgtctcatggctttgtgcaagaatctgcggccgtccatgttacaa cacctgttgagaaggctggtatttgatgtgccaattctcaatgaatatgccaaaatgcca ctcaagcttttgaccaatcactatgagcgttgttggaagtactattgcctgcccaacggc tggggcaactttggagtgtcatccgaggaggagctgcatctcacccgcaaactcttctgg ggcatctttgagtccctggcccacaagaaatttgatgctgagctgttcaaaattgccatg ccgtgcatatgcgccattgctggggccatccctccagattatgtagatgccagctactcc tccaagactgagaagaaagctttggtggatgcagagggaaactttgatcccaaaccagtg gagaccacaaatactatcatccctgagagattggatggcttcatcaacagatatgctgag tacacacatgacaagtgggcgtttgaaaagattcagaataattggacgtatggagagatg ttggatgaaaattcgaaaactcaccccatgctccgaccgtacaaaacattctccgagaag gacaaagagatctaccgttggcccatcaaagagtccatgaaggccatgattgcatgggag tggactctggatcaaacgagggaaggagatgaagccaagactgagcagaagaaggccgcc cggaagatctctcagactgcgcaggcaacatatgaccccagccatggctacagtccccaa ccaattgaaatctcccacacggcactgtcaagagagctgcagtcaatggcagaacaactt gcagagaactatcacaacacctggggtcgaaaaaagaagatggatctgcagtccaaagga ggaggcgcccaccctttgcttgtgccctatgacaccctgacagcgaaggagaaggcacga gacagggaaaaggctcacgagcttctcaaatttctccaactcaatggatttgcagtcacc agaggaatgaaagacatggagtcagacatctcatctatcgagaagcgctttgcctatggt ttcctgcagaagctgttgaagtggatggagatcgcccaagagttcatagctcatcttgag gctgtggtgagcagtggcagagtggagaagtcgcctcatgagcaggagatcaaattcttt gccaagatcttgttgcccctgatcaaccagtactttaaaaaccactgtctgtacttcctg tccacaccggccaaagtcctgggtagtggaggacattcctctaacaaggagaaagagatg attgccagtatcttctgtaaaatggctgctctggtgagacacagagtttctctcttcggg aacgacgctgctgctattgtcaattgtcttcacatcctggcacgatcactcgatgcaagg acggtgatgaagtctgggcctgagattgtgaaggcagggctccggtcgttctttgagggt gcagctgatgatatcgagaagatggtggagaacctcaaactgggcaaggtgtctaaaggc aaccagcaggtgaaaggcgtgtcccagaacatcaactacaccaccattgctctgctccca gtcctcacctccctgttcgaccacatctctcagcaccagtttggagatgatgttatgttg gatgatctccagatgtcgtgttaccgcatcatgtgcgccatctactccctgggcagtgtc aagaaccctcatgtggagaggcagaggccagccctgggggagtgtctggcccatctggcg gctgctatgcctgtggcctacctcgagccccatctcaatgagtacaatgccttctcggtt tacaccaccaagagccccagagaaagagccatcttgggtctgcccaacgaggtccaggag ttatgccaggacataccagagctagacgttctgcttaaagagatcggggacttggcagag tcaggtgcccgttacactgagatgccccatgtgatcgagatcactctgcccatgctgtgt aactacctgccccgctggtgggagagaggattagagaacttccctgagctggagggccag atctgcaccgacgtcacctctgaccagctcaaccagctgctgggcagcatcatgaagatc gtggtcaacaacctgggcattgatgaggcctcctggatgaagaggctggctgtcttctcc cagcctattgtgagcagggccaggccagagatgctcaagtcccatttcatccccaccatg gagaagctgaagaagaggacagggaaggtggtggccgaggaggaccacttgcgtatggag gggaaggccgagggggacgaggaggagggcaccatcagggatgagtttgctgtgctctgc agggacctgtacgccctctaccctctcctcatccgctatgtggacaataacagggcgagg tggttgacatgccctgacccagatgcagaggagctcttcagaatggttggagaggtcttc atcttctggtccaaatctcataacttcaagcgagaggagcagaactttgtggtgatgaat gagattaataacatgtctttcctcactgctgacagcaagagcaagatgagcaagggcagc gactcagaggctggtggctcagacgtggagcgtaccaagaagaagagacggggagaccgt tactcggtgcagacgtcacttattgtggctgccctgaaaaagatgctccccatcggcctc aacatgtgctcccctgctgatcatgagcttatcaacctggccaagatccgatactcgttg agggacactgatgaggaagtaagggagttcttgcaaaacaacctgcatcttcaaggcaag gtagagaacccgtccatgcgctggcagatgtccctgtataaggagatggcagggaaggct gaggatgctgacgctccagagaaggtggtgaagagggtgcaggaggtgtcagctgtgctc tatcacattgaggtgacggagcaccccttcaaatccaagaagatggtgtggcacaaactg ctgtccaagcagagacgcaaggctgtggtagcttgctttaggatgacgccactctacaac ctacccaggcatagagcttccaatatgttcttggaagggtacaaacgcaactggatccat actgagggctactcctttgaggaccgaatgatagacgacttgtctaaagccatggagcag gaaggagaggaggaggaagagacggagaccaagccagacccccttcaccagctcattttg catttcagccgtactgctctcacagaaaagagtaaacttgatacagattacctatatatg gcgtacgcggatattatggcaaagagctgccacattggtgaggaggacgaagggggagag gaggtggaggaaggggctgaggatgagatgtcctttgaggtgcgacagacagaactggaa aaagagatggagaagcagaggctcctataccagcagtcccgtctccacaaccgtggggcg gctgagatggtgctgcagatgatcagcgcttgcaaaggtgagactggctgcatggtgtcc tccactcttaaactgggcatctccatcctaaacggtggtaacgttgaggttcaacagaaa atgcttgaatacctgaaggataagaaggacgtcggcttctttttgagtgtccaggctcta atgcagacgtgcagtgtcctggacctgaatgcctttgagagacagaacaaggcagagggg ctgggtatggtgtcggaggagggaacaaacatgaagtccgaacggggtgagaaagtcatg gcggatgatgagttcacctgtgatctgttccgcatgttgcagctgctctgtgagggccac aataacgatttccagaactacttgcggacacagacaggcagcaccaccactataaacatc atcatctgcactgtggattacctcctccgactgcaggagtcaatcagtgatttctactgg tattactctgggaaagatatcattgatgagccaggcaagaagaacttctccaaggccatg acagtggctaaacagatcttcaacagtctgactgagtacatccagggtccatgtacaggc aaccagcagtccttgacccacagcaggctgtgggatgcagtggtgggcttcctccacgtc tttgcccacatgatgatgaagctggcacagggtaaagattccagccagattggcctgctg aaggagctactggacctccaaaaggacatggtggttatgctgctctctctacttgagggt aatgtggtgaacggcaccattgcccgtcagatggtggacatgctggtggagtcgtccagc aacgtggagatgatcctcaaattctttgacatgtttctcaaactgaaggacattgtggcg tcagacgccttccgtgattacgtgaccgacccccgagggttgatctctaagaaggacttt cagaaggcaatggacagccagaaacagtactctccctctgagatccaattcctgttgtcc tgctcagaggccgatgagaatgacatgatcaactttgaggagtttgccgaccgcttccag gagccagctaaagacattggatttaacattgcagtgttgctgaccaacctttctgaacat gtccctcatgacctcaggctgaagaacttcttagagcaggcagagagtgtactcaactac ttccgccccttcctgggccgtattgagatcatgggtgccagcaggaagatagagcgtatt tactttgagatcagcgaggtcaaccgcacacagtgggagatgcctcaggtcagagagtct aaacgacagttcatctttgatgttgtcaatgaggggggcgagtcggagaagatggagatg tttgtcaacttctgcgaggacaccatctttgagatgaacatcgcctcccagatctcagag caggaggaagagaaggaggaggaggatgatgatgagccggctgaaggaggagctgaggca ggaggaggtggagggggagatgaagagggcaatggggaggaaggagagccagagtccagc tctgcctttgcagacttcatcaatagcttattgaacttcctgagtatcttcaccttccgt aacctgcgcaggcagtaccgcagggtgaggaagatgaccatcaagcagatagtggtgggt ctggccaccttcttctggactatcctcattggcatcctgcacttcatctacagtgtatgt aagggcttcttcctgctcatttggcaaactctctttggaggaggcctggtggagggagcc aagaacatcacagtgacagagatcttggccagtatgcccgaccccacccaggacgaggtg cacggggacctgccaggggagcctaggactggggaggagcaggaggcaggaggggtgact gaccaaatggacacaggtggtggagaggaggaggaggaggacaaacaagacaaggaaggt ggggggcctccacgcattgatgctccaggaggacttggtgacatgggaattgaggccact gttgagcctcctactcctgagggtactcctttgaccaggaggaaacagcaaccagaggag ggtgctgctgcagctgctgatggccaagctgctgaacctgctcctgctcctgctcctgcc atagaggagccccctccagagcctgagaaggcagacaccgaaaatggagagaaggctgag aaagaagctgagaccaaagaggaggagaaacaggaggaaccgaaggaaaagaaggccaag gataagaaaactaagaaacaacacagggagcaagggttccaactctggactgagctggac atccaaagaaacaaattcttgaactacctctctcggaatttttacaatctgcgttttctg gcactgttcattgcatttgctctaaacttcattctactcttctacaaggtgtcggacagc ccccctggagaaggtgatgaggtggagggctctggcatgtttgagggctcgggggtgggg gcgctgtttgagggcagtgggctgtttgagggctcagcagaagagatggagggatctggt ggggatgaaggaggagacgaggaggaggaggaggagggcccagtctacttcttcttggag gagagcactggctacatgcagcccaccctcacattcctggccgccttgcacacagtcatc gccttcctctgcatcatcggctataactgtctaaagatccctctggtgatctttaagagg gagaaggagctggccaggaagctggagtttgatggtctttacatcacagagcagcctgag gatgatgacatcaaaggccaatgggacagactggtcctcaacacaccttctttcccaaac aactactgggacaagtttgtgaagcgaaaggtcctggataagtatggagacatttacggc agagagaggatcgcagagctcttaggcatggatctagcctcgctggacgtcagtcaacaa actgataagaagccggaggaaccagacaattccacgttggcctggtgtacatctattgac tttaagtaccagatctggaaatgtggagttgtgttcacagacgggacttttctctatctg tgttggtacacgatcatgtccttgcttggacattataacaacttcttctatgcctgtcac ttgctggacatagccatcggtgtgaaggatctgcgtactatcctgtcctctgtcacccac aatgggaaacagctcatgatgacattgggcttgttggcagtggtggtgtatctctacact gtagtggcctttatcttcttccgcaagttttacaacaagagtgaagatgaggatgagccg gatatgaaatgtgacgacatgatgacttgctacctcttccacatgtacgtgggagtgcgt gctggcggtggcataggggacgagatcgaggacccggcgggagacgtgtacgagctctac cgggtggtctttgacatcaccttcttcttctttgtcattgtcatcctgttggccatcatt cagggtctgatcattgacgccttcggagagctccgagaccaacaagagcaggttaaggaa gacatggagaccaagtgcttcatctgtggaattggaagcgactactttgatacaacgccg cacggcttcgagacccacaccctggaggaacacaacttggccaactacatgttcttctta atgtacctcatcaacaaagatgagacggagcacactggccaggagtcatatgtgtggaag atgtaccaggagcgagcgtgggacttcttccctgctggggactgtttcaggaagcaatat gaggatcagcttgcataa

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