Oncorhynchus nerka (sockeye salmon): 115101391 Help Entry 115101391         CDS       T07952                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism one  Oncorhynchus nerka (sockeye salmon) Pathway one04020   Calcium signaling pathway one04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:one00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     115101391    04020 Calcium signaling pathway     115101391  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:one01009]     115101391   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:one04147]     115101391    04040 Ion channels [BR:one04040]     115101391 Protein phosphatases and associated proteins [BR:one01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      115101391 Exosome [BR:one04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    115101391 Ion channels [BR:one04040]  Voltage-gated cation channels   Ryanodine receptor    115101391 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Motif Other DBs NCBI-GeneID:  115101391 NCBI-ProteinID:  XP_029476707 LinkDB All DBs Position LG19:27667760..27768639 Genome browser AA seq 5087 aa AA seqDB search MADGGDGEEEIQFLRTDDQVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLANTTELNEAVDLDKWSSQGGGHRTLLYGHAILLKHTHS SMYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYASGELMVDASFMQTLWTMNPVMSGCELAEGFLTGGYVLRLFHGHMDECLA IPAAEQGDNQRRIAHYEGGAVCSHARSLWRLEPLRIGWSGGHMKWGQSFRVRHITTGRYL CLDEEKGLMVVDPEKANAKMSAFCFRISKEKVEVVKKRDVEGMGTPEIKYGESMCFVQHV STGLWLTYASVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEEFLAARMIYNTAGLF TQFIKALDSLSGKNKSSSGSPSLPMDSVVLSLQDLIFYFQPPEELEHEEKQTRLRSLKNR QNLFQEEGMITLVLDCIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNR ANCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHG RNHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQSNIINYVTSVRPNIFLGTCG GSTQYKKWYFEVMVDHVEPFLTAQAFHLRVGWALTDGYSPYPGGGEGWGGNGVGDDLYSY AFDGLHLWSGRVPRHVATPNMHILAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNLD GLFFPVVSFSAGVKVRFLLGGRHGDFKFLPPPGYAPCYEAVLPKDRLHIEPIKEYKHDVN GVRNLLGPTQSLSHTAFTPCPVDTAQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYG SFRDDNQKLHSCLVDFQSLPEPERNYNLAMSVETLKTLLALGCHVGMGDEKAEENLKNIK MPKTYMMSSGYKPAPLDLNHVKLTPNQTNLVERLAENGHNVWARDRVHQGWTYSIVQDIM NKRNPRLVPYNLLDEKTKKTNRDAVCAAVRTLIGYGYNIEPPDQESSGHGEGHSRGDKIR VFRAERSYAVTQGKWYFEFEAVTVGEMRVGWARPSVRADTELGADELAYVFNGFKAQRWH VGNEPFGRIWLPGDVVGCMIDLVEQNIFFTLNGKMLISDSGSEMAFKDIDIGDGFIPVCS LGLSQVGRLNLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPIPTEHP HVDVSRVDGTVDNAPCLKLTHKTFGSQNANTDLLFLRLSMPVEFHETFKIMAGTTPLTRT LTIPEDQVLEVDPDSDFEVLKKSASRTEKEEEKEPSVPKEISVNGGENVKDASTEKSKKK GFLFKAKKAALTPPPVVPTMPRLREEVVPDDRDDDDIILNTTTYYYSVRVIAGQEPSGVW VGWITPDYHQYDLHFDLSKVRNVTVTVGDDKGNIHDSMKRSNCYMVWGGEFSSSQQTRVS QQDFVIGCLIDLDTGLMTFTANGKEINTFYQVEPNTKLFPAVFVLPSSQNMLQVDLGKLK NIMPISAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNHFLSPEMGRVNDRHGWMVEC REPITMMALHIPEENRCIDILELSERMDLLKFHYHTLKLYGSVCALGNNRVAHALCSHVD ESQLFYAIENTYLPGPMRSGYYDLLISIHLESAKRNRLMTNKEFIVPMTEETLSINLNSD TDKSHALPGVGLTTCLRPKLHFSPTGFVGTDLDIYTLSPFIPLHVLKAKALTMLTEAVQD GGQAMRDHVGGSVEFHFVPILKLISTLLIMGVFDNEDVKHILKVIEPTVFSGEAEAAAQG EGDQTLALKERGLEVKEEEEGAVESGHETEMEDEGMDEEDEEMEAELEELEPIEKEEDKG EDDGEKGAEETEKEVNPGEAEEQVGLEEGLLHMKLPESVKLQMCTLLQYFCDCELRHRVE AIIAFSDQFVSQVQANQRARYNELMLAYTMSAAETARKTREFRSPPQEQVNMLMNLKNIT EDEDCPVPDEVRDALQAFHKNLLFHCSVHIEEEEVEEELDMSLKGRLLRMLDKLRHLHKK KVEEEKPEEENKPSTLQELITHTMVHWAQESFIQNPELVRLMFSLLHRQYDGLGELIRAL PKAYTINAISIKDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMSNKVFYQHPNLM RALGMHETVMEVMVNVLGGGDSKEIRFPRMVTNCCRFLCYFCRISRQNQRSMFDHLSYLL QNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEKVVKYLAGCGLQSCPQLLAKGY PDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLA AIEEAIKISEDPARDGPTVKKDRRFPGMFPGGEGQHEENKVHLGNAIMSFYSALIDLLGR CAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLSVQIPDFGKDNSIIEPKMSSSFV PDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAFCTTEMALALNRYLS LAVLPLINKCAFLFAGTDHRAIMIDSMLHTIYRLYRGRAFTKAQRDVIEECLMALCKNLR PSMLQHLLRRLVFDVPILNEYAKMPLKLLNNHYERCWKYYCLPNGWGNFGVSSEEELHLT RKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYSSKTEKKASVDAEGNF DPKPVETTTTIIPERLDGFINKYAEYTHDKWAFEKIQNNWTYGEMLDEDSKTHPMLRPYK TFSEKDKEIYRWPIKESMKAIIAWEWTLDQMREGEEAKTEQKKAARKISQIAQATYDPSH GYSPQPIEIPHMALSRELQSMAEQLAENYHNTWGRKKKMELQSKGGGSHPLLVPYDTLTA KEKARDREKAQELLKFLQLNGFAVTRGIKDMESDISSIEKRFAYGFLQKLLKWMEMAQEF IAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHSLYFLSTPAKVLGTGGHSSN KEKEMIASIFCKMAALVRHRVSLFGNDAPAIVNCLHILARSLDARTVMKSGPEIVKAGLR SFFEGAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSLFDHISQHQFG DDVILDDLQMSCYRIMCAIYSLGTVKNPHVERHMPALGECLAHLAAAMPVAYLEPHLNEY NSFSVYTTKTPRERAILGLPNEVQELCQDIPELDVLLKEIGDLAESGARYTEMPHVIEIT LPMLCNYLPRWWERGVEIFPELEGQICTDVTSEQLNQLLGSIMKIVVNNLGIDEASWMKR LAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTGKVVAEEDHLRMEGKAEGDEEEGTIREE FAVLCRDLYALYPLLIRYVDNNRATWLTCPDPDAEELFRMVGEVFIFWSKSHNFKREEQN FVVMNEINNMSFLTADSKSKMSTGNDSEAGGSDVERTKKKRRGDRYSVQTSLIVAALKKM LPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLHLQGKVENPSMCWQMSLYKE MAGKAEDADAPEKVVKRVQEVSAVLYHIEVTEHPFKSKKIVWHKLLSKQRRKAVVACFRM TPLYNLPRHRASNMFLEGYKRNWIHTEGYSFEDRMIDDLSKAMEQEGEEEEETETKPDPL HQLILHFSRTALTEKSKLDTDYLYMAYADIMAKSCHIGEEDEGGEEVEEGAEDETSFEMR QTELEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGCMVSSTLKLGISILNGGNV EVQQKMLEYLKDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAEGLGMLSEEGTSEKVMS DDEFTCDLFRMLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLLRLQESISDFYWY YSGKEIIDEPGKKNFSKAMTVAKQIFNSLTEYIQGPCTGNQQSLTHSRLWDAVVGFLHVF AHLMMKLAQDSSQIGLLKELLDLQKEMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVE MILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYSPSEIQFLLSCSE ADENDMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDLRLKNFLEQAESVLNYFRP FLGRIEIMGASRKIERIYFEISEVNRTQWEMPQVRESKRQFIFDVVNEGGESEKMEMFVN FCEDTIFEMNIASQISEQVEEEEKDDDDDPAEGGTDTGGGGDEGGNGEEEEPESISAFAD FINSVLNFLSIFTFRNLRRQYRRVRKMTIKQIVVGLATFFWTILIGILHFIYSVCKGFFL LIWQTLFGGGLVEGAKNITVTEILASMPDPTQDEVHGDLAGEPGVGKEQEAGGVTDQIDT GGGEEEEEEDNKDKEGGGTPRIDAPGGLGDMGIEATVEPPTPEGTPLTKRKRQPEEGDAA AADGQAADGQAADGLAAEPASAPAIKEPPPEPEKADTENGEKAEEEAETKEEKQEEAIEK KPKSKKDKKQHREQGFQLWTELDIQRNKFLNYLSRNFYNLRFLALFIAFALNFILLFYKV SDSPRGEGDEVEGSGMFEGSGLGVLFEGIGLFEGSAEEMEGSGGEEGGDEEEEGGPVYFF LEESTGYMQPTLTFLATLHTVIAFLCIIGYNCLKIPLVIFKREKELARKLEFDGLYITEQ PEDDNIKGQWDRLVLNTLSFPSNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVS QQTDKKPEEPDNSTLARFTSIDFKYQIWKFGVVFTDGTFLYLCWYTIMSLLGHYNNFFYA CHLLDIAIGVKDLRTILSSVTHNGKQLMMTLGLLAVVVYLYTVVAFIFFRKFYNKSEDED EPDMKCDDMMTCYLFHIYVGVRAGGGIGDEIEDPAGDVYELYRVIFDITFFFFVIVILLA IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMF FLMYLINKDETEHTGQESYVWKMYQERAWDFFPAGDCFRKQYEDQLA NT seq 15264 nt NT seq  +upstreamnt  +downstreamnt atggcagacgggggagatggagaggaggagattcagttcttgcgtacggatgaccaggtt gtgctacaatgcacagcctccattctgaaagaacagatcaaactgtgtctgtcatgcgaa ggctttgggaaccgcctctgcttcctggagaccacctctaacgctcagaatgtgccacct gatttggcgatctgctgcttcatcctggagcagtccctgtcggtacgagccttacaggag atgctggccaacaccacggaactcaatgaggcagtcgatttggacaaatggtcatctcaa ggagggggccaccgtaccctgctgtatggccacgctatccttctgaaacacactcactcc agcatgtacctcagctgtttgaccacctcaaggtcactcacagacaaactggcctttgat gtgggcttacaggaagattccacaggggaggcgtgctggtggaccattcatcctgcgtcc aagcagaggtcagagggagagaaggtcagggtgggagatgacctcatcctggtcagcgtg tcctctgagagatacctgcatctctcctatgccagtggtgaactcatggtggacgcctcc ttcatgcagactctgtggaccatgaaccctgtgatgtctggctgtgaacttgcggaaggc tttctaactggaggctatgttctgagactgttccatggtcacatggatgagtgcttggct atccctgctgccgagcaaggagacaaccagcgcagaattgctcactatgaagggggtgct gtctgtagccatgcccggtcactatggagactagaacccctccggattggatggagtgga ggtcacatgaaatggggccagtcgttccgagtgcgtcatataaccacaggtcgctacctc tgcttggatgaagagaaaggactgatggtggtggaccctgaaaaagccaacgccaagatg tcagccttctgcttcagaatctccaaggaaaaggtggaggtggttaagaagcgagatgtg gagggcatgggcacgccagagatcaagtatggggagtccatgtgttttgtacagcacgtc tccactggcctctggcttacatacgcctctgtcgatgccaagtccgctcgcctgggacct cttaagaggaaggccatccttcataaggagggccacatggacgatgccctgaccgtggcc cgctcccagacagaggagttcctggctgctcgtatgatctacaacacagcaggcctcttc acccagttcatcaaagcgctggactctctgagtgggaagaacaagtcatcttcaggctca ccgtctctgcccatggactctgtggtcctctccctgcaggacctcatcttctacttccag cccccagaggagctggagcacgaggagaaacagaccagactacgctcccttaagaacaga cagaacctcttccaagaggagggcatgatcaccctggtgctggactgtatcgaccgactc aatgtctacaacacagcggcccacttctcagagtttgcaggggaggaggctgccgagtct tggaaggagatagttaatctcctctacgagctgctggcctcactgatcagggggaaccgg gcgaactgtgcactgttctgtgataatctggactggctggtcagcaaactggaccgtctg gaggcctcctcaggcatcctggaggtgctatactgtgttctgattgagagtccagaggtt ttgaacattatccaggagaaccacattaaatctatcatttctctactggataagcatgga cgcaatcacaaggtgttggatgtgctctgctctttgtgtgtgtgtaatggggtggctgta aggtccaatcagaatctcatcacagagaatctgcttccaggtcgcgatctcctcctgcag tccaacatcatcaattatgtcaccagtgtgaggcccaacatcttcctaggaacgtgtgga ggatcaactcagtataagaagtggtattttgaggtgatggtggaccatgtagagcccttc ttgaccgcccaggccttccacctgcgtgtgggctgggctctgactgatggctacagcccc taccctggaggtggtgagggctggggtggtaacggggtgggggacgacctctactcatac gcctttgatggactccacctgtggtcaggacgagtcccacgtcatgtcgccacccccaac atgcacatcctagccgcagacgatgtggtcagctgctgccttgatctgagtgtgcccagt atttcgttccgtatcaacgggcacccggtgcagggcatgtttgagaacttcaacctggat ggcttattcttccctgtcgtcagcttctctgcaggcgtcaaggttcgttttctcctggga gggcgccatggagactttaaattcctcccacccccaggctatgctccatgctatgaggct gtgctacccaaggatcgactgcatattgagcccatcaaggagtataagcatgatgtcaat ggtgtccgcaatctgttggggcctacacagtccctctcgcacacagccttcaccccctgc cctgtggacacagcacagattgtgcttccgcctcacttggagcgcattcgggagaagctg gcagaaaacagccatgagctatgggctgtcactcgcattgaacaaggatggacctatggg tcgttcagagatgacaaccagaaactgcactcctgcctggtagatttccagagcctgcca gagccagagaggaattacaaccttgccatgtcagtagaaacactcaagactctactggcg ctgggctgccatgtgggcatgggagatgagaaagcagaggagaacctgaagaacatcaag atgcccaagacgtatatgatgagtagtggatataagcctgcccctctggacctcaaccat gtcaagctgacacccaaccagaccaacctagtggagagactggcagagaatgggcacaac gtgtgggctcgtgacagggttcaccaagggtggacctacagcattgtacaggacataatg aacaagcgcaacccgcgcctggtgccgtacaacctgctggacgaaaagaccaagaagacc aacagagacgctgtctgtgcagctgtccgcactctcatcggctacggttacaacattgag ccacctgaccaggagagcagtggtcatggggaaggtcattctcgtggagataagatccgg gtgttccgggctgagaggtcatacgcggtgacccaggggaagtggtactttgagtttgag gctgtgactgtgggggagatgagagtgggttgggccagacccagtgtccgcgctgacaca gagctgggagcagatgagctcgcctatgtcttcaatggtttcaaggctcagcgttggcat gtgggcaatgagccgtttggtcgtatctggttgccaggtgacgtggtgggctgtatgatt gacctggtagagcagaacatcttcttcaccctgaacggaaagatgctgatcagtgactct ggatctgagatggccttcaaggacattgacataggagatggttttatccctgtgtgtagt ctgggcctgtctcaggttggccggctcaacctgggccagaacgtcagcagcctgcgctac ttcaccatctgtggccttcaggagggctttgaacccttcgccatcaacatgaagagagac atcaccatgtggttcagcaagagcctgccccaattcatccctattcctacagaacaccct cacgttgatgtgtcccgtgtggatgggacggtggacaacgccccctgtctgaaactgacc cacaagaccttcggctctcagaatgccaacaccgatctgttgttcctgaggctcagtatg cccgtggagttccacgagacctttaaaatcatggctgggaccacccccctgacacgaacc ctgaccatccccgaggaccaggtcctggaggtggacccagactctgactttgaggtgctg aagaagtctgccagccgcacagagaaggaggaggagaaggagccctctgtgcctaaggag atctccgtcaacggaggagagaatgtgaaagatgcctctacagagaagagcaagaagaag gggttcctgttcaaggccaagaaggcagctttaactccaccccctgttgttcccaccatg ccccgtctgagggaggaagtggtcccagacgacagagatgacgatgacatcatcctcaac accaccacatactattattcagtgcgagtgattgcgggacaagagcccagcggggtgtgg gtaggctggatcacccctgactaccaccaatatgacctgcactttgacctcagcaaagta agaaatgtcacagtcaccgtgggagatgacaaaggcaacatacatgacagtatgaagcgc agtaactgctacatggtgtggggaggggagttcagcagctcccagcagacccgtgtcagt cagcaggactttgtgattggctgccttattgaccttgacacaggactcatgactttcaca gccaatgggaaagagatcaacaccttctaccaggtggagcccaacactaaattgttccca gctgtctttgtcctgccctccagtcagaacatgctgcaagtggacctggggaagctcaag aacatcatgcctatttcagcagccatgttccggagtgagcgtaagaacccggtccctcag tgccctcccaggctggatgtccagatgctgaccccagtcatttggagccgcatgccaaac cacttcctgtccccagagatgggccgtgtgaacgacaggcacggctggatggtggagtgc agagagcctatcacaatgatggccctgcacatccccgaggagaacagatgtattgacatc ctggagttgtcggagcgtatggacctgctgaagttccactaccacactctgaaactgtac ggctcagtctgtgctctggggaacaaccgcgtggctcacgccctgtgcagccatgttgac gaatcccagctattctacgccatagagaacacctacctacctggaccaatgaggagcggc tactacgatctgctcatcagcattcacctggagtcggccaagcggaaccgcctcatgacc aataaggagttcattgtgcccatgactgaagagacgctcagcatcaacctcaactcagac actgacaaatcccatgctttaccaggggtgggcctcactacctgtctgcgccccaaactc cacttctcccccactgggtttgtagggacagacctggatatctacaccctcagccccttc atccccctacatgtgctgaaggcgaaggccctgaccatgctgacagaagctgtccaggat ggtggtcaagccatgcgggatcatgtaggaggcagtgttgagttccactttgtccccatc ctcaagctcatcagcaccctgctcatcatgggtgtgtttgataatgaagatgtcaagcac atcctgaaggtgatagagcccacagtgtttagtggagaggcagaggctgctgcccaggga gagggggaccaaacactggccctcaaagaacgggggttggaggtgaaggaagaagaggag ggagcagtagagagcggacatgaaacagaaatggaggatgaggggatggatgaggaagat gaggaaatggaggcagagctggaggagttggagcctatagaaaaagaggaagacaagggg gaggatgacggagagaaaggtgctgaggagactgagaaggaggtgaatcctggagaggca gaagaacaagtaggtctggaagagggattattgcacatgaagcttccagagtctgtcaaa ctacagatgtgcactctgctgcagtatttctgtgactgtgagttgcgccacagggtggag gccatcatagccttctcagaccagtttgtgagccaggtgcaggccaaccagagagcccgc tacaacgagctcatgctggcgtataccatgagcgctgctgagaccgctcgcaagacccgc gagttccgctccccaccacaggagcaggtcaacatgctgatgaacttgaagaacatcaca gaggatgaggattgtcctgtgcctgacgaggtccgcgatgccctgcaggcttttcacaag aacctgctgtttcactgcagtgtacatatcgaagaggaagaggtagaggaggagttggat atgtctctcaaagggcgactcctccgaatgctggacaagttgaggcacctccataagaag aaggtagaggaggagaaacctgaggaggagaacaaacccagcaccctccaggagctgatc acccacaccatggtccactgggcccaggagtcattcatccagaaccctgagctggtgcgt ctgatgttcagcctgctgcaccgtcagtatgacgggctgggggagctgatccgggccctg cccaaggcctacaccatcaacgccatctccataaaggataccatggacctgctggagtgc ctgggacagatccgctcgctgctcatcgtccagatgggccccgaggaggagaggctcatg atccagagcatcgggaacatcatgagcaacaaagtgttttatcagcaccccaacctaatg cgagcgctgggcatgcacgagactgtcatggaggtgatggtcaacgtgctgggtggtggt gactccaaggagatcagattccctcgtatggtcaccaactgctgtcgtttcctgtgctac ttctgtcgtatcagtcgtcagaaccaacgctccatgttcgatcacctcagctacctgctt cagaacagcggcatcggccttggaatgcgtggctccacccctctagacgtagctgcagca tcctgtattgataacaatgagctggctctggcgctacaggaacaagacctggagaaggtg gtgaagtaccttgcaggatgtgggcttcagagctgtccccagctcctggctaagggttac cctgacattggctggaacccttgtggcggagagaaatacctggacttcctccgcttcgct gtcttcgtcaacggagagagcgtagaggagaatgccaatgtggtggtgcgtcttctgatc cgtcggccagagtgttttggcccggccctgagaggagagggtgggaacggcctactggct gctatagaggaggccatcaagatctctgaagatcctgccagggacggccccactgtcaag aaagacaggcgcttccccggcatgtttcctggtggagaggggcagcatgaggagaacaag gtgcatctggggaatgccatcatgtccttctactcagctcttattgacttgctgggacgc tgcgctccagagatgcatttgatccaggctgggaagggtgaggctctgaggatcagggcc atcctgaggtccctggtgcccatagaggacctggtgggcgtcatcagcctgtctgtccaa atcccagactttggaaaggataacagcatcattgaacccaagatgtcttccagttttgtg ccggaccacaaggctcccatggtgctgttccttgacagagtgtatggtattgacaaccag gacttcctgctccatgtgctggaggtgggcttcctgcctgacatgagggcagctgcttct ctggacacagcagctttctgcaccacagagatggccctggctctgaaccgctacctctct ctggccgtgctgcccctcatcaacaagtgtgccttcctgtttgccggcacagaccaccgg gccatcatgatcgactccatgctgcacaccatctaccgtctgtaccgcggacgagccttc actaaggcccagagagatgtcattgaggaatgtctcatggctttgtgcaaaaatctacgg ccatccatgttacaacacctgttgagaaggctggtatttgatgtaccaattctcaatgaa tatgccaaaatgccacttaagcttttgaacaatcactatgagcgttgttggaagtactat tgcctgcccaacggctggggcaactttggagtgtcatcagaagaggagctgcatctcacc cgcaaactcttctggggcatctttgagtccctggcccacaagaaatttgatgctgagctg ttcaaaattgccatgccgtgcatatgtgccattgctggggccatccctccagattatgta gatgccagctactcctccaagactgagaagaaagcctcagtggatgcagagggaaacttt gatcccaagccagtggagaccacaactactatcatccctgagagattggatggtttcatc aacaaatatgctgaatacacacatgacaagtgggcttttgaaaagattcagaacaactgg acgtatggagagatgttggatgaagattctaaaactcaccccatgctccgaccgtacaaa acattctcagagaaggacaaagagatctaccgttggcccatcaaagagtccatgaaggct ataattgcgtgggagtggactctggatcaaatgagggaaggagaggaagccaagactgag caaaagaaggcggctcggaaaatctctcagattgcacaggcaacgtacgaccccagccat ggctacagtccccaaccgattgagatcccccacatggcactgtcaagagagctgcagtcc atggcagaacagcttgcagagaactatcacaatacctggggacgcaagaagaagatggag ctgcagtccaaaggaggaggctcccaccctttgcttgtaccctatgacaccctgacagca aaggaaaaggcacgagacagggaaaaggctcaggagcttcttaaattccttcaactcaat ggatttgcagtcaccagggggataaaagacatggagtcagacatctcatctatcgagaag cgctttgcttatggtttcctgcagaagctgttaaagtggatggagatggcccaggagttc atagctcaccttgaggctgtggtgagcagtggcagagtggagaagtcgcctcatgagcag gagatcaaattctttgcaaagatcctgttgcccctgatcaatcagtactttaaaaaccac tctctgtacttcctgtccacaccggccaaagtcctgggtactggaggacattcctctaac aaggagaaagagatgattgccagcatcttctgtaaaatggctgctctggtgagacacaga gtttctctctttggaaatgacgcccctgctattgtcaactgtcttcacatcctggcacga tctctggacgcaaggacggtgatgaagtctgggcctgaaatcgtgaaggcagggctcagg tcattctttgagggtgcagctgatgatatagagaagatggtggagaacctcaaactggga aaggtgtctaaaggcaaccagcaggtgaaaggcgtgtcccagaacatcaactacaccacc attgctctgctcccagtcctcacctccctgttcgaccacatctctcagcaccagtttgga gatgatgtcattttggatgatctccagatgtcgtgttaccgcatcatgtgcgccatttac tccctgggtactgtcaagaaccctcatgtggagaggcacatgccagccctaggggagtgt ctggcccatctggcggctgctatgccagtggcctacctggagccccatctcaatgagtac aactccttctctgtttacaccaccaagacccccagagaaagagccatcctgggtctgccc aatgaggtccaggagttatgccaggacataccagagctagacgttctattgaaagagatc ggggacttggcagagtcaggtgcccgttacacagagatgccccatgtgattgagataact ctgcccatgctgtgtaactacctgccccgctggtgggaaagaggagtagagatcttccct gagctggagggccagatctgcaccgacgtcacctctgagcagctcaaccagctgctgggc agcatcatgaagatcgtcgtcaataacctgggaattgacgaggcctcctggatgaagagg ctggctgtcttctcccagcctattgtgagcagggccaagccagagatgctcaagtcccat ttcatccccaccatggagaagctgaagaagaggacagggaaggtggtggcagaggaggac cacctgcgtatggaggggaaggccgagggggatgaggaggagggcaccatcagggaggag tttgctgtgctctgcagggacctgtacgccctctaccctctcctcatccgctatgtggac aataacagggcaacgtggttgacatgcccagacccagatgcagaggagctcttcagaatg gttggagaggtcttcatattctggtccaaatctcataacttcaaacgggaggagcagaac tttgtggtgatgaatgagattaataacatgtctttcctcactgctgacagcaagagcaag atgagcacgggcaacgactcagaggctggtggctcagacgtggagcgtaccaagaagaaa agacggggagatcgttactcagtgcagacgtcacttattgtggctgccctgaaaaagatg ctccccatcggcctcaacatgtgctcccctgctgatcaggagcttatcaacctggccaag atacgatactctttgagggacacggatgaggaagtaagagagtttttgcaaaacaacctg catcttcaaggcaaggtggagaacccgtccatgtgctggcagatgtccctgtataaggag atggcagggaaggctgaggatgctgacgctccagagaaagtggtgaagagggtgcaggag gtgtcagctgttctctatcacattgaggtgacggagcaccccttcaaatccaaaaagatt gtgtggcacaaactgctctccaagcagagacgcaaggctgtggtagcctgctttaggatg actccactctacaacctaccaaggcatagagcttccaatatgttcctggaaggatacaaa cgcaactggatccatactgaaggctactcctttgaggacagaatgatagatgacttgtct aaagccatggagcaggaaggtgaggaagaggaagagactgagaccaagccagatcccctt caccaactcattttgcatttcagccgtaccgctctcacagagaagagtaaacttgataca gattacctatatatggcatacgctgatattatggcaaagagctgccacattggtgaggag gacgaagggggagaggaggtggaggaaggggctgaggatgagacgtcctttgagatgcga cagacagaactggaaaaagagatggagaaacagagacttctgtaccagcagtcccgtctc cataaccgtggggcggctgagatggtgctgcagatgatcagtgcttgcaaaggtgagact ggctgcatggtgtcctccacccttaaattgggcatctccatcctaaacggtggtaacgtt gaggttcaacagaaaatgcttgagtacttgaaggacaagaaggatgttggcttctttttg agtgtccaggctctaatgcagacatgcagtgtcctggacctgaatgcctttgagagacag aacaaggcagagggtctgggcatgttgtcggaggagggaacaagtgagaaagtaatgtcg gatgatgagtttacatgtgatctgttccgcatgttgcagctgctctgtgagggccacaat aacgatttccagaactacttgaggacacagacaggcagcaccaccactatcaacatcatc atctgcactgtggattacctcctccgactgcaggagtcaatcagtgatttctactggtat tactctgggaaagagatcatcgatgagccaggcaagaagaacttctccaaggccatgaca gtggccaaacagatctttaacagtctgactgagtacatccagggtccgtgtacaggcaac cagcagtccctgacccacagcaggctgtgggatgcagtagtaggcttcctccacgtcttt gcccacttgatgatgaagctggcacaggactccagccagattggcctgctgaaggagcta ctggaccttcagaaagagatggtggttatgctgctctctctactagagggtaatgtggtg aacggcaccattgcccgtcagatggtggacatgctggtggagtcctccagcaacgtggag atgatcctcaagttctttgacatgttcctcaaactgaaggacattgtggcgtcagacgcc ttccgtgattacgtgaccgacccccgagggttaatctctaagaaagactttcagaaggcc atggacagccagaaacagtattctccctccgagatccaattcctgttgtcctgctcagag gctgatgagaacgacatgataaactttgaggagtttgccgaccgcttccaggagccggct aaagacattggctttaacattgcagtgttgctgacaaacctgtctgaacatgtgcctcat gacctcaggctgaagaacttcttagagcaggcagagagtgtactcaactacttccgcccc ttcctgggccgtatagagatcatgggtgccagtaggaagatagagcgtatttactttgag atcagcgaggtcaaccgcacacagtgggagatgcctcaggtcagagagtccaaacgacag ttcatatttgatgtggttaatgaggggggcgagtcggagaagatggagatgtttgtcaac ttctgcgaggacactatctttgagatgaacattgcctcccagatctcggagcaggtggag gaggaggagaaggatgatgatgatgatccagctgaaggaggaactgatacgggaggaggt ggagatgaaggcggcaatggagaggaagaagagccagagtccatctctgcctttgcagac ttcatcaacagcgtattgaacttcctgagtatcttcacattccgtaacctgcgacggcaa taccgcagggtaaggaagatgaccatcaagcagatagtggtgggtctggctaccttcttc tggactatcctcatcggcatcctgcacttcatctacagtgtatgtaagggcttcttcctg ctcatctggcaaactctatttggcggaggcctggtggagggagcaaagaacatcacagtg acagagatcctggccagtatgcctgaccccacccaggatgaggtgcatggggacctggca ggggagcctggggttgggaaggagcaggaggcaggaggggtgactgaccaaatagataca ggcggtggagaggaggaggaggaggaggacaataaagacaaggaaggtggggggacacca cgcatcgatgctcctggtggacttggtgacatgggaattgaggccactgttgagcctcct actcccgagggtactcctttgaccaagagaaaacggcaaccagaggagggtgatgctgca gcagctgatggccaagctgctgatggccaagcagctgatggcctagctgctgaaccggct tctgctcctgccataaaggagccccctccagagcctgagaaggcagacactgaaaatgga gagaaggccgaggaagaagctgagaccaaagaggagaagcaggaggaagcgatagaaaag aaacccaagtctaagaaagataagaagcaacacagggagcaagggttccaactctggact gagctggacatccaaagaaacaaattcttgaactacctctctcggaacttttacaatctg cgttttctggcactgttcattgcatttgccctgaactttattctactcttctacaaggtg tcggacagcccccgtggagaaggtgatgaggtggagggctctggcatgtttgagggctca gggttgggagtgctgtttgagggaattgggctgtttgagggctcagcagaggagatggag ggatctggtggagaggaaggaggagacgaggaagaggagggtggcccagtctacttcttc ttggaggagagcactggctacatgcagcccaccctcaccttcctggctaccctgcacacc gtcatcgccttcctctgcatcatcggttacaactgtctaaagatccctcttgtgatcttt aaaagagaaaaggagctggccaggaaactggagtttgatggtctttacatcacagagcag cctgaggatgataacatcaaaggccaatgggacagactggtcctcaacacactctctttc ccaagcaactactgggacaagtttgttaagcgaaaggtcctggataagtatggagacatt tatggcagagaaaggattgcagagctcctaggcatggatctagcctcgttggatgtcagt caacaaactgataagaagccggaggaacccgacaattctacgttggccaggtttacgtct attgacttcaagtaccagatctggaaatttggagttgtgttcacagacgggacgtttctc tacctgtgttggtacacgatcatgtccttgcttggacattacaacaacttcttctatgcc tgtcacttgctggacatcgccatcggtgtgaaggatctgcgtactatcctgtcctctgtc acccacaatgggaaacaactcatgatgacattgggcttgttggcagtggtggtgtatctc tacactgtagtggcctttatcttcttccgcaagttttacaacaagagtgaagatgaggat gagccggatatgaaatgtgacgacatgatgacttgctacctcttccatatatatgtgggc gtgcgtgctggcggtggcataggggacgagatcgaggacccggcaggagacgtgtacgag ctctaccgggtcatctttgacatcaccttcttcttctttgtcattgtcatcctgttggcc atcatccagggtctgatcattgatgccttcggagagctcagagaccaacaggagcaggtt aaggaagacatggagaccaagtgcttcatctgtggaattggaagcgactactttgatacg acgccacacggcttcgagacccacaccctagaggaacacaacttggccaactacatgttc ttcttaatgtacctcatcaacaaagatgagacggagcacactggccaggagtcgtatgtg tggaagatgtaccaggagcgagcgtgggacttcttccctgctggcgactgtttcagaaag caatatgaggatcagcttgcataa

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