Oreochromis niloticus (Nile tilapia): 100708262 Help Entry 100708262         CDS       T06104                                  Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism onl  Oreochromis niloticus (Nile tilapia) Pathway onl04020   Calcium signaling pathway onl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:onl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100708262    04020 Calcium signaling pathway     100708262  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:onl01009]     100708262   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:onl04147]     100708262    04040 Ion channels [BR:onl04040]     100708262 Protein phosphatases and associated proteins [BR:onl01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      100708262 Exosome [BR:onl04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100708262 Ion channels [BR:onl04040]  Voltage-gated cation channels   Ryanodine receptor    100708262 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  100708262 NCBI-ProteinID:  XP_025766651 Ensembl:  ENSONIG00000005030 LinkDB All DBs Position LG10:complement(13023541..13082590) Genome browser AA seq 5088 aa AA seqDB search MAEAADGEEEIQFLRTDDHVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLSNSSVDEAVDLDKWSSQGGGHRTLLYGHAILLKHTHSS MYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYASGDLMVDASFMQTLWTMTPVMSGCELAEGFLTGGYVLRLFHGHMDECLAI PAADQGDDQRRVAHYEGGPVCSHARSLWRLEPLRIAWSGGHIKWGQSFRIRHITTGRYLC LDEEKGLLLVDPEKANSKMSAFCFRISKEKIEVTQKRDVEGMGIPEIKYGESMCFVQHVS SGLWLTYAAVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEESQAARMIYSTTGLFN QFIKGLDALSGKNKSANAPSLPMDAVVLSLQDLIFYFRPPEEELEHEDKQFKLRSLKNRQ NLFQEEGMITLVLDCVDRLNVYNTAAHFSEYAGEEAAESWKEIVNLLYELLASLIRGNRA NCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGR NHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIINYVTSMRPNVFLGTCEG STQYKKWYFEVMVDHVEPFLTAQPYHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYG FDGLHLWSGRVPRHVATTNQHLLAAEDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDG LFFPVVSFSAGIRLRFLLGGRHGHFKFLPPPGYAPCYEAVLPRDRLRIEPIKEYKHDFDG VRNLLGPTQSLSHTAFTPCPVDTIQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGP FRDDNKKLHPCLVDFQSLPEPEKNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKRTKL PKTYMQSNGYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIVQDIMN KRNPRLVPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHGPGSSRGDKIRV FRAEKSYAVTQGKWYFEFEAVTVGEMRVGWSRPNVRADTELGADELAYVFNGFKAQRWHI GNEPFGRQWQSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSL GLSQVGRINLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPVPADHPH IEVSRVDGTVDTPPCIKATHKTFGSQNANTDLLFFRLSMPVEFHETFKIPAGTTLLTRTL TIPEDEVLEVDPGSDFEILKKSATRKEQEEEKKETSVPKETPAIKNGENEKDASTEKSKK KGFLFKAKKAALITPPPVVPTMPRLVEDVVPDDRDDMDIILNTTTYYYSVRVFAGQELNG VWVGWITPDYHQYDLHFDISKVRNVTVTVGDDKGNIHDSIKRSNCYIVWGGEFSSSQQTR VSQEDFVIGCLIDLDTGLMTFTGNGKEINTFYQVEPTTKLFPAVFVLPSSQNMVQLELGK LKNIMPISAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNNFLAPEMGRVSERLGWMV ECTEPLTMMALHIPEENRCIDILELSERMDLLKFHYHTLKLYSSVCALGNNRVAHALCSH VDESQLFYAIENTYLPGPMRSGFYDLLISMHLESAKRNRLGTNKEFIVPMTEETRSITLY SDKSHALPGVGLTTCLRPKLHFSSVGFVGTDQDIYTLSPVIPLQVLKTKALNMLTEAVQD GGQAMRDPVGGSVEFHFVPILKLISTLLIMGVFDDEDVTHILKMIEPTVFRGKQAEEPGE GDAKVQEEKDLPKVAAIKEGEQEALGEEEEEFEDDGLGYEEEEEELEEEEAIEEGESIVQ HEETVVETDPVNGEKGAEETEKEGKPLETGGEGKEEHLEQGLFQMKLPESVKLQMCTLLQ YFCDCELRHRVEAIIAFSDQFVSQIQSNQRQRYNELMQAFTMSAAETARKTREFRSPPQE QVNMLMNFKNSFEDEESPIPDEVRESLLAFHNTLLAHCGVHIEEEEQEEEVDNSVRGRLL RLLERVKKFREKKEEVESEPQEDKKPSTLQELISHTMIHWAQESFIQNPELVRMMFSLLH RQYDGLGELMRALPKAYTINAVSIQDTMDLLECLGQIRSLLIVQMGPEEERLIIQSIGNI MSNKVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRVVTNCCRFLCYFCRISRQ NQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVKYLAGC GLQSCPMLLAKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFG PALRGEGGNGLLAAIEEAIKISEDPARDGPSVKKDRRFPMFGGEEQHEENRVHLGNAIMS FYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPLQIPAFGKDNS VIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFSTT EMALALNRYLCSAVLPLITKCAPLFAGSDHRAIMIDSMLHTIYRLSRGRAFTKAQRDIIE ECLMALCKHLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANF GVASEEELHLTRKLFWGIFESLAHKKFDAEIFKISMPCICAIAGAIPPDYVDASYSSKTE KKASVDAEGNFDPKPVDTTNTIIPERLDPFINRYAEYTHDKWAFEKIQNNWSYGETLDEN AKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMIAWEWNIEKAREEEESEKKKATSRKISQ TAQATYDPSHGYSPQPIDISHMALSRDLQSMAEQLAENYHNTWGRKKKLELQAKGGGTHP LLVPYDTLTAKEKARDREKAYELLKFLQLNGYAVTRGLKDMESDISSIEKRFAYGFLQKL LKWMEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILMPLINQYFKNHCLYFLSTPAK VLGSGGHSSNKEKEMIASIFCKMSALVRHRVSLFGTDAPAIVNCLHILARSLDARTVMKS GPEIVKAGLRSFFESAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSL FDHIAQHQFGDDVILDDLQMSCYRIMCSIYSLGTVKNLHVERQRPALGECLAHLAAAMPV AYLEPHLNEFNAFSVYTTKTPRERAILGLPNEVQELCPDIPELDTLLKEIGDLAESGARY TEMPHVIEITLPMLCNYLIRWWERGPENFPEMEGRLCTEVTSEHLNQLLGSIMKIVVNNL GIDEASWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTSKVVAEEDHLRMEGKSEG DEEDGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSK SHNFKREEQNFVVMNEINNMSFLTADSKSKMSKGGDTEGGGSDTERTKKKKRGDRYSVQT SLIVAALKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLHLQGKVDNPS MRWQMALYKEMAGKAEDADAPPKVVKRVQEVSAVLYHLEVTEHPFKSKKMVWHKLLSKQR RRAVVACFRMTPLYNIPRHRASNMFLEGYRRNWLHPEGFSFEDRMIDDLSKAMEQEEGDE EEEKETKPDPLHQLILHFSRTALTEKSKLDTDHLYMAYADIMAKSCHIGEEEEGGEEMGE NAEDEMSFEVRQSELEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGPMVSTTLK LGISILNGGNSEVQRKMLEYLKDKKDVGFFLSVQALMQTCCVLDLNAFERQNKAEGLGMV SEEGTNLNLDRDEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICT VDYLLRLQESISDFYWYYSGKDVIDEPGKKNFSKAMTVAKQIFNSLTEYIQGPCNGNQQS LAHSRLWDAIVGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGT IARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDS QKQYSPSEIQFLLSCSEADENDMINYEEFASRFQEPAKDIGFNIAVLLTNLSEHVPHDTR LQNFLEQAESVLNYFRPFLGRIEIMGASRKIERIYFEISEVNRRQWEMPQVRESKRQFIF DVVNEGGESEKMEMFVNFCEDTIFEMNIASQISEQEEEEKGEEEDEGEEGGGEGGGGGEG NGGGDEDNNGREGPHESTSAFADFINSMLSFLGIFTFRNLRRQYRRVRKMTFKEIVVALS TFFWTILMSILHFIYNVCKGIFMIIWQTLFGGGLVEGAKNITVTEILASMPDPTQDDVHG DGPGEPRTGEEQDTGGVTDTGETGSGEEEEEDTQEKEGGRIPGMDAPGGLGDMGVEAPVE PPTPEGTPITKRKMAPEETDASQKPPEPPPVEEPPTEPEKADAETGEKTEKECESKEEVE PEKPKKSAAKKDKKLKKGGGFQIWTELETQRNKFMNYLSRNFYNLRFLALFLAFALNFIL LFYKVSDSPPEGEEMEGSGLSEGSGLFEGSALFEGSGEELEGSGINGGGDEDEEDVPVYY YLEESTGYMQPTLSFLAMLHTVISFICIIGYNCLKIPLVIFKREKELARKLEFDGLYITE QPEDDDIKGQWDRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGVDLASLDV SQQHEKKQEEPDNSVFAWATSIDIKYQIWKFGVVFTDGTFLYLCWYLVMSLLGHYNNFFF ACHLLDIAMGVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDE DEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILL AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTFDEHNLANYM FFLMYLINKDETEHTGPESYVWKMYQERCWDFFPAGDCFRKQFEDQLS NT seq 15267 nt NT seq  +upstreamnt  +downstreamnt atggcagaagctgcagacggagaggaagagattcaatttctgcgtacggatgaccatgta gtgctgcagtgcactgcatctattcttaaggaacagatcaagctgtgcctgtcatgtgaa ggttttggaaatcgtctgtgctttctcgagaccacgtcgaatgctcagaatgtccctcca gacctcgccatctgctgcttcattttggagcaatccctgtctgtgcgagcattacaggag atgttgtccaactcctctgtggatgaggcagtcgatttggacaaatggtcgtcacaaggt gggggtcatcgaaccctcctgtatggacatgccatcctcctgaaacacacccactccagc atgtacttgagctgtttgactacgtcgcgctcactgacagacaaactggcttttgatgtg ggcttgcaggaagactccacaggagaggcctgctggtggaccatccatccagcctctaag caaaggtctgaaggagagaaggtcagagtgggagatgacctcattcttgtcagtgtttct tcagagcgatacctgcacctgtcctatgccagtggtgatttaatggtagatgcttccttc atgcaaactctgtggaccatgacccctgtaatgtctggatgtgaactagctgaaggtttt ctgactggagggtatgtgctccggctgttccacggtcacatggacgagtgtttggcaatc ccagcagctgaccaaggggacgaccagcgcagagttgctcactatgaaggagggccagta tgcagtcatgctcgatccttatggagacttgagccactacgtattgcctggagtggaggc cacattaagtggggccagtctttccggatacgtcacataacaacaggccgatacctttgt ctggatgaggagaaaggacttctgttggtggacccagagaaggcaaattccaagatgtca gccttctgcttcaggatttcaaaggaaaaaattgaagtgacccagaaacgagatgtggag ggcatgggcatacctgagatcaagtatggagagtccatgtgctttgtacagcatgtttca tctggcctgtggcttacatatgctgctgttgatgccaaatctgcacgtctaggtcctctg aagagaaaggccatactccacaaagaaggtcacatggatgatgccctcacggttgctcga tctcagactgaagagtctcaagctgccaggatgatttacagcacaacaggcctcttcaac cagttcatcaaaggacttgatgctctaagtggaaaaaataagtctgccaatgccccgtct ctgcctatggacgcagtggtgctctcgttgcaggatctcattttctacttccgaccccct gaagaggaactggagcacgaggacaagcagttcaagctccgctccttaaaaaacagacag aacctttttcaggaagagggaatgattacgcttgttctggactgcgttgatcgcctcaat gtgtacaacacagcagcccatttctcagagtatgctggggaagaagctgctgagtcatgg aaagagattgtgaatttactgtatgaattgctagcttctttgatcagaggtaaccgtgcc aactgcgccctcttctgtgacaaccttgactggctggtcagtaaactggatcgtttggaa gcatcttcaggaatcctggaggtgttatattgcgtcctgattgagagtccagaggttttg aatattattcaagagaatcacatcaaatcaatcatctctctgctggataagcatggacgc aatcacaaggtcttggatgtgctttgttccctctgtgtgtgtaatggggtcgctgtaagg tcaaatcagaatctcatcacagagaatctgttaccaggacgtgaccttctacttcaaact aacatcatcaactatgtaaccagcatgagacccaatgttttccttggaacttgcgaagga tccactcagtataagaagtggtattttgaggtgatggtggaccacgtggagccgttcctt acagctcagccatatcatctccgtgtaggttgggctctgacagagggctacagtccttat cctggcggaggagaaggctgggggggtaacggggttggagatgatctctactcttatggt tttgacgggcttcacctctggtcaggacgtgttccacgtcatgtcgccacaacaaatcag cacctcctggcagcagaggatgtggtcagctgctgcttggatctgagcgtacccagcatt tcctttcgtataaatggccatcctgttcagggaatgtttgagaacttcaacctagatgga ctgttctttccagttgtgagcttctctgcaggcataagactgcgatttcttcttggaggt cgtcatgggcatttcaagtttctcccacctcccggctatgctccgtgctatgaagcagtg ctgcccagggaccgtttgcggatcgagcccatcaaagagtataagcatgattttgatggt gttcggaatctgctgggtccaactcagtccctttcacatacggccttcacaccttgccca gtcgacactatacagattgtgcttccacctcatttggagcgcattcgagagaagctcgca gaaaacagccacgagttatgggctgttacccgcattgaacaagggtggacgtatggacca tttcgcgatgataacaagaagctgcacccctgcctggtagatttccagagtctgcctgaa cctgagaagaactataatttagcaatgtctggagagacactgaagactctgttggcacta ggctgtcatgtaggaatgggagatgagaaagcagaagagaatctcaaaaggaccaaactc cctaaaacgtacatgcagagtaacggatacaagccagcccctttggaccttaaccatgtc aagctgactcctaatcaaaacactctagtggagagactggcagaaaatggacacaatgtt tgggcaagagaccgagtccgccagggatggacatacagtattgtccaggacattatgaac aagcgcaatcctcgtctggttccttataacctcctggatgaaaagacaaaaaagaccaac agagacacggtttgtgccgctgttcgcactctgattggttacggttacaacatagaacca cctgatcaggagagcagtggacatggaccaggcagctcccgtggagataaaatcagagtg ttcagagcagagaaatcttacgctgttacacaggggaagtggtactttgagtttgaagct gtgacagttggagagatgagagtgggctggtccaggcccaatgttcgtgcagacactgaa cttggtgcagatgagttggcgtatgtcttcaatggctttaaggcccaacgctggcacata ggaaatgagccatttggccgtcagtggcaatctggtgatgtggtgggttgtatgattgac ctcactgagatgaacatcatgttcacactcaatggagaaatgctgatcagtgattcgggc tcagagatggcctttaaggatatcgagataggagaaggcttcatacctgtgtgcagtctg ggcctgtctcaggtaggcaggatcaacctgggtcagaacgtcagcagtcttcgatacttt accatctgtggcctacaggaagggtttgaaccctttgctatcaacatgaaaagagacatt accatgtggttcagcaagagccttccccagtttattcctgtcccagctgatcatcctcac attgaggtgtcacgcgttgatgggacagttgatacccccccttgtattaaagcgacccac aagacatttggatctcagaatgccaacacagatctgctcttcttcagactcagcatgcca gttgagtttcatgagacctttaaaatcccagcagggaccactcttcttactcgcactttg accatcccggaggatgaagtgttggaggtggacccaggctctgattttgaaatactcaaa aagtctgctactcgcaaggagcaggaggaagagaagaaggaaacctcagttcctaaagag acgcctgctatcaaaaatggagaaaacgagaaggatgcctccactgagaaaagcaaaaag aaaggtttccttttcaaggctaaaaaggcagcgttaataactccaccccctgttgtaccc accatgccccgcttagtggaagatgtagtaccagatgacagggatgacatggacatcatc ctcaataccactacatactattactcagtacgagtgtttgctggacaggagcttaatggc gtgtgggttggctggataacacctgactatcaccagtacgaccttcattttgatatcagc aaagtcagaaatgtaactgtcactgtaggtgatgataaaggcaacattcatgacagtatc aaacgcagcaattgctatattgtatggggaggggagttcagtagctcccagcagacccga gtcagtcaggaggattttgtgattggctgtctcattgatttggacactggactaatgact ttcactggaaatggaaaagagatcaatacattttatcaggtagagccaaccacaaaattg tttccggctgtctttgttctgccttccagtcagaatatggttcagttggaattaggcaag ctcaagaacatcatgccgatctcagccgcgatgtttcgaagtgaacgcaaaaatccagtc ccccagtgtcctcctagactggatgtccagatgttaactccagttatctggagccgaatg cctaacaacttcctagctccagagatgggacgtgttagtgagagactaggctggatggtg gagtgtacggagccactcactatgatggcccttcacatccccgaggaaaacaggtgtatt gacatcttggagctgtctgaacggatggatttgctgaagttccactaccatactctaaag ctatacagctcagtttgtgcactgggaaacaaccgtgtggcacatgctttgtgcagccac gtggatgaatcgcagctcttttacgccatagagaacacctacctacctggaccaatgagg agcggcttttatgacctgctcatcagcatgcacctggagtcagctaaaaggaatcggctg gggaccaacaaggaattcatagttccaatgacagaagaaacacgtagtatcactctgtac tccgacaaatctcacgctttacctggcgtcggcctaactacatgtctgcgtccaaaactt catttctcttctgttgggtttgtgggaacagatcaagatatttacacacttagtccagtc attcccctacaggtgctaaagaccaaagctctgaacatgctgactgaggcagtgcaggat ggaggtcaagccatgagagatcctgtgggaggcagtgttgagtttcatttcgttccaatc ctaaagctcatcagtacccttctcataatgggtgtgtttgatgatgaagatgtcacacac atcctgaagatgattgagcccacagtctttagaggcaagcaagcggaggagcctggtgag ggggatgccaaggtgcaagaagagaaggatcttcctaaagtagcagcgattaaagaaggg gagcaggaagccctgggggaagaagaagaggaatttgaggatgatgggttgggttatgaa gaagaggaggaagaactggaggaagaagaagcaatagaggagggtgaatctatcgtgcaa catgaggaaacagtggttgagacagacccggtaaatggtgagaaaggagctgaggaaaca gagaaagaggggaaacctttagagacgggcggggagggaaaagaagaacatctagagcaa ggacttttccagatgaagctaccagagtctgtgaaactgcagatgtgcactctgctgcag tatttctgtgactgtgagctacgtcatagagtggaggccatcattgcattttctgaccag tttgtcagccagatacagtccaaccagaggcagcgctacaatgaactcatgcaggccttc accatgagtgctgccgagactgctcgcaagacccgtgaatttcgctccccaccacaggag caagtcaacatgctcatgaacttcaagaactcttttgaggatgaagagtccccaattcct gatgaagtccgcgaatctctgctcgcctttcacaacactttgctggcacactgtggtgtt cacattgaagaggaggaacaagaggaagaagtggataattctgtccgtggacggctcctt cgattgctggaaagggtgaaaaagtttcgtgagaagaaggaggaggtggagtctgagcca caagaagacaaaaaaccaagcacattgcaggagttgatttcacatactatgatccactgg gcgcaggagtcatttatccagaaccctgagctcgtgcgtatgatgttcagcctccttcac aggcagtatgatggactcggtgagctcatgcgtgcccttcctaaggcctacaccatcaat gcagtttccattcaggacaccatggacctcttggagtgcttgggccagatccgctcactg cttattgtccagatgggtccagaagaggagagacttataattcaaagcattgggaacatc atgagtaacaaagttttctatcagcaccccaacttgatgcgagctctgggcatgcatgaa actgtcatggaggtcatggtcaatgtacttggcggtggggactcaaaagagatcagattt cctcgggtggtgacaaactgctgccgtttcctctgctacttctgtcgcatcagtcgtcaa aatcagcgttccatgtttgaccatctcagctaccttctccagaacagtggcattggcctt ggaatgcgtggctccacccccttggatgtggctgcagcgtcttgtattgacaataacgag ctggcattggctcttcaagagcaggatcttgaaatggtagtgaagtatttagccggatgt ggacttcagagctgtccaatgctactggctaaaggataccctgacatcgggtggaatcct tgtggtggagagaaatatcttgattttcttcgttttgctgtttttgtcaatggagaaagc gtagaggagaatgcaaatgtggtggtgcgtctcctcatccgtaggcctgagtgctttggt ccagccttgagaggggagggtggtaatggactcctggctgcaattgaggaggcaatcaaa atatcagaggaccctgcaagggatggccctagtgttaagaaagatagacgctttcccatg tttggaggagaggaacagcatgaggagaacagggttcacctgggaaatgccattatgtct ttttactctgctcttattgacctgctgggaagatgtgctccagagatgcatttgatccag gctggtaaaggtgaggctctcaggatcagggccattctgaggtctctggtccctatagaa gatctggtgggagtcatcagtcttcctcttcagattccagcttttggaaaagacaacagc gttattgaaccaaagatgtctgctagctttgtgccagatcacaaggctcccatggttctg ttcttggacagagtttatggtattgacaaccaagatttccttctccatgtgctggaggtc ggctttttgcctgacatgagagctgctgcctccctggatacggttgcttttagcaccact gagatggctctggctttgaaccgctacctctgctctgctgtgttgccactcatcaccaag tgtgccccgctctttgctggcagtgaccatcgagccataatgattgactccatgttgcac acaatctacaggctgtctcgtggacgagccttcacaaaagcccaaagagacattattgaa gagtgcctcatggctctgtgcaagcatctacgtccatctatgcttcagcatctgctaagg cggctggtgtttgatgtgcccattctcaatgagtatgccaaaatgcctctaaagctttta accaatcactatgagcgttgttggaaatattattgcctccctaatggttgggctaatttt ggagttgcatcagaagaggagctgcatcttacacgcaaactgttttgggggatctttgaa tcactagctcacaagaaatttgatgctgaaattttcaaaatttcaatgccatgcatctgc gccattgctggagccattcctcctgactatgtagatgccagctactcctccaagacagag aaaaaggcatcagtagatgcagagggaaactttgatcctaaacctgtggatacaacaaac actatcatccctgagagattggatccctttatcaacagatatgccgaatacactcatgac aaatgggcctttgaaaagattcagaataactggtcatacggtgagacactggatgaaaat gcaaaaacccaccccatgcttagaccgtacaagacattctcagagaaggacaaagagatc taccgatggccaattaaagagtcaatcaaagccatgattgcatgggaatggaacattgag aaagctagagaggaggaagagtcagagaagaagaaggcaacatcacgaaaaatctcacag actgcacaggcaacttatgatccaagccatggctatagtccacagcccattgatatctcc catatggctctttcgagagatctgcagtcaatggcagaacaactggcagaaaattaccat aacacctggggaagaaagaaaaaattggagctgcaagcaaaaggaggtggaacacatcct ctgctcgtgccctacgataccctgacagctaaagaaaaggcacgagacagagagaaggct tatgagctgctgaagttcttgcagcttaatggatatgctgtcacaagaggccttaaagac atggagtcggacatatcatccattgaaaagaggtttgcgtatggtttccttcagaaactg ctgaaatggatggaaatcgcacaggagttcatcgcacatcttgaggctgtggttagcagc ggacgagtggaaaagtctccccatgagcaggaaatcaaattctttgccaagatcttgatg cctctaataaatcagtatttcaaaaatcactgcctctactttttgtctacacctgcaaaa gtcctgggtagtggcgggcattcttccaataaggagaaggagatgattgcaagtatcttc tgtaaaatgtctgctttggtgaggcacagagtttctctctttggaacggatgccccagca attgttaactgtcttcacattctggctcgatcactggatgcaaggacggtaatgaagtca ggacctgagattgttaaagcagggctacgatcgttctttgagagtgctgctgatgatatt gagaagatggttgaaaatctcaaactgggcaaagtatcgaaaggcaatcagcaagtgaaa ggcgtctctcagaacatcaactacaccaccattgcactgctcccagtacttacctccctg tttgatcacattgctcagcatcaatttggagatgatgtcatcttggatgatctgcagatg tcatgctatcggatcatgtgcagcatctactccctggggactgtgaagaatctacatgtt gagaggcagaggccagctcttggagagtgtttggcacaccttgcagcagctatgccggtg gcctacttagaaccccatctaaatgaatttaatgctttctctgtatacaccacaaagact cccagagagagagccatcttgggccttcccaatgaggtccaggaattatgtccagacatc ccagagctggatactctgctgaaggagatcggggacttggcagagtcgggggctcgttac actgagatgcctcatgtgattgaaattactttacccatgctttgtaactacctcattcgc tggtgggagagaggacctgaaaattttcctgagatggagggccgactgtgcactgaggtc acgtcagaacaccttaatcagctgctaggaagcatcatgaaaattgtagtgaacaacctg ggaatagatgaagcctcctggatgaagagattggctgtgttttcacagcccattgttagc agagcaaagccagaaatgctcaagtctcactttatcccaacaatggagaaactaaagaaa cgcacatcaaaggtggtggctgaggaggaccacttaaggatggagggaaaatcagaggga gatgaggaagatggtactatacgtgatgagtttgctgtcctctgtagagacttgtatgcc ctttaccctctacttattcgttatgtggacaataacagagcgaggtggctgacatgtcct gacccagatgcagaagagctcttccgaatggttggagaagtctttattttctggtccaaa tctcataacttcaagcgagaggaacaaaactttgtggtgatgaatgagatcaataacatg tcattcctcaccgctgacagcaagagtaaaatgagcaagggcggggacacagagggtgga ggctcagatactgagcgtaccaagaagaagaaacggggagatcgttactcagtccagact tcacttattgtggctgccttgaaaaagatgctccccataggcctaaacatgtgctctcct gctgatcaggagcttatcaacttggccaagatccgatactctttgagagacacagatgaa gaagtaagagagttcctgcagaataacctgcatctacagggcaaggtggacaacccatcc atgcgctggcagatggcgctgtacaaggagatggcagggaaggctgaagatgcagatgcc ccaccgaaagttgttaagagagtgcaggaggtttctgcggtcctctaccaccttgaagtg acggagcatccgtttaaatccaagaagatggtgtggcacaaactgttgtccaagcaacga cgcagagctgtggtcgcttgctttaggatgacaccactatataacattccaaggcacaga gcttcaaacatgttccttgagggatacaggcgcaactggcttcatcctgaaggcttctca tttgaagacagaatgatagatgacttatctaaagcaatggagcaagaggagggagatgag gaagaggagaaggaaacaaagccagatccccttcatcagctaattctccattttagtcgt actgctcttacagagaagagtaaactggatactgatcatctttatatggcatatgcggat attatggcaaagagttgtcatattggtgaggaagaagaaggtggagaggaaatgggggaa aatgctgaggatgagatgtcctttgaggtgcgacagtcagaactggaaaaagaaatggag aaacaaagactcttgtaccagcagtctagactgcataatcgtggcgctgcagaaatggtc ctgcaaatgatcagtgcctgcaaaggtgaaacgggcccaatggtgtctacaaccctcaag ctgggtatttctatccttaacggtgggaacagtgaggttcagcggaaaatgctggagtac ttaaaggacaagaaggatgtgggcttctttttgagtgtccaggcattgatgcagacttgc tgtgtcctggatctaaatgcctttgagaggcagaacaaggcagaggggctgggcatggtt tcagaggaaggcaccaacttgaacctagatcgggatgagaaagtgatggcagatgatgag ttcacctgtgacctcttccgtttcttgcagttgctttgtgaaggtcacaataatgatttt cagaactacttgcggactcaaacaggcagcacaaccaccatcaatgtcatcatctgtaca gtggactaccttctccgtctccaggagtctataagtgacttctactggtattactctggg aaggatgtcatcgatgaaccaggcaaaaaaaatttctccaaagctatgacagtggcaaaa cagattttcaacagtctaactgaatatatccagggtccatgcaatggcaaccaacagtcc ctggcccacagcaggctgtgggatgctattgttggctttcttcatgtctttgcccacatg atgatgaagctggcacaggactccagccagattggtctgctgaaggagcttcttgaccta cagaaagatatggttgttatgttgctgtctttattggagggaaatgtggtaaatggtaca atcgctcgccagatggtagacatgttggtagagtcctccagcaatgtggagatgatactc aagttctttgacatgttcctcaaactgaaagatatcgtggcctcagatgctttccgtgat tatgtgacagaccctcgagggctgatctcaaagaaggacttccagaaggcgatggacagt caaaagcagtactccccctctgagattcagtttcttttgtcctgctcagaagcagatgaa aatgacatgatcaattatgaagagtttgccagtcgcttccaggaacccgccaaagacatt ggcttcaacattgctgtgctgctcaccaatctgtctgagcatgtccctcatgacaccagg ctacagaacttcctggaacaagcagagagtgtgctgaactacttccgtccgttcttgggg cgtattgaaataatgggagccagcagaaaaattgaacgcatctactttgaaatcagtgag gttaaccgcagacagtgggagatgcctcaagtaagagagtccaaacggcagttcatcttt gatgtcgtcaatgagggtggcgaatcagagaagatggagatgtttgtcaacttctgtgaa gacaccatctttgagatgaatatagcctcacaaatttcagagcaggaggaagaggaaaag ggggaagaagaagatgaaggggaagaagggggaggtgagggtggaggaggtggggaagga aatggaggaggagatgaggataataatggaagggaagggccacatgaatcaacctctgcc tttgcagattttataaacagcatgttaagcttcctcggcattttcaccttccgtaacctt cgcagacagtatcgtagagtgagaaagatgaccttcaaggagattgtagtggccttgtcc acttttttctggaccatactgatgagtatactacacttcatttacaatgtatgcaaaggt atctttatgatcatctggcaaacactgtttggaggtggcttggtagagggagccaaaaat atcacagtcactgagattttagccagcatgccagatcccacccaggacgatgtgcatggc gatggaccaggggagccaaggacaggggaggaacaggacactggaggtgtaacagatact ggtgagactgggagtggagaggaagaagaggaggatacccaagaaaaagagggtgggagg ataccaggaatggatgctccaggtggacttggagatatgggtgtggaggcaccagttgaa cctccaactcctgaaggaactcccataacaaagagaaaaatggcaccagaagagactgat gctagtcagaaaccaccagaacctcctcctgtagaagaacctcctacggagcctgaaaag gctgatgctgaaactggagagaaaacagagaaagaatgtgagagcaaagaagaagtagaa ccagaaaaaccaaagaaatcagcagccaaaaaagacaagaagctgaaaaagggtggaggt tttcaaatctggactgagctggaaacccaaaggaataaatttatgaactatctttccaga aacttctacaacctgcgttttttggctctgttccttgcatttgccctgaacttcattctt cttttctataaggtgtcggacagcccgcctgagggtgaagagatggaaggctctggacta tctgagggaagcgggctgttcgaagggtctgcgttgtttgaaggttcaggcgaagagctt gaaggatccggaattaatggtggaggagatgaagatgaggaagatgttccagtttattac tatttagaggagagcactggatacatgcagcctactttgtcctttcttgcgatgcttcac acagtcatttcattcatctgtatcattggctacaactgcctgaagattcctctggtcatt tttaaaagagagaaagaacttgcgagaaagctggaatttgatggcctctacatcactgag caaccggaggatgatgacatcaaggggcagtgggacagattagtcctgaatacaccctct ttcccaaacaactactgggataaatttgtcaagcgaaaggttcttgataaatacggagac atttatggaagagaaagaattgctgagctcctgggggttgatttagcttccctggatgtg agtcaacaacatgagaagaaacaggaagaaccagataactctgtgtttgcatgggcgact tctattgacatcaagtaccagatctggaaatttggtgtggtgttcacagatggtactttt ctttacctctgttggtacttggtgatgtctttgcttgggcattacaacaacttcttcttc gcctgtcatttgctggatattgcgatgggtgtcaagactcttcgcactatcttgtcctca gtcacacacaatggcaaacagctcatgatgacagtgggcttgctggccgtggttgtgtat ctttacaccgtagttgccttcaatttcttccgcaagttttacaacaagagtgaagatgaa gacgaaccagatatgaaatgtgacgatatgatgacttgttatctgttccacatgtatgtg ggtgtccgagcaggcggaggcattggagatgagattgaagacccagctggagatgaatac gagctttatcgagtggtctttgatattactttctttttcttcgtcattgttatcctgctg gccatcattcagggtctgatcattgacgcctttggagaactcagagaccaacaagagcaa gtcaaggaagacatggagacgaaatgcttcatatgtggcattggaagtgactactttgat acaacgccgcatggctttgagactcacacttttgatgaacacaacctggccaattacatg ttctttttaatgtaccttatcaacaaagatgagaccgagcacactgggccggagtcatat gtgtggaagatgtaccaggagcgctgttgggacttcttcccagctggagactgtttcaga aaacagtttgaggatcagctctcttaa

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