Orcinus orca (killer whale): 101271418 Help Entry 101271418         CDS       T05247                                  Symbol LCK Name (RefSeq) tyrosine-protein kinase Lck   KO K05856   lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2] Organism oor  Orcinus orca (killer whale) Pathway oor04064   NF-kappa B signaling pathway oor04380   Osteoclast differentiation oor04650   Natural killer cell mediated cytotoxicity oor04658   Th1 and Th2 cell differentiation oor04659   Th17 cell differentiation oor04660   T cell receptor signaling pathway oor05135   Yersinia infection oor05166   Human T-cell leukemia virus 1 infection oor05235   PD-L1 expression and PD-1 checkpoint pathway in cancer oor05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:oor00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     101271418 (LCK)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     101271418 (LCK)    04660 T cell receptor signaling pathway     101271418 (LCK)    04658 Th1 and Th2 cell differentiation     101271418 (LCK)    04659 Th17 cell differentiation     101271418 (LCK)   09158 Development and regeneration    04380 Osteoclast differentiation     101271418 (LCK)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101271418 (LCK)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101271418 (LCK)   09171 Infectious disease: bacterial    05135 Yersinia infection     101271418 (LCK)   09163 Immune disease    05340 Primary immunodeficiency     101271418 (LCK)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oor01001]     101271418 (LCK)   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:oor03036]     101271418 (LCK) Enzymes [BR:oor01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101271418 (LCK) Protein kinases [BR:oor01001]  Non-receptor tyrosine kinases   SRC family    101271418 (LCK) Chromosome and associated proteins [BR:oor03036]  Eukaryotic type   Centrosome formation proteins    Kinases and associated factors     101271418 (LCK) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_2 SH3_9 ABC1 SH2_1 SH3_16 Haspin_kinase Kdo SH3_3 DUF7063 Motif Other DBs NCBI-GeneID:  101271418 NCBI-ProteinID:  XP_004266570 LinkDB All DBs Position 1:complement(187322531..187341779) Genome browser AA seq 509 aa AA seqDB search MGCSCSSNPEDDWMENIDVCENCHYPIVPLEGKAMLSIWNGSEVRDPLVTYEGSNPPASP LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQNGEWWKAQSVTTGQEGYIPFNFVARAN SLEPEPWFFKTLTRKDAERQLLAPGNTHGSFLIRESESTTGSFSLSVRDFDQTQGEVVKH YKIRNLDKGGFYISPRITFPGLHELVRHYMNSSDGLCTRLSRPCQTQKPQKPWWEDEWEV PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL VRLYAVVTQEPIYIITEYMENGSLVDFLKTSTGIKLTINKLLDMAAQIAEGMAFIEERNY IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLEQGYRMVRPDNCPDELYQLMMLCWKEL PEDRPTFDYLRSVLEDFFTATEGQYQPQP NT seq 1530 nt NT seq  +upstreamnt  +downstreamnt atgggctgtagctgcagctcaaaccctgaagatgactggatggaaaacatcgatgtgtgt gagaactgccattaccccatagttccactggagggcaaggccatgctgtccatctggaat ggctctgaagtgcgggatccactggtcacctacgagggctccaaccccccagcttctcca ctgcaagacaacctggttatcgccctgcacagctatgagccttcccacgatggagatctg ggcttcgagaagggtgaacagctacgtatcctggagcagaacggcgagtggtggaaggcg cagtccgtgaccacgggccaggaaggttacatccccttcaactttgtggccagagcgaac agcctggagcccgaaccctggttcttcaagaccctgacccgcaaggacgcggagaggcag ctcctggcgcccgggaacacgcacggctccttcctgatccgagagagtgaaagcaccacg ggatcgttttcactgtccgtccgggacttcgaccagacccagggagaagtggtgaaacat tacaagatccgtaacctggacaaaggcggcttctacatctccccccgcatcacttttcct ggcttgcatgagctggtccgccattacatgaattcttcggacgggctgtgcacgaggttg agccgcccctgccagacccagaagccccagaagccctggtgggaggatgagtgggaggtt cccagggagacgctgaagctggtggagcggctgggggctggccagttcggagaggtgtgg atggggtactacaacgggcacacgaaggtggcagtgaagagcctgaagcagggcagcatg tcccccgatgccttcctggccgaggccaacctcatgaagcagctgcaacaccagcggctg gtcaggctctacgcggtggtcacccaggagcccatctatatcatcacggaatacatggag aatgggagcctggtggattttctcaagacctccacaggcatcaagctgaccatcaacaaa ctcttggacatggcagcgcaaattgcagagggcatggcattcattgaagagcggaattat atccaccgtgacttgagggccgccaacatcctggtgtctgatacgctgagctgcaagatc gcagactttggcctagcacgcctcatcgaggacaatgagtacacagccagggagggggcc aagtttcccattaagtggacagcaccagaagccattaactatgggacattcaccatcaag tcggacgtgtggtctttcgggatcctgctgacggagattgtcactcatggccgcatccct tatccagggatgaccaatcctgaggtgattcagaacctggagcaaggctaccgcatggta cgacctgacaactgtccagatgagttgtaccaacttatgatgctgtgctggaaggagctc ccggaggaccggcccacctttgactacctgcgcagcgtgctggaggacttcttcacagcc acagagggccagtaccagccgcagccctga

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