Orcinus orca (killer whale): 101286207 Help Entry 101286207         CDS       T05247                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism oor  Orcinus orca (killer whale) Pathway oor00230   Purine metabolism oor01100   Metabolic pathways oor01522   Endocrine resistance oor04015   Rap1 signaling pathway oor04020   Calcium signaling pathway oor04022   cGMP-PKG signaling pathway oor04024   cAMP signaling pathway oor04062   Chemokine signaling pathway oor04072   Phospholipase D signaling pathway oor04081   Hormone signaling oor04082   Neuroactive ligand signaling oor04114   Oocyte meiosis oor04211   Longevity regulating pathway oor04213   Longevity regulating pathway - multiple species oor04261   Adrenergic signaling in cardiomyocytes oor04270   Vascular smooth muscle contraction oor04371   Apelin signaling pathway oor04540   Gap junction oor04611   Platelet activation oor04713   Circadian entrainment oor04714   Thermogenesis oor04723   Retrograde endocannabinoid signaling oor04724   Glutamatergic synapse oor04725   Cholinergic synapse oor04727   GABAergic synapse oor04750   Inflammatory mediator regulation of TRP channels oor04911   Insulin secretion oor04912   GnRH signaling pathway oor04913   Ovarian steroidogenesis oor04914   Progesterone-mediated oocyte maturation oor04915   Estrogen signaling pathway oor04916   Melanogenesis oor04918   Thyroid hormone synthesis oor04921   Oxytocin signaling pathway oor04922   Glucagon signaling pathway oor04923   Regulation of lipolysis in adipocytes oor04925   Aldosterone synthesis and secretion oor04926   Relaxin signaling pathway oor04927   Cortisol synthesis and secretion oor04928   Parathyroid hormone synthesis, secretion and action oor04934   Cushing syndrome oor04935   Growth hormone synthesis, secretion and action oor04970   Salivary secretion oor04971   Gastric acid secretion oor04972   Pancreatic secretion oor04976   Bile secretion oor05032   Morphine addiction oor05163   Human cytomegalovirus infection oor05166   Human T-cell leukemia virus 1 infection oor05200   Pathways in cancer oor05207   Chemical carcinogenesis - receptor activation oor05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:oor00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101286207 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101286207 (ADCY2)    04371 Apelin signaling pathway     101286207 (ADCY2)    04020 Calcium signaling pathway     101286207 (ADCY2)    04072 Phospholipase D signaling pathway     101286207 (ADCY2)    04024 cAMP signaling pathway     101286207 (ADCY2)    04022 cGMP-PKG signaling pathway     101286207 (ADCY2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     101286207 (ADCY2)    04081 Hormone signaling     101286207 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101286207 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     101286207 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101286207 (ADCY2)    04062 Chemokine signaling pathway     101286207 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     101286207 (ADCY2)    04922 Glucagon signaling pathway     101286207 (ADCY2)    04923 Regulation of lipolysis in adipocytes     101286207 (ADCY2)    04912 GnRH signaling pathway     101286207 (ADCY2)    04913 Ovarian steroidogenesis     101286207 (ADCY2)    04915 Estrogen signaling pathway     101286207 (ADCY2)    04914 Progesterone-mediated oocyte maturation     101286207 (ADCY2)    04921 Oxytocin signaling pathway     101286207 (ADCY2)    04926 Relaxin signaling pathway     101286207 (ADCY2)    04935 Growth hormone synthesis, secretion and action     101286207 (ADCY2)    04918 Thyroid hormone synthesis     101286207 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     101286207 (ADCY2)    04916 Melanogenesis     101286207 (ADCY2)    04925 Aldosterone synthesis and secretion     101286207 (ADCY2)    04927 Cortisol synthesis and secretion     101286207 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101286207 (ADCY2)    04270 Vascular smooth muscle contraction     101286207 (ADCY2)   09154 Digestive system    04970 Salivary secretion     101286207 (ADCY2)    04971 Gastric acid secretion     101286207 (ADCY2)    04972 Pancreatic secretion     101286207 (ADCY2)    04976 Bile secretion     101286207 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     101286207 (ADCY2)    04727 GABAergic synapse     101286207 (ADCY2)    04725 Cholinergic synapse     101286207 (ADCY2)    04723 Retrograde endocannabinoid signaling     101286207 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     101286207 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     101286207 (ADCY2)    04213 Longevity regulating pathway - multiple species     101286207 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     101286207 (ADCY2)    04714 Thermogenesis     101286207 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101286207 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     101286207 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101286207 (ADCY2)    05163 Human cytomegalovirus infection     101286207 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     101286207 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101286207 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101286207 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101286207 (ADCY2) Enzymes [BR:oor01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101286207 (ADCY2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  101286207 NCBI-ProteinID:  XP_004274546 LinkDB All DBs Position 3:complement(178758433..179192231) Genome browser AA seq 1098 aa AA seqDB search MWQEAMRRRRYLRDRAEAAAAAAAGGGGDGDRLQRSRDWLYESYYRMSQQHPLIVFLLLI VMGACLALLAVFFALRLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVI WICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTVVL SICLSAMPGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKL EFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILY ADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPN HAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLA NHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSP QHLFRPRATLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQH NFQSRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKILEKEYR ATALPAFKYYVTCACLIFFCIFIVQILVLPKTSILGISFGAAFLSLAFILFVCFAGQLLQ CSKKASASLLWLLKSSGIIAKRPWPRISLTAITTAIILTMAVFNMFFLSESEETILPTAN ASNTSLPALYSQVAMLRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGY NTIFLHTHAHLLDDYSQVLFERPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFL WKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEDLYHQSYDCVCVMFASI PDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSA VPSQEHAQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGA QKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKT YFVNTEMSRSLSQSNLAS NT seq 3297 nt NT seq  +upstreamnt  +downstreamnt atgtggcaggaggcgatgcggcggcgccgctacctgcgggaccgcgccgaggcggcggcg gcggcggcggcaggcggcggcggcgacggcgacaggctgcagcggtcccgggactggctc tacgagtcgtactaccgcatgagccagcagcacccgctcatcgtctttctgcttctcatc gtcatgggcgcctgcctcgccctgctcgccgtcttcttcgctctccggctggaagttgaa gaccacgtggcatttttaataacagttccaactgccctggcgattttctttgctatcttc atcctcgtgtgcatcgagtccgtgtttaagaagctgctccgccttttctctttggtgata tggatttgtctcgtggccatgggctacttgttcatgtgttttggaggcaccgtctctccc tgggaccaggtgtcattcttcctcttcatcatcttcgtggtgtacaccatgctgcccttc aacatgcgagatgccatcatcgccagtgtgcttacctcctcttcccacaccgtcgtgctg agcatctgcctgtctgcaatgccgggggccaaggagcacctggtctggcagatcctggcc aacgtgatcatcttcatctgcgggaacctggccggggcgtaccataagcacctcatggaa ctggctctgcagcagacgtatcaggacacttgcaattgcatcaagtcccggatcaagttg gaatttgaaaagcgtcagcaggagcggcttctgctgtccctgctgccagcgcacatagcc atggagatgaaagccgagatcatccagaggctgcagggccccaaagccggccaaatggaa aacaccaacaactttcacaacctgtacgtcaagcggcacaccaacgtcagtatcctctat gcggacattgttgggttcacccgtctggccagtgactgctccccaggagaactggtccac atgctgaatgaactctttggaaaatttgatcaaattgcaaaggagaatgaatgcatgaga ataaaaattctaggagactgctactactgtgtttccggactccctatctctctccctaac catgccaagaattgtgtgaaaatgggactggatatgtgtgaagccataaagaaagtgagg gacgccactggagtggacatcaacatgcgtgtgggagtgcattctgggaacgtcctctgc ggcgtgatcgggctgcagaagtggcagtatgacgtatggtcccatgacgttaccctggcc aaccacatggaagctggaggggtccccggacgtgttcacatctcttccgtcacactggaa cacttgaatggggcttataaagtggaggaaggagacggtgacatcagagacccatattta aagcagcacttggtgaagacctactttgtaatcaaccccaagggagaacgacggagcccc cagcacctcttcagacctcgagccaccctcgatggagccaagatgagggcttccgtccgc atgacccggtacctggagtcctggggagcggccaagccctttgcacacctgcatcacaga gacagcatgaccacggagaacggcaagatcagcaccacggatgtaccaatgggtcagcat aattttcaaagtcgcaccttaagaaccaagtcacaaaagaagagatttgaagaggaatta aatgaaaggatgattcaagcaattgatggaatcaatgcacaaaagcaatggctcaagtct gaagacattcagagaatctcattgcttttctacaataaaatactagaaaaagaataccga gccactgcactgccagccttcaagtattacgtgacctgcgcctgcctcatattcttctgc atcttcatcgtgcagatcctggtcttacccaaaacgtccattctcgggatttcctttgga gctgcatttctctcgcttgcctttatccttttcgtctgctttgctggacagcttttgcaa tgcagcaaaaaagcgtctgcctctctcctgtggcttttgaagtcgtcgggcatcatcgcc aagcgcccctggcctcggatctccctgacggccatcaccacggccatcatactaaccatg gccgtgttcaacatgtttttcctgagcgagtcagaggagacaattcttccaactgccaat gcgtcaaacacaagtcttcctgccttatacagtcaggtagcaatgctgcgtgcgcaaaat ttgtttttcctgccgtactttatatacagctgcatcctgggattgatatcctgttcggtt ttcctgcgcgtgaattatgagctaaagatgctgatcatgatggtggcattggtgggctac aacaccatctttctccacactcacgcccacctcctggatgactacagccaggtcttattt gagagaccaggcatttggaaagacctaaagaccatgggctcagtgtctctctttatattt ttcatcacactgcttgttctgggcagacagaatgaatattactgtaggttagacttctta tggaagaacaagttcaaaaaagagcgagaggagatagaaaccatggagaacttgaaccgc gtgctgctggagaacgtgctccctgcacacgtggctgagcacttcctggccaggagcctg aagaatgaggatttataccaccagtcctatgactgtgtctgcgtcatgtttgcctccatc ccggatttcaaagaattctatacagaatcggatgtgaacaaggagggcttggaatgcctt cggctcctaaacgagatcattgccgactttgacgatctgctgtccaagccaaagttcagt ggagttgaaaagatcaagaccatcggcagcacgtacatggcggcgacgggtctgagtgcc gtacccagccaggagcacgcccaggagcccgagaggcagtacatgcacatcggcaccatg gtggagtttgcattcgccctggtggggaaactggacgccatcaacaagcactccttcaac gacttcaagttacgagtaggtattaaccatggccctgtaatagccggtgtgatcggagct cagaagccacagtacgatatctggggcaacaccgtaaacgtggccagtaggatggacagc accggcgtcctggacaaaatccaggttactgaggagacgagcctcattctgcagaccctg ggatacacgtgcacatgtcgaggaataatcaacgtgaaaggaaagggggacctgaagaca tactttgtgaacacagagatgtcacggtccctttcccagagcaacctggcatcctga

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