Ogataea parapolymorpha: HPODL_02434
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Entry
HPODL_02434 CDS
T08137
Name
(RefSeq) Histidine biosynthesis trifunctional protein
KO
K14152
phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase [EC:
3.6.1.31
3.5.4.19
1.1.1.23
]
Organism
opa
Ogataea parapolymorpha
Pathway
opa00340
Histidine metabolism
opa01100
Metabolic pathways
opa01110
Biosynthesis of secondary metabolites
opa01230
Biosynthesis of amino acids
Module
opa_M00026
Histidine biosynthesis, PRPP => histidine
Brite
KEGG Orthology (KO) [BR:
opa00001
]
09100 Metabolism
09105 Amino acid metabolism
00340 Histidine metabolism
HPODL_02434
Enzymes [BR:
opa01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.23 histidinol dehydrogenase
HPODL_02434
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.19 phosphoribosyl-AMP cyclohydrolase
HPODL_02434
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.1.31 phosphoribosyl-ATP diphosphatase
HPODL_02434
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Histidinol_dh
PRA-CH
PRA-PH
Motif
Other DBs
NCBI-GeneID:
25771887
NCBI-ProteinID:
XP_013932213
UniProt:
W1Q6Q2
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Position
VII:70016..72502
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AA seq
828 aa
AA seq
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MVSPILVSVAQPRDVLSVPFVSEVLVSLKAAAAVQEIVALAKEYLGQIYVDWTLGSAEND
NEIDIVLALLNNGVSGLFVTSAVAEQIRNRVPNARLVIKDGKDAAENICVFGETEVKIGK
RRVFGYFEQPLQQIARGYTAVIELDQLTKEYENAGTKTPFVECYVAAMNTDRPDGLYTTL
VTDSRNQALGLVYSSKKSIAEAIRTGSGVYQSRKHGLWYKGQTSGATQKLLQLELDCDSD
CLKFVVEQAGAGFCHLDTASCFGSSKGLAALEATLWDRKANAPEGSYTKRLFEDEKLLNA
KIREEADELVEATSKDEIAWEAADLVYFALARCVKYGVSLADIERNLDIKALKVTRRKGD
AKAKYVEQETTEKKPEEPKEPKESVNGDGRIVMNRVDATTASKEDIEKCLQRPIQKSADI
MNLVTPIVEKVRIEGDAALVELTAKFDKVQLNSPVLNAPFPAEMMHISEDVRKAIDISFA
NIKTFHEAQNQAETLRVETCPGVVCSRFARPIERVGCYIPGGTAVLPSTSLMLSVPALVA
GCKDIVFASPPGKDGRLTPEVVYVAHKVGAKCIVLAGGAQAVAAMAYGTESVPKCDKIMG
PGNQFVTAAKMLVSNDSNAMCAIDMPAGPSEVLVVADKYADPDFVASDLLSQAEHGVDSQ
VILIAVDMTSAEIDKIDEAVHRQALQLPRVEIVRQCIAHSTTIIVNSYDEAFDMSNRYAP
EHLILQIQDAEKWVDKVDNAGSVFVGAYSPESCGDYSSGTNHTLPTYGYARMYSGVNTTT
FQKFITSQVVTKEGLKSIGKAVMDLAAVEGLDAHRNAVKIRMEKLGYI
NT seq
2487 nt
NT seq
+upstream
nt +downstream
nt
atggtttctcctatccttgtgagcgttgctcaaccaagggacgttttgagcgtgccgttt
gtgagcgaggtccttgtctcgctcaaggcggctgccgctgtgcaggaaattgtcgcgctg
gctaaagagtatttaggccagatctatgtcgactggactctggggtctgcggaaaatgat
aacgaaatagacatcgttctggctcttttgaacaacggcgtgtccggtctttttgtcacc
tctgctgttgcagagcagatcagaaaccgtgttcccaacgccagactggtcatcaaggat
ggaaaagatgctgccgagaatatctgtgtttttggtgagactgaagtgaaaattggaaaa
agaagagtctttggttattttgaacagccactccagcagatcgccagaggctacactgct
gttattgagcttgatcagctgactaaggagtacgaaaacgcgggcaccaaaacgccgttt
gtggagtgctatgtcgctgccatgaacaccgacagaccagatggcttatacacaactctt
gtcactgacagcaggaaccaggctcttggtttggtttactcgtccaagaagtccattgct
gaggcaatcaggactggctccggtgtctaccagtccagaaagcacggcttgtggtacaag
ggccagacatcgggagccacgcaaaaattgctccagttggagctagactgcgatagcgac
tgtttgaagtttgttgtggaacaggccggtgctggtttctgccaccttgacactgcttct
tgttttggctcgtccaagggtctggcagctctggaggccactttatgggaccgcaaggca
aatgctcctgaaggctcgtacacgaagagactgtttgaggatgagaagctgctaaatgcc
aaaattagggaagaggccgacgagctggtggaagccacctcgaaggacgagattgcgtgg
gaggctgccgatttggtctactttgcgttggccagatgtgtgaagtatggtgtttcgctt
gcagacattgaacggaatttggacatcaaggccctgaaggtgacgagacgtaagggcgac
gcaaaggcgaagtatgttgagcaggagactacggaaaaaaagccagaggagccaaaggag
ccaaaggagtctgtgaatggagatggccgcatcgtgatgaaccgtgtggatgccaccact
gcctcgaaagaagatatcgaaaaatgtcttcaaagaccaatccagaagtcggcagatatc
atgaacctggttacgccgatcgtcgagaaagtgagaatagaaggagacgctgcgttggtg
gagctgacagccaagttcgacaaggtgcagcttaactctcctgttttgaacgctccattc
ccagcagaaatgatgcacattagcgaagacgtgcgcaaggccattgacatctcgtttgct
aacatcaagaccttccacgaagctcagaatcaggcagagactctgcgcgtggaaacgtgt
cccggcgttgtgtgctcgcgatttgcgcgtccgatcgagcgtgttggctgctacatcccc
ggcggaactgccgtgctgccgtccacgtcccttatgctctctgtgcctgctctcgttgcc
ggttgcaaagacattgtgtttgcctctcctcccggcaaggacggccgtctgacgccagag
gtggtctatgtggcgcacaaggtgggtgccaagtgcattgtgcttgccggaggagcccag
gcagtcgccgcaatggcgtacggtaccgagtctgtgcctaaatgtgacaagatcatgggt
cccggaaaccagtttgtgacggcagccaagatgctcgtttccaatgactccaacgccatg
tgtgccatagatatgcctgccgggccgtccgaggtgctggttgtcgccgacaagtacgcc
gacccagactttgtggcctcggacctgctctcgcaggcagaacacggcgtggactcgcag
gtgatattgatcgccgtggacatgacatctgccgagatcgacaagatcgacgaggccgtc
caccgccaggcgctgcagctgccgcgtgtcgagatcgtgcgccagtgcattgcccactcc
accacgattattgtgaacagttacgatgaggcgttcgacatgagcaacagatacgctccg
gagcaccttatcctgcagatccaggacgccgagaaatgggttgacaaggtcgacaacgct
ggctctgtgtttgtgggtgcctattcgccggaaagctgcggtgactactcctcgggaacc
aatcacacgctgcctacctacggctacgccagaatgtactcgggagtcaacaccacgacg
ttccagaaattcattacatcgcaggtggtcaccaaggagggtctcaagagcattggtaag
gccgtgatggacctggctgccgtcgagggtctcgacgcgcaccgcaacgccgtcaagatt
agaatggaaaaacttggctacatatag
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