KEGG   Ochotona princeps (American pika): 101518695
Entry
101518695         CDS       T07609                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi01522  Endocrine resistance
opi04010  MAPK signaling pathway
opi04012  ErbB signaling pathway
opi04014  Ras signaling pathway
opi04024  cAMP signaling pathway
opi04068  FoxO signaling pathway
opi04071  Sphingolipid signaling pathway
opi04137  Mitophagy - animal
opi04140  Autophagy - animal
opi04141  Protein processing in endoplasmic reticulum
opi04210  Apoptosis
opi04215  Apoptosis - multiple species
opi04217  Necroptosis
opi04310  Wnt signaling pathway
opi04380  Osteoclast differentiation
opi04510  Focal adhesion
opi04530  Tight junction
opi04620  Toll-like receptor signaling pathway
opi04621  NOD-like receptor signaling pathway
opi04622  RIG-I-like receptor signaling pathway
opi04625  C-type lectin receptor signaling pathway
opi04657  IL-17 signaling pathway
opi04658  Th1 and Th2 cell differentiation
opi04659  Th17 cell differentiation
opi04660  T cell receptor signaling pathway
opi04664  Fc epsilon RI signaling pathway
opi04668  TNF signaling pathway
opi04722  Neurotrophin signaling pathway
opi04723  Retrograde endocannabinoid signaling
opi04728  Dopaminergic synapse
opi04750  Inflammatory mediator regulation of TRP channels
opi04910  Insulin signaling pathway
opi04912  GnRH signaling pathway
opi04914  Progesterone-mediated oocyte maturation
opi04917  Prolactin signaling pathway
opi04920  Adipocytokine signaling pathway
opi04926  Relaxin signaling pathway
opi04930  Type II diabetes mellitus
opi04931  Insulin resistance
opi04932  Non-alcoholic fatty liver disease
opi04933  AGE-RAGE signaling pathway in diabetic complications
opi04935  Growth hormone synthesis, secretion and action
opi04936  Alcoholic liver disease
opi05010  Alzheimer disease
opi05012  Parkinson disease
opi05016  Huntington disease
opi05017  Spinocerebellar ataxia
opi05020  Prion disease
opi05022  Pathways of neurodegeneration - multiple diseases
opi05132  Salmonella infection
opi05133  Pertussis
opi05135  Yersinia infection
opi05142  Chagas disease
opi05145  Toxoplasmosis
opi05152  Tuberculosis
opi05161  Hepatitis B
opi05162  Measles
opi05166  Human T-cell leukemia virus 1 infection
opi05167  Kaposi sarcoma-associated herpesvirus infection
opi05169  Epstein-Barr virus infection
opi05170  Human immunodeficiency virus 1 infection
opi05171  Coronavirus disease - COVID-19
opi05200  Pathways in cancer
opi05208  Chemical carcinogenesis - reactive oxygen species
opi05210  Colorectal cancer
opi05212  Pancreatic cancer
opi05231  Choline metabolism in cancer
opi05415  Diabetic cardiomyopathy
opi05417  Lipid and atherosclerosis
opi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:opi00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    101518695 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101518695 (MAPK8)
   04012 ErbB signaling pathway
    101518695 (MAPK8)
   04014 Ras signaling pathway
    101518695 (MAPK8)
   04310 Wnt signaling pathway
    101518695 (MAPK8)
   04668 TNF signaling pathway
    101518695 (MAPK8)
   04068 FoxO signaling pathway
    101518695 (MAPK8)
   04071 Sphingolipid signaling pathway
    101518695 (MAPK8)
   04024 cAMP signaling pathway
    101518695 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101518695 (MAPK8)
   04137 Mitophagy - animal
    101518695 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    101518695 (MAPK8)
   04215 Apoptosis - multiple species
    101518695 (MAPK8)
   04217 Necroptosis
    101518695 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101518695 (MAPK8)
   04530 Tight junction
    101518695 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    101518695 (MAPK8)
   04621 NOD-like receptor signaling pathway
    101518695 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    101518695 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    101518695 (MAPK8)
   04660 T cell receptor signaling pathway
    101518695 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    101518695 (MAPK8)
   04659 Th17 cell differentiation
    101518695 (MAPK8)
   04657 IL-17 signaling pathway
    101518695 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    101518695 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101518695 (MAPK8)
   04920 Adipocytokine signaling pathway
    101518695 (MAPK8)
   04912 GnRH signaling pathway
    101518695 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    101518695 (MAPK8)
   04917 Prolactin signaling pathway
    101518695 (MAPK8)
   04926 Relaxin signaling pathway
    101518695 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    101518695 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    101518695 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    101518695 (MAPK8)
   04722 Neurotrophin signaling pathway
    101518695 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101518695 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101518695 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101518695 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    101518695 (MAPK8)
   05231 Choline metabolism in cancer
    101518695 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101518695 (MAPK8)
   05212 Pancreatic cancer
    101518695 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101518695 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    101518695 (MAPK8)
   05161 Hepatitis B
    101518695 (MAPK8)
   05171 Coronavirus disease - COVID-19
    101518695 (MAPK8)
   05162 Measles
    101518695 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101518695 (MAPK8)
   05169 Epstein-Barr virus infection
    101518695 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101518695 (MAPK8)
   05135 Yersinia infection
    101518695 (MAPK8)
   05133 Pertussis
    101518695 (MAPK8)
   05152 Tuberculosis
    101518695 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101518695 (MAPK8)
   05142 Chagas disease
    101518695 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101518695 (MAPK8)
   05012 Parkinson disease
    101518695 (MAPK8)
   05016 Huntington disease
    101518695 (MAPK8)
   05017 Spinocerebellar ataxia
    101518695 (MAPK8)
   05020 Prion disease
    101518695 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    101518695 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101518695 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    101518695 (MAPK8)
   05415 Diabetic cardiomyopathy
    101518695 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101518695 (MAPK8)
   04936 Alcoholic liver disease
    101518695 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    101518695 (MAPK8)
   04931 Insulin resistance
    101518695 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101518695 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101518695 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    101518695 (MAPK8)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101518695 (MAPK8)
Protein kinases [BR:opi01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   101518695 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 RIO1 Kinase-like Kdo FTA2 APH
Other DBs
NCBI-GeneID: 101518695
NCBI-ProteinID: XP_036351592
LinkDB
Position
18:65338966..65374351
AA seq 385 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCRIIGLLNVFTPQKSLEEFQ
DVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD
CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGG
VLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPA
DSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQL
DEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVTSGCQHPSSSSSVNDVSSM
STDPTLASDTDSSLDAPAGPLGCCR
NT seq 1158 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacaacaatttttatagtgtagagattggggattctacattc
actgtcctgaagaggtatcagaatctaaaaccaataggttcgggagctcaaggaatagtt
tgccgtataattggccttttgaatgttttcacaccacagaaatctctagaagaattccaa
gatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcagatggaa
ctagatcacgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaagcacctt
cactccgctggaatcattcaccgggacttaaagcccagtaatatagtagtaaaatcagac
tgcactttgaaaattcttgactttggcctggccaggactgcaggaacaagtttcatgatg
acgccttatgtggtgactcgctactacagagcgcctgaggtcatcctaggcatgggctac
aaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaaggtggt
gttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacagcttgga
acaccgtgtcctgaattcatgaagaaactccagccaacagtaaggacttatgttgaaaac
agacctaaatatgccggatatagctttgagaaactcttccctgatgtgcttttcccagct
gactcggaacacaacaaacttaaagccagtcaggcaagggatttgctatccaaaatgctg
gtgatcgacgcgtccaagaggatctcggtagatgaagctctgcagcacccatacatcaac
gtctggtatgatccttcggaagcagaagccccaccaccaaagatacctgacaagcagtta
gatgaaagggaacacacaatagaagagtggaaagaattgatatacaaggaagtgatggat
ttggaagaaagaaccaagaatggagttatacgagggcagccctctcctttaggtgcagca
gtgaccagtggctgtcagcatccatcatcatcgtcgtctgtcaacgatgtgtcttcaatg
tcaacagacccgactttggcctcggatacagacagcagtctggacgccccagccgggcct
ctgggctgctgcagatga

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