Ochotona princeps (American pika): 101519057 Help Entry 101519057         CDS       T07609                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism opi  Ochotona princeps (American pika) Pathway opi05165   Human papillomavirus infection opi05203   Viral carcinogenesis Brite KEGG Orthology (KO) [BR:opi00001]  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     101519057 (UBR4)   09172 Infectious disease: viral    05165 Human papillomavirus infection     101519057 (UBR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:opi04121]     101519057 (UBR4) Enzymes [BR:opi01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      101519057 (UBR4) Ubiquitin system [BR:opi04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     101519057 (UBR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR Motif Other DBs NCBI-GeneID:  101519057 NCBI-ProteinID:  XP_004592371 LinkDB All DBs Position 13:9043100..9193489 Genome browser AA seq 5191 aa AA seqDB search MATSGGEEAAAVAAAAAAAPAPAPGATTPGPDATPTPGWEVAVRPLLSASYSAFEMKELP QLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEF SLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDV EDQKELASPVSPELRQKEVQMNFVNQLTSVFNPRTVASPPISPQALVEGEHDEQSSTDQA SAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVA DATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAIL HVGSAQQVRTGSTSSKEEDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLG AWCLLNSLFLILNLSPTALADKGREKDPLAALRVRDVLSRTKEGVGSPKLGPGKGHQGFG VLSVILANHAIKLLSSLFEDLQVEALHKGWETDGPPAVLSVMAQSTSIQRIQRLIDSVPL TNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPI LGQWFEETISPSKEKVAPPPPPPPPPLESSPRVKSPNKQSSSEKGNILASRKDPELFLGL ASNILNFITTSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAAL YHFNHSLVTSDLQSPNLQNTLLQQLGVSPFSEGPWPLYIHPQGLSVLSRLLLIWQHKADA QGDPDVPECLKVWDRFLSTMKQNALQGVVPSENEDLNVEHLQLLLLIFHNLSEKGRRSIF TLLIQTIQELSVHMDAQMRSVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPYG WASGSQDSSSRRAATPSYHGFKEVEENWAKHFSSDTVPQPRFYCVLSPEASEDDLNRLDA LACDVLFSKLVKYDELYTALTALLAAGSQLDTVRRKESKSVTALEACALQYYFLILWRIL GILPPSKTYMNQLAVNSPEMSECDILHTLRWSSRLRISSYVSWIKEHLVKQGMKMEHAAS LIELASAKCSSVKYDVEIVEEYFARQISSFCSIDYTTILQLHEIPSLQSIYTLDAAISKV QVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNLNEEGSTDKPP KEKLRGFAAVLAIGSSRCKANTLGPTLVQNLPSPVQAVCESWNNVNTNEFPNIGSWRNAF ANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVI QTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSG LDEAILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFF TKLFQLTEKSPNPSLLRLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQL LQLLTTYIVRDNSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGA GHLQLHSAAVDWLGRCKKYLSQKNVVEKLNASVMHGKHVIILECTCHIMSYLADVTNALS QSNGQGPSHLSMDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEF MNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRT PSSGMSSTMKESAFQSEPRVPESLVRHTSTSPADKAKVTISDGKVADEEKPKKSSLCRTV EGCREELQNQANFSFAPLVLDTLSFLMEAIQTSFQQASAVGSSSRAQQALSELHTVGKVL EMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHL AVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGL KDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLSVDA LSPTFYFLLPSSKMRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVL EISHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRMTLEVLQLFPINIK SSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVIMVRPDTLLIQEIKTLPAKAKIQ DMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSGVISIMKPVRKR KTATITTRPSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTK PGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTRE EALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSN LNQSNGTGDSDSAAPATTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLL LSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSTKEGKDLDPEVFQR LVITARSIAIMRPNNLVHFTESKLPQMETEGVDEGKEPQKQLEGDCCSFITQLVNHFWKL HASKPKNAFLAPACLPGLTHIEATVNALVDIVHGYCTCELDCINTAAKIYMQMLLCPDPA VSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPSGGHI RQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADD ETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEG STAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDAAAEGHPAGPGS VSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVG GVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVH LVVMRLLSVFMSRTKSGSKSSICESSSLLSSATAAALLSSGAVDYCLHVLKALLEHWKSQ QSEEEPVATSQLLKPHATSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIK KIADTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHT LDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQK FCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASTGTSSTASSSAPA ASSSGQATTQPKSSTKKSKKEEKEKEKDGESSGSQEDQLCTALVNQLNKFADKETLIQFL RCFLLESNSSSVRWQAHCLTLHIYRNSNKSQQELLLDLMWSIWPELPAYGRKAAQFVDLL GYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPC LVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINL YYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQ ASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFD FMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAP EKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYD LQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALAT NPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVS TALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENI TLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYEAWK KCLPIRGADGNGKTPSKAELRHLYLTEKYIWRWKQFLSRRGKRTSPLDLKLGHNNWLRQV LFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSVAGECAAEYLALYQKLIT SAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVE SIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAV CIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPY SSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTT NEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLDCMLNRL AGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKD SGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSV LQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNN SNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQ HPATQVLIGTDSITNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEK KRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKV LGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNA NTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQ SFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEV DGPHYYAALALHVLPPEQWRTVRLEMLRRLLVTSQARAVAPGGATRLADKAVKDYSTYRA SLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPVYEAADKALETFQEEFVPV ETFSEFLDVAGLLAEVPDPESFLKDLLNSVP NT seq 15576 nt NT seq  +upstreamnt  +downstreamnt atggcgacgagtggcggcgaggaggcggcggcggtggcggcggcggcggcggcggcgccc gcgcccgcacccggggctacgaccccggggccagacgccaccccgaccccgggctgggag gtggccgtgcggcccctgctgtccgcgtcctattccgcctttgagatgaaggagttgccg cagctggtggcctcggtcatcgagagcgaatcagaaatcttgcaccatgagaagcagtac gagccgttctactcctcttttgttgcactttccacacactatattacaaccgtctgcagc ctcattcctcggaaccagcttcagtcggtggcagcagcttgtaaagtcctgattgagttt tctcttctccgtctggagaatcctgatgaggcatgtgccgtgtcccagaaacacttgatc ctgctcatcaagggcctgtgcacaggctgcagccgactggacagaactgaaatcatcacg tttacagcaatgatgaagtctgccaagctgccgcagaccgtgaagacgctttctgacgtg gaggatcagaaagagctggcttccccagtaagcccggagctgaggcagaaggaggtgcag atgaattttgtgaaccagctgacctcggtttttaatcctcgaactgtagcatcaccaccc atcagtccacaggctctggtggaaggggagcatgatgagcagtcctctacagatcaagct tctgctatcaaaaccaagaatgtgttcatagctcagaatgtggcgagtcttcaggagctt ggtggctccgagaagctgctgcgtgtctgtttgaatttgccatatttcctacgttacatc aatcgattccaagatgcagtgttggccaattccttctttatcatgcctgccactgtagca gatgccactgcagttcgtaatggttttcattcccttgtgatagatgtgactatggctttg gataccctttctctgcctgtgttggaacctctcaatccttcccgtctgcaagatgtgaca gtcctcagcctaagttgtctgtatgcaggtgtgagtgtggcaacgtgcatggccatcctt catgtaggtagtgcccagcaagtgcggacaggatccacaagctccaaggaggaggactat gaaagtgatgcagctacaattgtccagaaatgtcttgaaatctatgacatgattggacaa gcaatcagcagttcacgccgggctggtggtgagcactatcagaacttccagctgctgggt gcctggtgcttgttaaacagccttttcctcattctgaacctgagtcccactgccttggct gacaaggggagagagaaagatccgctggccgcgctccgcgtcagagacgtcctatcccgt acaaaggagggagtgggctctcctaaactggggcctggaaaaggccatcagggctttggg gtgctttcagtaatactagctaaccatgcgatcaagctgctgtcgtcactgtttgaggac ctgcaagtggaggcccttcacaagggttgggagacagatgggccccctgcagtgctcagc gtgatggcccagagtacttccattcagaggattcaacggctgattgactcagtgccactg acgaacctgctcttgacgttactgtcaacttcctacagaaaggcctgtgtcctgcagcgg cagaggaagggctccatgagcagcgacgccagcgcctccaccgactccaacacgtactac gaggatgatttcagcagcacggaggaggacagcagccaagatgatgacagtgagcccatt ctggggcagtggtttgaggagaccatctctcccagtaaagagaaagtggctcctccaccc cctcctccgccgccgccactggaaagttctcctcgggtgaaaagccccaataagcagtcc tccagtgaaaagggcaacattttggctagtcgcaaagatcctgagttgttcttaggtctg gcttccaacattttgaacttcatcaccacttccatgctgaactctcggaacaattttatc cgaaactatctgagtgtgtctctttcagaacatcatatggccacgctggccagtatcatc aaggaggtggacaaagacgggctcaagggttcatcagatgaggagtttgctgctgctctc tatcacttcaaccactctttggtaacttcggaccttcaatcccccaatcttcagaacacc ctgctgcagcagctgggagtctcccctttttctgaaggcccttggcctttgtacattcac cctcaaggcctctcggtgctttcacgtctcctgctcatctggcaacataaggctgacgcc caaggtgaccctgatgtccctgaatgcctcaaggtttgggacaggtttttgtctacaatg aagcagaatgccctgcaaggtgtggtccccagtgagaatgaggacttgaacgtggagcac ctgcagctgctgctcctcatcttccacaacctctctgagaaaggccggcgctccatcttc accctcttgatccagaccatccaggagctgagtgtccacatggatgcgcagatgcgctcg gtgcctctcatcctggctcgcctccttctgatctttgattacctgctacatcagtactcc aaagcccctgtttatctgtttgaacaggtgcagcataacctgctcagtcctccttatggg tgggccagtggctcccaggacagcagcagccgccgggcagccactccttcctatcatggc ttcaaagaggtagaagagaactgggctaagcatttttcatcagatactgttccacaaccc agattctactgtgtgctgtccccagaggcctcagaggatgatctgaaccgactggatgct ttggcgtgtgatgtgcttttctccaagcttgtcaaatatgatgagctctacaccgctctg acagcgctgcttgcagctgggtcccagctcgacaccgtcaggaggaaggaaagcaagagt gtcacagccctggaggcctgtgcccttcagtattacttcttaatattatggaggatccta ggaattttgccaccgtcaaagacttacatgaatcagctggccgtgaactcccccgagatg agtgaatgtgacatcttgcataccctgagatggtcttcccgcctcaggatcagctcctat gtcagctggataaaggaacaccttgtcaaacaaggaatgaagatggagcatgctgcttcc ctcatagagctggcctccgctaagtgtagctcggtgaaatatgatgttgaaattgtagag gaatattttgctcgacagatctcgtcgttctgtagcatcgactacaccaccatcttgcag ctccatgaaattcccagtctgcagtccatttataccctggatgctgccatctccaaggtc caggtctctttggatgagcatttttctaagatggctgccgaaaccgatcctcacaagtcg tctgagatcaccaagaacctccttcccgcaactctgcagctcattgacacctacgcgtcc ttcaccagagcctatttgctgcagaacttgaatgaagagggaagcacggacaaacctcct aaggagaagctgcgtggctttgctgctgtgttggctattggctccagtaggtgcaaggca aacactttgggcccgacgctggttcagaatctgccctccccggtgcaggctgtgtgtgag tcatggaacaacgtcaataccaatgagtttcccaatattgggtcctggcgcaacgccttt gccaatgacaccatcccgtcggagagctacatcagtgctgtgcaggccgctcacctgggg accctctgcagccagagtctgccgctggctgcctccctgaagcacaccctcctctccctg gttcggctcactggggacctgatagtttggtcagatgagatgaaccctccccaggtgatc cagacccttctgccgctgctgctggagtctagcacggagagcgtggccgagatcagcagc aactccctggagcgcatcctgggccctgctgagtcagatgagttcttggcccgagtgtat gagaagctgatcactggctgttacaacattctggccaatcatgctgaccccaacagtggg ctggatgaagccatcttggaggaatgtctgcagtatttggaaaaacagctggaaagcagc caggcccgcaaagctatggaggagtttttctccgacagtggagaacttgtgcagatcatg atggcaacagccaatgagaacctctctgctaaattctgtaaccgagttttgaaattcttc accaaactcttccagctgactgagaagagccccaacccaagcctgctgcgtctgtgtggc tctctggctcagctggcttgtgtggagcccgtgcgcctgcaggcctggctcacccgcatg accacgtcacccccgaaagattcggatcagctggatgtcattcaggagaaccggcagctg ctgcagttactgaccacttacatcgtccgggacaacagccaagttggggaaggtgtgtgt gccgtgctcctgggcaccctgacccccatggcaacagagatgcttgcgaatggtgatggg actggctttcctgaactcatggttgtgatggccactctggccagtgcaggccaaggtgcc ggtcatcttcagcttcacagcgctgctgtggactggctggggagatgtaagaagtacctg tcacagaagaacgtggttgaaaagctgaatgccagtgtcatgcatggcaagcacgtgata atcttggagtgcacctgtcacattatgtcttacttggctgatgtcacgaatgctttgagc cagagtaacgggcaaggtccaagccacctgtccatggatggtgaggaacgggccattgag gtggactcagattgggtagaagagttggcagtggaagaggaggattcccaggctgaggac tcggatgaagattcgctttgcaataaactctgcacttttacaatcacacagaaagaattc atgaaccagcattggtatcattgtcacacctgcaagatggtcgatggggtgggtgtgtgc acggtgtgtgctaaggtttgccacaaggatcatgaaatttcctatgccaagtatgggtcc ttcttctgtgattgtggggccaaggaagatggcagctgtttggcactggtgaagagaact cccagcagtggcatgagctccaccatgaaagagtcagcatttcagagtgaacccagggtt ccagagagtctggtgcgccacaccagtacctcgccagccgacaaagccaaggtcaccatc agtgatggaaaagtggctgatgaagagaaacccaagaagagcagcctgtgccgcacggtg gagggttgccgggaggagctgcagaaccaggccaacttctccttcgctcctcttgtgcta gacacgctcagtttcctcatggaagccattcagaccagcttccagcaggcgtccgctgtc gggagcagcagccgggctcagcaggccctcagtgagctgcatacagtgggcaaggtgctt gagatgacagatcagctgatggttcccaccttaggctctcaggagggtgcctttgagaat gttcggatgaattacagtggagaccaaggccagacaattcgacagctcatcagtgcgcat gtgctcaggcgggttgcgatgtgtgtgctctcctcccctcacgggcgccgccagcatttg gctgtcagccacgaaaaaggaaagatcactgtgctgcagctctctgccctcctgaagcaa gctgattccagcaagaggaagctcactctgacccgcctggcctccgccccggtccccttc accgtgctgagcctcactgggaatccctgcaaggaggactacctggcggtgtgcgggctg aaggactgccacgtacttaccttcagtagctcaggttctgtttcagatcacttggtgttg catccccagttggccacagggaacttcatcatcaaagctgtgtggttgccaggttcacag actgagttagcaattgtcactgcggactttgtcaagatttatgacctgtctgttgatgcc ttgagtccaactttctactttcttctgccaagctcaaagatgagagacgtcactttcctt ttcaatgaggaggggaagaacatcattgtcataatgtcttcggctggctacatctacaca cagctcatggaggaggccagcagtgcccagcaggggcccttctatgtcaccaatgtgctg gaaatcagccatgaggacttgaaggacagtaacagccaggtggcgggcggtggcgtgtcc gtgtactactcccatgtgctacagatgctcttcttcagctattgtcaagggaaatcattt gcagccaccatcagcaggatgaccctggaggttttgcagcttttccctatcaacatcaaa agttccaatggtggcagtaagacttctcctgcgctttgccagtggtctgaggtaatgaac caccctggactggtgtgctgcgtccagcaaaccacaggggtgccgctggtgatcatggtg aggccagacacactcctcatccaggaaatcaagactcttcctgcgaaagcaaagatccag gacatggttgccatcaggcacacagcctgcaacgagcagcagcggacgaccatgatcttg ctgtgtgaagatggcagcttgcgcatttatatggccaatgtggaaaatacctcctactgg cttcagccgtccctgcagcccagtggtgtcattagcataatgaagcctgtgcgaaagcgc aagacagcaaccatcacaacccgcccatctagccaggtgactttccctattgacttcttt gaacacaaccagcagctgacagacgtggagttcggtggtaatgacctcctgcaggtctac aatgcacaacagataaaacaccggctgaattccaccggcatgtatgtggccaacaccaag cctggtggcttcaccattgagattagtaacaacaatagcaccatggtaatgacaggcatg cggatccagatcgggacccaggccattgaacgagccccgtcgtacattgaaatcttcggc cggaccatgcagctgaacctgagtcgctcgcgctggtttgacttcccgttcaccagagag gaagccctgcaggctgacaagaagctgaacctcttcatcggggcctcggtggatccagca ggtgtcaccatgatagatgctgtaaaaatttatgggaagactaaggagcagtttggctgg cctgatgagccccctgaagaattcccttctgcctctgtcagcaacatctgcccttcaaac ctgaaccagagtaatggcactggagacagcgactcagctgcccctgctacgaccagtggg actgttctggagaggctggttgtgagttctttagaagccctggaaagctgctttgctgtt ggtccaatcatcgagaaggagagaaataagaatgcggctcaagagctggccactttgttg ctgtccctgccggcacctgccagtgtccagcagcagtccaagagcctcctggccagcctg cacaccagccgctcggcctatcacagccacaaggatcaggccttgttgagcaaagctgtg cagtgtctcaacacatccaccaaagaaggcaaggatttggaccctgaggtgttccagcgg ctggtgatcacagcccgctccattgccatcatgcgccccaacaacctagttcacttcacg gagtccaagcttcctcagatggaaacagaaggagtggatgaggggaaagaaccgcagaag cagctggagggagactgctgtagtttcatcacccagcttgtgaaccacttctggaagctc catgcatccaaacccaagaatgcctttctggcacctgcctgccttccaggcctaactcac atagaagccactgtcaatgcactggtagacattgttcatggctattgtacctgtgagctg gactgtattaacacagcagccaagatctacatgcagatgctgttgtgtcctgaccctgcc gtgagcttctcttgtaaacaagctttaattcgagtcctcaggcccaggaacaaacggaga catgtgacactgccctcctcccctcgaagcaacaccccaatgggagacaaggatgatgat gacgatgatgatgcagacgagaaaatgcagtcgtcggggatcccgagtggcggtcacatc cgtcaggagagccaggagcagagtgaagtggatcatggggactttgagatggtgtcagag tcgatggttctggagacagcagaaaatgtcaacaacggcaacccatctcccctggaggcc ctcctggcaggtgccgagggcttccccccgatgctggacatcccacctgatgcagatgat gagaccatggtggaactagccattgccctgagcctgcagcaggaccaacaaggcagcagc agcagtgccctgggcctgcagagcctgggactgtccggccaggcacccagctcttcctct ctggacgcaggaaccctctctgacaccacagcatcagctccagcctcagatgatgagggc agcacagcagcgacggatggctctacgcttcggacctctcctgctgaccatggtgggagt gtgggctcggagagcgggggaagcgcagtggactcggtggctggcgagcacagtgtgtct ggtcggagcagtgcttacggagatgctgcagcagaggggcatccagctggaccaggaagt gtcagctcaagcactggcgccatcagcaccaccactgggcaccaggagggagatggctcc gagggagaaggagaaggcgagactgaaggcgatgtccacaccagcaataggctgcacatg gtccgtctgatgctgttggagagattgctgcaaaccttgccacagttacgcaatgttgga ggtgtccgggccatcccttacatgcaggtcattctgatgctgactacagatctggatgga gaagatgagaaagacaagggggccctggacaacctgctctctcagcttattgctgagcta ggcatggataaaaaggatgtctccaagaagaatgagcgcagtgctctgaatgaagtccac ctggtggtgatgcgactcctgagtgtcttcatgtcccgcaccaaatctggctccaagtct tccatctgtgagtcatcctccctcctctccagtgccacagcagcagccctgctgagctcc ggggccgtggactactgcctgcatgtgctcaaagcactgctggagcattggaagagccag cagagtgaggaggagcctgtagctaccagccagctgctgaagccacatgccacttcatcc ccacctgacatgagccccttctttctacgccagtatgtgaagggccatgctgctgatgtg tttgaggcctacactcagcttctgacagagatggtgctcaggcttccgtaccaaatcaag aagattgccgacaccaactcgcggatcccgccacctgtctttgatcactcctggttttac ttcctctcagagtacctgatgatccagcagacgccatttgtgcgtcgtcaagtccgcaag ctactgctcttcatctgtggctccaaggagaaataccgccagctccgggatttgcacacc ttagactcccatgtgcgtggaatcaagaaactgctggaggaacaggggatattccttcgg gccagtgtggtgacagccagctccggctctgccttgcagtatgacacgctcatcagcttg atggagcacctgaaagcctgtgcagagattgccgcccagcgaaccatcaactggcagaaa ttctgcatcaaagatgactccgtcctgtacttcctcctccaagtgagtttcctggtggat gagggagtgtcccctgtgctgctgcagctgttgtcctgcgctctctgtggcagcaaagtg ctcgctgccctggcagcctctacagggacttccagcacagcttcctcctcagcccctgcg gcctccagttctggacaagccacaacacagcccaagtcttccactaaaaagagcaagaaa gaagaaaaagagaaggagaaagacggcgagagctcaggcagccaggaggaccagctgtgc acagctttggtgaaccagttgaacaaatttgctgataaggaaaccctgatccagtttctg cgctgcttcctgttggagtccaattcctcctctgtgcgctggcaggcccactgcctgact ctgcacatctacagaaactccaacaagtcccagcaggagctcctgctggatctcatgtgg tccatatggccagaactccctgcctacggtcggaaagcagcccagtttgtagaccttctt ggatatttctccttgaaaacaccacagacggagaagaagctgaaggagtactcccagaag gctgtggagatcctgcgcactcagaaccatattcttaccaaccatcccaactccaacatt tataacaccttgtccggcctggtggagtttgacggctattacctggagagtgacccctgc ctagtgtgcaataatccagaagtgccattctgttacatcaagctatcttctattaaagtg gacacacgatacaccaccacccagcaagtggtgaagcttattggcagtcataccatcagc aaagtgacagtgaaaattggagacctgaaacggaccaagatggtgcggactatcaacctg tattacaacaaccgaactgtgcaggccatcgtggagctgaaaaacaagccagctcggtgg cacaaagccaagaaggtccagctgactcctgggcagaccgaggtgaagatcgacctgcca ttgcccatcgtggcctccaatctgatgattgagtttgcagacttctatgaaaactaccag gcctccacagagaccctccagtgcccacgctgcagtgcctctgttcccgccaacccaggg gtgtgtggcaactgtggagagaacgtttaccagtgtcacaaatgcaggtccatcaattat gatgaaaaggatcctttcctttgcaacgcctgtggcttctgtaaatacgctcgcttcgac ttcatgctgtatgccaaaccttgttgtgccgtggatcccatagagaatgaagaggaccgg aagaaggctgtctccaacatcaatacacttttggacaaagcagatcgtgtgtatcatcag ctgatggggcatcggccgcagctggagaacctgctgtgcaaagtgaatgaggcagctcca gagaagccacaggatgactcgggaacagcaggaggcatcagctccacttcggccagcgtg aatcgctacatcctgcagttagctcaggagtactgcggagactgcaagaactcttttgac gaactctccaaaatcatccagaaagtctttgcttcacgcaaggagttgttggaatatgat ctgcagcagagggaagcggccaccaagtcatcccggacttctgtgcagcccacgttcact gccagccagtaccgcgccttgtctgtcctgggctgtggccatacctcctccaccaagtgc tatggctgtgcctcagctgtcacagagcattgcatcacactgctgcgggctctggccacc aacccagccctgaggcatatccttgtctctcagggacttatccgggagctgtttgattat aatcttcgtcgaggggctgcagccatgcgggaggaggtccgccagctcatgtgcctcctg actcgagacaatccagaagctacgcagcagatgaatgacctgatcatcggcaaagtctcc actgccctcaagggccactgggccaaccccgatctggcgagtagccttcagtacgagatg ctgctgctgacagattccatctcaaaggaggacagctgctgggaactccggttacgctgt gctctcagccttttcctcatggctgtgaacattaagactcccgtggttgttgagaacatc accctcatgtgcctgcggatcttgcagaagctgatcaagccacctgctccgaccagcaag aagaacaaggatgtccccgttgaggctctcaccacagtgaagccttattgcaatgagatc cacgcccaggcccagctgtggctcaagagagatcccaaggcgtcctatgaagcctggaag aagtgtcttcctatccgaggggcagatggcaatgggaaaacccccagcaaagcagagctc cgccatctctacttgaccgagaagtacatctggaggtggaagcagttcctgagtcgccgg ggcaagaggacctcccccttggatctcaaattggggcataacaactggctgcgacaggtg ctcttcaccccagcaacgcaggccgcacggcaagcagcctgcaccatcgtggaagctcta gccaccatccccagccgcaagcagcaggtcctcgacctcctcaccagttacttggatgag ctgagtgtggctggggagtgtgctgcagagtacctggctctgtaccagaagctcatcact tcggctcactggaaagtctacctggccgctcggggagtcctgccctacgtgggcaacctc atcaccaaggaaatcgcccggttgttggccctggaggaggccaccttgagcactgatcta caacaaggctatgccctcaaaagtctcacaggccttctctcctccttcgttgaggtggaa tccatcaaaaggcactttaagagtcgcttggtaggcacagtgctgaatggctatctgtgc ctgcggaagctggtggtgcagagaaccaagctgatcgatgagacccaggatatgctgctg gagatgctggaggacatgaccacaggtacagaatcggaaactaaggctttcatggctgtg tgcatcgagacagccaagcgctacaacctggacgactaccgaacgccggtgttcatcttt gagaggctctgcagcatcatctaccctgaggagaatgaagtcactgagttctttgtgacc ttggagaaggacccccagcaagaagacttcttacagggcaggatgcccgggaacccgtat agcagcaatgagcctggcattgggccactcatgagggacatcaagaacaagatttgccag gactgcgacctggtggctctgctggaggatgacagtgggatggagctcctagtgaacaat aaaatcattagcttggacctgcctgtggctgaggtttacaagaaggtctggtgtaccaca aatgagggggagcccatgagaattgtttatcggatgcgagggttgctgggtgatgccact gaggagtttatcgagtccctggactccaccacagatgaagaagaagatgaagaagaagtg tacaagatggctggggtgatggcccagtgtgggggcctggactgcatgcttaacagactg gcaggaatcagagattttaagcaggggcgccaccttcttacagtgctactgaaattgttc agttactgtgtgaaggtgaaagtcaaccgtcaacaactggtcaagctggaaatgaacacc ttgaacgtcatgctggggactctaaacctggccctggtagctgagcaggaaagcaaggac agtgggggagcagccgtggctgaacaagtgcttagcatcatggagatcattctagatgag tccaacgctgagcccctgagtgaagacaagggaaacctcctcttgacgggtgacaaggat cagcttgtgatgctcttggaccagatcaacagcaccttcgtgcgctccaaccccagtgtg ctccagggcctgcttcgcattattccatacctttcctttggagaggtagagaaaatgcag atcctggtggaacgattcaaaccctactgcaactttgacaagtatgatgaagaccacagt ggcgatgacaaagtcttcctggactgcttctgtaagatagcagctggcatcaagaacaac agcaatgggcatcagctgaaggacctcatcctgcagaagggcattacccagaatgccctg gactacatgaaaaaacacatccccagtgccaagaatttggacgcggacatctggaaaaag tttctgtctcgcccagcgctgccgtttatcctgaggcttctccgggggctggccatccag caccctgccacccaggttctgattggaactgactccatcacaaacctgcataagctggag caggtgtccagtgatgagggcatcgggaccctggcagagaacctgctggaggccctgaga gaacaccctgatgtaaataagaagatcgacgcggcccgcagggagacccgggctgagaag aagcgcatggccatggcgatgaggcagaaggctctgggcaccctgggcatgacgacaaac gaaaagggccaggtcgtgaccaagacggcgctactgaagcagatggaggagttaattgag gagccgggcctcacatgctgcatctgcagggaggggtacaagttccagcccaccaaggtg ttgggcatctacacattcactaagcgggtcgccttagaggagatggagaacaagcctcgg aagcagcagggctacagcaccgtgtcccacttcaacatcgtgcactacgactgccacctg gctgccgtcaggttggctcgaggccgggaagagtgggaaagtgctgcccttcagaatgcc aacaccaagtgcaatgggctccttcccgtctgggggccccacgtccctgagtcagctttt gccacttgcttggcgaggcacaacacttacctccaggaatgcacaggccagcgggagccc acgtaccagctcaacatccacgacatcaagctgcttttcctgcgctttgccatggaacag tcattcagtgccgacaccggcgggggaggccgggagagcaacatccacctgatcccatac atcattcacactgtgctttatgtcctgaacacaactcgagcaacttcccgagaagaaaag aacctccaaggcttcttggagcagcccaaggagaagtgggtggaaagcgccttcgaggtg gatgggccacactattatgcagcactggccctgcacgtcctgcccccggagcagtggaga accgtgcgcctggagatgctgcgcaggctgctggtgacctcacaggctcgggctgtggct ccaggaggcgccaccaggctggcggacaaggcagtgaaggactactctacctatcgggct tccctgctcttctgggccctcgtcgatctcatttacaacatgtttaagaaggtgcctacc agtaacacggagggaggctggtcctgctctctggccgagtacatccgccacaacgacatg cccgtctacgaggctgccgacaaagccctggagaccttccaggaggagtttgtgcccgtg gagaccttctcagagttcctcgacgtggccggtctcctcgcagaagtccctgatccggag agcttcctgaaggacctgttgaattcagtcccctga

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