Ochotona princeps (American pika): 101523638
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Entry
101523638 CDS
T07609
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
opi
Ochotona princeps (American pika)
Pathway
opi00230
Purine metabolism
opi01100
Metabolic pathways
opi04927
Cortisol synthesis and secretion
opi04934
Cushing syndrome
opi05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
opi00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
101523638 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
101523638 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
101523638 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
101523638 (PDE8A)
Enzymes [BR:
opi01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
101523638 (PDE8A)
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Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS_9
PAS
PDE8
PAS_4
PAS_3
PAS_8
Sina_ZnF
Motif
Other DBs
NCBI-GeneID:
101523638
NCBI-ProteinID:
XP_012785101
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Position
17:complement(87307012..87469905)
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AA seq
877 aa
AA seq
DB search
MGCAPSIHVSEDRPVYQGGKEAGDAPGPAAAPPSSGEPRLPLGPKTAAVQPGTRGTPSLV
ESEPRDGSSKKVAIADVQFGPMRFHQDQLQVLLVFTKEDSQCNGFCRACEKAGFKCTVTK
EAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRTINSNQISKADKEELSVMPLIAAGFT
RRYVENPNITACYNELLQLEFGEVRSQLKLRACNSIFTALEKSQEAIEITSEDHIIQYAN
PAFETTMGYQSGELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIHYAKKKNGDNIQ
QNVKIIPVVGQGGKIRHYVSIIRMCNGNNKAEKIPEVVQSETPADNQTGKHRDRRKGSLD
VRALASRTNEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPVPVTEALDRVLEI
LRTTELYSPQFGVKDDDPHANDLVGGLMSDGLRRLSGNEYVLSSKSLSQVSSSMIAPTTL
HDIPPRIARAMEDEETWDFNIFELEAATQNRPLIYLGLKTFARFGICEFLNCSESTLRSW
LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERVKKTLDPIDEVAALIAATIHDVDHP
GRTNSFLCNAGSELAVLYNDIAVLESHHSALAFQLTMGDDKCNIFKNMERNDYRTLRQGI
VDMVLATEMTKHFEHVNKFVNSINKPLAALEEAGETEKDHEAINAMLRTPENRILIKRML
IKCADVSNPCRPLDYCIEWAARISEEYFAQTDEEKRLGLPVVMPVFDRNTCSIPKSQISF
IDYFITDMFDAWDAFVDLPGLMQHLDNNFKYWKGLDEMKLLSLRPPRERQPEEPPQPLPV
TRASNRPGEAQLWSPRAAGSCGCPPHSQGPEHTLEHY
NT seq
2634 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgccccgagcatccacgtctccgaggaccggccggtgtaccagggcggcaaa
gaggccggggacgcgccgggccccgcggcggcgcctccgtcgtccggcgagccgcgcctc
cccctgggccccaagacagcagccgtccagccggggacccgcggcacccccagcctcgtg
gagtccgagcctcgcgacggcagcagcaagaaggtagcaatagctgatgtgcagtttggc
cccatgagatttcatcaagatcagcttcaggtacttttagtgtttaccaaagaagatagc
cagtgtaatggattctgcagggcgtgtgaaaaagcagggtttaaatgtacggtcactaag
gaggcccaggccgtcctggcctgtttcctggacaagcatcatgatatcatcatcatagac
cacaggaacccgcggcagctggatgcggaggcgctgtgcaggactataaacagtaatcaa
atctcaaaggcggataaggaggagctgtctgtcatgcccttgattgccgctggcttcacc
aggaggtacgtagagaaccccaacatcacggcctgctacaacgagctgctgcagctggag
tttggagaggtgcggtcacagctaaaactcagggcttgtaactcaatattcactgcgtta
gagaaaagccaagaagccattgaaatcacaagtgaagaccacattatacagtatgcaaat
cctgcatttgaaacaacaatgggctatcagtcgggtgaattaatagggaaggaattagca
gaagtgcctataaatgagaaaaaggccgacttgctggatactataaattcatgcatcagg
ataggcaaggaatggcaaggaattcactatgccaaaaagaaaaatggagataatatacaa
caaaatgtgaagataatacctgttgttggacagggaggaaaaattagacactatgtgtcc
attatcagaatgtgcaacggcaacaacaaggctgagaaaatacctgaagttgttcagtct
gaaactccagcagataaccagacgggcaagcaccgagacaggaggaaaggctccctggac
gtccgagctctcgcttcgcggacaaacgaagtgtccagccagcgacgccactcctccatg
gcccgcatccattccatgacgatcgaggcgcccatcaccaaggtgatcaatatcatcaat
gcagcgcaggaaagcagccccgtgcctgtgacagaagccttggaccgtgtgttggaaatc
ctgagaaccactgaactgtattctccccagtttggcgttaaggatgacgacccccatgcc
aatgaccttgttgggggcttaatgtctgatggtttgcggaggctgtcggggaatgaatac
gtcctttcatccaaaagcctctcccaggtttccagcagcatgatcgctcccaccaccctg
cacgacatccccccacggatagctcgggccatggaagatgaggaaacctgggacttcaac
atttttgaactggaggctgccacccagaacaggcctttgatttaccttggtctcaaaact
tttgctcgctttggaatctgtgaattcttaaactgctcagagtcaacgctgagatcatgg
ctgcagatcattgaagccaattaccactcctccaacccctaccacaactcgacgcattcc
gccgacgtgctgcacgccaccgcctacttcctctccaaggagcgcgtcaagaaaacttta
gatccgatcgatgaggtggctgccctcattgctgccacaattcacgatgtggaccaccct
gggaggaccaactccttcctgtgcaacgccgggagcgagctggccgtcctgtacaatgac
atcgccgtgctggagagccaccactcggccttggccttccagctgaccatgggagatgac
aagtgcaacatctttaaaaacatggagaggaatgattaccggacactacgccagggaatt
gttgacatggtgctggccacagagatgacgaagcacttcgagcacgtcaacaaatttgtc
aacagcatcaacaagcccttggcggccctggaagaagctggggagactgagaaagaccat
gaggctataaacgccatgctcagaactccagagaaccgaatcctaatcaaacggatgctg
atcaagtgtgccgacgtgtccaacccctgccggccgctggactactgcatcgagtgggcc
gcacgcatttcagaagagtactttgctcagaccgatgaagagaagcggctgggcttgccc
gtggtgatgccggtgttcgaccggaatacctgcagcatccccaagtcccagatctccttc
atcgactacttcatcaccgacatgttcgacgcctgggacgcctttgtcgacctcccgggt
ctcatgcagcacctggacaacaacttcaagtactggaaaggactggacgagatgaagctg
ctgagtctgcggcctccccgggagaggcagcccgaggaacccccgcagccactgcctgtc
actcgagcctccaaccggcctggtgaggcgcagctctggagccccagggccgcgggctcg
tgcggctgccccccgcactcgcagggcccagagcacacgctggaacactactga
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