KEGG   Ochotona princeps (American pika): 101526188
Entry
101526188         CDS       T07609                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi01521  EGFR tyrosine kinase inhibitor resistance
opi01522  Endocrine resistance
opi04010  MAPK signaling pathway
opi04012  ErbB signaling pathway
opi04015  Rap1 signaling pathway
opi04024  cAMP signaling pathway
opi04062  Chemokine signaling pathway
opi04068  FoxO signaling pathway
opi04150  mTOR signaling pathway
opi04270  Vascular smooth muscle contraction
opi04510  Focal adhesion
opi04650  Natural killer cell mediated cytotoxicity
opi04720  Long-term potentiation
opi04722  Neurotrophin signaling pathway
opi04726  Serotonergic synapse
opi04730  Long-term depression
opi04810  Regulation of actin cytoskeleton
opi04910  Insulin signaling pathway
opi04914  Progesterone-mediated oocyte maturation
opi04928  Parathyroid hormone synthesis, secretion and action
opi04934  Cushing syndrome
opi05010  Alzheimer disease
opi05022  Pathways of neurodegeneration - multiple diseases
opi05034  Alcoholism
opi05160  Hepatitis C
opi05161  Hepatitis B
opi05200  Pathways in cancer
opi05205  Proteoglycans in cancer
opi05208  Chemical carcinogenesis - reactive oxygen species
opi05210  Colorectal cancer
opi05211  Renal cell carcinoma
opi05212  Pancreatic cancer
opi05213  Endometrial cancer
opi05214  Glioma
opi05215  Prostate cancer
opi05216  Thyroid cancer
opi05218  Melanoma
opi05219  Bladder cancer
opi05220  Chronic myeloid leukemia
opi05221  Acute myeloid leukemia
opi05223  Non-small cell lung cancer
opi05224  Breast cancer
opi05225  Hepatocellular carcinoma
opi05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:opi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101526188 (BRAF)
   04012 ErbB signaling pathway
    101526188 (BRAF)
   04015 Rap1 signaling pathway
    101526188 (BRAF)
   04068 FoxO signaling pathway
    101526188 (BRAF)
   04024 cAMP signaling pathway
    101526188 (BRAF)
   04150 mTOR signaling pathway
    101526188 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101526188 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101526188 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101526188 (BRAF)
   04062 Chemokine signaling pathway
    101526188 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101526188 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    101526188 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    101526188 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101526188 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    101526188 (BRAF)
   04720 Long-term potentiation
    101526188 (BRAF)
   04730 Long-term depression
    101526188 (BRAF)
   04722 Neurotrophin signaling pathway
    101526188 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101526188 (BRAF)
   05205 Proteoglycans in cancer
    101526188 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    101526188 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101526188 (BRAF)
   05212 Pancreatic cancer
    101526188 (BRAF)
   05225 Hepatocellular carcinoma
    101526188 (BRAF)
   05226 Gastric cancer
    101526188 (BRAF)
   05214 Glioma
    101526188 (BRAF)
   05216 Thyroid cancer
    101526188 (BRAF)
   05221 Acute myeloid leukemia
    101526188 (BRAF)
   05220 Chronic myeloid leukemia
    101526188 (BRAF)
   05218 Melanoma
    101526188 (BRAF)
   05211 Renal cell carcinoma
    101526188 (BRAF)
   05219 Bladder cancer
    101526188 (BRAF)
   05215 Prostate cancer
    101526188 (BRAF)
   05213 Endometrial cancer
    101526188 (BRAF)
   05224 Breast cancer
    101526188 (BRAF)
   05223 Non-small cell lung cancer
    101526188 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101526188 (BRAF)
   05160 Hepatitis C
    101526188 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101526188 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    101526188 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    101526188 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101526188 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101526188 (BRAF)
   01522 Endocrine resistance
    101526188 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    101526188 (BRAF)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101526188 (BRAF)
Protein kinases [BR:opi01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   101526188 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal Kdo
Other DBs
NCBI-GeneID: 101526188
NCBI-ProteinID: XP_004594410
LinkDB
Position
7A:3379593..3498966
AA seq 762 aa
MAALSGGGGAEQGQALFNGDMESEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEAL
LDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSSS
SSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKA
LMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFT
LAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEE
ASLAETALASGSSPSAPPTDSLGPQILTTPSPSKSIPIPQPFRPAEEDHRNQFGQRDRSS
SAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQR
ERKSSSSSEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKM
LNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHII
ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW
SGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYLNINNRDQ
IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI
HRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
NT seq 2289 nt   +upstreamnt  +downstreamnt
atggcggcgctgagtggcggcggcggcgcggagcagggccaggctctgttcaacggggac
atggagtccgaggccggcgccggcgccgcggcctcttcggctgcggaccctgccattccc
gaggaggtgtggaatatcaaacagatgattaagttgacacaggaacatatagaggccctc
ttggacaaatttggtggggagcataatccaccatcaatatatctggaggcctatgaagaa
tacaccagcaagctagatgcactccagcaaagagagcagcagttgttggaatccctgggg
aatggaactgatttttctgtttctagctcagcatcaacggacaccgttacgtcttcttcc
tcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccacagatgtg
tcacggagcaaccccaagtccccacaaaaacctatcgttagagtcttcctgcccaacaaa
cagaggacagtggtacctgcaagatgtggagttacagtccgagacagtctaaagaaagca
ctgatgatgagagggctaatcccagaatgctgtgctgtttacagaattcaggatggagag
aagaaaccaattggctgggacactgacatttcctggcttactggagaagaactacatgta
gaagtattggagaatgttccactcacaacgcacaactttgtacggaaaacttttttcacc
ttagcgttttgtgacttctgtcgaaagctgctcttccagggtttccgctgtcaaacgtgt
ggttacaaatttcaccagcgttgcagcacggaggtgccgctgatgtgtgttaattatgac
caacttgatttgctgtttgtctccaagttctttgaacaccacccagtaccacaggaggag
gcctccctagcagagacagccctcgcctctggatcctccccctcggctcctcccacagac
tcccttgggccccaaattctcaccactccgtctccttcaaaatccattccaattccacag
cccttccgaccagcggaagaagaccatcgaaatcagtttgggcaacgagatcggtcatca
tcagcccccaatgttcatattaacacaatagaacctgttaatattgatgacttgattaga
gaccaagggtttcgtggtgatggaggctcaaccacaggtttatctgccactccccccgcc
tcgctacctggctcactcactaacgtgaaagccttacagaaatcccccgggcctcagcgg
gaaaggaagtcctcttcgtcctcagaagacaggagtcgaatgaaaacccttggtagacgg
gattcaagtgatgactgggagattcctgatgggcagattaccgtgggacagagaattgga
tctgggtcatttggaaccgtctataagggaaaatggcacggtgatgtggcagtaaaaatg
ttgaatgtgacagcacctacacctcagcagttacaggccttcaaaaatgaagtaggagta
ctcaggaaaacacgacatgtgaatatcctacttttcatgggctattccacaaaaccacaa
ctagctattgttacccagtggtgtgagggctccagtttatatcaccatctgcacatcata
gagaccaaatttgagatgatcaaacttatagacattgcacgacagactgcacagggcatg
gattacttacacgccaagtcaatcatccacagagacctcaagagtaataatatatttctt
catgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcgatgg
agtgggtcccatcagtttgagcagttatctggatccattctgtggatggcaccagaagta
attagaatgcaagacaaaaacccgtatagctttcagtcagatgtatatgcatttgggatt
gttctgtatgaattgatgactggacaattaccttatttaaacatcaacaacagggaccag
atcatttttatggtgggacgtggatacctgtctccagatctcagtaaggtacggagtaac
tgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagatgagaga
ccactcttcccccagattctcgcctctatcgagctgctggcccgctcattgccaaaaatt
caccgcagtgcgtcagaaccctccttgaatcgggctggtttccagacggaggattttagt
ctgtacgcttgtgcttctccaaaaacacccatccaggcagggggctatggtgcgtttcct
gtccactga

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