KEGG   Ochotona princeps (American pika): 101528246
Entry
101528246         CDS       T07609                                 
Symbol
RPS6KB1
Name
(RefSeq) ribosomal protein S6 kinase beta-1 isoform X1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi01521  EGFR tyrosine kinase inhibitor resistance
opi01522  Endocrine resistance
opi04012  ErbB signaling pathway
opi04066  HIF-1 signaling pathway
opi04140  Autophagy - animal
opi04150  mTOR signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04152  AMPK signaling pathway
opi04211  Longevity regulating pathway
opi04213  Longevity regulating pathway - multiple species
opi04350  TGF-beta signaling pathway
opi04371  Apelin signaling pathway
opi04666  Fc gamma R-mediated phagocytosis
opi04714  Thermogenesis
opi04910  Insulin signaling pathway
opi04931  Insulin resistance
opi05163  Human cytomegalovirus infection
opi05165  Human papillomavirus infection
opi05170  Human immunodeficiency virus 1 infection
opi05200  Pathways in cancer
opi05205  Proteoglycans in cancer
opi05207  Chemical carcinogenesis - receptor activation
opi05210  Colorectal cancer
opi05212  Pancreatic cancer
opi05221  Acute myeloid leukemia
opi05224  Breast cancer
opi05225  Hepatocellular carcinoma
opi05226  Gastric cancer
opi05231  Choline metabolism in cancer
opi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:opi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101528246 (RPS6KB1)
   04350 TGF-beta signaling pathway
    101528246 (RPS6KB1)
   04371 Apelin signaling pathway
    101528246 (RPS6KB1)
   04066 HIF-1 signaling pathway
    101528246 (RPS6KB1)
   04151 PI3K-Akt signaling pathway
    101528246 (RPS6KB1)
   04152 AMPK signaling pathway
    101528246 (RPS6KB1)
   04150 mTOR signaling pathway
    101528246 (RPS6KB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101528246 (RPS6KB1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    101528246 (RPS6KB1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101528246 (RPS6KB1)
  09149 Aging
   04211 Longevity regulating pathway
    101528246 (RPS6KB1)
   04213 Longevity regulating pathway - multiple species
    101528246 (RPS6KB1)
  09159 Environmental adaptation
   04714 Thermogenesis
    101528246 (RPS6KB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101528246 (RPS6KB1)
   05205 Proteoglycans in cancer
    101528246 (RPS6KB1)
   05207 Chemical carcinogenesis - receptor activation
    101528246 (RPS6KB1)
   05231 Choline metabolism in cancer
    101528246 (RPS6KB1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101528246 (RPS6KB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101528246 (RPS6KB1)
   05212 Pancreatic cancer
    101528246 (RPS6KB1)
   05225 Hepatocellular carcinoma
    101528246 (RPS6KB1)
   05226 Gastric cancer
    101528246 (RPS6KB1)
   05221 Acute myeloid leukemia
    101528246 (RPS6KB1)
   05224 Breast cancer
    101528246 (RPS6KB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101528246 (RPS6KB1)
   05163 Human cytomegalovirus infection
    101528246 (RPS6KB1)
   05165 Human papillomavirus infection
    101528246 (RPS6KB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    101528246 (RPS6KB1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101528246 (RPS6KB1)
   01522 Endocrine resistance
    101528246 (RPS6KB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    101528246 (RPS6KB1)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101528246 (RPS6KB1)
Protein kinases [BR:opi01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   101528246 (RPS6KB1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 DUF1015
Other DBs
NCBI-GeneID: 101528246
NCBI-ProteinID: XP_004591015
LinkDB
Position
19:complement(27231220..27278039)
AA seq 525 aa
MRRRRKRDGFYQAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTTSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
NT seq 1578 nt   +upstreamnt  +downstreamnt
atgaggcgacgacggaagcgggacggcttttaccaagcgcctgacttccgagacagggaa
gctgaggacatggctggagtgtttgacatagacctggaccagccagaggacgcgggctca
gaggatgagctggaggaagggggtcagttaaatgaaagcatggaccatgggggagttgga
ccatatgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaac
agagggccagaaaaaatcagaccagagtgttttgagctacttcgggtacttggtaaaggg
ggctatggaaaggtttttcaagtacggaaagtaacaggagcaaatactgggaaaatattt
gctatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaggatacagctcataca
aaagcagaacggaatattctggaggaagtaaagcatcccttcattgtggatttaatttat
gcctttcagaccggtggaaaactctacctcatccttgagtatctcagtggaggagaacta
tttatgcagttagaaagagagggaatatttatggaagatacagcctgcttttacttggca
gaaatttccatggctttggggcatttacatcaaaagggaatcatctacagagacctgaag
ccggagaatatcatgcttaatcaccaaggtcatgtgaaactaacagactttggactatgc
aaagaatccattcatgatggaacagtcacacacacattttgcggaacaatagaatacatg
gcccctgaaatcttgatgagaagtggccacaatcgtgcagtggattggtggagtttggga
gcattaatgtatgacatgctgactggagcaccccctttcactggggaaaatagaaagaaa
acaattgataaaatcctcaaatgtaaacttaatttgcctccctacctcacacaagaagcc
agagatctgcttaaaaagctgctgaaaagaaatgctgcttcacgtcttggagctggccct
ggggatgctggagaagttcaagctcatccattcttcagacacattaattgggaagaactt
ctggcacggaaggtggagcccccctttaaacctctgttgcaatctgaagaggatgtgagt
cagtttgactcaaagtttacacgtcagacacctgtagatagccccgatgactcaactctc
agtgagagtgccaaccaggtcttcttgggttttacatatgtggctccatctgtacttgaa
agtgtgaaagaaaagttttcctttgaaccaaaaatccgatcacctcgaagatttattggc
agcccacggacgcctgtcagcccagtcaaattttctcctggggatttctggggaagaggt
gcttcagccagcacggcaaatcctcagacgcctgtggaatacccgatggaaacaagtgga
atagaacagatggatgtgacgacgagcggggaagcatcagcaccgcttccaatacgacag
ccaaactccggaccatacaaaaagcaagcctttcccatgatctccaaacggccagagcac
ctacgcatgaatctatga

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