KEGG   Ochotona princeps (American pika): 101529871
Entry
101529871         CDS       T07609                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi01521  EGFR tyrosine kinase inhibitor resistance
opi01522  Endocrine resistance
opi04010  MAPK signaling pathway
opi04012  ErbB signaling pathway
opi04068  FoxO signaling pathway
opi04270  Vascular smooth muscle contraction
opi04650  Natural killer cell mediated cytotoxicity
opi04720  Long-term potentiation
opi04726  Serotonergic synapse
opi04730  Long-term depression
opi04810  Regulation of actin cytoskeleton
opi04910  Insulin signaling pathway
opi04914  Progesterone-mediated oocyte maturation
opi04928  Parathyroid hormone synthesis, secretion and action
opi05010  Alzheimer disease
opi05022  Pathways of neurodegeneration - multiple diseases
opi05034  Alcoholism
opi05160  Hepatitis C
opi05161  Hepatitis B
opi05200  Pathways in cancer
opi05205  Proteoglycans in cancer
opi05208  Chemical carcinogenesis - reactive oxygen species
opi05210  Colorectal cancer
opi05211  Renal cell carcinoma
opi05212  Pancreatic cancer
opi05213  Endometrial cancer
opi05214  Glioma
opi05215  Prostate cancer
opi05218  Melanoma
opi05219  Bladder cancer
opi05220  Chronic myeloid leukemia
opi05221  Acute myeloid leukemia
opi05223  Non-small cell lung cancer
opi05224  Breast cancer
opi05225  Hepatocellular carcinoma
opi05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:opi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101529871 (ARAF)
   04012 ErbB signaling pathway
    101529871 (ARAF)
   04068 FoxO signaling pathway
    101529871 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101529871 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101529871 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101529871 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    101529871 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    101529871 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101529871 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    101529871 (ARAF)
   04720 Long-term potentiation
    101529871 (ARAF)
   04730 Long-term depression
    101529871 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101529871 (ARAF)
   05205 Proteoglycans in cancer
    101529871 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    101529871 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101529871 (ARAF)
   05212 Pancreatic cancer
    101529871 (ARAF)
   05225 Hepatocellular carcinoma
    101529871 (ARAF)
   05226 Gastric cancer
    101529871 (ARAF)
   05214 Glioma
    101529871 (ARAF)
   05221 Acute myeloid leukemia
    101529871 (ARAF)
   05220 Chronic myeloid leukemia
    101529871 (ARAF)
   05218 Melanoma
    101529871 (ARAF)
   05211 Renal cell carcinoma
    101529871 (ARAF)
   05219 Bladder cancer
    101529871 (ARAF)
   05215 Prostate cancer
    101529871 (ARAF)
   05213 Endometrial cancer
    101529871 (ARAF)
   05224 Breast cancer
    101529871 (ARAF)
   05223 Non-small cell lung cancer
    101529871 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101529871 (ARAF)
   05160 Hepatitis C
    101529871 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101529871 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    101529871 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    101529871 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101529871 (ARAF)
   01522 Endocrine resistance
    101529871 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    101529871 (ARAF)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101529871 (ARAF)
Protein kinases [BR:opi01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   101529871 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 101529871
NCBI-ProteinID: XP_004587939
LinkDB
Position
X
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMNTNRRQFYHSVQDLSGGSRQHEAPSSRPMNEPL
TPQAPSSCTQHRDPGHFPFPVPANAPLQRIRSTSTPNVHMVSTTAPMDSSLMQLTAQSFG
TDAVGSRGGSDGASRGSPSPASVSSGRKSPHSKSPSEQRERKSTADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacgagggccccctgccaacggggctgagccatcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtaactgtccgcgatggcatgagc
gtctacgactctctggacaaggccctcaaagtgcgcgggctcaatcaggactgctgtgtg
gtctaccgactcatcaaggggcgaaagacagtcactgcctgggatacagccatcgccccc
cttgatggtgaagagctcattgttgaggtccttgaagatgtgccgctgaccatgcacaat
tttgtccggaagacgttcttcagcctggcattctgcgacttctgccttaagtttctgttc
catggttttcgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtg
cccacagtctgcgtggatatgaacaccaaccgccgacagttctaccacagtgtccaggat
ttgtctggaggctcccggcagcatgaggctccctccagccgccccatgaatgagccgctc
accccccaggctcccagctcctgcacccagcacagggatccagggcatttccccttccct
gtcccggccaacgcccccctccagcgcatccgctccacatccactcccaacgtccatatg
gtcagcaccaccgcccccatggactccagcctcatgcagctcactgctcagagtttcggc
actgatgctgttggtagtagaggtggcagtgatggagcttctcgggggagccccagccca
gccagtgtgtcttcggggaggaagtccccacattccaagtcaccatctgagcagcgggag
cggaagtccacagctgatgacaagaagaaagtgaagaacctggggtaccgggactcagga
tattactgggaggtgccccccagtgaggtgcagctgctgaagaggatcgggacaggctca
tttggcaccgtgttccgtggccggtggcacggtgacgtggccgtgaaggtgctcaaggtg
gcccagcccacagctgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaag
acccggcacgtcaacatcttgctgttcatgggcttcatgacccgcccaggctttgccatc
atcacccagtggtgtgagggctccagcctctaccatcacctccacgtggctgacacacgc
tttgacatggtccaactcatcgacgtggctcggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagacctcaagtctaacaatatcttcctacacgagggg
ctcacagtgaagattggtgactttggcctggccactgtgaagacacggtggagtggagcc
cagcccttggagcagccctcaggctctgtgctttggatggcggctgaggtgatccgcatg
caggacccgaacccctacagtttccagtcagacgtctacgcctacggggtcgtgctctac
gaactcatgaccggctcactgccttatagccacattggcagccgtgaccagatcatcttt
atggtaggccgtggctacctgtcccctgacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccaccattgagctgctacagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggccgatgaattgcctgcctgcctcctcagc
gcagcccgccttgtgccttag

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