Ochotona princeps (American pika): 101530753
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Entry
101530753 CDS
T07609
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
opi
Ochotona princeps (American pika)
Pathway
opi00270
Cysteine and methionine metabolism
opi00480
Glutathione metabolism
opi01100
Metabolic pathways
opi01240
Biosynthesis of cofactors
opi04216
Ferroptosis
Module
opi_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
opi00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
101530753 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
101530753 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
101530753 (GCLC)
Enzymes [BR:
opi01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
101530753 (GCLC)
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Gene cluster
GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
101530753
NCBI-ProteinID:
XP_004599500
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Position
12:complement(49967873..50012691)
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AA seq
637 aa
AA seq
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MGLLSQGSPLSWEETKRHADHVRRHGILQFLNIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVQLVLSGEQVLETLQEQGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSVLGENQALCTITSFPRLGCPGFTLPEYKPSPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVAINVPIFKDKNTPAPFIESFPKDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNSNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLK
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
KELFYFRKDICKGGSAVVDGCGKAQSGTELAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIGSHPDYKQDSIITDEMNYS
LILKCNQIANELCECPELLGSTLRKAKYSGSKTDPST
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctctccgctgagctgggaggaaaccaagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgaacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaaatggggcgacgaggtggaatacatgctggtatctttcgatcac
gaaaataaaaaagtccagttggtcctgtccggggaacaagtccttgaaacgctacaagag
cagggggaaaggacaaacccaaaccaccccaccctttggagaccagagtacgggagttac
atgattgaagggacccctggacagccctatggaggaaccatgtccgaattcaacaccgtg
gaagacaacatgcgaaagcgccggaaggaggctacttctgtcttgggagaaaatcaggct
ctttgcaccataacatcatttcccagattaggctgtcctgggttcacattgcccgagtac
aaacccagcccggtcgaaggcggagcttccaagtccctcttctttccagatgaagccata
aacaagcaccctcgcttcagtaccctaacgagaaatatacggcataggagaggagagaag
gtggccatcaacgttccaatatttaaggacaagaacacaccagctccatttatagagtca
tttcccaaggacgaggaggcagcaaaggcttctaagccagaccatatttacatggacgcc
atgggatttggaatgggcaactgttgtctccaggtgacattccaagcctgcagcatatct
gaggccagatacctttatgatcaattggccacaatctgcccaattgttatggctctcagt
gctgcatctcctttttaccgaggctacgtgtctgacattgattgtcgctggggcgtgatt
tctgcatctgtagacgacagaactcgggaggagagaggcctggagccactgaagaacagt
aactataggattagtaaatcacgatatgattcaatagacagctacttgtccaagtgtggt
gagaagtataatgacattgacttgacgatagataaagagatctacgaacagctgttgaag
gaaggcatcgatcatctcctggcccagcatgtggctcatctcttcatcagagaccccttg
actctgtttgaggagaaaatacacctggatgatgctaatgagtctgaccattttgagaat
attcagtccacaaattggcagacaatgaggtttaagccgcctcctccaaactcagatatt
ggctggagagtggaattccgacccatggaggttcagctaactgacttcgagaactctgcc
tatgtggtgtttgtggtgctgctcaccagggtgatcctctcatacaaactggattttctc
attccactgtccaaggttgatgagaacatgaaagtagcgcagaaacgagatgctgtcctg
aaggagctgttttatttcaggaaggatatctgcaaaggtggcagtgccgtggtggacggg
tgtggcaaggcgcagagcggcacagagctggcggcagaggagtacaccctcatgagcata
gacactatcatcaacgggaaggaaggtgtgtttcctgggctcatccctatcctgaactcc
taccttgagaacatggaggtggatgtggacaccagatgtagtattctgaactacctgaag
ctgattaagaagagagcatccggagaattgatgacggttgcccggtggatgcgggagttc
atcgggagccatcctgactataagcaggacagtatcatcaccgatgaaatgaactacagc
cttattttgaagtgtaaccaaattgccaatgaattgtgtgaatgcccagagttattaggg
tccacccttaggaaagcaaagtatagcggaagtaaaactgacccttccacctag
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