KEGG   Ochotona princeps (American pika): 101533024
Entry
101533024         CDS       T07609                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi00562  Inositol phosphate metabolism
opi01100  Metabolic pathways
opi01521  EGFR tyrosine kinase inhibitor resistance
opi01522  Endocrine resistance
opi01524  Platinum drug resistance
opi04012  ErbB signaling pathway
opi04014  Ras signaling pathway
opi04015  Rap1 signaling pathway
opi04024  cAMP signaling pathway
opi04062  Chemokine signaling pathway
opi04066  HIF-1 signaling pathway
opi04068  FoxO signaling pathway
opi04070  Phosphatidylinositol signaling system
opi04071  Sphingolipid signaling pathway
opi04072  Phospholipase D signaling pathway
opi04081  Hormone signaling
opi04140  Autophagy - animal
opi04150  mTOR signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04152  AMPK signaling pathway
opi04210  Apoptosis
opi04211  Longevity regulating pathway
opi04213  Longevity regulating pathway - multiple species
opi04218  Cellular senescence
opi04360  Axon guidance
opi04370  VEGF signaling pathway
opi04380  Osteoclast differentiation
opi04510  Focal adhesion
opi04550  Signaling pathways regulating pluripotency of stem cells
opi04611  Platelet activation
opi04613  Neutrophil extracellular trap formation
opi04620  Toll-like receptor signaling pathway
opi04625  C-type lectin receptor signaling pathway
opi04630  JAK-STAT signaling pathway
opi04650  Natural killer cell mediated cytotoxicity
opi04660  T cell receptor signaling pathway
opi04662  B cell receptor signaling pathway
opi04664  Fc epsilon RI signaling pathway
opi04666  Fc gamma R-mediated phagocytosis
opi04668  TNF signaling pathway
opi04670  Leukocyte transendothelial migration
opi04722  Neurotrophin signaling pathway
opi04725  Cholinergic synapse
opi04750  Inflammatory mediator regulation of TRP channels
opi04810  Regulation of actin cytoskeleton
opi04910  Insulin signaling pathway
opi04914  Progesterone-mediated oocyte maturation
opi04915  Estrogen signaling pathway
opi04917  Prolactin signaling pathway
opi04919  Thyroid hormone signaling pathway
opi04923  Regulation of lipolysis in adipocytes
opi04926  Relaxin signaling pathway
opi04929  GnRH secretion
opi04930  Type II diabetes mellitus
opi04931  Insulin resistance
opi04932  Non-alcoholic fatty liver disease
opi04933  AGE-RAGE signaling pathway in diabetic complications
opi04935  Growth hormone synthesis, secretion and action
opi04960  Aldosterone-regulated sodium reabsorption
opi04973  Carbohydrate digestion and absorption
opi05010  Alzheimer disease
opi05017  Spinocerebellar ataxia
opi05020  Prion disease
opi05100  Bacterial invasion of epithelial cells
opi05132  Salmonella infection
opi05135  Yersinia infection
opi05142  Chagas disease
opi05146  Amoebiasis
opi05160  Hepatitis C
opi05161  Hepatitis B
opi05162  Measles
opi05163  Human cytomegalovirus infection
opi05164  Influenza A
opi05165  Human papillomavirus infection
opi05166  Human T-cell leukemia virus 1 infection
opi05167  Kaposi sarcoma-associated herpesvirus infection
opi05168  Herpes simplex virus 1 infection
opi05169  Epstein-Barr virus infection
opi05170  Human immunodeficiency virus 1 infection
opi05171  Coronavirus disease - COVID-19
opi05200  Pathways in cancer
opi05203  Viral carcinogenesis
opi05205  Proteoglycans in cancer
opi05206  MicroRNAs in cancer
opi05207  Chemical carcinogenesis - receptor activation
opi05208  Chemical carcinogenesis - reactive oxygen species
opi05210  Colorectal cancer
opi05211  Renal cell carcinoma
opi05212  Pancreatic cancer
opi05213  Endometrial cancer
opi05214  Glioma
opi05215  Prostate cancer
opi05218  Melanoma
opi05220  Chronic myeloid leukemia
opi05221  Acute myeloid leukemia
opi05222  Small cell lung cancer
opi05223  Non-small cell lung cancer
opi05224  Breast cancer
opi05225  Hepatocellular carcinoma
opi05226  Gastric cancer
opi05230  Central carbon metabolism in cancer
opi05231  Choline metabolism in cancer
opi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
opi05415  Diabetic cardiomyopathy
opi05417  Lipid and atherosclerosis
opi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:opi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101533024 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101533024 (PIK3CB)
   04014 Ras signaling pathway
    101533024 (PIK3CB)
   04015 Rap1 signaling pathway
    101533024 (PIK3CB)
   04370 VEGF signaling pathway
    101533024 (PIK3CB)
   04630 JAK-STAT signaling pathway
    101533024 (PIK3CB)
   04668 TNF signaling pathway
    101533024 (PIK3CB)
   04066 HIF-1 signaling pathway
    101533024 (PIK3CB)
   04068 FoxO signaling pathway
    101533024 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    101533024 (PIK3CB)
   04072 Phospholipase D signaling pathway
    101533024 (PIK3CB)
   04071 Sphingolipid signaling pathway
    101533024 (PIK3CB)
   04024 cAMP signaling pathway
    101533024 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    101533024 (PIK3CB)
   04152 AMPK signaling pathway
    101533024 (PIK3CB)
   04150 mTOR signaling pathway
    101533024 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101533024 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101533024 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    101533024 (PIK3CB)
   04218 Cellular senescence
    101533024 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101533024 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    101533024 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101533024 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101533024 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    101533024 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    101533024 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    101533024 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    101533024 (PIK3CB)
   04660 T cell receptor signaling pathway
    101533024 (PIK3CB)
   04662 B cell receptor signaling pathway
    101533024 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    101533024 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    101533024 (PIK3CB)
   04670 Leukocyte transendothelial migration
    101533024 (PIK3CB)
   04062 Chemokine signaling pathway
    101533024 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101533024 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    101533024 (PIK3CB)
   04929 GnRH secretion
    101533024 (PIK3CB)
   04915 Estrogen signaling pathway
    101533024 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    101533024 (PIK3CB)
   04917 Prolactin signaling pathway
    101533024 (PIK3CB)
   04926 Relaxin signaling pathway
    101533024 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    101533024 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    101533024 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101533024 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101533024 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    101533024 (PIK3CB)
   04722 Neurotrophin signaling pathway
    101533024 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101533024 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    101533024 (PIK3CB)
   04380 Osteoclast differentiation
    101533024 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    101533024 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    101533024 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101533024 (PIK3CB)
   05206 MicroRNAs in cancer
    101533024 (PIK3CB)
   05205 Proteoglycans in cancer
    101533024 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    101533024 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    101533024 (PIK3CB)
   05203 Viral carcinogenesis
    101533024 (PIK3CB)
   05230 Central carbon metabolism in cancer
    101533024 (PIK3CB)
   05231 Choline metabolism in cancer
    101533024 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101533024 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101533024 (PIK3CB)
   05212 Pancreatic cancer
    101533024 (PIK3CB)
   05225 Hepatocellular carcinoma
    101533024 (PIK3CB)
   05226 Gastric cancer
    101533024 (PIK3CB)
   05214 Glioma
    101533024 (PIK3CB)
   05221 Acute myeloid leukemia
    101533024 (PIK3CB)
   05220 Chronic myeloid leukemia
    101533024 (PIK3CB)
   05218 Melanoma
    101533024 (PIK3CB)
   05211 Renal cell carcinoma
    101533024 (PIK3CB)
   05215 Prostate cancer
    101533024 (PIK3CB)
   05213 Endometrial cancer
    101533024 (PIK3CB)
   05224 Breast cancer
    101533024 (PIK3CB)
   05222 Small cell lung cancer
    101533024 (PIK3CB)
   05223 Non-small cell lung cancer
    101533024 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101533024 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    101533024 (PIK3CB)
   05161 Hepatitis B
    101533024 (PIK3CB)
   05160 Hepatitis C
    101533024 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    101533024 (PIK3CB)
   05164 Influenza A
    101533024 (PIK3CB)
   05162 Measles
    101533024 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    101533024 (PIK3CB)
   05163 Human cytomegalovirus infection
    101533024 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101533024 (PIK3CB)
   05169 Epstein-Barr virus infection
    101533024 (PIK3CB)
   05165 Human papillomavirus infection
    101533024 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101533024 (PIK3CB)
   05135 Yersinia infection
    101533024 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    101533024 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101533024 (PIK3CB)
   05142 Chagas disease
    101533024 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101533024 (PIK3CB)
   05017 Spinocerebellar ataxia
    101533024 (PIK3CB)
   05020 Prion disease
    101533024 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101533024 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    101533024 (PIK3CB)
   05415 Diabetic cardiomyopathy
    101533024 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101533024 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    101533024 (PIK3CB)
   04931 Insulin resistance
    101533024 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101533024 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101533024 (PIK3CB)
   01524 Platinum drug resistance
    101533024 (PIK3CB)
   01522 Endocrine resistance
    101533024 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:opi04131]
    101533024 (PIK3CB)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101533024 (PIK3CB)
Membrane trafficking [BR:opi04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101533024 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4145
Other DBs
NCBI-GeneID: 101533024
NCBI-ProteinID: XP_004588401
LinkDB
Position
14A:complement(21167002..21224752)
AA seq 1070 aa
MCLSDTMPPAMADSLDIWAVGSQTASDGSIPVDFLLPTGIYIQLEVPREAPISYIKQLLW
KHAHSYPMFNLLLEVDAYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRSKMRRFSEEKTQSLVGLSWMEWLRQTYPPEL
DPATLDDLEEKLYGGRLIVAVHFEDSQDVFSFQVSPNMNPVKVSELAIQKRWTVRGKEEE
VSPQDYVLQVSGRVEYVFGDHPLIQFQYVRNCVMNRTLPHFMLVECCKIKKMYEQEVIAI
EAAISRNSSNLPLPLPPKKTRVVSHVWENSSPFQVVLIKGSKLNMEETVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVSDKAKTKKSTKTM
NPPKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGETILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVAVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLSRWKGKEAMHACLKQSAYRDALSGLQSPLNPCVILSELHVEKCKYMD
SKMKPLWLVYSSKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgtctcagcgacactatgcctcctgccatggcagacagccttgacatctgggcagtg
ggctcacagacggcatctgatggctccatccctgtggacttccttctgcccactgggatt
tacatccagctggaggtgccgcgggaagctcccatttcttacattaagcagttgctatgg
aagcacgctcacagttacccgatgtttaacctgctcctggaggttgacgcctacatgttt
gcttgtgtgaatcagacggccgtgtacgaagagcttgaggacgagacacggagactctgt
gacgtgaggcctttccttccagttctcaagctggtgacaaggagctgtgacccaggcgaa
aaattagactcgaaaattggcgtcctcataggaaaaggtttgcatgaatttgatgccttg
aaggatcctgaagtgaatgaatttcgaagtaagatgcgcagattcagtgaggagaagacc
cagtcgctggtgggcttgtcctggatggagtggctgcggcagacctacccgccggagctc
gacccggccacgctcgacgacctggaggagaagctctacgggggaaggctcatcgtggcg
gtgcactttgaagactcgcaggatgtatttagctttcaagtgtcccctaatatgaaccct
gtcaaagtcagtgagctggcgatccagaagcgttggactgtgcgtgggaaggaggaggag
gttagcccccaggactatgtgctgcaagtcagcggcagagtggaatatgtgtttggtgac
cacccgcttatccagttccagtatgtccggaactgtgtgatgaacaggactttgccccat
tttatgcttgtggaatgctgcaagatcaagaaaatgtatgagcaggaagtcattgccata
gaagctgccataagtcgaaattcatccaatctgcctctccccttaccgccaaagaaaaca
cgagttgtttctcatgtttgggagaatagcagtccattccaagttgtgttgattaaaggc
agtaagcttaacatggaagaaactgtcaaagttcatgtcagagctggtctgtttcatggt
actgagctcctgtgtaaaaccatcgtcagctcagagatttcagggaaaaatgatcacatt
tggaatgaaccattggaatttgatattaatacttgtgatttgccaagaatggctcgattg
tgttttgctgtttatgcagtttcagataaagcgaaaacaaagaaatcaactaaaactatg
aatccccctaagtatcagactatcaggaaagctggaaaagtgcattaccctgtggcctgg
gtaaatactatggtttttgactttaaaggacaattgagatctggagagacaatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatacactgaaaatgcaacagctttgcatattaaatttcctgagaataaaaaa
cagccttactattaccctccttttgataagattattgagaaggcagctgagattgcaagc
agtgatagtgctaacgtatccagtcgaggtgggaaaaagtttcttgcagtactgaaagaa
attttggacagagaccctttgtcccagctgtgtgagaatgaaatggatctcatctggact
ctgcgacaagactgcagagagaatttcccacagtcccttccaaaattactcctgtcaatc
aagtggaataaacttgaagacgttgctcagcttcaagcactgcttcagatttggcctaaa
ctgccccctcgggaggcgctggagctcctggacttcaactacccagaccagtacgtgcgg
gaatacgccgtgggctgcctgcgacagatgagtgacgaagagctctctcagtatctttta
caactggtgcaagttttaaaatatgagccgtttctcgactgtgcgctgtctagattcctt
ttagaacgagcacttgctaatcggcggatcggtcagtttctcttctggcaccttaggtcc
gaggtgcacatccctgctgttgccgtacagtttggggtcatcctggaagcctactgccgg
ggcagcgtcggccacatgaaggtgctttccaagcaggttgaagcactcaataagttaaag
accttaaatagtttaataaagctgaacgcagtgaagctcagcagatggaaggggaaggag
gccatgcacgcgtgcttaaagcagagcgcttaccgcgacgccctgtccggcctgcagtcc
cccctgaacccctgcgtcatcctctcggagctccatgttgaaaagtgcaagtacatggat
tctaaaatgaagcctttgtggctggtgtacagcagcaaggtgtttggggaggattccgtt
ggagtgatctttaaaaatggtgatgatttacgacaggatatgttaacacttcagatgcta
cgcttgatggatttactgtggaaagaagctggtctggatcttcggatgctgccttacggt
tgcttagcaaccggagaccgctctggcctcattgaagtggtgagcacctctgagaccatc
gctgacattcagctgaacagcagcaacgtggctgccacagcagccttcaacaaggacgcc
ctgctgaactggctgaaggagtacaattccggggatgacctggaccgagccattgaggag
ttcaccctgtcctgtgctggctactgtgtagcttcttacgtcctcggaattggtgacaga
cacagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaagagggagcgagtgccttttatactt
acttatgattttattcatgtcattcaacaaggaaaaacaggaaacacagagaagtttggc
cggttccggcagtgctgtgaggacgcctatctcatcctgcggcggcacgggaacctcttc
atcacgctctttgcgctcatgctgacggcggggcttcctgagctcacctcggtcaaggac
atccagtatctgaaggactctcttgccttaggaaagagtgaagaggaagcactcaaacaa
tttaagcagaaatttgatgaggcgctcagggaaagctggaccactaaagtgaactggatg
gcccacacggtccgcaaagactacaggtcctaa

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