KEGG   Ochotona princeps (American pika): 101533296
Entry
101533296         CDS       T07609                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi01521  EGFR tyrosine kinase inhibitor resistance
opi01522  Endocrine resistance
opi01524  Platinum drug resistance
opi04010  MAPK signaling pathway
opi04012  ErbB signaling pathway
opi04014  Ras signaling pathway
opi04015  Rap1 signaling pathway
opi04022  cGMP-PKG signaling pathway
opi04024  cAMP signaling pathway
opi04062  Chemokine signaling pathway
opi04066  HIF-1 signaling pathway
opi04068  FoxO signaling pathway
opi04071  Sphingolipid signaling pathway
opi04072  Phospholipase D signaling pathway
opi04140  Autophagy - animal
opi04150  mTOR signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04152  AMPK signaling pathway
opi04210  Apoptosis
opi04211  Longevity regulating pathway
opi04213  Longevity regulating pathway - multiple species
opi04218  Cellular senescence
opi04261  Adrenergic signaling in cardiomyocytes
opi04370  VEGF signaling pathway
opi04371  Apelin signaling pathway
opi04380  Osteoclast differentiation
opi04510  Focal adhesion
opi04550  Signaling pathways regulating pluripotency of stem cells
opi04611  Platelet activation
opi04613  Neutrophil extracellular trap formation
opi04620  Toll-like receptor signaling pathway
opi04625  C-type lectin receptor signaling pathway
opi04630  JAK-STAT signaling pathway
opi04660  T cell receptor signaling pathway
opi04662  B cell receptor signaling pathway
opi04664  Fc epsilon RI signaling pathway
opi04666  Fc gamma R-mediated phagocytosis
opi04668  TNF signaling pathway
opi04722  Neurotrophin signaling pathway
opi04725  Cholinergic synapse
opi04728  Dopaminergic synapse
opi04810  Regulation of actin cytoskeleton
opi04910  Insulin signaling pathway
opi04914  Progesterone-mediated oocyte maturation
opi04915  Estrogen signaling pathway
opi04917  Prolactin signaling pathway
opi04919  Thyroid hormone signaling pathway
opi04920  Adipocytokine signaling pathway
opi04922  Glucagon signaling pathway
opi04923  Regulation of lipolysis in adipocytes
opi04926  Relaxin signaling pathway
opi04929  GnRH secretion
opi04931  Insulin resistance
opi04932  Non-alcoholic fatty liver disease
opi04933  AGE-RAGE signaling pathway in diabetic complications
opi04935  Growth hormone synthesis, secretion and action
opi04936  Alcoholic liver disease
opi04973  Carbohydrate digestion and absorption
opi05010  Alzheimer disease
opi05017  Spinocerebellar ataxia
opi05132  Salmonella infection
opi05135  Yersinia infection
opi05142  Chagas disease
opi05145  Toxoplasmosis
opi05152  Tuberculosis
opi05160  Hepatitis C
opi05161  Hepatitis B
opi05162  Measles
opi05163  Human cytomegalovirus infection
opi05164  Influenza A
opi05165  Human papillomavirus infection
opi05166  Human T-cell leukemia virus 1 infection
opi05167  Kaposi sarcoma-associated herpesvirus infection
opi05168  Herpes simplex virus 1 infection
opi05169  Epstein-Barr virus infection
opi05170  Human immunodeficiency virus 1 infection
opi05200  Pathways in cancer
opi05205  Proteoglycans in cancer
opi05207  Chemical carcinogenesis - receptor activation
opi05208  Chemical carcinogenesis - reactive oxygen species
opi05210  Colorectal cancer
opi05211  Renal cell carcinoma
opi05212  Pancreatic cancer
opi05213  Endometrial cancer
opi05214  Glioma
opi05215  Prostate cancer
opi05218  Melanoma
opi05220  Chronic myeloid leukemia
opi05221  Acute myeloid leukemia
opi05222  Small cell lung cancer
opi05223  Non-small cell lung cancer
opi05224  Breast cancer
opi05225  Hepatocellular carcinoma
opi05226  Gastric cancer
opi05230  Central carbon metabolism in cancer
opi05231  Choline metabolism in cancer
opi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
opi05415  Diabetic cardiomyopathy
opi05417  Lipid and atherosclerosis
opi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:opi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101533296 (AKT2)
   04012 ErbB signaling pathway
    101533296 (AKT2)
   04014 Ras signaling pathway
    101533296 (AKT2)
   04015 Rap1 signaling pathway
    101533296 (AKT2)
   04370 VEGF signaling pathway
    101533296 (AKT2)
   04371 Apelin signaling pathway
    101533296 (AKT2)
   04630 JAK-STAT signaling pathway
    101533296 (AKT2)
   04668 TNF signaling pathway
    101533296 (AKT2)
   04066 HIF-1 signaling pathway
    101533296 (AKT2)
   04068 FoxO signaling pathway
    101533296 (AKT2)
   04072 Phospholipase D signaling pathway
    101533296 (AKT2)
   04071 Sphingolipid signaling pathway
    101533296 (AKT2)
   04024 cAMP signaling pathway
    101533296 (AKT2)
   04022 cGMP-PKG signaling pathway
    101533296 (AKT2)
   04151 PI3K-Akt signaling pathway
    101533296 (AKT2)
   04152 AMPK signaling pathway
    101533296 (AKT2)
   04150 mTOR signaling pathway
    101533296 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101533296 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    101533296 (AKT2)
   04218 Cellular senescence
    101533296 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101533296 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101533296 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101533296 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101533296 (AKT2)
   04613 Neutrophil extracellular trap formation
    101533296 (AKT2)
   04620 Toll-like receptor signaling pathway
    101533296 (AKT2)
   04625 C-type lectin receptor signaling pathway
    101533296 (AKT2)
   04660 T cell receptor signaling pathway
    101533296 (AKT2)
   04662 B cell receptor signaling pathway
    101533296 (AKT2)
   04664 Fc epsilon RI signaling pathway
    101533296 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    101533296 (AKT2)
   04062 Chemokine signaling pathway
    101533296 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101533296 (AKT2)
   04922 Glucagon signaling pathway
    101533296 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    101533296 (AKT2)
   04920 Adipocytokine signaling pathway
    101533296 (AKT2)
   04929 GnRH secretion
    101533296 (AKT2)
   04915 Estrogen signaling pathway
    101533296 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    101533296 (AKT2)
   04917 Prolactin signaling pathway
    101533296 (AKT2)
   04926 Relaxin signaling pathway
    101533296 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    101533296 (AKT2)
   04919 Thyroid hormone signaling pathway
    101533296 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101533296 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101533296 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    101533296 (AKT2)
   04728 Dopaminergic synapse
    101533296 (AKT2)
   04722 Neurotrophin signaling pathway
    101533296 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101533296 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    101533296 (AKT2)
   04213 Longevity regulating pathway - multiple species
    101533296 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101533296 (AKT2)
   05205 Proteoglycans in cancer
    101533296 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    101533296 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101533296 (AKT2)
   05230 Central carbon metabolism in cancer
    101533296 (AKT2)
   05231 Choline metabolism in cancer
    101533296 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101533296 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101533296 (AKT2)
   05212 Pancreatic cancer
    101533296 (AKT2)
   05225 Hepatocellular carcinoma
    101533296 (AKT2)
   05226 Gastric cancer
    101533296 (AKT2)
   05214 Glioma
    101533296 (AKT2)
   05221 Acute myeloid leukemia
    101533296 (AKT2)
   05220 Chronic myeloid leukemia
    101533296 (AKT2)
   05218 Melanoma
    101533296 (AKT2)
   05211 Renal cell carcinoma
    101533296 (AKT2)
   05215 Prostate cancer
    101533296 (AKT2)
   05213 Endometrial cancer
    101533296 (AKT2)
   05224 Breast cancer
    101533296 (AKT2)
   05222 Small cell lung cancer
    101533296 (AKT2)
   05223 Non-small cell lung cancer
    101533296 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101533296 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    101533296 (AKT2)
   05161 Hepatitis B
    101533296 (AKT2)
   05160 Hepatitis C
    101533296 (AKT2)
   05164 Influenza A
    101533296 (AKT2)
   05162 Measles
    101533296 (AKT2)
   05168 Herpes simplex virus 1 infection
    101533296 (AKT2)
   05163 Human cytomegalovirus infection
    101533296 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101533296 (AKT2)
   05169 Epstein-Barr virus infection
    101533296 (AKT2)
   05165 Human papillomavirus infection
    101533296 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101533296 (AKT2)
   05135 Yersinia infection
    101533296 (AKT2)
   05152 Tuberculosis
    101533296 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101533296 (AKT2)
   05142 Chagas disease
    101533296 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101533296 (AKT2)
   05017 Spinocerebellar ataxia
    101533296 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101533296 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    101533296 (AKT2)
   05415 Diabetic cardiomyopathy
    101533296 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101533296 (AKT2)
   04932 Non-alcoholic fatty liver disease
    101533296 (AKT2)
   04931 Insulin resistance
    101533296 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101533296 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101533296 (AKT2)
   01524 Platinum drug resistance
    101533296 (AKT2)
   01522 Endocrine resistance
    101533296 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    101533296 (AKT2)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101533296 (AKT2)
Protein kinases [BR:opi01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   101533296 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 101533296
NCBI-ProteinID: XP_004598136
LinkDB
Position
5:7543253..7563413
AA seq 412 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDERWQSWLRMDALPSPAGPGSPSLTLC
VQDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE
ERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT
FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILLEEIRF
PRTLSPEAKSLLSGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVHKKLPPPFKPQ
VTSEVDTRYFDDEFTAQSITLTPPDRSDSPGSLELDQRTHFPQFSYSASIRE
NT seq 1239 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaggagggttggctgcacaagcgcggtgaatacatcaag
acttggcggccccgctacttcctgctgaagagtgatggctccttcattggctataaggag
cggcctgaggcccccgaccagaccctgccccccttgaataacttctctgtggcagaatgc
cagctgatgaagactgagcggccacggccaaacaccttcgtcatccgctgcctacagtgg
accacggtcattgagaggaccttccacgtggactctccggatgagagatggcagtcgtgg
ctaaggatggatgccctgccctccccagctgggccgggcagcccctcactcaccctttgt
gtgcaggatgaagtcgcccacacagtcaccgagagccgggttctgcagaacaccaggcac
ccgttcctcacagcactgaaatacgccttccagacgcatgaccgcctctgcttcgtgatg
gagtacgccaacggcggtgagctgttcttccacctgtcgcgggagcgcgtgttcacggaa
gagcgggcgcggttttacggtgcagagattgtctcggctctcgagtacttgcattcgcgg
gatgtggtgtaccgtgacatcaagctggaaaacctcatgctggacaaggacggccacatc
aagatcacggactttggcctgtgcaaggagggcatcagtgacggggccaccatgaagacc
ttctgcgggacgcctgagtacctggcgcccgaggtgctggaagacaatgactacggccga
gcggtggactggtgggggctgggcgtggtcatgtatgagatgatgtgcggccgcctgccc
ttctacaaccaagaccacgagcgcctcttcgaactcatcctcttggaggagatccgcttc
ccacgcacactcagccccgaggccaagtccctgctctcagggctgctcaagaaggacccc
aagcagaggcttggtgggggacccagcgatgccaaggaggttatggagcacaggttcttc
ctcagcatcaactggcaggacgtggtgcacaagaagctcccgccgcccttcaagcctcag
gtgacatccgaggtcgacaccaggtacttcgacgacgagttcaccgcccagtccatcaca
ctcacacctccggatcgctctgacagcccgggctcgctggagctggaccagcggacgcac
ttcccccagttctcctactcggccagcatccgcgagtga

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