KEGG   Ochotona princeps (American pika): 101533612
Entry
101533612         CDS       T07609                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
opi  Ochotona princeps (American pika)
Pathway
opi01521  EGFR tyrosine kinase inhibitor resistance
opi01522  Endocrine resistance
opi04010  MAPK signaling pathway
opi04012  ErbB signaling pathway
opi04014  Ras signaling pathway
opi04015  Rap1 signaling pathway
opi04022  cGMP-PKG signaling pathway
opi04024  cAMP signaling pathway
opi04062  Chemokine signaling pathway
opi04066  HIF-1 signaling pathway
opi04068  FoxO signaling pathway
opi04071  Sphingolipid signaling pathway
opi04072  Phospholipase D signaling pathway
opi04114  Oocyte meiosis
opi04140  Autophagy - animal
opi04148  Efferocytosis
opi04150  mTOR signaling pathway
opi04151  PI3K-Akt signaling pathway
opi04210  Apoptosis
opi04218  Cellular senescence
opi04270  Vascular smooth muscle contraction
opi04370  VEGF signaling pathway
opi04371  Apelin signaling pathway
opi04380  Osteoclast differentiation
opi04510  Focal adhesion
opi04540  Gap junction
opi04550  Signaling pathways regulating pluripotency of stem cells
opi04613  Neutrophil extracellular trap formation
opi04620  Toll-like receptor signaling pathway
opi04650  Natural killer cell mediated cytotoxicity
opi04660  T cell receptor signaling pathway
opi04662  B cell receptor signaling pathway
opi04664  Fc epsilon RI signaling pathway
opi04666  Fc gamma R-mediated phagocytosis
opi04668  TNF signaling pathway
opi04720  Long-term potentiation
opi04722  Neurotrophin signaling pathway
opi04725  Cholinergic synapse
opi04726  Serotonergic synapse
opi04730  Long-term depression
opi04810  Regulation of actin cytoskeleton
opi04910  Insulin signaling pathway
opi04912  GnRH signaling pathway
opi04914  Progesterone-mediated oocyte maturation
opi04915  Estrogen signaling pathway
opi04916  Melanogenesis
opi04917  Prolactin signaling pathway
opi04919  Thyroid hormone signaling pathway
opi04921  Oxytocin signaling pathway
opi04926  Relaxin signaling pathway
opi04928  Parathyroid hormone synthesis, secretion and action
opi04929  GnRH secretion
opi04934  Cushing syndrome
opi04935  Growth hormone synthesis, secretion and action
opi05010  Alzheimer disease
opi05022  Pathways of neurodegeneration - multiple diseases
opi05034  Alcoholism
opi05132  Salmonella infection
opi05135  Yersinia infection
opi05160  Hepatitis C
opi05161  Hepatitis B
opi05163  Human cytomegalovirus infection
opi05164  Influenza A
opi05165  Human papillomavirus infection
opi05166  Human T-cell leukemia virus 1 infection
opi05167  Kaposi sarcoma-associated herpesvirus infection
opi05170  Human immunodeficiency virus 1 infection
opi05200  Pathways in cancer
opi05205  Proteoglycans in cancer
opi05206  MicroRNAs in cancer
opi05207  Chemical carcinogenesis - receptor activation
opi05208  Chemical carcinogenesis - reactive oxygen species
opi05210  Colorectal cancer
opi05211  Renal cell carcinoma
opi05212  Pancreatic cancer
opi05213  Endometrial cancer
opi05214  Glioma
opi05215  Prostate cancer
opi05216  Thyroid cancer
opi05218  Melanoma
opi05219  Bladder cancer
opi05220  Chronic myeloid leukemia
opi05221  Acute myeloid leukemia
opi05223  Non-small cell lung cancer
opi05224  Breast cancer
opi05225  Hepatocellular carcinoma
opi05226  Gastric cancer
opi05230  Central carbon metabolism in cancer
opi05231  Choline metabolism in cancer
opi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:opi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101533612 (MAP2K1)
   04012 ErbB signaling pathway
    101533612 (MAP2K1)
   04014 Ras signaling pathway
    101533612 (MAP2K1)
   04015 Rap1 signaling pathway
    101533612 (MAP2K1)
   04370 VEGF signaling pathway
    101533612 (MAP2K1)
   04371 Apelin signaling pathway
    101533612 (MAP2K1)
   04668 TNF signaling pathway
    101533612 (MAP2K1)
   04066 HIF-1 signaling pathway
    101533612 (MAP2K1)
   04068 FoxO signaling pathway
    101533612 (MAP2K1)
   04072 Phospholipase D signaling pathway
    101533612 (MAP2K1)
   04071 Sphingolipid signaling pathway
    101533612 (MAP2K1)
   04024 cAMP signaling pathway
    101533612 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    101533612 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    101533612 (MAP2K1)
   04150 mTOR signaling pathway
    101533612 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101533612 (MAP2K1)
   04148 Efferocytosis
    101533612 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    101533612 (MAP2K1)
   04210 Apoptosis
    101533612 (MAP2K1)
   04218 Cellular senescence
    101533612 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101533612 (MAP2K1)
   04540 Gap junction
    101533612 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101533612 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101533612 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101533612 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    101533612 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    101533612 (MAP2K1)
   04660 T cell receptor signaling pathway
    101533612 (MAP2K1)
   04662 B cell receptor signaling pathway
    101533612 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    101533612 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    101533612 (MAP2K1)
   04062 Chemokine signaling pathway
    101533612 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101533612 (MAP2K1)
   04929 GnRH secretion
    101533612 (MAP2K1)
   04912 GnRH signaling pathway
    101533612 (MAP2K1)
   04915 Estrogen signaling pathway
    101533612 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    101533612 (MAP2K1)
   04917 Prolactin signaling pathway
    101533612 (MAP2K1)
   04921 Oxytocin signaling pathway
    101533612 (MAP2K1)
   04926 Relaxin signaling pathway
    101533612 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    101533612 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    101533612 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    101533612 (MAP2K1)
   04916 Melanogenesis
    101533612 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101533612 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    101533612 (MAP2K1)
   04726 Serotonergic synapse
    101533612 (MAP2K1)
   04720 Long-term potentiation
    101533612 (MAP2K1)
   04730 Long-term depression
    101533612 (MAP2K1)
   04722 Neurotrophin signaling pathway
    101533612 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101533612 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101533612 (MAP2K1)
   05206 MicroRNAs in cancer
    101533612 (MAP2K1)
   05205 Proteoglycans in cancer
    101533612 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    101533612 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101533612 (MAP2K1)
   05230 Central carbon metabolism in cancer
    101533612 (MAP2K1)
   05231 Choline metabolism in cancer
    101533612 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101533612 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101533612 (MAP2K1)
   05212 Pancreatic cancer
    101533612 (MAP2K1)
   05225 Hepatocellular carcinoma
    101533612 (MAP2K1)
   05226 Gastric cancer
    101533612 (MAP2K1)
   05214 Glioma
    101533612 (MAP2K1)
   05216 Thyroid cancer
    101533612 (MAP2K1)
   05221 Acute myeloid leukemia
    101533612 (MAP2K1)
   05220 Chronic myeloid leukemia
    101533612 (MAP2K1)
   05218 Melanoma
    101533612 (MAP2K1)
   05211 Renal cell carcinoma
    101533612 (MAP2K1)
   05219 Bladder cancer
    101533612 (MAP2K1)
   05215 Prostate cancer
    101533612 (MAP2K1)
   05213 Endometrial cancer
    101533612 (MAP2K1)
   05224 Breast cancer
    101533612 (MAP2K1)
   05223 Non-small cell lung cancer
    101533612 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101533612 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    101533612 (MAP2K1)
   05161 Hepatitis B
    101533612 (MAP2K1)
   05160 Hepatitis C
    101533612 (MAP2K1)
   05164 Influenza A
    101533612 (MAP2K1)
   05163 Human cytomegalovirus infection
    101533612 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101533612 (MAP2K1)
   05165 Human papillomavirus infection
    101533612 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101533612 (MAP2K1)
   05135 Yersinia infection
    101533612 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101533612 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    101533612 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    101533612 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101533612 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101533612 (MAP2K1)
   01522 Endocrine resistance
    101533612 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:opi01001]
    101533612 (MAP2K1)
Enzymes [BR:opi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     101533612 (MAP2K1)
Protein kinases [BR:opi01001]
 Serine/threonine kinases: STE group
  STE7 family
   101533612 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 101533612
NCBI-ProteinID: XP_004578017
LinkDB
Position
17:77916154..77989560
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGEAAETPARPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaaccccgcgcccgacggctcggcggtg
aacggcaccagctcggccgagaccaacctagaggccttgcagaagaagctggaggagctg
gagctggacgagcagcagcggaagcgccttgaggcgtttctcacccagaagcagaaggtg
ggagagctgaaagacgatgactttgaaaagatcagtgagttgggagccggcaacggtggc
gtggtctttaaggtctcccacaagccatccggcctggtcatggccaggaagctcattcac
ctggagatcaagccggccatccgcaaccagatcatacgggagctgcaggtcctgcatgag
tgcaactcgccttacatcgtgggcttctacggggccttctacagtgatggcgagatcagc
atctgcatggagcacatggatggtggttccttggatcaagtcctcaagaaagctggacgg
attcctgagcagattctggggaaagttagcattgctgtgatcaagggcctgacgtacctg
agggagaagcacaagatcatgcaccgagatgtcaagccctccaacatcctggtcaactca
cgtggggagataaagctctgtgactttggggtcagtgggcagctcatcgactccatggcc
aactccttcgtgggcactaggtcctacatgtcgccggagagactgcagggcacgcactac
tccgtgcagtccgacatctggagcatggggctttctctggtggagatggctgtgggccgc
taccccatcccgccacctgacgccaaggagctggagctgctgttcgggtgccaggtggag
ggagaggcggccgagaccccggccaggccccggacccctggcaggcccctcagctcgtac
ggcatggacagccggcctcccatggcgatttttgagctgctggattacatcgtcaatgag
cctcctccgaaactgcccagtgcagtcttcagcctggagtttcaagattttgtgaataaa
tgcttgataaagaaccctgccgagagagcggatctgaagcagcttatggttcatgctttc
atcaagagatcggatgctgaggaagtagattttgcaggttggctgtgctccaccatcggc
ctgaaccagcccagcacaccgacccacgcagctggcgtgtga

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