Ochotona princeps (American pika): 101535293 Help Entry 101535293         CDS       T07609                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism opi  Ochotona princeps (American pika) Pathway opi01521   EGFR tyrosine kinase inhibitor resistance opi04151   PI3K-Akt signaling pathway opi04217   Necroptosis opi04380   Osteoclast differentiation opi04550   Signaling pathways regulating pluripotency of stem cells opi04620   Toll-like receptor signaling pathway opi04621   NOD-like receptor signaling pathway opi04630   JAK-STAT signaling pathway opi04658   Th1 and Th2 cell differentiation opi04659   Th17 cell differentiation opi05140   Leishmaniasis opi05145   Toxoplasmosis opi05152   Tuberculosis opi05160   Hepatitis C opi05161   Hepatitis B opi05162   Measles opi05163   Human cytomegalovirus infection opi05164   Influenza A opi05165   Human papillomavirus infection opi05166   Human T-cell leukemia virus 1 infection opi05167   Kaposi sarcoma-associated herpesvirus infection opi05168   Herpes simplex virus 1 infection opi05169   Epstein-Barr virus infection opi05171   Coronavirus disease - COVID-19 opi05200   Pathways in cancer opi05203   Viral carcinogenesis opi05212   Pancreatic cancer opi05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:opi00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101535293 (JAK1)    04151 PI3K-Akt signaling pathway     101535293 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     101535293 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101535293 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     101535293 (JAK1)    04621 NOD-like receptor signaling pathway     101535293 (JAK1)    04658 Th1 and Th2 cell differentiation     101535293 (JAK1)    04659 Th17 cell differentiation     101535293 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     101535293 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101535293 (JAK1)    05203 Viral carcinogenesis     101535293 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101535293 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     101535293 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101535293 (JAK1)    05161 Hepatitis B     101535293 (JAK1)    05160 Hepatitis C     101535293 (JAK1)    05171 Coronavirus disease - COVID-19     101535293 (JAK1)    05164 Influenza A     101535293 (JAK1)    05162 Measles     101535293 (JAK1)    05168 Herpes simplex virus 1 infection     101535293 (JAK1)    05163 Human cytomegalovirus infection     101535293 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     101535293 (JAK1)    05169 Epstein-Barr virus infection     101535293 (JAK1)    05165 Human papillomavirus infection     101535293 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     101535293 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101535293 (JAK1)    05140 Leishmaniasis     101535293 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101535293 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:opi01001]     101535293 (JAK1) Enzymes [BR:opi01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101535293 (JAK1) Protein kinases [BR:opi01001]  Non-receptor tyrosine kinases   JAK family [OT]    101535293 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 TarS_C1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  101535293 NCBI-ProteinID:  XP_004588790 LinkDB All DBs Position 13:complement(55027205..55074711) Genome browser AA seq 1156 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSRRTEVDLEAPEPGVEVIFYLSDRESLRLGNGEYTAEEV CIRAAQECRISPLCHNLFALFDESAKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DSEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDAKTEQ DGHDIENECLGMAVLAISHYAMMKKLQLPELPREISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDGSVSTHDLKVKYLATLETLTKHYGAEIFETSKLLISSENEMN WFHSNDSGIVVYYEVMVTGNLGIQWRPKPNVVPVEKEKSKLKRKKLENKLKKDEEKNKLR EEWNNFSYFPEITHIVIKESMVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVPGGQRQFKNFQIEVQKGCYSLHGSDRSFPSLGELMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFYRILKKDIVQGDHLGRGTRTHIYAGT LVDHKEDEGTSEEKRIKVILKVLDSSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDL ENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSE YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDQVYQLMRKCWEFQPSSRTT FQNLIEGFEAILKKHE NT seq 3471 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaagatgagg agctccaggcggaccgaggtggatctggaggcccctgaacccggggtagaagttatcttc tatctgtcggacagggagtccctccgactgggcaatggggagtacactgcggaggaggtg tgcatcagggccgcacaagaatgccgtatctctcctctatgtcacaacctctttgccttg tttgatgagagcgccaagctgtggtatgctccgaatcgtaccatcactgttgatgacaag acatcccttcggctgcactaccggatgagattctatttcaccaactggcatggaaccaat gacagtgaacagtctgtgtggcgacattctccgaagaagcagaaaaatggctatgagaaa aagaaggttccagatgcaacccctctccttgatgccagctctctggaatatctgtttgct cagggacagtatgatttggtcaaatgcctggctcctattcgagacgccaagacagaacag gatggacatgacattgaaaatgagtgcctagggatggccgtcctggctatctcacactat gccatgatgaagaagctgcagttgcctgagctccccagggaaatcagctataagcgatat attccagaaacattgaataaatcaatcagacagaggaacctgctcaccaggatgcggatt aataatgtgttcaaggatttcctgaaggaatttaacaacaagaccatttgtgatggcagt gtgtctacgcacgacctgaaggtgaaatatctggcaactttggagactttgaccaaacat tatggtgctgaaatatttgagacatccaagttgctgatctcatcagaaaatgagatgaat tggtttcattcaaatgacagcggaattgttgtctactatgaagtgatggtgactggaaat ctcgggatccagtggaggccgaaaccaaatgttgtgcctgttgaaaaagaaaaaagtaaa ctgaagcggaagaaactggaaaataagctcaagaaagatgaggagaaaaacaaactccgg gaggagtggaacaatttttcttactttcctgaaatcactcacattgtaataaaggagtct atggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctcgtctcatgag gaggccttgtccttcgtgtccctggtggacggctacttccggctcacggcagatgcccat cattacctctgtacagatgtggctccaccactgatcgtccacaacatacagaatggctgt cacggcccaatctgcacagagtacgccatcaataagctgcggcaagaaggcagtgaggag ggcatgtacgtgctgaggtggagctgtaccgactttgacaacatcctcatgaccgtcact tgctttgagaagtctgaggtgccaggcggccagaggcagttcaagaactttcagatcgag gtgcagaaaggttgctacagcctgcacggctcggaccgcagcttccccagcctgggggaa ctcatgagccacctcaagaagcagatcctgcgcacagacaacatcagcttcgtgctgaaa cgctgctgccagcccaaaccccgagagatctccaatctgctggtggctactaagaaagcc caagagtggcagcccgtctactccatgagccagctgagcttttaccggatcctcaagaaa gatatcgtgcaaggcgatcacctgggcagaggcaccagaacccacatctacgcggggacc ctggtagaccacaaggaggacgaaggcacttctgaagagaagagaatcaaagtgatcctc aaagtcttggactccagccacagggacatttctctggccttctttgaggcggccagcatg atgagacaggtctcccacaagcacatcgtgtacctctacggcgtctgtgtccgtgacctg gagaatatcatggtggaagagtttgtggagggagggccactggatctcttcatgcatcgc aaaagcgacgccctcaccacaccttggaagttcaaagtcgccaaacagttggccagcgcc ctgagttacttggaggacaaggacctggtccatgggaatgtgtgcaccaagaacctcctc ctggcacgtgaaggcatcgacagtgagtgcggcccattcatcaagctcagcgaccctggc atccccatcactgtgctgtccaggcaagagtgcatagagcggatcccatggatcgctccc gagtgtgtggaagactccaagaacctgagtgtggctgccgacaagtggagcttcggaacc acgctctgggagatctgctacaacggcgaaatccccctcaaagacaagacgctgatcgag aaagagagattctatgagagccgctgccggccggtgacgccatcctgcaaggagctggcc gacctcatgacgcgctgcatgaactatgaccccaaccagagacccttcttccgtgccatc atgagagacatcaacaaactagaagagcagaatccagacattgtctcggaaaggaagcca gccaccgaggtagaccccacgcattttgaaaaacgcttcctcaagaggatccgagatttg ggtgagggccactttggaaaggtggagctgtgcaggtatgaccccgagggggacaacact ggggagcaggtggcagtcaagtccctgaagcctgagagtggcggtaaccacatagctgac ctgaagaaggaaatcgaaatcctgaggaacctctatcatgagaacattgtgaagtacaaa ggcatctgcaccgaggacggaggaaacggtattaagctcatcatggaatttctgccttcg ggaagccttaaggagtatcttcctaagaacaagaacaaaattaatctcaaacaacagcta aaatatgctgtgcagatttgtaaggggatggactacctggggtctcggcagtatgtccac agggacttagccgcaaggaatgtcctcgtggagagcgaacaccaagtgaaaattggagac tttggtttaaccaaagccatcgaaacggacaaggagtactacactgtcaaggacgatcgg gacagccctgtattctggtatgcgccggaatgtttaattcaatgtaaattctatattgcc tctgatgtctggtcatttggagtgactctgcatgaactgcttacctactgtgattcagaa tacagtcccatggccttgttcctgaaaatgataggcccaactcatggccaaatgacagta acaagacttgtgaatacgctgaaggaaggaaaacgtttgccatgcccacccaactgtcct gatcaggtttatcagcttatgagaaaatgctgggaattccaaccatccagtcggacgacg tttcagaatcttattgaaggatttgaagcaattttaaaaaagcatgaataa

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