KEGG   Odobenus rosmarus divergens (Pacific walrus): 101374787
Entry
101374787         CDS       T05148                                 
Symbol
PIK3R3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
oro  Odobenus rosmarus divergens (Pacific walrus)
Pathway
oro01521  EGFR tyrosine kinase inhibitor resistance
oro01522  Endocrine resistance
oro01524  Platinum drug resistance
oro04012  ErbB signaling pathway
oro04014  Ras signaling pathway
oro04015  Rap1 signaling pathway
oro04024  cAMP signaling pathway
oro04062  Chemokine signaling pathway
oro04066  HIF-1 signaling pathway
oro04068  FoxO signaling pathway
oro04070  Phosphatidylinositol signaling system
oro04071  Sphingolipid signaling pathway
oro04072  Phospholipase D signaling pathway
oro04081  Hormone signaling
oro04140  Autophagy - animal
oro04150  mTOR signaling pathway
oro04151  PI3K-Akt signaling pathway
oro04152  AMPK signaling pathway
oro04210  Apoptosis
oro04211  Longevity regulating pathway
oro04213  Longevity regulating pathway - multiple species
oro04218  Cellular senescence
oro04360  Axon guidance
oro04370  VEGF signaling pathway
oro04380  Osteoclast differentiation
oro04510  Focal adhesion
oro04550  Signaling pathways regulating pluripotency of stem cells
oro04611  Platelet activation
oro04613  Neutrophil extracellular trap formation
oro04620  Toll-like receptor signaling pathway
oro04625  C-type lectin receptor signaling pathway
oro04630  JAK-STAT signaling pathway
oro04650  Natural killer cell mediated cytotoxicity
oro04660  T cell receptor signaling pathway
oro04662  B cell receptor signaling pathway
oro04664  Fc epsilon RI signaling pathway
oro04666  Fc gamma R-mediated phagocytosis
oro04668  TNF signaling pathway
oro04670  Leukocyte transendothelial migration
oro04722  Neurotrophin signaling pathway
oro04725  Cholinergic synapse
oro04750  Inflammatory mediator regulation of TRP channels
oro04810  Regulation of actin cytoskeleton
oro04910  Insulin signaling pathway
oro04914  Progesterone-mediated oocyte maturation
oro04915  Estrogen signaling pathway
oro04917  Prolactin signaling pathway
oro04919  Thyroid hormone signaling pathway
oro04923  Regulation of lipolysis in adipocytes
oro04926  Relaxin signaling pathway
oro04929  GnRH secretion
oro04930  Type II diabetes mellitus
oro04931  Insulin resistance
oro04932  Non-alcoholic fatty liver disease
oro04933  AGE-RAGE signaling pathway in diabetic complications
oro04935  Growth hormone synthesis, secretion and action
oro04960  Aldosterone-regulated sodium reabsorption
oro04973  Carbohydrate digestion and absorption
oro05010  Alzheimer disease
oro05017  Spinocerebellar ataxia
oro05020  Prion disease
oro05100  Bacterial invasion of epithelial cells
oro05135  Yersinia infection
oro05142  Chagas disease
oro05146  Amoebiasis
oro05160  Hepatitis C
oro05161  Hepatitis B
oro05162  Measles
oro05163  Human cytomegalovirus infection
oro05164  Influenza A
oro05165  Human papillomavirus infection
oro05166  Human T-cell leukemia virus 1 infection
oro05167  Kaposi sarcoma-associated herpesvirus infection
oro05168  Herpes simplex virus 1 infection
oro05169  Epstein-Barr virus infection
oro05170  Human immunodeficiency virus 1 infection
oro05171  Coronavirus disease - COVID-19
oro05200  Pathways in cancer
oro05203  Viral carcinogenesis
oro05205  Proteoglycans in cancer
oro05206  MicroRNAs in cancer
oro05207  Chemical carcinogenesis - receptor activation
oro05208  Chemical carcinogenesis - reactive oxygen species
oro05210  Colorectal cancer
oro05211  Renal cell carcinoma
oro05212  Pancreatic cancer
oro05213  Endometrial cancer
oro05214  Glioma
oro05215  Prostate cancer
oro05218  Melanoma
oro05220  Chronic myeloid leukemia
oro05221  Acute myeloid leukemia
oro05222  Small cell lung cancer
oro05223  Non-small cell lung cancer
oro05224  Breast cancer
oro05225  Hepatocellular carcinoma
oro05226  Gastric cancer
oro05230  Central carbon metabolism in cancer
oro05231  Choline metabolism in cancer
oro05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oro05415  Diabetic cardiomyopathy
oro05417  Lipid and atherosclerosis
oro05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101374787 (PIK3R3)
   04014 Ras signaling pathway
    101374787 (PIK3R3)
   04015 Rap1 signaling pathway
    101374787 (PIK3R3)
   04370 VEGF signaling pathway
    101374787 (PIK3R3)
   04630 JAK-STAT signaling pathway
    101374787 (PIK3R3)
   04668 TNF signaling pathway
    101374787 (PIK3R3)
   04066 HIF-1 signaling pathway
    101374787 (PIK3R3)
   04068 FoxO signaling pathway
    101374787 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    101374787 (PIK3R3)
   04072 Phospholipase D signaling pathway
    101374787 (PIK3R3)
   04071 Sphingolipid signaling pathway
    101374787 (PIK3R3)
   04024 cAMP signaling pathway
    101374787 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    101374787 (PIK3R3)
   04152 AMPK signaling pathway
    101374787 (PIK3R3)
   04150 mTOR signaling pathway
    101374787 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101374787 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101374787 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    101374787 (PIK3R3)
   04218 Cellular senescence
    101374787 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101374787 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    101374787 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101374787 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101374787 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    101374787 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    101374787 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    101374787 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    101374787 (PIK3R3)
   04660 T cell receptor signaling pathway
    101374787 (PIK3R3)
   04662 B cell receptor signaling pathway
    101374787 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    101374787 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    101374787 (PIK3R3)
   04670 Leukocyte transendothelial migration
    101374787 (PIK3R3)
   04062 Chemokine signaling pathway
    101374787 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101374787 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    101374787 (PIK3R3)
   04929 GnRH secretion
    101374787 (PIK3R3)
   04915 Estrogen signaling pathway
    101374787 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    101374787 (PIK3R3)
   04917 Prolactin signaling pathway
    101374787 (PIK3R3)
   04926 Relaxin signaling pathway
    101374787 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    101374787 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    101374787 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101374787 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101374787 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    101374787 (PIK3R3)
   04722 Neurotrophin signaling pathway
    101374787 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101374787 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    101374787 (PIK3R3)
   04380 Osteoclast differentiation
    101374787 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    101374787 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    101374787 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101374787 (PIK3R3)
   05206 MicroRNAs in cancer
    101374787 (PIK3R3)
   05205 Proteoglycans in cancer
    101374787 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    101374787 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    101374787 (PIK3R3)
   05203 Viral carcinogenesis
    101374787 (PIK3R3)
   05230 Central carbon metabolism in cancer
    101374787 (PIK3R3)
   05231 Choline metabolism in cancer
    101374787 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101374787 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101374787 (PIK3R3)
   05212 Pancreatic cancer
    101374787 (PIK3R3)
   05225 Hepatocellular carcinoma
    101374787 (PIK3R3)
   05226 Gastric cancer
    101374787 (PIK3R3)
   05214 Glioma
    101374787 (PIK3R3)
   05221 Acute myeloid leukemia
    101374787 (PIK3R3)
   05220 Chronic myeloid leukemia
    101374787 (PIK3R3)
   05218 Melanoma
    101374787 (PIK3R3)
   05211 Renal cell carcinoma
    101374787 (PIK3R3)
   05215 Prostate cancer
    101374787 (PIK3R3)
   05213 Endometrial cancer
    101374787 (PIK3R3)
   05224 Breast cancer
    101374787 (PIK3R3)
   05222 Small cell lung cancer
    101374787 (PIK3R3)
   05223 Non-small cell lung cancer
    101374787 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101374787 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    101374787 (PIK3R3)
   05161 Hepatitis B
    101374787 (PIK3R3)
   05160 Hepatitis C
    101374787 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    101374787 (PIK3R3)
   05164 Influenza A
    101374787 (PIK3R3)
   05162 Measles
    101374787 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    101374787 (PIK3R3)
   05163 Human cytomegalovirus infection
    101374787 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101374787 (PIK3R3)
   05169 Epstein-Barr virus infection
    101374787 (PIK3R3)
   05165 Human papillomavirus infection
    101374787 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101374787 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    101374787 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101374787 (PIK3R3)
   05142 Chagas disease
    101374787 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101374787 (PIK3R3)
   05017 Spinocerebellar ataxia
    101374787 (PIK3R3)
   05020 Prion disease
    101374787 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101374787 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    101374787 (PIK3R3)
   05415 Diabetic cardiomyopathy
    101374787 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101374787 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    101374787 (PIK3R3)
   04931 Insulin resistance
    101374787 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101374787 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101374787 (PIK3R3)
   01524 Platinum drug resistance
    101374787 (PIK3R3)
   01522 Endocrine resistance
    101374787 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oro04131]
    101374787 (PIK3R3)
Membrane trafficking [BR:oro04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101374787 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1
Other DBs
NCBI-GeneID: 101374787
NCBI-ProteinID: XP_004400645
UniProt: A0A2U3VYN3
LinkDB
Position
Unknown
AA seq 507 aa
MGPSQPVRAPRPRGLSSPYRRPGLGWPRPRNPRMFKCSRRRYRQKPQGPAATTAATNPAT
VATDINNTPTTTTSVWILPPQTLPPKPPKPMTSAVTNGMKDSSVSLQDAEWYWGDISREE
VNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVV
ELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKE
YDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIE
RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLV
WLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYG
KPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQ
TSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1524 nt   +upstreamnt  +downstreamnt
atggggccttctcagcctgtccgtgcccctcggccccggggcctaagttccccctaccgc
aggccagggctgggctggcctcggcctcgaaatcccaggatgttcaagtgtagccgcaga
aggtaccggcagaaaccccaaggcccagctgccaccactgcagccaccaatcctgccacc
gtggccacagatatcaacaacactcctaccaccaccaccagtgtgtggatccttccgcca
caaactcttccaccaaagccacctaagccaatgacttcagccgttacaaatggaatgaag
gacagttctgtttctcttcaggatgcagaatggtactggggggatatttcaagggaggag
gtaaatgacaaattacgggatatgccagatggtacgttcttggtcagagatgcctcaaca
aaaatgcagggggattacactttgactttgcggaagggaggcaataataagttaataaag
atctatcatcgagatggtaaatacggcttttctgatcctctgacatttaattctgtggtg
gagctcattaaccactatcatcatgaatctcttgctcagtacaatcccaaacttgatgtg
aagctaatgtacccagtgtccagataccaacaggatcagttggtaaaagaagacaacatt
gatgcagttggtaaaaaactgcaagagtaccactctcagtatcaggaaaagagtaaagag
tatgacaggctatatgaggaatataccagaacgtcccaggaaatacagatgaagaggact
gcaattgaagcttttaatgaaacaattaaaatatttgaagagcagtgtcacacacaagaa
caacatagcaaagaatatattgagcggtttcgcagagaggggaatgaaaaggaaattgaa
cgaattatgatgaattatgacaaattgaaatcacgtctgggtgagattcatgatagcaaa
atgcgtctagagcaggatttgaagaaacaagctttggacaaccgggaaatagataaaaaa
atgaacagtatcaaacctgacctgatccagctgcgcaagatccgagatcagcaccttgta
tggctcaatcacaaaggagtgagacagaagcgcctaaatgcctggctgggaatcaagaat
gaggatgctgatgagacctattttatcaatgaggaagatgaaaacctgccccattatgat
gagaaaacctggtttgttgaggatatcaatcgagtacaagcagaggacttgctttatggg
aaacctgatggtgcatttttaattcgtgagagtagcaagaaaggatgttatgcttgctct
gtggttgccgacggggaagtgaagcactgtgtgatctacagcactgctcggggctatggc
tttgcagagccctacaacctgtacagctccctgaaggagctagtgctccattaccagcag
acctccctcgttcagcacaacgactccctcaacgtcaggcttgcctaccctgtccacgca
cagatgccctcactctgcagataa

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