KEGG   Pteropus alecto (black flying fox): 102879034
Entry
102879034         CDS       T02993                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale01521  EGFR tyrosine kinase inhibitor resistance
pale01522  Endocrine resistance
pale04010  MAPK signaling pathway
pale04012  ErbB signaling pathway
pale04014  Ras signaling pathway
pale04015  Rap1 signaling pathway
pale04022  cGMP-PKG signaling pathway
pale04024  cAMP signaling pathway
pale04066  HIF-1 signaling pathway
pale04068  FoxO signaling pathway
pale04071  Sphingolipid signaling pathway
pale04072  Phospholipase D signaling pathway
pale04140  Autophagy - animal
pale04148  Efferocytosis
pale04150  mTOR signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04210  Apoptosis
pale04218  Cellular senescence
pale04270  Vascular smooth muscle contraction
pale04370  VEGF signaling pathway
pale04371  Apelin signaling pathway
pale04540  Gap junction
pale04550  Signaling pathways regulating pluripotency of stem cells
pale04613  Neutrophil extracellular trap formation
pale04620  Toll-like receptor signaling pathway
pale04650  Natural killer cell mediated cytotoxicity
pale04660  T cell receptor signaling pathway
pale04662  B cell receptor signaling pathway
pale04664  Fc epsilon RI signaling pathway
pale04720  Long-term potentiation
pale04722  Neurotrophin signaling pathway
pale04730  Long-term depression
pale04810  Regulation of actin cytoskeleton
pale04910  Insulin signaling pathway
pale04912  GnRH signaling pathway
pale04915  Estrogen signaling pathway
pale04916  Melanogenesis
pale04917  Prolactin signaling pathway
pale04919  Thyroid hormone signaling pathway
pale04921  Oxytocin signaling pathway
pale04926  Relaxin signaling pathway
pale04929  GnRH secretion
pale04934  Cushing syndrome
pale04935  Growth hormone synthesis, secretion and action
pale05010  Alzheimer disease
pale05022  Pathways of neurodegeneration - multiple diseases
pale05132  Salmonella infection
pale05135  Yersinia infection
pale05160  Hepatitis C
pale05161  Hepatitis B
pale05163  Human cytomegalovirus infection
pale05164  Influenza A
pale05165  Human papillomavirus infection
pale05166  Human T-cell leukemia virus 1 infection
pale05167  Kaposi sarcoma-associated herpesvirus infection
pale05170  Human immunodeficiency virus 1 infection
pale05200  Pathways in cancer
pale05205  Proteoglycans in cancer
pale05206  MicroRNAs in cancer
pale05207  Chemical carcinogenesis - receptor activation
pale05208  Chemical carcinogenesis - reactive oxygen species
pale05210  Colorectal cancer
pale05211  Renal cell carcinoma
pale05213  Endometrial cancer
pale05214  Glioma
pale05215  Prostate cancer
pale05216  Thyroid cancer
pale05218  Melanoma
pale05219  Bladder cancer
pale05220  Chronic myeloid leukemia
pale05221  Acute myeloid leukemia
pale05223  Non-small cell lung cancer
pale05224  Breast cancer
pale05225  Hepatocellular carcinoma
pale05226  Gastric cancer
pale05230  Central carbon metabolism in cancer
pale05231  Choline metabolism in cancer
pale05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pale00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102879034 (MAP2K2)
   04012 ErbB signaling pathway
    102879034 (MAP2K2)
   04014 Ras signaling pathway
    102879034 (MAP2K2)
   04015 Rap1 signaling pathway
    102879034 (MAP2K2)
   04370 VEGF signaling pathway
    102879034 (MAP2K2)
   04371 Apelin signaling pathway
    102879034 (MAP2K2)
   04066 HIF-1 signaling pathway
    102879034 (MAP2K2)
   04068 FoxO signaling pathway
    102879034 (MAP2K2)
   04072 Phospholipase D signaling pathway
    102879034 (MAP2K2)
   04071 Sphingolipid signaling pathway
    102879034 (MAP2K2)
   04024 cAMP signaling pathway
    102879034 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    102879034 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    102879034 (MAP2K2)
   04150 mTOR signaling pathway
    102879034 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102879034 (MAP2K2)
   04148 Efferocytosis
    102879034 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    102879034 (MAP2K2)
   04218 Cellular senescence
    102879034 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102879034 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102879034 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102879034 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102879034 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    102879034 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    102879034 (MAP2K2)
   04660 T cell receptor signaling pathway
    102879034 (MAP2K2)
   04662 B cell receptor signaling pathway
    102879034 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    102879034 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102879034 (MAP2K2)
   04929 GnRH secretion
    102879034 (MAP2K2)
   04912 GnRH signaling pathway
    102879034 (MAP2K2)
   04915 Estrogen signaling pathway
    102879034 (MAP2K2)
   04917 Prolactin signaling pathway
    102879034 (MAP2K2)
   04921 Oxytocin signaling pathway
    102879034 (MAP2K2)
   04926 Relaxin signaling pathway
    102879034 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    102879034 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    102879034 (MAP2K2)
   04916 Melanogenesis
    102879034 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102879034 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    102879034 (MAP2K2)
   04730 Long-term depression
    102879034 (MAP2K2)
   04722 Neurotrophin signaling pathway
    102879034 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102879034 (MAP2K2)
   05206 MicroRNAs in cancer
    102879034 (MAP2K2)
   05205 Proteoglycans in cancer
    102879034 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    102879034 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    102879034 (MAP2K2)
   05230 Central carbon metabolism in cancer
    102879034 (MAP2K2)
   05231 Choline metabolism in cancer
    102879034 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102879034 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102879034 (MAP2K2)
   05225 Hepatocellular carcinoma
    102879034 (MAP2K2)
   05226 Gastric cancer
    102879034 (MAP2K2)
   05214 Glioma
    102879034 (MAP2K2)
   05216 Thyroid cancer
    102879034 (MAP2K2)
   05221 Acute myeloid leukemia
    102879034 (MAP2K2)
   05220 Chronic myeloid leukemia
    102879034 (MAP2K2)
   05218 Melanoma
    102879034 (MAP2K2)
   05211 Renal cell carcinoma
    102879034 (MAP2K2)
   05219 Bladder cancer
    102879034 (MAP2K2)
   05215 Prostate cancer
    102879034 (MAP2K2)
   05213 Endometrial cancer
    102879034 (MAP2K2)
   05224 Breast cancer
    102879034 (MAP2K2)
   05223 Non-small cell lung cancer
    102879034 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102879034 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    102879034 (MAP2K2)
   05161 Hepatitis B
    102879034 (MAP2K2)
   05160 Hepatitis C
    102879034 (MAP2K2)
   05164 Influenza A
    102879034 (MAP2K2)
   05163 Human cytomegalovirus infection
    102879034 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102879034 (MAP2K2)
   05165 Human papillomavirus infection
    102879034 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102879034 (MAP2K2)
   05135 Yersinia infection
    102879034 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102879034 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    102879034 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102879034 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102879034 (MAP2K2)
   01522 Endocrine resistance
    102879034 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pale01001]
    102879034 (MAP2K2)
Enzymes [BR:pale01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102879034 (MAP2K2)
Protein kinases [BR:pale01001]
 Serine/threonine kinases: STE group
  STE7 family
   102879034 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase CAMSAP_CC1 Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 102879034
NCBI-ProteinID: XP_024898867
LinkDB
Position
Unknown
AA seq 454 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKWVRVASPASSVH
GVEWAPNVTGETRTCCGLGAPPGTPWSGRHLVTRPGPDPGGAGTLPSLWKRQPLTVTENH
TFIKRSEVEEVDFAGWLCKTLRLDQPSTPTRTAV
NT seq 1365 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagaagagctagagcttgacgagcagcagaagaagcggctggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgacttcgaaaggatctcggagctgggagcc
gggaacggcggagtggtcaccaaggtccagcacagaccttctggtctcatcatggcaaga
aagctgattcacctggagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctgcatgagtgcaactcgccgtacatcgtgggcttctacggggccttctacagcgac
ggggagatcagcatctgcatggagcacatggacggcggctccctggaccaggtgctgaag
gaagccaagagaattccggaggagatcctggggaaggtcagcattgcggttctgcggggc
ctggcgtatctccgggagaagcaccagatcatgcaccgagatgtgaagccgtccaacatc
ctcgtcaactccagaggcgagatcaagctgtgcgacttcggggtgagcgggcagctcatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccggagcggttgcag
ggcacccactactcggtgcagtcggacatctggagcatgggcctgtccttggtggagctg
tccatcgggaggtaccccatccccccaccggacgccaaggagctggaggccatctttggt
cggcccatggtcgacggggcagaaggagagcctcatagcatctcgccgcggccgagaccc
cccggacgccccatcagcggtcacgggatggacagccggccggccatggccatcttcgaa
ctgctggactacattgtgaacgagcctcctcccaagctgcccagcggcgtcttcacccag
gacttccaggaatttgtgaataaatgggtgcgggtggcctcacctgcctccagcgtgcac
ggggtggaatgggcccccaacgtcactggggagactaggacctgctgtgggctcggggcc
ccgcccggcacgccctggtcaggaaggcatctggtcacccgacccggcccagacccagga
ggcgctggcactctgccgtccctgtggaagcgccagccactcacggtgactgagaatcac
accttcatcaaacggtccgaggtggaggaagtggattttgccggctggctgtgtaagacg
ctgcgtctggaccagcccagcacacccacgcggaccgccgtgtga

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