KEGG   Pteropus alecto (black flying fox): 102879453
Entry
102879453         CDS       T02993                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale01521  EGFR tyrosine kinase inhibitor resistance
pale01522  Endocrine resistance
pale01524  Platinum drug resistance
pale04012  ErbB signaling pathway
pale04014  Ras signaling pathway
pale04015  Rap1 signaling pathway
pale04024  cAMP signaling pathway
pale04062  Chemokine signaling pathway
pale04066  HIF-1 signaling pathway
pale04068  FoxO signaling pathway
pale04070  Phosphatidylinositol signaling system
pale04071  Sphingolipid signaling pathway
pale04072  Phospholipase D signaling pathway
pale04081  Hormone signaling
pale04140  Autophagy - animal
pale04150  mTOR signaling pathway
pale04151  PI3K-Akt signaling pathway
pale04152  AMPK signaling pathway
pale04210  Apoptosis
pale04211  Longevity regulating pathway
pale04213  Longevity regulating pathway - multiple species
pale04218  Cellular senescence
pale04360  Axon guidance
pale04370  VEGF signaling pathway
pale04380  Osteoclast differentiation
pale04510  Focal adhesion
pale04550  Signaling pathways regulating pluripotency of stem cells
pale04611  Platelet activation
pale04613  Neutrophil extracellular trap formation
pale04620  Toll-like receptor signaling pathway
pale04625  C-type lectin receptor signaling pathway
pale04630  JAK-STAT signaling pathway
pale04650  Natural killer cell mediated cytotoxicity
pale04660  T cell receptor signaling pathway
pale04662  B cell receptor signaling pathway
pale04664  Fc epsilon RI signaling pathway
pale04666  Fc gamma R-mediated phagocytosis
pale04668  TNF signaling pathway
pale04670  Leukocyte transendothelial migration
pale04722  Neurotrophin signaling pathway
pale04725  Cholinergic synapse
pale04750  Inflammatory mediator regulation of TRP channels
pale04810  Regulation of actin cytoskeleton
pale04910  Insulin signaling pathway
pale04914  Progesterone-mediated oocyte maturation
pale04915  Estrogen signaling pathway
pale04917  Prolactin signaling pathway
pale04919  Thyroid hormone signaling pathway
pale04923  Regulation of lipolysis in adipocytes
pale04926  Relaxin signaling pathway
pale04929  GnRH secretion
pale04930  Type II diabetes mellitus
pale04931  Insulin resistance
pale04932  Non-alcoholic fatty liver disease
pale04933  AGE-RAGE signaling pathway in diabetic complications
pale04935  Growth hormone synthesis, secretion and action
pale04960  Aldosterone-regulated sodium reabsorption
pale04973  Carbohydrate digestion and absorption
pale05010  Alzheimer disease
pale05017  Spinocerebellar ataxia
pale05020  Prion disease
pale05100  Bacterial invasion of epithelial cells
pale05135  Yersinia infection
pale05142  Chagas disease
pale05146  Amoebiasis
pale05160  Hepatitis C
pale05161  Hepatitis B
pale05162  Measles
pale05163  Human cytomegalovirus infection
pale05164  Influenza A
pale05165  Human papillomavirus infection
pale05166  Human T-cell leukemia virus 1 infection
pale05167  Kaposi sarcoma-associated herpesvirus infection
pale05168  Herpes simplex virus 1 infection
pale05169  Epstein-Barr virus infection
pale05170  Human immunodeficiency virus 1 infection
pale05171  Coronavirus disease - COVID-19
pale05200  Pathways in cancer
pale05203  Viral carcinogenesis
pale05205  Proteoglycans in cancer
pale05206  MicroRNAs in cancer
pale05207  Chemical carcinogenesis - receptor activation
pale05208  Chemical carcinogenesis - reactive oxygen species
pale05210  Colorectal cancer
pale05211  Renal cell carcinoma
pale05212  Pancreatic cancer
pale05213  Endometrial cancer
pale05214  Glioma
pale05215  Prostate cancer
pale05218  Melanoma
pale05220  Chronic myeloid leukemia
pale05221  Acute myeloid leukemia
pale05222  Small cell lung cancer
pale05223  Non-small cell lung cancer
pale05224  Breast cancer
pale05225  Hepatocellular carcinoma
pale05226  Gastric cancer
pale05230  Central carbon metabolism in cancer
pale05231  Choline metabolism in cancer
pale05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pale05415  Diabetic cardiomyopathy
pale05417  Lipid and atherosclerosis
pale05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pale00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102879453 (PIK3R2)
   04014 Ras signaling pathway
    102879453 (PIK3R2)
   04015 Rap1 signaling pathway
    102879453 (PIK3R2)
   04370 VEGF signaling pathway
    102879453 (PIK3R2)
   04630 JAK-STAT signaling pathway
    102879453 (PIK3R2)
   04668 TNF signaling pathway
    102879453 (PIK3R2)
   04066 HIF-1 signaling pathway
    102879453 (PIK3R2)
   04068 FoxO signaling pathway
    102879453 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    102879453 (PIK3R2)
   04072 Phospholipase D signaling pathway
    102879453 (PIK3R2)
   04071 Sphingolipid signaling pathway
    102879453 (PIK3R2)
   04024 cAMP signaling pathway
    102879453 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    102879453 (PIK3R2)
   04152 AMPK signaling pathway
    102879453 (PIK3R2)
   04150 mTOR signaling pathway
    102879453 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102879453 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102879453 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    102879453 (PIK3R2)
   04218 Cellular senescence
    102879453 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102879453 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102879453 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102879453 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102879453 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    102879453 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    102879453 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    102879453 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    102879453 (PIK3R2)
   04660 T cell receptor signaling pathway
    102879453 (PIK3R2)
   04662 B cell receptor signaling pathway
    102879453 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    102879453 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    102879453 (PIK3R2)
   04670 Leukocyte transendothelial migration
    102879453 (PIK3R2)
   04062 Chemokine signaling pathway
    102879453 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102879453 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    102879453 (PIK3R2)
   04929 GnRH secretion
    102879453 (PIK3R2)
   04915 Estrogen signaling pathway
    102879453 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    102879453 (PIK3R2)
   04917 Prolactin signaling pathway
    102879453 (PIK3R2)
   04926 Relaxin signaling pathway
    102879453 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    102879453 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    102879453 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102879453 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102879453 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    102879453 (PIK3R2)
   04722 Neurotrophin signaling pathway
    102879453 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102879453 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    102879453 (PIK3R2)
   04380 Osteoclast differentiation
    102879453 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    102879453 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    102879453 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102879453 (PIK3R2)
   05206 MicroRNAs in cancer
    102879453 (PIK3R2)
   05205 Proteoglycans in cancer
    102879453 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    102879453 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    102879453 (PIK3R2)
   05203 Viral carcinogenesis
    102879453 (PIK3R2)
   05230 Central carbon metabolism in cancer
    102879453 (PIK3R2)
   05231 Choline metabolism in cancer
    102879453 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102879453 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102879453 (PIK3R2)
   05212 Pancreatic cancer
    102879453 (PIK3R2)
   05225 Hepatocellular carcinoma
    102879453 (PIK3R2)
   05226 Gastric cancer
    102879453 (PIK3R2)
   05214 Glioma
    102879453 (PIK3R2)
   05221 Acute myeloid leukemia
    102879453 (PIK3R2)
   05220 Chronic myeloid leukemia
    102879453 (PIK3R2)
   05218 Melanoma
    102879453 (PIK3R2)
   05211 Renal cell carcinoma
    102879453 (PIK3R2)
   05215 Prostate cancer
    102879453 (PIK3R2)
   05213 Endometrial cancer
    102879453 (PIK3R2)
   05224 Breast cancer
    102879453 (PIK3R2)
   05222 Small cell lung cancer
    102879453 (PIK3R2)
   05223 Non-small cell lung cancer
    102879453 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102879453 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    102879453 (PIK3R2)
   05161 Hepatitis B
    102879453 (PIK3R2)
   05160 Hepatitis C
    102879453 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    102879453 (PIK3R2)
   05164 Influenza A
    102879453 (PIK3R2)
   05162 Measles
    102879453 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    102879453 (PIK3R2)
   05163 Human cytomegalovirus infection
    102879453 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102879453 (PIK3R2)
   05169 Epstein-Barr virus infection
    102879453 (PIK3R2)
   05165 Human papillomavirus infection
    102879453 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102879453 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    102879453 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102879453 (PIK3R2)
   05142 Chagas disease
    102879453 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102879453 (PIK3R2)
   05017 Spinocerebellar ataxia
    102879453 (PIK3R2)
   05020 Prion disease
    102879453 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102879453 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    102879453 (PIK3R2)
   05415 Diabetic cardiomyopathy
    102879453 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102879453 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    102879453 (PIK3R2)
   04931 Insulin resistance
    102879453 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102879453 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102879453 (PIK3R2)
   01524 Platinum drug resistance
    102879453 (PIK3R2)
   01522 Endocrine resistance
    102879453 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pale04131]
    102879453 (PIK3R2)
Membrane trafficking [BR:pale04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102879453 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_9 Ribosomal_L22e ATG11
Other DBs
NCBI-GeneID: 102879453
NCBI-ProteinID: XP_006904360
LinkDB
Position
Unknown
AA seq 728 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDLLVVSRAALQVLGVAEGSERCPQNVGWMPGL
NERTRQRGDFPGTYVEFLGPVALSRPGPRPRGPRPLPARPQEGAPEPGPTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESLYRPELPPLRTDWSLSDVDQWDAATLADGIKGFLLA
LPSPIMTPEAAAEARRALREAVGPIGPVLEPPTLPLHHALTLRFLLQHLGRMARRAPAPG
PAVRALGTAFGPLLQLRAAPPSPPPPGGAPDGTELFPDFPALLVEKLLQEHLEEQEVAPP
ALPPKPPKAKPTPIGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLIAHYRHESLAQYNAKLDTR
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRXXLNSERLKSRIAEIHESRT
KLEQELRAQALDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGTRQKKINEWLGIKNE
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLNGKRDGTFLIRESSQRGCYACSVV
VDGDTKHCVIYRTATGLGFAEPYNLYGSLKELVLHYQHTSLVQHNDALTVTLAHPVRAPG
PGPPPTTR
NT seq 2187 nt   +upstreamnt  +downstreamnt
atggctggcgctgagggcttccagtaccgtgcactgtacccatttcgtcgggagcggcca
gaggacctggagctgctaccaggcgacttgctggtggtgagccgggcggccctgcaggtc
ctgggtgtggccgagggcagtgagcgctgcccacagaacgtgggctggatgcctggcctc
aacgaacgcacacggcagcgcggtgattttccaggcacctatgtcgagttcctggggcct
gtggccctgtccaggcctggccctcgcccccgtggcccccgcccactgcctgccaggccc
caagagggggcccccgagccaggccccacactccctgacctgcctgagcagttctcccca
cctgatgtggctccccctctcctggtgaagcttgtggaggccattgagcggacagggcta
gacagcgaatccctctacaggcctgagctgcctcccctgcgcacagactggtccttgagc
gacgtggatcagtgggatgcggcaactctggcggatggcatcaagggcttcttgctggcg
ctgccctcgcccatcatgacaccggaggccgcggccgaggctcgccgggccctgcgggag
gccgtgggacccatagggccggtgctggagcccccgacgctgccactgcaccatgcgctc
acgctgcgcttcctgctccagcaccttggtcgcatggcccggcgtgcccctgcccctggc
ccagcggtgcgagccctgggcactgccttcgggccgctcctgcagctgcgcgctgctccg
ccttcgccgccgccgccagggggcgcacccgatgggactgagctcttccccgacttcccg
gccttgctggtggaaaagttgcttcaggagcacctggaggagcaggaggttgcaccacca
gcactgccacctaaaccacccaaagcaaagcccacccccatagggctggccaatgggggg
agcccaccctccctgcaggatgctgagtggtactggggtgacatctccagggaagaggtg
aacgaaaaactccgggacacacctgatggtaccttcctggtccgagatgcctccagcaag
atccagggagagtacactctgaccctcaggaaaggcgggaacaacaagctgattaaggtc
ttccaccgcgacgggcactacggcttctcggaaccactcaccttctgctctgttgtggac
ctcattgcccactaccgccatgagtccctggcccagtacaacgccaaactggacacgcgg
ctcctctaccctgtatccaagtaccagcaggaccagattgtcaaggaggacagtgtggag
gcagtgggtgcccagctcaaagtctaccaccagcagtaccaggacaagagccgcgagtac
gaccagctctacgaggagtacacacgtacctcccaggaactacagatgaagcgcaccgca
attgaggccttcaatgaaaccatcaagatctttgaagagcagggccagacgcaagagaag
tgtagcaaggaatatctggaacgcttccggcgtgagggcaatgagaaagagatgcagagg
nnnnnnctgaactcggagcgactcaagtctcgcattgctgaaatccatgagagccgcacg
aagctggaacaggagctgcgggcacaggccttggacaaccgggagatcgacaagcgcatg
aacagcctaaagccagacctcatgcagctgcgcaagatccgagaccagtacctggtatgg
ctcacccagaaaggcacccggcagaagaaaatcaacgaatggttggggatcaaaaatgag
actgaggaccagtacgccctgatggaggacgaggatgacctgccccaccacgaggaacgc
acctggtacgtgggcaagatcaaccgcacacaggctgaggaaatgctgaacggcaaacga
gatggcaccttcctcatccgtgagagcagccagcgaggctgctacgcctgctctgtggtg
gtggatggcgacaccaagcactgcgttatctaccgcacggccaccggcttgggctttgca
gagccctacaatctgtatgggtccttaaaggagctggtgctgcattaccaacacacctcc
ttggtgcagcacaacgacgcgctcactgtcacattggcccaccctgttcgagcccctggc
cccgggcccccacccaccacccgctga

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