KEGG   PATHWAY: aali03060
Entry
aali03060                   Pathway                                
Name
Protein export - Anopheles albimanus
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
aali03060  Protein export
aali03060

Other DBs
GO: 0043952 0043953
Organism
Anopheles albimanus [GN:aali]
Gene
118462681  mitochondrial inner membrane protein OXA1L-like [KO:K03217]
118461653  signal recognition particle 54 kDa protein-like [KO:K03106] [EC:3.6.5.4]
118458744  protein transport protein Sec61 subunit alpha [KO:K10956]
118463564  protein transport protein Sec61 subunit beta-like [KO:K09481]
118464948  protein transport protein Sec61 subunit gamma [KO:K07342]
118461293  translocation protein SEC62-like [KO:K12275]
118466296  translocation protein SEC63 homolog [KO:K09540]
118460642  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
118464322  signal recognition particle 9 kDa protein-like [KO:K03109]
118459540  signal recognition particle 14 kDa protein-like [KO:K03104]
118468493  signal recognition particle subunit SRP72-like [KO:K03108]
118461906  signal recognition particle subunit SRP68-like [KO:K03107]
118462864  signal recognition particle 19 kDa protein-like [KO:K03105]
118463891  signal recognition particle receptor subunit alpha homolog [KO:K13431]
118464315  signal recognition particle receptor subunit beta-like [KO:K12272]
118462921  ATPase ASNA1 homolog [KO:K01551] [EC:7.3.2.7 7.3.-.-]
118463855  Golgi to ER traffic protein 4 homolog [KO:K23387]
118457959  uncharacterized protein LOC118457959 [KO:K23388]
118467453  guided entry of tail-anchored proteins factor 1-like [KO:K22384]
118457558  transmembrane protein 208-like isoform X1 [KO:K27164]
118459385  signal peptidase complex subunit 1-like [KO:K12946] [EC:3.4.-.-]
118465080  signal peptidase complex subunit 2-like [KO:K12947] [EC:3.4.-.-]
118466955  signal peptidase complex subunit 3-like [KO:K12948] [EC:3.4.-.-]
118461266  signal peptidase complex catalytic subunit SEC11A-like [KO:K13280] [EC:3.4.21.89]
118465409  mitochondrial inner membrane protease subunit 2-like [KO:K09648] [EC:3.4.21.-]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   
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