KEGG   PATHWAY: ack02010
Entry
ack02010                    Pathway                                
Name
ABC transporters - Acidovorax sp. KKS102
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
ack02010  ABC transporters
ack02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Acidovorax sp. KKS102 [GN:ack]
Gene
C380_13235  sulfate ABC transporter periplasmic sulfate-binding protein [KO:K02048]
C380_10210  sulfate ABC transporter periplasmic sulfate-binding protein [KO:K23163]
C380_13230  sulfate ABC transporter inner membrane subunit CysT [KO:K02046]
C380_13225  sulfate ABC transporter inner membrane subunit cysw [KO:K02047]
C380_13220  sulfate ABC transporter ATPase [KO:K02045] [EC:7.3.2.3]
C380_17985  ABC transporter substrate-binding protein [KO:K05772]
C380_17995  binding-protein-dependent transport systems inner membrane component [KO:K05773]
C380_17990  ABC transporter-like protein [KO:K06857] [EC:7.3.2.6]
C380_02865  twin-arginine translocation pathway signal protein [KO:K15576]
C380_17415  twin-arginine translocation pathway signal protein [KO:K15576]
C380_02870  nitrate ABC transporter inner membrane subunit [KO:K15577]
C380_17420  nitrate ABC transporter inner membrane subunit [KO:K15577]
C380_02875  ABC transporter-like protein [KO:K15578] [EC:7.3.2.4]
C380_17425  nitrate ABC transporter ATPases C [KO:K15578] [EC:7.3.2.4]
C380_10295  sulfate ester transporter periplasmic binding component [KO:K15553]
C380_10275  aliphatic sulfonates transporter substrate-binding protein [KO:K15553]
C380_10220  aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
C380_09370  putative signal peptide protein [KO:K15553]
C380_10280  ABC transporter permease [KO:K15554]
C380_10285  TauT family taurine ABC transporter permease [KO:K15554]
C380_10235  binding-protein-dependent transport systems inner membrane component [KO:K15554]
C380_10290  TauT family taurine ABC transporter permease [KO:K15555] [EC:7.6.2.14]
C380_10240  ABC transporter-like protein [KO:K15555] [EC:7.6.2.14]
C380_17980  molybdenum ABC transporter substrate-binding protein [KO:K02020]
C380_11860  molybdenum abc transporter, periplasmic molybdate-binding protein [KO:K02020]
C380_22730  putative ABC transporter periplasmic molybdate binding protein [KO:K02020]
C380_11855  molybdate ABC transporter inner membrane subunit [KO:K02018]
C380_11850  molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
C380_04000  family 1 extracellular solute-binding protein [KO:K02012]
C380_13745  family 1 extracellular solute-binding protein [KO:K02012]
C380_19485  family 1 extracellular solute-binding protein [KO:K02012]
C380_19570  binding-protein-dependent transport systems inner membrane component [KO:K02011]
C380_04005  binding-protein-dependent transport systems inner membrane component [KO:K02011]
C380_11885  ABC transporter [KO:K02010] [EC:7.2.2.7]
C380_19575  Fe(3+)-transporting ATPase [KO:K02010] [EC:7.2.2.7]
C380_04010  ABC transporter [KO:K02010] [EC:7.2.2.7]
C380_08935  ABC transporter-like protein [KO:K10111] [EC:7.5.2.-]
C380_04050  ABC transporter-like protein [KO:K10112] [EC:7.5.2.-]
C380_08920  extracellular solute-binding protein [KO:K10227]
C380_08925  binding-protein-dependent transport system inner membrane protein [KO:K10228]
C380_08930  binding-protein-dependent transport system inner membrane protein [KO:K10229]
C380_10485  sugar ABC transporter periplasmic sugar-binding protein [KO:K10546]
C380_10475  monosaccharide-transporting ATPase [KO:K10547]
C380_10480  monosaccharide-transporting ATPase [KO:K10548] [EC:7.5.2.-]
C380_04360  toluene tolerance family protein [KO:K07323]
C380_01700  hypothetical protein [KO:K02067]
C380_04350  hypothetical protein [KO:K02067]
C380_14945  mammalian cell entry related domain-containing protein [KO:K02067]
C380_01690  hypothetical protein [KO:K02066]
C380_04345  ABC transporter ATP-binding protein [KO:K02066]
C380_14950  hypothetical protein [KO:K02066]
C380_04365  sulfate transporter/antisigma-factor antagonist STAS [KO:K07122]
C380_01695  ABC transporter-like protein [KO:K02065]
C380_04340  ABC transporter [KO:K02065]
C380_12860  basic membrane lipoprotein [KO:K07335]
C380_05460  basic membrane lipoprotein [KO:K07335]
C380_05480  basic membrane lipoprotein [KO:K07335]
C380_05450  inner-membrane translocator [KO:K23535]
C380_12880  inner-membrane translocator [KO:K23535]
C380_12885  inner-membrane translocator [KO:K23536]
C380_05455  ABC transporter permease [KO:K23536]
C380_12870  monosaccharide-transporting ATPase [KO:K23537]
C380_05445  monosaccharide-transporting ATPase [KO:K23537]
C380_04030  extracellular solute-binding protein [KO:K17315]
C380_04040  binding-protein-dependent transport system inner membrane protein [KO:K17316]
C380_04045  binding-protein-dependent transport system inner membrane protein [KO:K17317]
C380_21050  periplasmic-binding protein/LacI transcriptional regulator [KO:K10439]
C380_21060  inner-membrane translocator [KO:K10440]
C380_21055  monosaccharide-transporting ATPase [KO:K10441] [EC:7.5.2.7]
C380_21075  D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
C380_10490  periplasmic binding protein/LacI transcriptional regulator [KO:K23508]
C380_10460  inner-membrane translocator [KO:K23509]
C380_10465  inner-membrane translocator [KO:K23509]
C380_10470  monosaccharide-transporting ATPase [KO:K10820] [EC:7.5.2.9]
C380_20405  periplasmic-binding protein/LacI transcriptional regulator [KO:K10552]
C380_20400  inner-membrane translocator [KO:K10553]
C380_20395  ABC transporter [KO:K10554]
C380_21920  extracellular solute-binding protein [KO:K17321]
C380_21935  binding-protein-dependent transport system inner membrane protein [KO:K17322]
C380_21930  binding-protein-dependent transport system inner membrane protein [KO:K17323]
C380_21945  ABC transporter-like protein [KO:K17324]
C380_21940  ABC transporter-like protein [KO:K17325]
C380_04690  extracellular solute-binding protein [KO:K05813]
C380_04685  ABC transporter permease [KO:K05814]
C380_04680  ABC transporter permease [KO:K05815]
C380_04675  ABC transporter-like protein [KO:K05816] [EC:7.6.2.10]
C380_15320  periplasmic phosphate-binding protein [KO:K02040]
C380_09275  phosphate ABC transporter periplasmic phosphate-binding protein [KO:K02040]
C380_09280  phosphate ABC transporter inner membrane subunit PstC [KO:K02037]
C380_09285  phosphate ABC transporter permease [KO:K02038]
C380_09290  phosphate ABC transporter ATPase [KO:K02036] [EC:7.3.2.1]
C380_02600  phosphonate ABC transporter substrate-binding protein [KO:K02044]
C380_02605  phosphonate ABC transporter inner membrane subunit [KO:K02042]
C380_02595  phosphonate ABC transporter ATPase [KO:K02041] [EC:7.3.2.2]
C380_03470  extracellular solute-binding protein [KO:K10001]
C380_06910  family 3 extracellular solute-binding protein [KO:K10001]
C380_03480  polar amino acid ABC transporter permease [KO:K10002]
C380_03475  polar amino acid ABC transporter permease [KO:K10003]
C380_03485  ABC transporter-like protein [KO:K10004] [EC:7.4.2.1]
C380_03380  extracellular ligand-binding receptor [KO:K01999]
C380_19370  putative branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
C380_02245  extracellular ligand-binding receptor [KO:K01999]
C380_16405  extracellular ligand-binding receptor [KO:K01999]
C380_00335  ABC transporter substrate-binding protein [KO:K01999]
C380_01165  extracellular ligand-binding receptor [KO:K01999]
C380_02690  hypothetical protein [KO:K01999]
C380_11740  extracellular ligand-binding receptor [KO:K01999]
C380_10050  extracellular ligand-binding receptor [KO:K01999]
C380_23715  ABC transporter leu/Ile/val-binding signal peptide protein [KO:K01999]
C380_07730  ABC-type transporter, periplasmic component [KO:K01999]
C380_21595  extracellular ligand-binding receptor [KO:K01999]
C380_12700  extracellular ligand-binding receptor [KO:K01999]
C380_17070  extracellular ligand-binding receptor [KO:K01999]
C380_17335  putative transporter signal peptide protein [KO:K01999]
C380_17370  putative branched-chain amino acid binding protein [KO:K01999]
C380_17405  extracellular ligand-binding receptor [KO:K01999]
C380_13400  extracellular ligand-binding receptor [KO:K01999]
C380_13465  twin-arginine translocation pathway signal protein [KO:K01999]
C380_22770  extracellular ligand-binding receptor [KO:K01999]
C380_16230  extracellular ligand-binding receptor [KO:K01999]
C380_16385  inner-membrane translocator [KO:K01997]
C380_00345  ABC transporter permease [KO:K01997]
C380_01170  inner-membrane translocator [KO:K01997 K01998]
C380_02700  inner-membrane translocator [KO:K01997]
C380_11745  inner-membrane translocator [KO:K01997]
C380_16225  inner-membrane translocator [KO:K01997]
C380_19390  ABC transporter permease [KO:K01997]
C380_03405  inner-membrane translocator [KO:K01997]
C380_07735  ABC branched-chain amino acid family transporter, inner membrane subunit [KO:K01997]
C380_17075  inner-membrane translocator [KO:K01997]
C380_06720  inner-membrane translocator [KO:K01997]
C380_17375  High-affinity branched-chain amino acid transport system permease protein livh [KO:K01997]
C380_13395  inner-membrane translocator [KO:K01997]
C380_13470  inner-membrane translocator [KO:K01997]
C380_22765  inner-membrane translocator [KO:K01997]
C380_00340  inner-membrane translocator [KO:K01998]
C380_02695  inner-membrane translocator [KO:K01998]
C380_11750  inner-membrane translocator [KO:K01998]
C380_16220  inner-membrane translocator [KO:K01998]
C380_16380  inner-membrane translocator [KO:K01998]
C380_03400  inner-membrane translocator [KO:K01998]
C380_07740  inner-membrane translocator [KO:K01998]
C380_17080  inner-membrane translocator [KO:K01998]
C380_17380  branched-chain amino acid transport system permease protein LivM [KO:K01998]
C380_13390  inner-membrane translocator [KO:K01998]
C380_13475  inner-membrane translocator [KO:K01998]
C380_22760  inner-membrane translocator [KO:K01998]
C380_19385  branched chain amino acid ABC transporter inner membrane protein [KO:K01998]
C380_06725  inner-membrane translocator [KO:K01998]
C380_16395  ABC transporter-like protein [KO:K01995]
C380_00350  ABC transporter-like protein [KO:K01995]
C380_11755  ABC transporter [KO:K01995]
C380_02705  sulfate-transporting ATPase [KO:K01995]
C380_16215  ABC transporter [KO:K01995]
C380_01175  ABC transporter [KO:K01995]
C380_19380  ABC transporter-like protein [KO:K01995]
C380_03395  ABC transporter-like protein [KO:K01995]
C380_07720  ABC transporter [KO:K01995]
C380_17085  high-affinity branched-chain amino acidtransport ATP-binding protein livG [KO:K01995]
C380_06730  monosaccharide-transporting ATPase [KO:K01995]
C380_17385  ABC transporter-like protein [KO:K01995]
C380_13385  ABC transporter [KO:K01995]
C380_13480  ABC transporter-like protein [KO:K01995]
C380_22755  ABC transporter-like protein [KO:K01995]
C380_00330  ABC transporter-like protein [KO:K01996]
C380_01180  ABC transporter [KO:K01996]
C380_02685  ABC transporter-like protein [KO:K01996]
C380_11760  ABC transporter [KO:K01996]
C380_16210  ABC transporter-like protein [KO:K01996]
C380_16390  ABC transporter [KO:K01996]
C380_03390  ABC transporter-like protein [KO:K01996]
C380_07725  ABC transporter-like protein [KO:K01996]
C380_17090  high-affinity branched-chain amino acidtransport ATP-binding protein livF [KO:K01996]
C380_17390  ABC transporter-like protein [KO:K01996]
C380_13380  ABC transporter [KO:K01996]
C380_13485  ABC transporter-like protein [KO:K01996]
C380_22750  ABC transporter-like protein [KO:K01996]
C380_19375  ABC transporter [KO:K01996]
C380_06735  ABC transporter-like protein [KO:K01996]
C380_13280  lipoprotein [KO:K02073]
C380_10580  binding-protein-dependent transport system inner membrane protein [KO:K02072]
C380_10575  metN; DL-methionine transporter ATP-binding subunit [KO:K02071]
C380_05115  twin-arginine translocation pathway signal protein [KO:K11959]
C380_05120  inner-membrane translocator [KO:K11960]
C380_05125  inner-membrane translocator [KO:K11961]
C380_05130  ABC transporter-like protein [KO:K11962]
C380_05135  ABC transporter-like protein [KO:K11963]
C380_14880  extracellular solute-binding protein [KO:K13893]
C380_14875  binding-protein-dependent transport systems inner membrane component [KO:K13894]
C380_14870  binding-protein-dependent transport system inner membrane protein [KO:K13895]
C380_14865  ABC transporter-like protein [KO:K13896]
C380_03100  hypothetical protein [KO:K09690]
C380_03105  ABC transporter-like protein [KO:K09691] [EC:7.5.2.14]
C380_02850  ABC transporter [KO:K09694]
C380_02950  Fe(3+)-transporting ATPase [KO:K09695]
C380_06470  LolC/E family lipoprotein releasing system, transmembrane protein [KO:K09808]
C380_06475  lipoprotein releasing system ATP-binding protein [KO:K09810] [EC:7.6.2.-]
C380_12720  permease [KO:K07091]
C380_12725  permease [KO:K11720]
C380_22275  sulfate-transporting ATPase [KO:K06861] [EC:7.5.2.5]
C380_10710  lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA [KO:K11085] [EC:7.5.2.6]
C380_03430  ABC transporter permease and ATPase [KO:K24821]
C380_12405  ABC transporter [KO:K18893]
C380_01315  ABC transporter [KO:K12541]
C380_03220  type I secretion system ATPase [KO:K12536]
C380_03215  type I secretion system ATPase [KO:K12536]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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