KEGG   PATHWAY: actn02010
Entry
actn02010                   Pathway                                
Name
ABC transporters - Actinoplanes sp. N902-109
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
actn02010  ABC transporters
actn02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Actinoplanes sp. N902-109 [GN:actn]
Gene
L083_4696  putative ABC transporter substrate-binding protein [KO:K15551]
L083_4697  putative ABC transporter permease [KO:K15552]
L083_4695  ABC transporter ATP-binding protein [KO:K10831] [EC:7.6.2.7]
L083_5525  sulfonate ABC transporter [KO:K15553]
L083_6305  sulfonate/nitrate/taurine ABC transporter periplasmic protein [KO:K15553]
L083_7271  aliphatic sulfonates ABC transporter substrate-binding protein [KO:K15553]
L083_5524  nitrate/sulfonate/bicarbonate ABC transporter permease [KO:K15554]
L083_7273  ABC transporter integral membrane protein [KO:K15554]
L083_6304  sulfonate/nitrate/taurine ABC transporter permease [KO:K15554]
L083_5523  ABC transporter [KO:K15555] [EC:7.6.2.14]
L083_7272  ABC transporter ATPase [KO:K15555] [EC:7.6.2.14]
L083_6303  2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT [KO:K15555] [EC:7.6.2.14]
L083_6448  modA; molybdenum ABC transporter periplasmic molybdate-binding protein [KO:K02020]
L083_6449  modB; molybdate ABC transporter inner membrane subunit [KO:K02018]
L083_6450  modC; ABC transporter [KO:K02017] [EC:7.3.2.5]
L083_4190  potD; family 1 extracellular solute-binding protein [KO:K11069]
L083_4192  potI; binding-protein-dependent transporter inner membrane component [KO:K11070]
L083_4191  potH; binding-protein-dependent transport systems inner membrane component [KO:K11071]
L083_4189  spermidine/putrescine ABC transporter ATPase [KO:K11072] [EC:7.6.2.11]
L083_4088  proline/glycine betaine ABC transporter periplasmic component-like protein [KO:K02002]
L083_4089  binding-protein-dependent transporter inner membrane component [KO:K02001]
L083_4090  choline ABC transporter, ATP-binding protein [KO:K02000] [EC:7.6.2.9]
L083_7865  glycine betaine ABC transporter substrate-binding protein [KO:K05845]
L083_7866  binding-protein-dependent transport systems inner membrane component [KO:K05846]
L083_7867  binding-protein-dependent transport systems inner membrane component [KO:K05846]
L083_7868  glycine betaine/L-proline ABC transporter, ATPase subunit [KO:K05847] [EC:7.6.2.9]
L083_7813  ABC transporter [KO:K10112] [EC:7.5.2.-]
L083_4175  msmK; ABC transporter-like protein [KO:K10112] [EC:7.5.2.-]
L083_2367  ABC transporter-like protein [KO:K10112] [EC:7.5.2.-]
L083_0542  potG; ABC transporter-like protein [KO:K10112] [EC:7.5.2.-]
L083_7185  msiK; ABC transporter [KO:K10112] [EC:7.5.2.-]
L083_4108  family 1 extracellular solute-binding protein [KO:K10117]
L083_4636  family 1 extracellular solute-binding protein [KO:K10117]
L083_3182  family 1 extracellular solute-binding protein [KO:K10117]
L083_5589  extracellular solute-binding protein family 1 [KO:K10117]
L083_4107  binding-protein-dependent transporters inner membrane component [KO:K10118]
L083_3183  carbohydrate ABC transporter membrane protein 1, CUT1 family [KO:K10118]
L083_4637  binding protein dependent transporter [KO:K10118]
L083_5588  binding-protein-dependent transport systems inner membrane component [KO:K10118]
L083_4106  ABC transporter permease [KO:K10119]
L083_3184  binding-protein-dependent transport systems inner membrane component [KO:K10119]
L083_4638  binding-protein-dependent transport systems inner membrane component [KO:K10119]
L083_5587  binding-protein-dependent transport systems inner membrane component [KO:K10119]
L083_0646  family 1 extracellular solute-binding protein [KO:K10227]
L083_4915  extracellular solute-binding protein family 1 protein [KO:K10227]
L083_0647  putative ABC transporter permease protein [KO:K10228]
L083_4914  putative ABC transporter permease protein [KO:K10228]
L083_0648  binding-protein-dependent transport systems inner membrane component [KO:K10229]
L083_4913  binding-protein-dependent transport systems inner membrane component [KO:K10229]
L083_4669  extracellular solute-binding protein family 1 [KO:K10232]
L083_4670  binding-protein-dependent transport systems inner membrane component [KO:K10233]
L083_4671  binding-protein-dependent transport systems inner membrane component [KO:K10234]
L083_2364  family 1 extracellular solute-binding protein [KO:K10236]
L083_2365  binding-protein-dependent transport system inner membrane protein [KO:K10237]
L083_2366  binding-protein-dependent transport system inner membrane protein [KO:K10238]
L083_2286  sugar ABC transporter periplasmic protein [KO:K10200]
L083_6582  family 1 extracellular solute-binding protein [KO:K10200]
L083_2287  sugar ABC transporter permease [KO:K10201]
L083_6581  binding-protein-dependent transport systems inner membrane component [KO:K10201]
L083_2289  sugar ABC transporter permease [KO:K10202]
L083_6580  binding-protein-dependent transport systems inner membrane component [KO:K10202]
L083_6982  cebE; family 1 extracellular solute-binding protein [KO:K10240]
L083_5580  family 1 extracellular solute-binding protein [KO:K10240]
L083_6981  binding-protein-dependent transport system inner membrane protein [KO:K10241]
L083_5581  binding-protein-dependent transport systems inner membrane component [KO:K10241]
L083_6980  binding-protein-dependent transport system inner membrane protein [KO:K10242]
L083_5582  binding-protein-dependent transport systems inner membrane component [KO:K10242]
L083_0811  sugar ABC transporter substrate-binding protein [KO:K17244]
L083_0810  binding-protein-dependent transport systems inner membrane component [KO:K17245]
L083_0809  carbohydrate ABC transporter membrane protein [KO:K17246]
L083_3261  chvE; putative sugar ABC transporter, substrate-binding protein [KO:K10546]
L083_5321  multiple sugar-binding periplasmic receptor [KO:K10546]
L083_4937  ABC transporter solute-binding protein [KO:K10546]
L083_5421  ABC transporter [KO:K10546]
L083_3263  inner-membrane translocator [KO:K10547]
L083_5322  L-arabinose ABC transporter permease [KO:K10547]
L083_4935  araH; inner-membrane translocator [KO:K10547]
L083_3262  ABC transporter related protein [KO:K10548] [EC:7.5.2.-]
L083_5323  monosaccharide ABC transporter ATP-binding protein, CUT2 family [KO:K10548] [EC:7.5.2.-]
L083_4936  ABC transporter [KO:K10548] [EC:7.5.2.-]
L083_3379  basic membrane lipoprotein [KO:K07335]
L083_7527  basic membrane lipoprotein [KO:K07335]
L083_7525  inner-membrane translocator [KO:K23535]
L083_3381  inner-membrane translocator [KO:K23535]
L083_3382  inner-membrane translocator [KO:K23536]
L083_7524  inner-membrane translocator [KO:K23536]
L083_3380  YufO2 [KO:K23537]
L083_7526  ABC transporter-like protein [KO:K23537]
L083_1664  periplasmic binding protein/LacI transcriptional regulator [KO:K10439]
L083_5666  ABC transporter [KO:K10439]
L083_1663  inner-membrane translocator [KO:K10440]
L083_1662  ABC transporter [KO:K10441] [EC:7.5.2.7]
L083_3773  periplasmic binding protein/LacI transcriptional regulator [KO:K23508]
L083_0577  ABC sugar transporter [KO:K23508]
L083_3776  inner-membrane translocator [KO:K23509]
L083_0575  ABC transporter permease [KO:K23509]
L083_0574  rbsC; ABC transporter permease [KO:K23509]
L083_3775  monosaccharide-transporting ATPase [KO:K23509]
L083_0576  ABC sugar transporter ATP-binding protein [KO:K10820] [EC:7.5.2.9]
L083_3774  ABC transporter ATP-binding protein [KO:K10820] [EC:7.5.2.9]
L083_3647  LacI family transcriptional regulator [KO:K10543]
L083_1006  hypothetical protein [KO:K10543]
L083_4320  hypothetical protein [KO:K10543]
L083_1004  lsrC; inner-membrane translocator [KO:K10544]
L083_1005  frcA; ABC transporter-like protein [KO:K10545] [EC:7.5.2.10]
L083_0715  frcB; periplasmic binding protein/LacI transcriptional regulator [KO:K10552]
L083_0716  frcC; ABC transporter permease [KO:K10553]
L083_0717  monosaccharide-transporting ATPase [KO:K10554]
L083_7761  pstS; phosphate ABC transporter periplasmic phosphate-binding protein [KO:K02040]
L083_7762  pstC; phosphate ABC transporter permease pstC [KO:K02037]
L083_7763  pstA; phosphate ABC transporter inner membrane subunit PstA [KO:K02038]
L083_7764  pstB; phosphate ABC transporter ATPase subunit [KO:K02036] [EC:7.3.2.1]
L083_4625  Amino acid ABC transporter substrate-binding protein, PAAT family [KO:K09969]
L083_6750  family 3 extracellular solute-binding protein [KO:K10005]
L083_6751  binding-protein-dependent transporter inner membrane component [KO:K10006]
L083_6752  amino acid permease [KO:K10007]
L083_6749  ABC transporter related protein [KO:K10008] [EC:7.4.2.1]
L083_2108  extracellular ligand-binding receptor [KO:K01999]
L083_3164  extracellular ligand-binding receptor [KO:K01999]
L083_0974  extracellular ligand-binding receptor [KO:K01999]
L083_7390  ilvJ; extracellular ligand-binding receptor [KO:K01999]
L083_2109  inner-membrane translocator [KO:K01997]
L083_3162  branched-chain amino acid ABC transporter permease [KO:K01997]
L083_7388  inner-membrane translocator [KO:K01997]
L083_3161  inner-membrane translocator [KO:K01998]
L083_2110  livM; inner-membrane translocator [KO:K01998]
L083_7389  inner-membrane translocator [KO:K01998]
L083_2111  ABC transporter-like protein [KO:K01995]
L083_3165  branched-chain amino acid ABC transporter ATPase [KO:K01995]
L083_7386  ABC transporter-like protein [KO:K01995]
L083_3163  branched-chain amino acid ABC transporter ATPase [KO:K01996]
L083_2112  livF; ABC transporter [KO:K01996]
L083_7387  ABC transporter-like protein [KO:K01996]
L083_1035  family 5 extracellular solute-binding protein [KO:K15580]
L083_1036  dppB; binding-protein-dependent transport systems inner membrane component [KO:K15581]
L083_1037  dppC; binding-protein-dependent transport systems inner membrane component [KO:K15582]
L083_1038  peptide ABC transporter ATPase [KO:K15583]
L083_1039  oligopeptide/dipeptide ABC transporter, ATPase subunit [KO:K10823]
L083_5505  extracellular solute-binding dependent transport lipoprotein [KO:K13889]
L083_5506  oppB; peptide ABC transporter permease [KO:K13890]
L083_5507  oligopeptide/dipeptide ABC superfamily ATP binding cassette transporter [KO:K13891 K13892]
L083_1574  periplasmic binding protein [KO:K25286]
L083_7102  periplasmic binding protein [KO:K25286]
L083_1562  fepD; ABC transporter permease protein [KO:K23186]
L083_7101  transport system permease protein [KO:K23186]
L083_1563  ferric enterobactin transport system permease protein FepG [KO:K23187]
L083_7100  fepG; iron-siderophore ABC transporter permease [KO:K23187]
L083_1564  hemin ABC superfamily ATP binding cassette transporter, ABC protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
L083_7099  iron-vibriobactin/enterobactin uptake porter [KO:K23188] [EC:7.2.2.17 7.2.2.-]
L083_4277  hypothetical protein [KO:K23227]
L083_4276  hypothetical protein [KO:K23228]
L083_4278  fepC; thiamine ABC transporter, ATP-binding protein [KO:K10829] [EC:7.2.2.16]
L083_1624  scbA; periplasmic solute binding protein [KO:K09815]
L083_1622  ABC-3 protein [KO:K09816]
L083_1623  mntB; ABC transporter [KO:K09817] [EC:7.2.2.20]
L083_4457  hypothetical protein [KO:K02009]
L083_4456  cbiM; cobalamin (vitamin B12) biosynthesis protein CbiM [KO:K02007]
L083_4458  cobalt ABC transporter, inner membrane subunit CbiQ [KO:K02008]
L083_4459  cobalt ABC transporter ATPase subunit [KO:K02006]
L083_1728  biotin synthase [KO:K03523]
L083_1615  cobalt transport protein [KO:K16785]
L083_0554  rfbA; ABC transporter [KO:K09692]
L083_0553  tagH; ABC transporter [KO:K09693] [EC:7.5.2.4]
L083_1656  ABC transporter [KO:K09694]
L083_1657  nodJ; ABC transporter [KO:K09694]
L083_1655  ABC transporter-like protein [KO:K09695]
L083_0679  ABC-2 type transporter [KO:K18233]
L083_3120  ABC transporter [KO:K18233]
L083_0678  daunorubicin resistance ABC transporter ATPase subunit [KO:K18232]
L083_3119  daunorubicin resistance ABC transporter ATPase subunit [KO:K18232]
L083_1190  hypothetical protein [KO:K09811]
L083_6513  hypothetical protein [KO:K09811]
L083_1189  ftsE; cell division ATP-binding protein ftse [KO:K09812]
L083_6458  multidrug ABC transporter ATPase/permease [KO:K18887]
L083_6459  multidrug ABC transporter ATPase/permease [KO:K18888]
L083_4662  ABC transporter ATP-binding protein [KO:K16012]
L083_4664  cydCD; cysteine ABC transporter permease/ATP-binding protein CydD [KO:K16013]
L083_4587  ABC transporter transmembrane protein, type 1 [KO:K16014]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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