KEGG PATHWAY: afm04138

KEGG

PATHWAY: afm04138

Entry

afm04138                    Pathway

Name

Autophagy - yeast - Aspergillus fumigatus

Description

Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.

Class

Cellular Processes; Transport and catabolism

Pathway map

Autophagy - yeast

Other DBs

GO:

Organism

Aspergillus fumigatus [GN:afm]

Gene

RAS small monomeric GTPase RasA [KO:K07827]

Ras small monomeric GTPase RasB [KO:K07827]

cAMP-dependent protein kinase catalytic subunit PkaC1 [KO:K04345] [EC:2.7.11.11]

cAMP-dependent protein kinase catalytic subunit, putative [KO:K04345] [EC:2.7.11.11]

serine/threonine protein kinase [KO:K21157] [EC:2.7.11.1]

carbon catabolite derepressing protein kinase Snf1, putative [KO:K12761] [EC:2.7.11.1]

serine/threonine protein kinase (Pdd7p) [KO:K08269] [EC:2.7.11.1]

autophagy protein Atg13 [KO:K08331]

kinase activator (Atg17) [KO:K08329]

autophagy protein Apg9 [KO:K17907]

autophagy regulatory protein Atg2 [KO:K17906]

protein-vacuolar targeting protein Atg18 [KO:K17908]

autophagy protein Atg27 [KO:K21141]

Taz1-interacting factor 1 (TAF1) [KO:K08330]

Arp2/3 complex subunit (Arp2) [KO:K17260]

Arp2/3 complex subunit (Arp3) [KO:K18584]

actin-related protein 2/3 complex subunit 1A [KO:K05757]

ARP2/3 complex 34 kDa subunit [KO:K05758]

ARP2/3 complex subunit Arc18 [KO:K05756]

ARP2/3 complex 20 kDa subunit (p20-ARC) [KO:K05755]

Arp2/3 complex subunit Arc16 [KO:K05754]

cAMP-dependent protein kinase-like [KO:K19800] [EC:2.7.11.1]

MAP kinase MpkA [KO:K04464] [EC:2.7.11.24]

serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]

serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]

serine palmitoyl CoA transferase subunit LcbA [KO:K00654] [EC:2.3.1.50]

TORC1 growth control complex subunit Kog1 [KO:K07204]

TOR pathway phosphatidylinositol 3-kinase TorA, putative [KO:K07203] [EC:2.7.11.1]

protein transport protein (LST8) [KO:K08266]

TOR signalling pathway regulator (TapA) [KO:K17606]

protein phosphatase 2A catalytic subunit Pph21, putative [KO:K04382] [EC:3.1.3.16]

TOR signalling pathway protein TipA [KO:K17607]

serine threonine protein kinase [KO:K12767] [EC:2.7.11.36]

protein kinase (Gcn2) [KO:K16196] [EC:2.7.11.1]

translation initiation factor 2 alpha subunit [KO:K03237]

G1/S-specific cyclin Pcl5 [KO:K21197]

autophagic death protein Aut7/IDI-7 [KO:K08341]

autophagy protein Apg6 [KO:K08334]

protein kinase (VPS15) [KO:K08333] [EC:2.7.11.1]

phosphoinositide 3-kinase [KO:K00914] [EC:2.7.1.137]

arginine metabolism regulation protein iii [KO:K00915] [EC:2.7.1.140 2.7.1.151]

inositol hexaphosphate kinase KCS1 [KO:K07756] [EC:2.7.4.21]

protein phosphatase [KO:K18083] [EC:3.1.3.64 3.1.3.95]

autophagy protein Apg12 [KO:K08336]

autophagy ubiquitin-activating enzyme ApgG [KO:K08337]

autophagy protein Apg5 [KO:K08339]

autophagocytosis protein Aut1 [KO:K08343]

autophagy cysteine endopeptidase Atg4 [KO:K08342] [EC:3.4.22.-]

SNARE complex subunit (Vam7) [KO:K08502]

vesicle transport v-snare protein [KO:K08493]

SNARE protein Ykt6 [KO:K08516]

vesicular fusion ATPase [KO:K06027] [EC:3.6.4.6]

vesicular-fusion protein sec17 [KO:K15296]

Rab small monomeric GTPase Rab7 [KO:K07897]

hypothetical protein [KO:K20195]

vacuolar protein sorting protein (VPS11) [KO:K20179]

vacuolar protein sorting vps16 [KO:K20180]

vacuolar protein sorting protein DigA [KO:K20181]

vacuolar sorting protein [KO:K20182]

TGF beta receptor associated protein 1 [KO:K20177]

Golgi complex component (Vps8) [KO:K20178]

vacuolar morphogenesis protein AvaB [KO:K20183]

vacuolar assembly protein [KO:K20184]

vacuolar protein sorting-associated protein VpsB [KO:K12479]

aspartic endopeptidase Pep2 [KO:K01381] [EC:3.4.23.25]

autophagy related lipase Atg15 [KO:K17900] [EC:3.1.1.3]

autophagy protein Atg22 [KO:K06902]

MFS transporter family protein [KO:K06902]

amino acid transporter [KO:K14209]

amino acid transporter [KO:K14209]

Compound

Phosphatidylethanolamine

1-Phosphatidyl-D-myo-inositol

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Klionsky DJ, Emr SD.

Title

Autophagy as a regulated pathway of cellular degradation.

Journal

Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717

Reference

Authors

Thompson AR, Vierstra RD.

Title

Autophagic recycling: lessons from yeast help define the process in plants.

Journal

Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013

Reference

Authors

Lum JJ, DeBerardinis RJ, Thompson CB.

Title

Autophagy in metazoans: cell survival in the land of plenty.

Journal

Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660

Reference

Authors

Reggiori F, Klionsky DJ.

Title

Autophagosomes: biogenesis from scratch?

Journal

Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007

Reference

Authors

Levine B, Yuan J.

Title

Autophagy in cell death: an innocent convict?

Journal

J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390

Reference

Authors

Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y

Title

Dynamics and diversity in autophagy mechanisms: lessons from yeast.

Journal

Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708

Reference

Authors

He C, Klionsky DJ

Title

Regulation mechanisms and signaling pathways of autophagy.

Journal

Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910

Reference

Authors

Yang Z, Klionsky DJ

Title

An overview of the molecular mechanism of autophagy.

Journal

Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1

Reference

Authors

Chen Y, Klionsky DJ

Title

The regulation of autophagy - unanswered questions.

Journal

J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576

Reference

Authors

Mizushima N, Yoshimori T, Ohsumi Y

Title

The role of Atg proteins in autophagosome formation.

Journal

Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005

Reference

Authors

Reggiori F, Klionsky DJ

Title

Autophagic processes in yeast: mechanism, machinery and regulation.

Journal

Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013

Reference

Authors

Jin M, Klionsky DJ

Title

Regulation of autophagy: modulation of the size and number of autophagosomes.

Journal

FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015

Reference

Authors

Noda NN, Fujioka Y

Title

Atg1 family kinases in autophagy initiation.

Journal

Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z

KO pathway

LinkDB

DBGET integrated database retrieval system