KEGG   PATHWAY: afv04138
Entry
afv04138                    Pathway                                
Name
Autophagy - yeast - Aspergillus flavus
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
afv04138  Autophagy - yeast
afv04138

Other DBs
GO: 0006914
Organism
Aspergillus flavus [GN:afv]
Gene
AFLA_000923  hypothetical protein [KO:K07827]
AFLA_008311  hypothetical protein [KO:K07827]
AFLA_005569  hypothetical protein [KO:K07827]
AFLA_005857  hypothetical protein [KO:K04345] [EC:2.7.11.11]
AFLA_009425  hypothetical protein [KO:K04345] [EC:2.7.11.11]
AFLA_005283  hypothetical protein [KO:K12761] [EC:2.7.11.1]
AFLA_006992  hypothetical protein [KO:K08269] [EC:2.7.11.1]
AFLA_001407  hypothetical protein [KO:K08331]
AFLA_006170  hypothetical protein [KO:K08329]
AFLA_011171  hypothetical protein [KO:K17907]
AFLA_001246  hypothetical protein [KO:K17906]
AFLA_009502  hypothetical protein [KO:K17908]
AFLA_004027  hypothetical protein [KO:K21141]
AFLA_000971  hypothetical protein [KO:K08330]
AFLA_002268  hypothetical protein [KO:K17260]
AFLA_005619  hypothetical protein [KO:K18584]
AFLA_001672  hypothetical protein [KO:K05757]
AFLA_003642  hypothetical protein [KO:K05758]
AFLA_000337  hypothetical protein [KO:K05756]
AFLA_009340  hypothetical protein [KO:K05755]
AFLA_001068  hypothetical protein [KO:K05754]
AFLA_012552  hypothetical protein [KO:K19800] [EC:2.7.11.1]
AFLA_011178  hypothetical protein [KO:K00654] [EC:2.3.1.50]
AFLA_008716  hypothetical protein [KO:K00654] [EC:2.3.1.50]
AFLA_010879  hypothetical protein [KO:K00654] [EC:2.3.1.50]
AFLA_005697  hypothetical protein [KO:K07204]
AFLA_008011  hypothetical protein [KO:K07203] [EC:2.7.11.1]
AFLA_002636  hypothetical protein [KO:K08266]
AFLA_009512  hypothetical protein [KO:K17606]
AFLA_001866  hypothetical protein [KO:K04382] [EC:3.1.3.16]
AFLA_008332  hypothetical protein [KO:K17607]
AFLA_002138  hypothetical protein [KO:K12767] [EC:2.7.11.36]
AFLA_004711  hypothetical protein [KO:K16196] [EC:2.7.11.1]
AFLA_002496  hypothetical protein [KO:K03237]
AFLA_001448  hypothetical protein [KO:K06655] [EC:2.7.11.22]
AFLA_010868  hypothetical protein [KO:K21197]
AFLA_002722  hypothetical protein [KO:K08341]
AFLA_003436  hypothetical protein [KO:K08334]
AFLA_006842  hypothetical protein [KO:K08333] [EC:2.7.11.1]
AFLA_010233  hypothetical protein [KO:K00914] [EC:2.7.1.137]
AFLA_005605  hypothetical protein [KO:K00915] [EC:2.7.1.140 2.7.1.151]
AFLA_009675  hypothetical protein [KO:K07756] [EC:2.7.4.21]
AFLA_010978  hypothetical protein [KO:K18083] [EC:3.1.3.64 3.1.3.95]
AFLA_012727  hypothetical protein [KO:K08336]
AFLA_012879  hypothetical protein [KO:K08337]
AFLA_002669  hypothetical protein [KO:K08339]
AFLA_005249  hypothetical protein [KO:K08343]
AFLA_010646  hypothetical protein [KO:K08342] [EC:3.4.22.-]
AFLA_005685  hypothetical protein [KO:K08502]
AFLA_000522  hypothetical protein [KO:K08493]
AFLA_006930  hypothetical protein [KO:K08516]
AFLA_003531  hypothetical protein [KO:K06027] [EC:3.6.4.6]
AFLA_005940  hypothetical protein [KO:K15296]
AFLA_009551  hypothetical protein [KO:K07897]
AFLA_001385  hypothetical protein [KO:K20195]
AFLA_006604  hypothetical protein [KO:K20179]
AFLA_009719  hypothetical protein [KO:K20180]
AFLA_010761  hypothetical protein [KO:K20181]
AFLA_006074  hypothetical protein [KO:K20182]
AFLA_007779  hypothetical protein [KO:K20177]
AFLA_000858  hypothetical protein [KO:K20178]
AFLA_003233  hypothetical protein [KO:K20183]
AFLA_001016  hypothetical protein [KO:K20184]
AFLA_004542  hypothetical protein [KO:K12479]
AFLA_000995  hypothetical protein [KO:K01381] [EC:3.4.23.25]
AFLA_012491  hypothetical protein [KO:K01381] [EC:3.4.23.25]
AFLA_007935  hypothetical protein [KO:K17900] [EC:3.1.1.3]
AFLA_002005  hypothetical protein [KO:K06902]
AFLA_012867  hypothetical protein [KO:K06902]
AFLA_005143  hypothetical protein [KO:K14209]
AFLA_007141  hypothetical protein [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:15752997
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:19491929
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:23733851
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
PMID:24928445
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   
LinkDB

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