KEGG   PATHWAY: azr02010
Entry
azr02010                    Pathway                                
Name
ABC transporters - Azoarcus sp. DD4
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
azr02010  ABC transporters
azr02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Azoarcus sp. DD4 [GN:azr]
Gene
CJ010_08390  thiosulfate transporter subunit [KO:K02048]
CJ010_14445  sulfate transporter subunit [KO:K23163]
CJ010_11205  sulfate transporter subunit [KO:K23163]
CJ010_08385  cysT; sulfate ABC transporter permease subunit CysT [KO:K02046]
CJ010_08380  cysW; sulfate ABC transporter permease subunit CysW [KO:K02047]
CJ010_08375  sulfate ABC transporter ATP-binding protein [KO:K02045] [EC:7.3.2.3]
CJ010_24090  tungsten ABC transporter substrate-binding protein [KO:K05772]
CJ010_24150  tungsten ABC transporter permease [KO:K05772]
CJ010_18280  ABC transporter permease [KO:K05773]
CJ010_18275  ABC transporter ATP-binding protein [KO:K06857] [EC:7.3.2.6]
CJ010_22135  nitrate ABC transporter substrate-binding protein [KO:K15576]
CJ010_05640  nitrate transporter [KO:K15576]
CJ010_22130  ntrB; nitrate ABC transporter, permease protein [KO:K15577]
CJ010_05645  ntrB; nitrate ABC transporter, permease protein [KO:K15577]
CJ010_22125  nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein [KO:K15578] [EC:7.3.2.4]
CJ010_05650  nitrate ABC transporter ATP-binding protein [KO:K15578] [EC:7.3.2.4]
CJ010_14975  aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553]
CJ010_14985  sulfonate ABC transporter substrate-binding protein [KO:K15553]
CJ010_21985  ABC transporter substrate-binding protein [KO:K15553]
CJ010_14970  ssuC; alkanesulfonate transporter permease subunit [KO:K15554]
CJ010_21980  ABC transporter permease [KO:K15554]
CJ010_14965  hypothetical protein [KO:K15555] [EC:7.6.2.14]
CJ010_21975  sulfonate ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
CJ010_24130  modA; molybdate ABC transporter substrate-binding protein [KO:K02020]
CJ010_24170  modA; molybdate ABC transporter substrate-binding protein [KO:K02020]
CJ010_24125  modB; molybdate ABC transporter permease subunit [KO:K02018]
CJ010_24165  molybdate ABC transporter permease subunit [KO:K02018]
CJ010_24120  modC; molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
CJ010_24145  molybdenum ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
CJ010_22175  iron ABC transporter substrate-binding protein [KO:K02012]
CJ010_13955  Fe(3+) ABC transporter substrate-binding protein [KO:K02012]
CJ010_07265  iron ABC transporter substrate-binding protein [KO:K02012]
CJ010_22185  ABC transporter permease [KO:K02011]
CJ010_13960  iron ABC transporter permease [KO:K02011]
CJ010_22180  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
CJ010_13965  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
CJ010_12105  ABC transporter [KO:K10111] [EC:7.5.2.-]
CJ010_12090  ABC transporter substrate-binding protein [KO:K10236]
CJ010_12095  ABC transporter permease [KO:K10237]
CJ010_12100  sugar ABC transporter permease [KO:K10238]
CJ010_04950  hypothetical protein [KO:K07323]
CJ010_03715  hypothetical protein [KO:K07323]
CJ010_07720  ABC transporter permease [KO:K02067]
CJ010_04940  mlaD; outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067]
CJ010_11830  organic solvent ABC transporter substrate-binding protein [KO:K02067]
CJ010_07730  ABC transporter permease [KO:K02066]
CJ010_04935  ABC transporter permease [KO:K02066]
CJ010_11820  ABC transporter permease [KO:K02066]
CJ010_04955  NTP-binding protein [KO:K07122]
CJ010_07725  ABC transporter ATP-binding protein [KO:K02065]
CJ010_04930  ABC transporter ATP-binding protein [KO:K02065]
CJ010_11825  ABC transporter ATP-binding protein [KO:K02065]
CJ010_01340  BMP family ABC transporter substrate-binding protein [KO:K07335]
CJ010_24885  BMP family ABC transporter substrate-binding protein [KO:K07335]
CJ010_07140  BMP family ABC transporter substrate-binding protein [KO:K07335]
CJ010_14020  BMP family ABC transporter substrate-binding protein [KO:K07335]
CJ010_24880  ABC transporter permease [KO:K23535]
CJ010_14010  sugar ABC transporter permease [KO:K23535]
CJ010_24875  ABC transporter permease [KO:K23536]
CJ010_14015  ABC transporter permease [KO:K23536]
CJ010_24865  ABC transporter ATP-binding protein [KO:K23537]
CJ010_14005  ABC transporter [KO:K23537]
CJ010_12035  ABC transporter [KO:K10439]
CJ010_12040  ribose ABC transporter permease [KO:K10440]
CJ010_12045  D-xylose ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
CJ010_08675  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
CJ010_02175  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
CJ010_08680  pstC; phosphate ABC transporter permease subunit PstC [KO:K02037]
CJ010_08685  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
CJ010_08690  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
CJ010_02935  amino acid ABC transporter substrate-binding protein [KO:K10001]
CJ010_02925  amino acid ABC transporter permease [KO:K10002]
CJ010_02930  glutamate ABC transporter permease [KO:K10003]
CJ010_02920  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
CJ010_08365  amino acid ABC transporter substrate-binding protein [KO:K09969]
CJ010_08360  hypothetical protein [KO:K09970]
CJ010_08355  amino acid ABC transporter permease [KO:K09971]
CJ010_08590  amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_22055  ABC transporter substrate-binding protein [KO:K01999]
CJ010_15725  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_18875  ABC transporter permease [KO:K01999]
CJ010_00905  ABC transporter permease [KO:K01999]
CJ010_01945  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_15335  hypothetical protein [KO:K01999]
CJ010_20970  ABC transporter permease [KO:K01999]
CJ010_24060  amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_07325  ABC transporter substrate-binding protein [KO:K01999]
CJ010_02335  ABC transporter substrate-binding protein [KO:K01999]
CJ010_02390  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_06780  ABC transporter substrate-binding protein [KO:K01999]
CJ010_12920  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_12955  ABC transporter substrate-binding protein [KO:K01999]
CJ010_22735  branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_22740  branched chain amino acid ABC transporter substrate-binding protein [KO:K01999]
CJ010_22050  ABC transporter permease [KO:K01997 K01998]
CJ010_15740  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_18870  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_00910  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_01950  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_15340  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_24070  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_20980  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_07320  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_02340  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_06760  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_12925  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_12960  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_22745  branched-chain amino acid ABC transporter permease [KO:K01997]
CJ010_15735  metal-dependent hydrolase [KO:K01995 K01998]
CJ010_01955  metal-dependent hydrolase [KO:K01995 K01998]
CJ010_12930  metal-dependent hydrolase [KO:K01995 K01998]
CJ010_00915  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_15345  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_24065  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_20975  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_02345  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_06765  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_07315  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_12965  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_22750  ABC transporter ATP-binding protein [KO:K01998]
CJ010_18865  branched-chain amino acid ABC transporter permease [KO:K01998]
CJ010_22045  ABC transporter ATP-binding protein [KO:K01995]
CJ010_18860  ABC transporter ATP-binding protein [KO:K01995]
CJ010_00895  ABC transporter ATP-binding protein [KO:K01995]
CJ010_15350  ABC transporter ATP-binding protein [KO:K01995]
CJ010_07310  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
CJ010_02350  ABC transporter ATP-binding protein [KO:K01995]
CJ010_06770  ABC transporter ATP-binding protein [KO:K01995]
CJ010_12970  ABC transporter ATP-binding protein [KO:K01995]
CJ010_20985  ABC transporter ATP-binding protein [KO:K01995]
CJ010_22755  ABC transporter ATP-binding protein [KO:K01995]
CJ010_00900  ABC transporter ATP-binding protein [KO:K01996]
CJ010_15355  ABC transporter ATP-binding protein [KO:K01996]
CJ010_15730  ABC transporter ATP-binding protein [KO:K01996]
CJ010_01960  ABC transporter ATP-binding protein [KO:K01996]
CJ010_20965  ABC transporter ATP-binding protein [KO:K01996]
CJ010_02355  ABC transporter ATP-binding protein [KO:K01996]
CJ010_06775  ABC transporter ATP-binding protein [KO:K01996]
CJ010_07305  ABC transporter ATP-binding protein [KO:K01996]
CJ010_22040  ABC transporter ATP-binding protein [KO:K01996]
CJ010_12935  ABC transporter ATP-binding protein [KO:K01996]
CJ010_12975  ABC transporter ATP-binding protein [KO:K01996]
CJ010_22760  ABC transporter ATP-binding protein [KO:K01996]
CJ010_18855  ABC transporter ATP-binding protein [KO:K01996]
CJ010_17140  metal ABC transporter substrate-binding protein [KO:K02073]
CJ010_17135  methionine ABC transporter ATP-binding protein [KO:K02072]
CJ010_17130  ABC transporter [KO:K02071]
CJ010_04255  urtA; urea ABC transporter substrate-binding protein [KO:K11959]
CJ010_04260  urtB; urea ABC transporter permease subunit UrtB [KO:K11960]
CJ010_04265  urtC; urea ABC transporter permease subunit UrtC [KO:K11961]
CJ010_04270  urtD; urea ABC transporter ATP-binding protein UrtD [KO:K11962]
CJ010_04275  urtE; urea ABC transporter ATP-binding subunit UrtE [KO:K11963]
CJ010_07465  manganese transporter [KO:K11707]
CJ010_07475  manganese transporter [KO:K11708]
CJ010_07480  zinc ABC transporter permease [KO:K11709]
CJ010_07470  manganese ABC transporter ATP-binding protein [KO:K11710] [EC:7.2.2.5]
CJ010_14040  cobalamin biosynthesis protein CbiM [KO:K02007]
CJ010_14045  hypothetical protein [KO:K02008]
CJ010_14050  cobalt ABC transporter ATP-binding protein [KO:K02006]
CJ010_14030  cobalt transporter [KO:K10094]
CJ010_14035  hypothetical protein [KO:K16915]
CJ010_21800  ABC transporter permease [KO:K09690]
CJ010_21795  sugar ABC transporter ATP-binding protein [KO:K09691] [EC:7.5.2.14]
CJ010_02235  nodulation protein NodJ [KO:K09694]
CJ010_02290  nodulation factor ABC transporter ATP-binding protein NodI [KO:K09695]
CJ010_09300  lipoprotein-releasing system transmembrane subunit LolC [KO:K09808]
CJ010_09305  lolD; lipoprotein-releasing system ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
CJ010_24660  ccmD; heme exporter protein CcmD [KO:K02196]
CJ010_24665  heme ABC transporter permease [KO:K02195]
CJ010_24670  ccmB; heme exporter protein CcmB [KO:K02194]
CJ010_24675  heme ABC exporter ATP-binding protein CcmA [KO:K02193] [EC:7.6.2.5]
CJ010_18175  lptF; LPS export ABC transporter permease LptF [KO:K07091]
CJ010_18170  lptG; LPS export ABC transporter permease LptG [KO:K11720]
CJ010_03395  lptB; LPS export ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
CJ010_19215  hypothetical protein [KO:K19341]
CJ010_19220  copper ABC transporter ATP-binding protein [KO:K19340]
CJ010_04745  cell division protein FtsX [KO:K09811]
CJ010_04740  cell division ATP-binding protein FtsE [KO:K09812]
CJ010_14855  msbA; lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
CJ010_21620  msbA; lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
CJ010_10080  peptidase C39 [KO:K11004]
CJ010_02960  metal ABC transporter permease [KO:K24821]
CJ010_04190  multidrug ABC transporter ATP-binding protein [KO:K18893]
CJ010_04115  type I secretion system permease/ATPase [KO:K12541]
CJ010_03945  macrolide ABC transporter permease/ATP-binding protein MacB [KO:K05685] [EC:7.6.2.-]
CJ010_14840  ABC transporter [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
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