KEGG   PATHWAY: bbrc02010
Entry
bbrc02010                   Pathway                                
Name
ABC transporters - Bifidobacterium breve JCM 7019
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bbrc02010  ABC transporters
bbrc02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bifidobacterium breve JCM 7019 [GN:bbrc]
Gene
B7019_2077  ATP-binding protein of ABC transporter system for sugars [KO:K10112] [EC:7.5.2.-]
B7019_0115  Maltose/maltodextrin-binding protein [KO:K15770]
B7019_0116  Maltodextrin transport system permease protein malC [KO:K15771]
B7019_0117  Maltose transport system permease protein malG [KO:K15772]
B7019_2051  Solute binding protein of ABC transporter system for sugars [KO:K10117]
B7019_2053  Solute binding protein of ABC transporter system for sugars [KO:K10117]
B7019_2058  Raffinose-binding protein [KO:K10117]
B7019_2050  Permease protein of ABC transporter system for sugars [KO:K10118]
B7019_2057  Raffinose transport system permease protein [KO:K10118]
B7019_2049  Permease protein of ABC transporter system for sugars [KO:K10119]
B7019_2056  Raffinose transport system permease protein [KO:K10119]
B7019_0272  Solute-binding protein of ABC transporter system for sugars, galactan metabolism [KO:K10188]
B7019_0273  Permease protein of ABC transporter system [KO:K10189]
B7019_0274  Sugar ABC transporter, permease protein [KO:K10190]
B7019_0848  Solute binding protein of ABC transporter system for sugars [KO:K17318]
B7019_0846  Permease protein of ABC transporter system for sugars [KO:K17319]
B7019_0847  Permease protein of ABC transporter system for sugars [KO:K17320]
B7019_1216  Sugar-binding protein [KO:K17244]
B7019_1215  Sugar transport system permease protein [KO:K17245]
B7019_1214  Transporter [KO:K17246]
B7019_2024  Sugar-binding protein of ABC transporter system [KO:K10439]
B7019_2022  ABC sugar transport system, permease protein [KO:K10440]
B7019_2023  ABC sugar transport system, ATP-binding protein [KO:K10441] [EC:7.5.2.7]
B7019_1860  Phosphate-binding protein [KO:K02040]
B7019_1859  Phosphate transport system permease protein pstC [KO:K02037]
B7019_1858  Phosphate transport system permease protein pstA [KO:K02038]
B7019_1857  Phosphate transport ATP-binding protein pstB [KO:K02036] [EC:7.3.2.1]
B7019_1533  Glutamate-binding protein gluB [KO:K10005]
B7019_1200  putative solute binding protein of ABC transporter system [KO:K10005]
B7019_1532  Glutamate transport system permease protein gluC [KO:K10006]
B7019_1531  Glutamate transport system permease protein gluD [KO:K10007]
B7019_1534  Glutamate transport ATP-binding protein gluA [KO:K10008] [EC:7.4.2.1]
B7019_1928  Solute binding protein of ABC transporter system for amino acids [KO:K16957]
B7019_1929  Permease protein of ABC transporter system for amino acids [KO:K16958]
B7019_1930  Permease protein of ABC transporter system for amino acids [KO:K16959]
B7019_1932  ATP-binding protein of ABC transporter system for amino acids [KO:K16960] [EC:7.4.2.1]
B7019_1674  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
B7019_1673  Branched-chain amino acid transport system permease protein livH [KO:K01997]
B7019_1672  Branched-chain amino acid transport system permease protein livM [KO:K01998]
B7019_1671  Branched-chain amino acid transport ATP-binding protein livG [KO:K01995]
B7019_1670  Branched-chain amino acid transport ATP-binding protein livF [KO:K01996]
B7019_0764  Solute-binding protein of ABC transporter system [KO:K02073]
B7019_0766  Permease protein of ABC transporter system [KO:K02072]
B7019_0765  ATP-binding protein of ABC transporter system [KO:K02071]
B7019_1302  Oligopeptide-binding protein oppA [KO:K15580]
B7019_0521  Solute-binding protein of ABC transporter system for peptides [KO:K15580]
B7019_1021  Solute binding protein of ABC transporter system for peptides [KO:K15580]
B7019_1301  Oligopeptide transport system permease protein oppB [KO:K15581]
B7019_1300  Oligopeptide transport system permease protein oppC [KO:K15582]
B7019_1299  Oligopeptide transport ATP-binding protein oppD [KO:K10823 K15583]
B7019_2000  Oligopeptide-binding protein oppA [KO:K13889]
B7019_2003  Oligopeptide transport system permease protein oppB [KO:K13890]
B7019_2002  Oligopeptide transport system permease protein oppC [KO:K13891]
B7019_2001  Oligopeptide transport ATP-binding protein oppD [KO:K13892]
B7019_1888  BioY protein [KO:K03523]
B7019_0637  ATP-binding protein of ABC transporter system [KO:K16784] [EC:7.6.2.-]
B7019_0650  Permease protein of ABC transporter system, probably involved in thiamine metabolism [KO:K16785]
B7019_1185  hypothetical protein [KO:K20460]
B7019_1186  hypothetical protein [KO:K20461]
B7019_1184  bacitracin ABC transporter ATP-binding protein [KO:K20459]
B7019_0477  Cell division protein ftsX [KO:K09811]
B7019_0476  Cell division ATP-binding protein ftsE [KO:K09812]
B7019_1996  ATP-binding and permease protein of ABC multidrug transporter system [KO:K18889]
B7019_1995  ATP-binding and permease protein of ABC multidrug transporter system [KO:K18890]
B7019_2012  ATP-binding and permease protein of ABC transporter system [KO:K18887]
B7019_1606  ATP-binding protein of ABC transporter system [KO:K18887]
B7019_1605  ATP-binding protein of ABC transporter system [KO:K18888]
B7019_2011  ATP-binding and permease protein of ABC transporter system [KO:K18888]
B7019_0379  ATP-binding and permeaase modules of ABC transporter system [KO:K16014]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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