PATHWAY: bch02010 Help
Entry
Name
ABC transporters - Burkholderia cenocepacia HI2424
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
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Organism
Burkholderia cenocepacia HI2424 [GN:
bch ]
Gene
Bcen2424_6753 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Bcen2424_4250 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Bcen2424_4671 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Bcen2424_4014 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Bcen2424_1545 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Bcen2424_6201 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Bcen2424_6597 ABC nitrate/sulfonate/bicarbonate transporter, periplasmic ligand binding protein [KO:K15553 ]
Bcen2424_4022 ABC nitrate/sulfonate/bicarbonate family transporter, periplasmic ligand binding protein [KO:K15553 ]
Bcen2424_3529 ABC nitrate/sulfonate/bicarbonate family transporter, periplasmic ligand binding protein [KO:K15553 ]
Bcen2424_4026 ABC nitrate/sulfonate/bicarbonate family transporter, periplasmic ligand binding protein [KO:K15553 ]
Bcen2424_4434 aliphatic sulfonates family ABC transporter, periplasmic ligand-binding protein [KO:K15553 ]
Bcen2424_0034 ABC nitrate/sulfonate/bicarbonate transporter, periplasmic ligand binding protein [KO:K15553 ]
Bcen2424_4254 ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic component [KO:K15553 ]
Bcen2424_3590 ABC nitrate/sulfonate/bicarbonate transporter, periplasmic ligand binding protein [KO:K15553 ]
Bcen2424_1974 nitrate ABC transporter, periplasmic nitrate-binding protein, putative [KO:K15553 ]
Bcen2424_5052 Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002 ]
Bcen2424_5071 Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002 ]
Bcen2424_5076 Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002 ]
Bcen2424_5169 Substrate-binding region of ABC-type glycine betaine transport system [KO:K02002 ]
Bcen2424_6100 Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845 ]
Bcen2424_5141 Substrate-binding region of ABC-type glycine betaine transport system [KO:K05845 ]
Bcen2424_5656 carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10111 ] [EC:7.5.2.-]
Bcen2424_2591 mannitol ABC transporter ATP-binding protein / sorbitol ABC transporter ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
Bcen2424_3284 carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10111 ] [EC:7.5.2.-]
Bcen2424_6306 carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112 ] [EC:7.5.2.-]
Bcen2424_0971 carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112 ] [EC:7.5.2.-]
Bcen2424_5796 carbohydrate ABC transporter ATP-binding protein, CUT1 family [KO:K10112 ] [EC:7.5.2.-]
Bcen2424_2594 mannitol ABC transporter membrane protein / sorbitol ABC transporter membrane protein [KO:K10228 ]
Bcen2424_2593 mannitol ABC transporter membrane protein / sorbitol ABC transporter membrane protein [KO:K10229 ]
Bcen2424_5037 monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439 ]
Bcen2424_6707 monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439 ]
Bcen2424_1541 monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439 ]
Bcen2424_1606 monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439 ]
Bcen2424_4820 monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K10439 ]
Bcen2424_5992 monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K23508 ]
Bcen2424_1424 monosaccharide ABC transporter substrate-binding protein, CUT2 family [KO:K17213 ]
Bcen2424_0671 L-aspartate ABC transporter membrane protein / L-glutamate ABC transporter membrane protein [KO:K10002 ]
Bcen2424_0670 L-aspartate ABC transporter membrane protein / L-glutamate ABC transporter membrane protein [KO:K10003 ]
Bcen2424_0672 L-glutamate ABC transporter ATP-binding protein / L-aspartate ABC transporter ATP-binding protein [KO:K10004 ] [EC:7.4.2.1 ]
Bcen2424_0278 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_2255 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_0089 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_0085 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_0114 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_1165 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_2477 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_4095 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_3474 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_5019 L-isoleucine-binding protein / L-leucine-binding protein / L-valine-binding protein [KO:K01999 ]
Bcen2424_6092 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_3583 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_6643 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_3492 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_4359 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_6148 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_5315 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_5309 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_6393 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K01999 ]
Bcen2424_5018 L-valine ABC transporter membrane protein / L-isoleucine ABC transporter membrane protein / L-leucine ABC transporter membrane protein [KO:K01997 ]
Bcen2424_3584 amino acid/amide ABC transporter membrane protein 1, HAAT family / amino acid/amide ABC transporter membrane protein 2, HAAT family [KO:K01997 K01998 ]
Bcen2424_0091 amino acid/amide ABC transporter membrane protein 2, HAAT family / amino acid/amide ABC transporter ATP-binding protein 1, HAAT family [KO:K01995 K01998 ]
Bcen2424_5017 L-leucine ABC transporter membrane protein / L-valine ABC transporter membrane protein / L-isoleucine ABC transporter membrane protein [KO:K01998 ]
Bcen2424_5016 L-leucine ABC transporter ATP-binding protein / L-valine ABC transporter ATP-binding protein / L-isoleucine ABC transporter ATP-binding protein [KO:K01995 ]
Bcen2424_5015 L-leucine ABC transporter ATP-binding protein / L-isoleucine ABC transporter ATP-binding protein / L-valine ABC transporter ATP-binding protein [KO:K01996 ]
Bcen2424_0910 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K11959 ]
Bcen2424_4636 amino acid/amide ABC transporter substrate-binding protein, HAAT family [KO:K11959 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
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