KEGG   PATHWAY: bld01210
Entry
bld01210                    Pathway                                
Name
2-Oxocarboxylic acid metabolism - Bacillus licheniformis DSM 13 = ATCC 14580
Description
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea.
Class
Pathway map
bld01210  2-Oxocarboxylic acid metabolism
bld01210

Module
bld_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:bld01210]
bld_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:bld01210]
bld_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:bld01210]
bld_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:bld01210]
bld_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:bld01210]
bld_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:bld01210]
Organism
Bacillus licheniformis DSM 13 = ATCC 14580 [GN:bld]
Related
pathway
bld00020  Citrate cycle (TCA cycle)
bld00220  Arginine biosynthesis
bld00250  Alanine, aspartate and glutamate metabolism
bld00260  Glycine, serine and threonine metabolism
bld00270  Cysteine and methionine metabolism
bld00290  Valine, leucine and isoleucine biosynthesis
bld00300  Lysine biosynthesis
bld00310  Lysine degradation
bld00620  Pyruvate metabolism
bld00640  Propanoate metabolism
bld00680  Methane metabolism
KO pathway
ko01210   
LinkDB

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