KEGG   PATHWAY: bmal03070
Entry
bmal03070                   Pathway                                
Name
Bacterial secretion system - Burkholderia mallei 23344
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
bmal03070  Bacterial secretion system
bmal03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia mallei 23344 [GN:bmal]
Gene
DM55_862  outer membrane efflux family protein [KO:K12340]
DM55_4879  eprI; type III secretion apparatus needle protein [KO:K03221]
DM55_4929  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
DM55_3217  secretory of YscJ/FliF family protein [KO:K03222]
DM55_3211  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
DM55_3210  type III secretion , HrpO family protein [KO:K03227]
DM55_3222  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
DM55_3214  type III secretion , YscU/HrpY family protein [KO:K03229]
DM55_3213  type III secretion , HrcV family protein [KO:K03230]
DM55_4874  invA; invasion protein invA [KO:K03230]
DM55_3220  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
DM55_3212  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
DM55_4869  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
DM55_3219  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
DM55_1142  gspD; type II secretion system protein D [KO:K02453]
DM55_1145  type IV pilus biogenesis family protein [KO:K02452]
DM55_1144  gspF; type II secretion system protein F [KO:K02455]
DM55_1146  gspG; type II secretion system protein G [KO:K02456]
DM55_1147  gspH; type II secretion system protein H [KO:K02457]
DM55_1148  gspI; type II secretion system protein I [KO:K02458]
DM55_1149  putative general secretion pathway protein J [KO:K02459]
DM55_1150  type II secretion system (T2SS), K family protein [KO:K02460]
DM55_1151  gspL; type II secretion system protein L [KO:K02461]
DM55_1152  type II secretion system (T2SS), M family protein [KO:K02462]
DM55_1143  gspE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
DM55_4934  type II/IV secretion system family protein [KO:K02454] [EC:7.4.2.8]
DM55_1402  secD; export membrane protein SecD [KO:K03072]
DM55_1403  secF; export membrane protein SecF [KO:K03074]
DM55_1282  secE; preprotein translocase, SecE subunit [KO:K03073]
DM55_2605  secG; preprotein translocase, SecG subunit [KO:K03075]
DM55_1317  secY; preprotein translocase, SecY subunit [KO:K03076]
DM55_1401  yajC; preprotein translocase, YajC subunit [KO:K03210]
DM55_396  yidC; membrane protein insertase, YidC/Oxa1 family [KO:K03217]
DM55_735  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
DM55_1068  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
DM55_826  secB; protein-export chaperone SecB [KO:K03071]
DM55_707  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
DM55_1221  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03116]
DM55_1220  tatB; twin arginine-targeting protein translocase TatB [KO:K03117]
DM55_1219  tatC; twin arginine-targeting protein translocase TatC [KO:K03118]
DM55_3886  Rhs element Vgr family protein [KO:K11904]
DM55_4705  Rhs element Vgr family protein [KO:K11904]
DM55_3338  Rhs element Vgr family protein [KO:K11904]
DM55_4028  Rhs element Vgr family protein [KO:K11904]
DM55_4029  Rhs element Vgr family protein [KO:K11904]
DM55_4251  Rhs element Vgr family protein [KO:K11904]
DM55_3875  type VI secretion system effector, Hcp1 family protein [KO:K11903]
DM55_4700  type VI secretion system effector, Hcp1 family protein [KO:K11903]
DM55_4023  hypothetical protein [KO:K11903]
DM55_3874  type VI secretion lipofamily protein [KO:K11906]
DM55_3352  type VI secretion lipofamily protein [KO:K11906]
DM55_4034  type VI secretion lipofamily protein [KO:K11906]
DM55_3871  intracellular multiplication and macrophage-killing family protein [KO:K11891]
DM55_4713  hypothetical protein [KO:K11891]
DM55_3349  intracellular multiplication and macrophage-killing family protein [KO:K11891]
DM55_865  intracellular multiplication and macrophage-killing family protein [KO:K11891]
DM55_4038  intracellular multiplication and macrophage-killing family protein [KO:K11891]
DM55_3872  type VI secretion system OmpA/MotB family protein [KO:K11892]
DM55_4712  type IV/VI secretion system , DotU family domain protein [KO:K11892]
DM55_3350  type VI secretion system OmpA/MotB family protein [KO:K11892]
DM55_4037  type IV/VI secretion system , DotU family domain protein [KO:K11892]
DM55_3878  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
DM55_4704  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
DM55_3339  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
DM55_869  AAA domain family protein [KO:K11907]
DM55_4027  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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