KEGG   PATHWAY: bmec03070
Entry
bmec03070                   Pathway                                
Name
Bacterial secretion system - Burkholderia metallica
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
bmec03070  Bacterial secretion system
bmec03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia metallica [GN:bmec]
Gene
WJ16_06380  channel protein TolC [KO:K12340]
WJ16_28060  RND transporter [KO:K12340]
WJ16_28900  secretin [KO:K03219]
WJ16_28880  type III secretion protein [KO:K03222]
WJ16_28825  ssaR; type III secretion system protein SsaR [KO:K03226]
WJ16_28905  type III secretion protein HrpO [KO:K03227]
WJ16_28855  type III secretion system protein [KO:K03228]
WJ16_28850  type III secretion protein [KO:K03229]
WJ16_28910  type III secretion protein [KO:K03230]
WJ16_28865  fliI; type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
WJ16_28820  type III secretion protein [KO:K03225]
WJ16_28870  serine kinase [KO:K03223]
WJ16_00320  type II secretion system protein GspD [KO:K02453]
WJ16_00305  general secretion pathway protein GspC [KO:K02452]
WJ16_00310  type II secretion system protein GspF [KO:K02455]
WJ16_00300  type II secretion system protein GspG [KO:K02456]
WJ16_00295  type II secretion system protein GspH [KO:K02457]
WJ16_00290  type II secretion system protein GspI [KO:K02458]
WJ16_00285  general secretion pathway protein GspJ [KO:K02459]
WJ16_00280  general secretion pathway protein GspK [KO:K02460]
WJ16_00275  type II secretion system protein GspL [KO:K02461]
WJ16_00270  general secretion pathway protein GspM [KO:K02462]
WJ16_00315  type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
WJ16_03210  preprotein translocase subunit SecD [KO:K03072]
WJ16_03205  preprotein translocase subunit SecF [KO:K03074]
WJ16_01300  preprotein translocase subunit SecE [KO:K03073]
WJ16_11705  preprotein translocase subunit SecG [KO:K03075]
WJ16_01470  secY; preprotein translocase subunit SecY [KO:K03076]
WJ16_03215  preprotein translocase subunit YajC [KO:K03210]
WJ16_16055  insertase [KO:K03217]
WJ16_02465  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
WJ16_14315  signal recognition particle-docking protein FtsY [KO:K03110]
WJ16_14535  preprotein translocase subunit SecB [KO:K03071]
WJ16_02575  signal recognition particle [KO:K03106] [EC:3.6.5.4]
WJ16_01815  tatA; preprotein translocase subunit SecA [KO:K03116]
WJ16_01820  tatB; preprotein translocase [KO:K03117]
WJ16_01825  twin-arginine protein translocation system subunit TatC [KO:K03118]
WJ16_28830  lytic transglycosylase [KO:K03194]
WJ16_06305  type VI secretion protein Vgr [KO:K11904]
WJ16_00100  hypothetical protein [KO:K11904]
WJ16_01895  Rhs element Vgr protein [KO:K11904]
WJ16_30350  type IV secretion protein Rhs [KO:K11904]
WJ16_17395  type VI secretion protein ImpA [KO:K11904]
WJ16_21370  type VI secretion protein [KO:K11904]
WJ16_28255  type IV secretion protein Rhs [KO:K11904]
WJ16_22940  type VI secretion protein Vgr [KO:K11904]
WJ16_21970  type IV secretion protein Rhs [KO:K11904]
WJ16_11345  type IV secretion protein Rhs [KO:K11904]
WJ16_01995  type VI secretion protein ImpA [KO:K11904]
WJ16_20085  type VI secretion protein [KO:K11904]
WJ16_01965  hypothetical protein [KO:K11903]
WJ16_17380  Hcp1 family type VI secretion system effector [KO:K11903]
WJ16_22910  Hcp family T6SS protein CtsH1 [KO:K11903]
WJ16_01945  hypothetical protein [KO:K11906]
WJ16_30305  type VI secretion protein [KO:K11906]
WJ16_17385  hypothetical protein [KO:K11906]
WJ16_28230  hypothetical protein [KO:K11906]
WJ16_22990  type VI secretion protein [KO:K11906]
WJ16_02040  type VI secretion protein VasK [KO:K11891]
WJ16_30320  type VI secretion protein VasK [KO:K11891]
WJ16_17430  type VI secretion protein VasK [KO:K11891]
WJ16_28240  type VI secretion protein VasK [KO:K11891]
WJ16_22970  type VI secretion protein VasK [KO:K11891]
WJ16_01935  type VI secretion system protein ImpK [KO:K11892]
WJ16_30365  DotU family type IV / VI secretion system protein [KO:K11892]
WJ16_17425  hypothetical protein [KO:K11892]
WJ16_17435  type IV secretion protein DotU [KO:K11892]
WJ16_22920  type IV secretion protein DotU [KO:K11892]
WJ16_01985  ClpV1 family T6SS ATPase [KO:K11907]
WJ16_17365  ClpV1 family T6SS ATPase [KO:K11907]
WJ16_22905  ClpV1 family T6SS ATPase [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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