KEGG   PATHWAY: bpeu02010
Entry
bpeu02010                   Pathway                                
Name
ABC transporters - Bordetella pertussis 137
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bpeu02010  ABC transporters
bpeu02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bordetella pertussis 137 [GN:bpeu]
Gene
Q425_9020  sbp; sulfate-binding protein [KO:K23163]
Q425_9050  cysA; sulfate transport ATP-binding protein [KO:K02045] [EC:7.3.2.3]
Q425_13460  hypothetical protein [KO:K05772]
Q425_13450  ABC transporter ATP-binding protein [KO:K06857] [EC:7.3.2.6]
Q425_37730  taurine ABC transporter substrate-binding protein [KO:K15551]
Q425_37720  ABC transporter permease [KO:K15552]
Q425_38660  hypothetical protein [KO:K15553]
Q425_39040  taurine ABC transporter substrate-binding protein [KO:K15553]
Q425_39020  ABC transporter permease [KO:K15554]
Q425_38640  ABC transporter permease [KO:K15554]
Q425_39030  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
Q425_38650  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
Q425_30790  modB; molybdate ABC transporter substrate-binding protein [KO:K02020]
Q425_30800  modC; molybdenum transport system permease [KO:K02018]
Q425_30810  modD; molybdenum transport ATP-binding protein [KO:K02017] [EC:7.3.2.5]
Q425_16360  iron ABC transporter substrate-binding protein [KO:K02012]
Q425_17840  iron binding protein [KO:K02012]
Q425_20670  ABC transporter substrate-binding protein [KO:K02012]
Q425_16390  regulatory lipoprotein [KO:K02012]
Q425_17830  binding-protein-dependent transport system inner membrane protein [KO:K02011]
Q425_13250  ABC transporter permease [KO:K02011]
Q425_20680  ABC transporter substrate-binding protein [KO:K02011]
Q425_16340  ABC transporter permease [KO:K02011]
Q425_13240  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
Q425_20690  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
Q425_16330  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
Q425_22800  putrescine ABC transporter [KO:K11073]
Q425_22830  inner membrane permease polyamine transport protein [KO:K11074]
Q425_22820  inner membrane permease polyamine transport protein [KO:K11075]
Q425_22810  polyamine transport ATP-binding protein [KO:K11076] [EC:7.6.2.16]
Q425_5310  glycine/betaine ABC transporter substrate-binding protein [KO:K02002]
Q425_29940  glycine/betaine ABC transporter substrate-binding protein [KO:K02002]
Q425_29930  binding-protein-dependent transport protein [KO:K02001]
Q425_29920  ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
Q425_25470  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
Q425_1320  hypothetical protein [KO:K07323]
Q425_1340  mce related protein [KO:K02067]
Q425_2120  hypothetical protein [KO:K02066]
Q425_1350  hypothetical protein [KO:K02066]
Q425_2130  ABC transporter ATP-binding protein [KO:K02065]
Q425_1360  ABC transporter ATP-binding protein [KO:K02065]
Q425_11960  ABC transporter substrate-binding protein [KO:K17321]
Q425_11940  ABC transporter permease [KO:K17323]
Q425_11920  ABC transporter ATP-binding protein [KO:K17325]
Q425_27470  ugpB; glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K05813]
Q425_2370  glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K05813]
Q425_27460  ugpA; sn-glycerol-3-phosphate ABC transporter permease [KO:K05814]
Q425_2360  binding-protein-dependent transport system inner membrane protein [KO:K05814]
Q425_27450  ugpE; sn-glycerol-3-phosphate transport system permease [KO:K05815]
Q425_2350  binding-protein-dependent transport system inner membrane protein [KO:K05815]
Q425_27440  ugpC; glycerol-3-phosphate transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
Q425_2380  sugar ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
Q425_10040  pstS; phosphate ABC transporter substrate-binding protein [KO:K02040]
Q425_10030  pstC; phosphate ABC transporter permease [KO:K02037]
Q425_10020  pstA; phosphate ABC transporter permease [KO:K02038]
Q425_10010  pstB; phosphate transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
Q425_6210  phosphonate ABC transporter substrate-binding protein [KO:K02044]
Q425_6240  binding-protein-dependent transport system inner membrane protein [KO:K02042]
Q425_6250  binding-protein-dependent transport system permease [KO:K02042]
Q425_17530  glnH; glutamine ABC transporter substrate-binding protein [KO:K10036]
Q425_17540  glnP; glutamine ABC transporter permease [KO:K10037]
Q425_17550  glnQ; glutamine ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
Q425_590  amino acid ABC transporter binding protein [KO:K10001]
Q425_33500  extracellular solute-binding protein [KO:K10001]
Q425_570  gltK; glutamate/aspartate transport system permease [KO:K10002]
Q425_33520  gltK; glutamate/aspartate transport system permease [KO:K10002]
Q425_580  gltJ; glutamate/aspartate transport system permease [KO:K10003]
Q425_560  gltL; arginine ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
Q425_33530  gltL; arginine ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
Q425_37280  amino acid ABC transporter substrate-binding protein [KO:K09969]
Q425_13960  amino acid ABC transporter substrate-binding protein [KO:K09969]
Q425_35910  amino acid ABC transporter substrate-binding protein [KO:K09969]
Q425_37290  amino acid ABC transporter permease [KO:K09970]
Q425_37300  amino acid ABC transporter permease [KO:K09971]
Q425_37310  amino acid ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
Q425_12300  amino acid ABC transporter substrate-binding protein [KO:K02424]
Q425_12290  amino acid ABC transporter permease [KO:K10009]
Q425_12280  amino acid ABC transporter ATP-binding protein [KO:K10010] [EC:7.4.2.1]
Q425_22120  ABC transporter substrate-binding protein [KO:K01999]
Q425_29600  ABC transporter substrate-binding protein [KO:K01999]
Q425_24870  putative branched-chain amino acid-binding protein [KO:K01999]
Q425_26290  ABC transporter substrate-binding protein [KO:K01999]
Q425_10290  livK; amino acids binding protein [KO:K01999]
Q425_13730  amino acid ABC transporter substrate-binding protein [KO:K01999]
Q425_14940  branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999]
Q425_31760  amino acid binding protein [KO:K01999]
Q425_35350  ABC transporter substrate-binding protein [KO:K01999]
Q425_5280  hypothetical protein [KO:K01999]
Q425_5350  hypothetical protein [KO:K01999]
Q425_1770  hypothetical protein [KO:K01999]
Q425_27430  livJ; leu/Ile/val-binding protein [KO:K01999]
Q425_27510  livJ; leu/Ile/val-binding protein [KO:K01999]
Q425_3670  leu/Ile/val-binding protein [KO:K01999]
Q425_7020  branched-chain amino acid ABC transporter permease [KO:K01997]
Q425_29610  ABC transporter permease [KO:K01997]
Q425_24890  branched chain amino acid ABC transporter permease [KO:K01997]
Q425_26300  ABC transporter permease [KO:K01997]
Q425_10270  livH; high-affinity branched-chain amino acid transport system permease [KO:K01997]
Q425_14950  permease of branched-chain amino acid transport system [KO:K01997 K01998]
Q425_31730  ABC transporter permease [KO:K01997]
Q425_35340  branched chain amino acid ABC transporter permease [KO:K01997]
Q425_5290  branched-chain amino acid ABC transporter permease [KO:K01997]
Q425_5340  branched-chain amino acid ABC transporter permease [KO:K01997]
Q425_1730  branched-chain amino acid ABC transporter permease [KO:K01997]
Q425_27520  livH; high-affinity branched-chain amino acid transport system permease [KO:K01997]
Q425_3660  branched-chain amino acid ABC transporter permease [KO:K01997]
Q425_5330  branched-chain amino acid ABC transporter [KO:K01995 K01998]
Q425_3650  branched-chain amino acid ABC transporter permease [KO:K01995 K01998]
Q425_5300  branched-chain amino acid ABC transporter permease [KO:K01998]
Q425_1740  branched-chain amino acid ABC transporter permease [KO:K01998]
Q425_35330  branched chain amino acid ABC transporter permease [KO:K01998]
Q425_24900  branched chain amino acid ABC transporter permease [KO:K01998]
Q425_26310  ABC transporter ATP-binding protein [KO:K01998]
Q425_27530  livM; leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Q425_31720  ABC transporter permease [KO:K01998]
Q425_1750  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995 K01996]
Q425_7030  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
Q425_26320  ABC transporter ATP-binding protein [KO:K01995]
Q425_10260  livG; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
Q425_14960  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
Q425_18150  livG; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
Q425_31750  ABC transporter ATP-binding protein [KO:K01995]
Q425_35320  branched-chain amino acid transporter ATP-binding protein [KO:K01995]
Q425_5260  ABC transporter ATP-binding protein [KO:K01995]
Q425_27540  livG; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
Q425_31740  ABC transporter ATP-binding protein [KO:K01996]
Q425_5270  ABC transporter ATP-binding protein [KO:K01996]
Q425_35310  high-affinity branched-chain amino acid transporter ATP-binding protein [KO:K01996]
Q425_10300  livF; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
Q425_7040  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
Q425_14970  ABC transporter ATP-binding protein [KO:K01996]
Q425_18140  livF; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
Q425_3640  branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
Q425_24930  high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
Q425_26330  ABC transporter ATP-binding protein [KO:K01996]
Q425_27550  livF; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
Q425_7070  hypothetical protein [KO:K02073]
Q425_27650  hypothetical protein [KO:K02073]
Q425_25600  hypothetical protein [KO:K02073]
Q425_34520  hypothetical protein [KO:K02073]
Q425_25610  ABC transporter permease [KO:K02072]
Q425_25620  ABC transporter ATP-binding protein [KO:K02071]
Q425_22340  peptide ABC transporter substrate-binding protein [KO:K13889]
Q425_22350  binding-protein-dependent transport permease [KO:K13890]
Q425_22360  binding-protein-dependent transport permease [KO:K13891]
Q425_22330  ABC transporter ATP-binding protein [KO:K13892]
Q425_5360  BioY family protein [KO:K03523]
Q425_5370  cobalt transport protein [KO:K16783]
Q425_5380  ABC transporter ATP-binding protein [KO:K16784] [EC:7.6.2.-]
Q425_18010  kpsE; capsule polysaccharide export inner-membrane protein [KO:K10107]
Q425_17990  kpsM; polysialic acid ABC transporter permease [KO:K09688]
Q425_18000  kpsT; polysialic acid transport ATP-binding protein [KO:K09689] [EC:7.6.2.12]
Q425_26850  nodJ; ABC transporter permease [KO:K09694]
Q425_26840  nodI; ABC transporter ATP-binding protein [KO:K09695]
Q425_10390  lolC; lipoprotein releasing system transmembrane protein [KO:K09808]
Q425_10400  lolD; lipoprotein releasing system ATP-binding protein [KO:K09810] [EC:7.6.2.-]
Q425_22100  hypothetical protein [KO:K07091]
Q425_35120  hypothetical protein [KO:K11720]
Q425_4420  ABC transporter permease [KO:K06861] [EC:7.5.2.5]
Q425_37260  permease [KO:K09811]
Q425_37270  ftsE; cell division ATP-binding protein [KO:K09812]
Q425_23070  ABC transporter [KO:K11085] [EC:7.5.2.6]
Q425_33460  cyaB; cyclolysin secretion ATP-binding protein [KO:K11004]
Q425_8340  ABC transporter ATP-binding protein [KO:K24821]
Q425_36630  ABC transporter ATP-binding protein [KO:K16012]
Q425_36640  ABC transporter ATP-binding protein [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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