KEGG   PATHWAY: bpsu03070
Entry
bpsu03070                   Pathway                                
Name
Bacterial secretion system - Burkholderia pseudomallei MSHR146
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
bpsu03070  Bacterial secretion system
bpsu03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia pseudomallei MSHR146 [GN:bpsu]
Gene
BBN_324  outer membrane efflux family protein [KO:K12340]
BBN_4723  outer membrane efflux family protein [KO:K12340]
BBN_4992  eprI; type III secretion apparatus needle protein [KO:K03221]
BBN_4835  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
BBN_5043  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
BBN_4842  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
BBN_5076  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
BBN_4849  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
BBN_5069  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
BBN_4850  type III secretion , HrpO family protein [KO:K03227]
BBN_5068  type III secretion , HrpO family protein [KO:K03227]
BBN_4837  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
BBN_5081  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
BBN_4845  type III secretion , YscU/HrpY family protein [KO:K03229]
BBN_5073  type III secretion , YscU/HrpY family protein [KO:K03229]
BBN_4846  type III secretion , HrcV family protein [KO:K03230]
BBN_4987  invA; invasion protein invA [KO:K03230]
BBN_5072  type III secretion , HrcV family protein [KO:K03230]
BBN_4839  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
BBN_5079  type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
BBN_4848  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
BBN_4982  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
BBN_5070  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
BBN_4840  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
BBN_5078  type III secretion apparatus protein, HrpE/YscL family [KO:K03223]
BBN_3519  gspD; type II secretion system protein D [KO:K02453]
BBN_3516  type IV pilus biogenesis family protein [KO:K02452]
BBN_3517  gspF; type II secretion system protein F [KO:K02455]
BBN_3515  gspG; type II secretion system protein G [KO:K02456]
BBN_3514  gspH; type II secretion system protein H [KO:K02457]
BBN_3513  gspI; type II secretion system protein I [KO:K02458]
BBN_3512  prepilin-type N-terminal cleavage/methylation domain protein [KO:K02459]
BBN_3511  type II secretion system (T2SS), K family protein [KO:K02460]
BBN_3510  gspL; type II secretion system protein L [KO:K02461]
BBN_3509  type II secretion system (T2SS), M family protein [KO:K02462]
BBN_3518  gspE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
BBN_5048  type II/IV secretion system family protein [KO:K02454] [EC:7.4.2.8]
BBN_565  secD; export membrane protein SecD [KO:K03072]
BBN_564  secF; export membrane protein SecF [KO:K03074]
BBN_192  secE; preprotein translocase, SecE subunit [KO:K03073]
BBN_2374  secG; preprotein translocase, SecG subunit [KO:K03075]
BBN_226  secY; preprotein translocase, SecY subunit [KO:K03076]
BBN_566  yajC; preprotein translocase, YajC subunit [KO:K03210]
BBN_3435  yidC; membrane protein insertase, YidC/Oxa1 family, N-terminal domain protein [KO:K03217]
BBN_414  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
BBN_3014  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
BBN_3085  secB; protein-export chaperone SecB [KO:K03071]
BBN_436  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
BBN_292  tatA; twin arginine-targeting translocase, TatA/E family protein [KO:K03116]
BBN_293  tatB; twin arginine-targeting protein translocase TatB [KO:K03117]
BBN_294  tatC; twin arginine-targeting protein translocase TatC [KO:K03118]
BBN_3401  trbL/VirB6 plasmid conjugal transfer family protein [KO:K03201]
BBN_5963  Rhs element Vgr family protein [KO:K11904]
BBN_5530  Rhs element Vgr family protein [KO:K11904]
BBN_4419  Rhs element Vgr family protein [KO:K11904]
BBN_4952  Rhs element Vgr family protein [KO:K11904]
BBN_5575  Rhs element Vgr family protein [KO:K11904]
BBN_3923  Rhs element Vgr family protein [KO:K11904]
BBN_3561  Rhs element Vgr family protein [KO:K11904]
BBN_3924  Rhs element Vgr family protein [KO:K11904]
BBN_2051  Rhs element Vgr family protein [KO:K11904]
BBN_4641  Rhs element Vgr family protein [KO:K11904]
BBN_5935  Rhs element Vgr family protein [KO:K11904]
BBN_313  type VI secretion system effector, Hcp1 family protein [KO:K11903]
BBN_3551  hcp1; protein hcp1 [KO:K11903]
BBN_5957  hcp1; protein hcp1 [KO:K11903]
BBN_4947  type VI secretion system effector, Hcp1 family protein [KO:K11903]
BBN_3918  hypothetical protein [KO:K11903]
BBN_309  type VI secretion lipofamily protein [KO:K11906]
BBN_3929  type VI secretion lipofamily protein [KO:K11906]
BBN_3550  type VI secretion lipofamily protein [KO:K11906]
BBN_5589  type VI secretion lipofamily protein [KO:K11906]
BBN_5958  type VI secretion lipofamily protein [KO:K11906]
BBN_321  intracellular multiplication and macrophage-killing family protein [KO:K11891]
BBN_3932  intracellular multiplication and macrophage-killing family protein [KO:K11891]
BBN_3547  intracellular multiplication and macrophage-killing family protein [KO:K11891]
BBN_4960  imcF-related N-terminal domain protein [KO:K11891]
BBN_5961  intracellular multiplication and macrophage-killing family protein [KO:K11891]
BBN_5586  intracellular multiplication and macrophage-killing family protein [KO:K11891]
BBN_307  type IV/VI secretion system , DotU family domain protein [KO:K11892]
BBN_3931  type IV/VI secretion system , DotU family domain protein [KO:K11892]
BBN_3548  type VI secretion system OmpA/MotB family protein [KO:K11892]
BBN_5953  hypothetical protein [KO:K11892]
BBN_5960  type VI secretion system OmpA/MotB family protein [KO:K11892]
BBN_4959  type IV/VI secretion system , DotU family domain protein [KO:K11892]
BBN_5587  type VI secretion system OmpA/MotB family protein [KO:K11892]
BBN_317  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
BBN_3554  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
BBN_4951  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
BBN_5974  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
BBN_3922  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
BBN_5576  clpV; type VI secretion ATPase, ClpV1 family [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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