KEGG   PATHWAY: bud03070
Entry
bud03070                    Pathway                                
Name
Bacterial secretion system - Burkholderia humptydooensis MSMB43
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
bud03070  Bacterial secretion system
bud03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia humptydooensis MSMB43 [GN:bud]
Gene
AQ610_02165  channel protein TolC [KO:K12340]
AQ610_12435  channel protein TolC [KO:K12340]
AQ610_24360  hypothetical protein [KO:K12340]
AQ610_23105  type III secretion system protein PrgI [KO:K03221]
AQ610_09570  type III secretion system needle protein SsaG [KO:K03221]
AQ610_22780  secretin [KO:K03219]
AQ610_09515  outer membrane secretin SsaC [KO:K03219]
AQ610_09555  type III secretion protein SsaJ [KO:K03222]
AQ610_22620  type III secretion protein [KO:K03222]
AQ610_09465  ssaR; type III secretion system protein SsaR [KO:K03226]
AQ610_22660  ssaR; type III secretion system protein SsaR [KO:K03226]
AQ610_09460  type III secretion system protein SsaS [KO:K03227]
AQ610_22665  aldolase [KO:K03227]
AQ610_09455  type III secretion protein [KO:K03228]
AQ610_22445  type III secretion protein [KO:K03228]
AQ610_22595  type III secretion protein [KO:K03228]
AQ610_09450  secretion system apparatus protein SsaU [KO:K03229]
AQ610_22450  type III secretion protein [KO:K03229]
AQ610_22640  type III secretion system protein HrcU [KO:K03229]
AQ610_23130  type III secretion system protein InvA [KO:K03230]
AQ610_22455  type III secretion protein [KO:K03230]
AQ610_09490  secretion system apparatus protein SsaV [KO:K03230]
AQ610_22645  hypersensitivity response secretion protein hrcV [KO:K03230]
AQ610_22460  fliI; type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
AQ610_09485  type III secretion protein ATPase [KO:K03224] [EC:7.4.2.8]
AQ610_22605  fliI; type III secretion apparatus H+-transporting two-sector ATPase [KO:K03224] [EC:7.4.2.8]
AQ610_23155  type III secretion system protein [KO:K03225]
AQ610_09470  translocation protein in type III secretion [KO:K03225]
AQ610_22655  type III secretion protein [KO:K03225]
AQ610_22610  type III secretion system protein [KO:K03223]
AQ610_00375  type II secretion system protein GspD [KO:K02453]
AQ610_00360  general secretion pathway protein GspC [KO:K02452]
AQ610_09135  type II secretion system protein GspF [KO:K02455]
AQ610_00365  type II secretion system protein GspF [KO:K02455]
AQ610_00355  type II secretion system protein GspG [KO:K02456]
AQ610_09145  type II secretion system protein GspH [KO:K02457]
AQ610_00350  type II secretion system protein GspH [KO:K02457]
AQ610_09100  type II secretion system protein GspI [KO:K02458]
AQ610_00345  type II secretion system protein GspI [KO:K02458]
AQ610_09105  type II secretory pathway protein [KO:K02459]
AQ610_00340  general secretion pathway protein GspJ [KO:K02459]
AQ610_09180  general secretion pathway protein GspK [KO:K02460]
AQ610_00335  general secretion pathway protein GspK [KO:K02460]
AQ610_00330  type II secretion system protein GspL [KO:K02461]
AQ610_00325  general secretion pathway protein GspM [KO:K02462]
AQ610_00370  type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
AQ610_22755  secretion system protein E [KO:K02454] [EC:7.4.2.8]
AQ610_03550  preprotein translocase subunit SecD [KO:K03072]
AQ610_03545  preprotein translocase subunit SecF [KO:K03074]
AQ610_01480  preprotein translocase subunit SecE [KO:K03073]
AQ610_13115  preprotein translocase subunit SecG [KO:K03075]
AQ610_01650  secY; preprotein translocase subunit SecY [KO:K03076]
AQ610_03555  preprotein translocase subunit YajC [KO:K03210]
AQ610_18200  insertase [KO:K03217]
AQ610_02690  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
AQ610_16195  signal recognition particle-docking protein FtsY [KO:K03110]
AQ610_16455  preprotein translocase subunit SecB [KO:K03071]
AQ610_02930  signal recognition particle [KO:K03106] [EC:3.6.5.4]
AQ610_01995  tatA; preprotein translocase subunit SecA [KO:K03116]
AQ610_02000  tatB; preprotein translocase [KO:K03117]
AQ610_02005  twin-arginine protein translocation system subunit TatC [KO:K03118]
AQ610_12060  type IV secretion protein Rhs [KO:K11904]
AQ610_09080  type IV secretion protein Rhs [KO:K11904]
AQ610_02070  Rhs element Vgr protein [KO:K11904]
AQ610_23295  type IV secretion protein Rhs [KO:K11904]
AQ610_25895  type IV secretion protein Rhs [KO:K11904]
AQ610_28025  type IV secretion protein Rhs [KO:K11904]
AQ610_28030  type IV secretion protein Rhs [KO:K11904]
AQ610_24435  type IV secretion protein Rhs [KO:K11904]
AQ610_20215  type IV secretion protein Rhs [KO:K11904]
AQ610_30860  type IV secretion protein Rhs [KO:K11904]
AQ610_20090  type IV secretion protein Rhs [KO:K11904]
AQ610_23015  type IV secretion protein Rhs [KO:K11904]
AQ610_13790  type IV secretion protein Rhs [KO:K11904]
AQ610_22820  type IV secretion protein Rhs [KO:K11904]
AQ610_18335  type IV secretion protein Rhs [KO:K11904]
AQ610_28655  type IV secretion protein Rhs [KO:K11904]
AQ610_02110  hypothetical protein [KO:K11903]
AQ610_23320  type VI secretion protein [KO:K11903]
AQ610_28055  type VI secretion protein [KO:K11903]
AQ610_20165  Hcp1 family type VI secretion system effector [KO:K11903]
AQ610_02090  hypothetical protein [KO:K11906]
AQ610_28000  type VI secretion lipofamily protein [KO:K11906]
AQ610_20160  hypothetical protein [KO:K11906]
AQ610_30930  type VI secretion lipofamily protein [KO:K11906]
AQ610_02150  type VI secretion protein VasK [KO:K11891]
AQ610_23255  type VI secretion system protein ImpL [KO:K11891]
AQ610_27985  type VI secretion protein IcmF [KO:K11891]
AQ610_30915  hypothetical protein [KO:K11891]
AQ610_02080  type VI secretion system protein ImpK [KO:K11892]
AQ610_23260  type VI secretion system protein ImpK [KO:K11892]
AQ610_27990  hypothetical protein [KO:K11892]
AQ610_20150  hypothetical protein [KO:K11892]
AQ610_30920  hypothetical protein [KO:K11892]
AQ610_02130  ClpV1 family T6SS ATPase [KO:K11907]
AQ610_23300  ClpV1 family T6SS ATPase [KO:K11907]
AQ610_28035  ClpV1 family T6SS ATPase [KO:K11907]
AQ610_20180  ClpV1 family T6SS ATPase [KO:K11907]
AQ610_30865  ClpV1 family T6SS ATPase [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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