KEGG   PATHWAY: bww02010
Entry
bww02010                    Pathway                                
Name
ABC transporters - Bacillus mycoides WSBC 10204
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bww02010  ABC transporters
bww02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bacillus mycoides WSBC 10204 [GN:bww]
Gene
bwei_4261  thiY; Hydroxymethylpyrimidine ABC transporter, substrate-binding component [KO:K15598]
bwei_4262  thiX; Hydroxymethylpyrimidine transport system permease protein [KO:K15599]
bwei_4263  thiZ; Hydroxymethylpyrimidine transport ATP-binding protein [KO:K15600]
bwei_5536  modA; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
bwei_5537  modB; molybdate ABC transporter, permease protein [KO:K02018]
bwei_4527  bacterial extracellular solute-binding family protein [KO:K02012]
bwei_3281  fbpB; Ferric iron ABC transporter, iron-binding protein [KO:K02012]
bwei_3686  afuA; Ferric iron ABC transporter, iron-binding protein [KO:K02012]
bwei_3280  fbpA; Ferric iron ABC transporter, permease protein [KO:K02011]
bwei_3684  afuB; Ferric iron ABC transporter, permease protein [KO:K02011]
bwei_3282  fbpC; Ferric iron ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
bwei_3685  phnT; Ferric iron ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
bwei_3720  potD; Spermidine/putrescine ABC transporter, spermidine/putrescine [KO:K11069]
bwei_3721  potC; Spermidine/putrescine ABC transporter, permease protein [KO:K11070]
bwei_3722  potB; Spermidine/putrescine ABC transporter, permease protein [KO:K11071]
bwei_3723  potA; Spermidine/putrescine import ATP-binding protein potA [KO:K11072] [EC:7.6.2.11]
bwei_2243  opuAC; Glycine betaine-binding protein [KO:K02002]
bwei_2245  opuAB; Glycine betaine/L-proline ABC transporter, permease protein [KO:K02001]
bwei_2244  opuAA; Glycine betaine ABC transport system, ATP-binding protein OpuAA [KO:K02000] [EC:7.6.2.9]
bwei_2765  opuAB2; Glycine betaine/L-proline ABC transporter, permease protein [KO:K05845 K05846]
bwei_2766  opuAA2; glycine betaine/L-proline transport ATP binding subunit [KO:K05847] [EC:7.6.2.9]
bwei_0936  malK; Maltose/maltodextrin transport ATP-binding protein MalK [KO:K10112] [EC:7.5.2.-]
bwei_0939  malE; Maltose/maltodextrin ABC transporter, substrate binding periplasmic protein MalE [KO:K15770]
bwei_0940  malF; Maltose/maltodextrin ABC transporter, permease protein MalF [KO:K15771]
bwei_0941  malD; Maltose/maltodextrin ABC transporter, permease protein MalG [KO:K15772]
bwei_1166  basic membrane family protein [KO:K07335]
bwei_1168  branched-chain amino acid transport system / permease component family protein [KO:K23535]
bwei_1169  branched-chain amino acid transport system / permease component family protein [KO:K23536]
bwei_1167  ABC transporter family protein [KO:K23537]
bwei_4929  RbsB; periplasmic sugar-binding protein [KO:K10439]
bwei_4930  rbsC; Ribose ABC transporter, permease [KO:K10440]
bwei_4931  rbsA; Ribose ABC transporter, ATP-binding protein [KO:K10441] [EC:7.5.2.7]
bwei_4932  rbsD; D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
bwei_5035  ugpB; Glycerol-3-phosphate ABC transporter, glycerol-3-phosphate-binding protein [KO:K05813]
bwei_5037  ugpA; Glycerol-3-phosphate ABC transporter, permease protein [KO:K05814]
bwei_5036  ugpE; Glycerol-3-phosphate ABC transporter, permease protein [KO:K05815]
bwei_5038  ugpC; glycerol-3-phosphate transport ATP-binding protein ugpC [KO:K05816] [EC:7.6.2.10]
bwei_0664  pstS; Phosphate ABC transporter, periplasmic phosphate-binding protein PstS [KO:K02040]
bwei_4879  pstS2; Phosphate ABC transporter, periplasmic phosphate-binding protein PstS [KO:K02040]
bwei_0665  pstC; phosphate ABC transporter, permease protein PstC [KO:K02037]
bwei_4878  pstC2; phosphate ABC transporter, permease protein PstC [KO:K02037]
bwei_0666  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
bwei_4877  pstA2; phosphate ABC transporter, permease protein PstA [KO:K02038]
bwei_0667  pstB; phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
bwei_1271  phnD; phosphate/phosphite/phosphonate ABC transporters, periplasmic binding family protein [KO:K02044]
bwei_1273  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
bwei_1274  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
bwei_1272  phnC; phosphonate ABC transporter, ATP-binding protein [KO:K02041] [EC:7.3.2.2]
bwei_4958  glnH; Glutamine ABC transporter substrate-binding protein [KO:K10039]
bwei_4956  glnP; ABC transporter, permease probable glutamine ABC transporter, permease [KO:K10040]
bwei_4957  glnM; glutamine ABC transporter permease protein GlnM [KO:K10040]
bwei_4959  glnQ; Glutamate/glutamine/aspartate/asparagine transport ATP-binding protein [KO:K10041] [EC:7.4.2.1]
bwei_4151  tcyA; L-cystine-binding protein tcyA [KO:K02424]
bwei_4150  tcyB; L-cystine transport system permease protein tcyB [KO:K10009]
bwei_4149  tcyC; L-cystine import ATP-binding protein TcyC [KO:K10010] [EC:7.4.2.1]
bwei_1408  yxeM; Amino acid ABC transporter, amino-acid-binding protein yxeM [KO:K16961]
bwei_1406  yxeN; Amino acid ABC transporter, permease protein yxeN [KO:K16962]
bwei_1407  yxeO; Amino acid ABC transporter, ATP-binding protein [KO:K16963]
bwei_0791  artP; arginine-binding extracellular protein ArtP [KO:K23059]
bwei_0792  artQ; arginine transport system permease protein ArtQ [KO:K17077]
bwei_0793  artM; arginine transport ATP-binding protein ArtM [KO:K23060] [EC:7.4.2.1]
bwei_3085  braC; Branched-chain amino acid ABC transporter, amino acid-binding protein [KO:K01999]
bwei_3082  livH; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
bwei_3081  livM; Branched-chain amino acid transport system permease protein LivM [KO:K01998]
bwei_3084  livG; Branched-chain amino acid transport ATP-binding protein LivG [KO:K01995]
bwei_3083  livF; Branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
bwei_5560  metQ4; Methionine ABC transporter substrate-binding protein [KO:K02073]
bwei_4786  metQ2; Methionine/Amino acid ABC transporter (Substrate binding protein) [KO:K02073]
bwei_4787  metQ; methionine-binding lipoprotein metQ [KO:K02073]
bwei_5128  metQ3; Methionine ABC transporter, substrate-binding protein [KO:K02073]
bwei_5562  metI3; Methionine ABC transporter permease protein [KO:K02072]
bwei_4785  metI; Methionine ABC transporter permease protein [KO:K02072]
bwei_5127  metI2; Methionine ABC transporter permease protein [KO:K02072]
bwei_5561  metN3; methionine import ATP-binding protein MetN [KO:K02071]
bwei_4784  metN; methionine import ATP-binding protein MetN [KO:K02071]
bwei_5126  metN2; Methionine import ATP-binding protein MetN 2 [KO:K02071]
bwei_5544  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
bwei_5547  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
bwei_2985  Oligopeptide ABC transporter, oligopeptide-binding protein [KO:K15580]
bwei_3162  Oligopeptide transporter, periplasmic-binding protein [KO:K15580]
bwei_3821  Oligopeptide ABC transporter, oligopeptide-binding protein oppA [KO:K15580]
bwei_1368  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K15580]
bwei_1369  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K15580]
bwei_1371  Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA [KO:K15580]
bwei_2182  Oligopeptide ABC transporter, oligopeptide-binding protein [KO:K15580]
bwei_3820  Oligopeptide transport system permease protein oppB [KO:K15581]
bwei_3819  Oligopeptide ABC transporter, permease protein [KO:K15582]
bwei_3818  Oligopeptide transport ATP-binding protein oppD [KO:K15583]
bwei_3817  Oligopeptide ABC transporter, ATP-binding protein OppF [KO:K10823]
bwei_0368  fhuD; Iron compound ABC transporter, iron compound-binding protein [KO:K23227]
bwei_0367  fhuB; Ferrichrome transport system permease protein fhuB [KO:K23228]
bwei_1868  sitA; Manganese ABC transporter, periplasmic-binding protein SitA [KO:K19975]
bwei_1867  znuB2; Zinc ABC transporter, inner membrane permease protein ZnuB [KO:K19976]
bwei_1866  znuC2; Zinc ABC transporter, ATP-binding protein ZnuC [KO:K19973] [EC:7.2.2.5]
bwei_2991  znuA; High-affinity zinc uptake system periplasmic-binding protein [KO:K09815]
bwei_0653  znuB; Zinc ABC transporter, inner membrane permease protein ZnuB [KO:K09816]
bwei_0652  znuC; Zinc uptake system ATP-binding protein znuC [KO:K09817] [EC:7.2.2.20]
bwei_1328  bioY; Substrate-specific component BioY of biotin ECF transporter [KO:K03523]
bwei_4850  bioYB; biotin transporter BioYB [KO:K03523]
bwei_1619  cbiQ2; cobalt transport protein [KO:K16785]
bwei_5645  ecfT; energy-coupling factor transporter transmembrane protein EcfT [KO:K16785]
bwei_2334  cbiQ1; cobalt transport family protein [KO:K16785]
bwei_5643  cbiO2; Cobalt import ATP-binding protein cbiO 1 [KO:K16786] [EC:7.-.-.-]
bwei_5644  cbiO1; Cobalt import ATP-binding protein cbiO 2 [KO:K16787] [EC:7.-.-.-]
bwei_2052  lsrB; autoinducer 2-binding protein lsrB [KO:K10555]
bwei_2050  lsrC; Autoinducer 2 (AI-2) ABC transport system, membrane channel protein LsrC [KO:K10556]
bwei_2051  lsrD; Autoinducer 2 (AI-2) ABC transport system, membrane channel protein LsrD [KO:K10557]
bwei_2049  lsrA; ABC transporter (Autoinducer 2 import ATP-binding protein LsrA) [KO:K10558]
bwei_1809  hrtB; Heme efflux system permease HrtB [KO:K09813]
bwei_1810  hrtA; Heme efflux system ATPase HrtA [KO:K09814] [EC:7.6.2.-]
bwei_0054  bceB; Bacitracin export permease protein BceB [KO:K11632]
bwei_0053  bceA; Bacitracin export ATP-binding protein BceA [KO:K11631]
bwei_4610  ftsX; cell division protein ftsX [KO:K09811]
bwei_4609  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
bwei_0870  Acetoin transport permease protein [KO:K16919]
bwei_0872  Acetoin ABC transporter ATP-binding protein [KO:K16921]
bwei_4153  yheI; putative multidrug resistance ABC transporter ATP-binding/permease protein YheI [KO:K18889]
bwei_1278  cydC2; Transport ATP-binding protein CydC [KO:K18889]
bwei_4152  yheH; putative multidrug resistance ABC transporter ATP-binding/permease protein YheH [KO:K18890]
bwei_1279  msbA3; Lipid A export ATP-binding/permease protein MsbA [KO:K18890]
bwei_3059  bmrA; multidrug resistance ABC transporter ATP-binding/permease protein BmrA [KO:K18104] [EC:7.6.2.2]
bwei_2595  ABC transporter, permease/ATP-binding protein [KO:K18887]
bwei_2396  ABC transporter family protein [KO:K18888]
bwei_2594  msbA2; Lipid A export ATP-binding/permease protein MsbA [KO:K18888]
bwei_5755  lagD2; lactococcin-G-processing and transport ATP-binding protein LagD [KO:K20344]
bwei_5839  lagD1; lactococcin-G-processing and transport ATP-binding protein LagD [KO:K20344]
bwei_3070  cydC1; Transport ATP-binding protein CydC [KO:K16012]
bwei_3071  cydD; thiol reductant ABC exporter, CydD subunit [KO:K16013]
bwei_4615  vba; Macrolide efflux pump [KO:K18231]
bwei_2294  ccmA2; heme ABC exporter, ATP-binding protein CcmA [KO:K18231]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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