KEGG   PATHWAY: cml02010
Entry
cml02010                    Pathway                                
Name
ABC transporters - Carnobacterium maltaromaticum
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
cml02010  ABC transporters
cml02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Carnobacterium maltaromaticum [GN:cml]
Gene
BN424_515  sip11; bacterial extracellular solute-binding family protein [KO:K02012]
BN424_517  bitE; binding--dependent transport system inner membrane component family protein [KO:K02011]
BN424_516  fbpC; ABC transporter family protein [KO:K02010] [EC:7.2.2.7]
BN424_391  potD; bacterial extracellular solute-binding family protein [KO:K11069]
BN424_390  potC; binding--dependent transport system inner membrane component family protein [KO:K11070]
BN424_389  potB; binding--dependent transport system inner membrane component family protein [KO:K11071]
BN424_388  potA; polyamine ABC transporter, ATP-binding family protein [KO:K11072] [EC:7.6.2.11]
BN424_1417  opuAC; glycine betaine-binding protein [KO:K02002]
BN424_1418  busAB; betaine ABC transporter permease and substrate binding protein [KO:K02001]
BN424_1419  proV; glycine betaine/L-proline transport ATP binding subunit [KO:K02000] [EC:7.6.2.9]
BN424_1446  opuCC; substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K05845]
BN424_2805  opuCC; substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K05845]
BN424_1007  proX; binding--dependent transport system inner membrane component family protein [KO:K05845 K05846]
BN424_1445  opuCB; binding--dependent transport system inner membrane component family protein [KO:K05846]
BN424_1447  opuCD; binding--dependent transport system inner membrane component family protein [KO:K05846]
BN424_1444  proV; glycine betaine/L-proline transport ATP binding subunit [KO:K05847] [EC:7.6.2.9]
BN424_1008  proV; ABC transporter family protein [KO:K05847] [EC:7.6.2.9]
BN424_295  msmK; ABC transporter family protein [KO:K10112] [EC:7.5.2.-]
BN424_2544  mdxE; maltodextrin-binding protein mdxE [KO:K15770]
BN424_2543  malC; binding--dependent transport system inner membrane component family protein [KO:K15771]
BN424_2542  malD; binding--dependent transport system inner membrane component family protein [KO:K15772]
BN424_2384  ypcG; bacterial extracellular solute-binding family protein [KO:K17318]
BN424_2386  ypdA; binding--dependent transport system inner membrane component family protein [KO:K17319]
BN424_2385  ypcH; binding--dependent transport system inner membrane component family protein [KO:K17320]
BN424_2109  tcsA; basic membrane family protein [KO:K07335]
BN424_2819  tcsA; basic membrane family protein [KO:K07335]
BN424_2817  rnsC; branched-chain amino acid transport system / permease component family protein [KO:K23535]
BN424_2106  rnsC; branched-chain amino acid transport system / permease component family protein [KO:K23535]
BN424_2105  rbsC-2; branched-chain amino acid transport system / permease component family protein [KO:K23536]
BN424_2816  rbsC-2; branched-chain amino acid transport system / permease component family protein [KO:K23536]
BN424_2107  rbsA3; ABC transporter family protein [KO:K23537]
BN424_2818  rbsA3; ABC transporter family protein [KO:K23537]
BN424_2891  RbsB; periplasmic sugar-binding proteins [KO:K10439]
BN424_2892  rbsC; branched-chain amino acid transport system / permease component family protein [KO:K10440]
BN424_2893  rbsA; ABC transporter family protein [KO:K10441] [EC:7.5.2.7]
BN424_2894  rbsD; D-ribose pyranase [KO:K06726] [EC:5.4.99.62]
BN424_2375  periplasmic binding s and sugar binding domain of the LacI family protein [KO:K17213]
BN424_2373  CTC00906; branched-chain amino acid transport system / permease component family protein [KO:K17214]
BN424_2374  mglA; galactose/methyl galactoside import ATP-binding protein MglA [KO:K17215]
BN424_3119  glpP; bacterial extracellular solute-binding family protein [KO:K05813]
BN424_3121  glpB; binding--dependent transport system inner membrane component family protein [KO:K05814]
BN424_3120  glpA; binding--dependent transport system inner membrane component family protein [KO:K05815]
BN424_3122  ugpC; ABC transporter family protein [KO:K05816] [EC:7.6.2.10]
BN424_2724  pstS; phosphate binding family protein [KO:K02040]
BN424_2725  pstS; phosphate binding family protein [KO:K02040]
BN424_2723  pstC; phosphate ABC transporter, permease protein PstC [KO:K02037]
BN424_2722  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
BN424_2720  pstB; phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
BN424_2721  pstB; phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
BN424_510  phnD; phosphate/phosphite/phosphonate ABC transporters, periplasmic binding family protein [KO:K02044]
BN424_2377  phnD; phosphate/phosphite/phosphonate ABC transporters, periplasmic binding family protein [KO:K02044]
BN424_2298  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
BN424_2299  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
BN424_2300  phnC; phosphonate ABC transporter, ATP-binding protein [KO:K02041] [EC:7.3.2.2]
BN424_547  glnP; amino ABC transporter, permease, 3-TM region,His/Glu/Gln/Arg/opine family domain protein [KO:K10036 K10037]
BN424_546  artP; amino acid ABC transporter [KO:K10038] [EC:7.4.2.1]
BN424_1011  glnH; bacterial extracellular solute-binding s, 3 family protein [KO:K10039]
BN424_1009  glnP; amino ABC transporter, permease, 3-TM region,His/Glu/Gln/Arg/opine family domain protein [KO:K10040]
BN424_1010  glnM; amino ABC transporter, permease, 3-TM region,His/Glu/Gln/Arg/opine family domain protein [KO:K10040]
BN424_1012  glnQ; ABC transporter family protein [KO:K10041] [EC:7.4.2.1]
BN424_522  yckB; putative ABC transporter extracellular-binding protein yckB [KO:K02424]
BN424_1087  fliY2; bacterial extracellular solute-binding s, 3 family protein [KO:K02424]
BN424_1088  yecS; amino ABC transporter, permease, 3-TM region,His/Glu/Gln/Arg/opine family domain protein [KO:K10009]
BN424_523  yecS; inner membrane amino-acid ABC transporter permease protein yecS [KO:K10009]
BN424_1089  tcyC; L-cystine import ATP-binding protein TcyC [KO:K10010] [EC:7.4.2.1]
BN424_1988  glnPH2; amino ABC transporter, permease, 3-TM region,His/Glu/Gln/Arg/opine family domain protein [KO:K17077 K23059]
BN424_301  amino ABC transporter, permease, 3-TM region,His/Glu/Gln/Arg/opine family domain protein [KO:K17077 K23059]
BN424_1987  ABC transporter family protein [KO:K23060] [EC:7.4.2.1]
BN424_403  bacterial extracellular solute-binding s, 3 family protein [KO:K17073]
BN424_404  glnP; amino ABC transporter, permease, 3-TM region,His/Glu/Gln/Arg/opine family domain protein [KO:K17074]
BN424_405  glnQ; ABC transporter family protein [KO:K17076]
BN424_828  livJ; receptor ligand binding region family protein [KO:K01999]
BN424_829  livH; branched-chain amino acid transport system / permease component family protein [KO:K01997]
BN424_830  livM; branched-chain amino acid transport system / permease component family protein [KO:K01998]
BN424_831  livG; ABC transporter family protein [KO:K01995]
BN424_832  livF; ABC transporter family protein [KO:K01996]
BN424_2879  metQ; NLPA lipofamily protein [KO:K02073]
BN424_182  metQ; NLPA lipofamily protein [KO:K02073]
BN424_954  metQ2; NLPA lipofamily protein [KO:K02073]
BN424_2878  metI2; binding--dependent transport system inner membrane component family protein [KO:K02072]
BN424_953  metI2; binding--dependent transport system inner membrane component family protein [KO:K02072]
BN424_2877  metN1; ABC transporter family protein [KO:K02071]
BN424_952  metN2; methionine import ATP-binding protein MetN 2 [KO:K02071]
BN424_1263  oppA2; bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
BN424_931  oppA; bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
BN424_252  oppA; bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
BN424_1168  oppA; bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
BN424_1169  oppA; bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
BN424_1936  oppA; bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
BN424_454  oppA3; bacterial extracellular solute-binding s, 5 Middle family protein [KO:K15580]
BN424_2393  oppB; binding--dependent transport system inner membrane component family protein [KO:K15581]
BN424_2392  oppC; binding--dependent transport system inner membrane component family protein [KO:K15582]
BN424_2391  oppD2; oligopeptide/dipeptide ABC transporter,ATP-binding, C-terminal domain protein [KO:K15583]
BN424_2390  nikE; oligopeptide/dipeptide ABC transporter,ATP-binding, C-terminal domain protein [KO:K10823]
BN424_3192  ssaB; manganese ABC transporter substrate-binding lipo domain protein [KO:K19975 K19976]
BN424_3193  mtsB; ABC transporter family protein [KO:K19973] [EC:7.2.2.5]
BN424_570  adcA; putative zinc transport system zinc-binding lipoprotein AdcA [KO:K09815]
BN424_406  adcA; putative zinc transport system zinc-binding lipoprotein AdcA [KO:K09815]
BN424_408  zurM-1; ABC 3 transport family protein [KO:K09816]
BN424_407  zurA2; ABC transporter family protein [KO:K09817] [EC:7.2.2.20]
BN424_3228  bioY; bioY family protein [KO:K03523]
BN424_1260  cobalt transport protein [KO:K16785]
BN424_3405  cbiO; cobalt transport family protein [KO:K16785]
BN424_383  cbiQ; cobalt transport family protein [KO:K16785]
BN424_424  cbiQ; cobalt transport family protein [KO:K16785]
BN424_1259  hypothetical protein [KO:K16785]
BN424_3407  cbiO; ABC transporter family protein [KO:K16786] [EC:7.-.-.-]
BN424_3406  cbiO2; ABC transporter family protein [KO:K16787] [EC:7.-.-.-]
BN424_1207  ABC-2 type transporter family protein [KO:K11051]
BN424_1206  ABC transporter family protein [KO:K11050]
BN424_2030  permease family protein [KO:K09813]
BN424_2031  hrtA; ABC transporter family protein [KO:K09814] [EC:7.6.2.-]
BN424_1167  permease family protein [KO:K11632]
BN424_1166  macB; ABC transporter family protein [KO:K11631]
BN424_2731  ftsX; cell division protein ftsX [KO:K09811]
BN424_2732  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
BN424_1947  mdlA1; ABC transporter transmembrane region family protein [KO:K18889]
BN424_490  mdlA2; ABC transporter transmembrane region family protein [KO:K18889]
BN424_1946  mdlB; ABC transporter transmembrane region family protein [KO:K18890]
BN424_491  ndvA; ABC transporter transmembrane region family protein [KO:K18890]
BN424_752  bmrA; multidrug resistance ABC transporter ATP-binding/permease protein BmrA [KO:K18104] [EC:7.6.2.2]
BN424_657  lmrA3; ABC transporter transmembrane region family protein [KO:K18891]
BN424_658  lmrA4; ABC transporter transmembrane region family protein [KO:K18892]
BN424_1350  ABC transporter transmembrane region family protein [KO:K18887]
BN424_766  ycfI; ABC transporter transmembrane region family protein [KO:K18887]
BN424_532  ABC transporter transmembrane region family protein [KO:K18887]
BN424_1351  ndvA; ABC transporter transmembrane region family protein [KO:K18888]
BN424_531  ABC transporter transmembrane region family protein [KO:K18888]
BN424_767  mdlA3; ABC transporter transmembrane region family protein [KO:K18888]
BN424_896  cydC; ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC [KO:K16012]
BN424_895  cydD; ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013]
BN424_2976  Uup; ABC transporter family protein [KO:K18231]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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