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Entry
Name
Phosphotransferase system (PTS) - Klebsiella aerogenes EA1509E
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
ear02060 Phosphotransferase system (PTS)
Ortholog table
Other DBs
Organism
Klebsiella aerogenes EA1509E [GN:
ear ]
Gene
CCG28840 Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9) [KO:K08483 ] [EC:2.7.3.9 ]
CCG28841 Phosphotransferase system, phosphocarrier protein HPr [KO:K02784 ]
CCG28839 PTS system, glucose-specific IIA component (EC 2.7.1.69) [KO:K02777 ] [EC:2.7.1.-]
CCG30641 PTS system, glucose-specific IIB component (EC 2.7.1.69) / PTS system, glucose-specific IIC component (EC 2.7.1.69) [KO:K02779 ] [EC:2.7.1.199 ]
CCG31171 PTS system, N-acetylglucosamine-specific IIA component (EC 2.7.1.69), PTS system, N-acetylglucosamine-specific IIB component (EC 2.7.1.69), PTS system, N-acetylglucosamine-specific IIC component (EC 2.7.1.69) [KO:K02804 ] [EC:2.7.1.193 ]
CCG30287 PTS system, maltose and glucose-specific IIC component (EC 2.7.1.69) / PTS system, maltose and glucose-specific IIB component (EC 2.7.1.69) [KO:K02791 ] [EC:2.7.1.199 2.7.1.208 ]
CCG30810 PTS system, sucrose-specific IIB component (EC 2.7.1.69) / PTS system, sucrose-specific IIC component (EC 2.7.1.69) [KO:K02810 ] [EC:2.7.1.211 ]
CCG29104 PTS system, beta-glucoside-specific IIB component (EC 2.7.1.69) / PTS system, beta-glucoside-specific IIC component (EC 2.7.1.69) / PTS system, beta-glucoside-specific IIA component (EC 2.7.1.69) [KO:K02757 ] [EC:2.7.1.-]
CCG33668 PTS system, arbutin-, cellobiose-, and salicin-specific IIBC component (EC 2.7.1.69) [KO:K02753 ] [EC:2.7.1.-]
CCG32618 PTS system, maltose and glucose-specific IIC component (EC 2.7.1.69) / PTS system, maltose and glucose-specific IIB component (EC 2.7.1.69) [KO:K02750 ] [EC:2.7.1.208 2.7.1.-]
CCG32695 PTS system, maltose and glucose-specific IIC component (EC 2.7.1.69) / PTS system, maltose and glucose-specific IIB component (EC 2.7.1.69) [KO:K02750 ] [EC:2.7.1.208 2.7.1.-]
CCG32100 PTS system, trehalose-specific IIB component (EC 2.7.1.69) / PTS system, trehalose-specific IIC component (EC 2.7.1.69) [KO:K02819 ] [EC:2.7.1.201 ]
CCG32669 PTS system, N-acetylmuramic acid-specific IIB component (EC 2.7.1.69) / PTS system, N-acetylmuramic acid-specific IIC component (EC 2.7.1.69) [KO:K11192 ] [EC:2.7.1.192 ]
CCG32762 PTS system, mannitol-specific IIC component (EC 2.7.1.69) / PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIA component (EC 2.7.1.69) [KO:K02800 ] [EC:2.7.1.197 ]
CCG29627 PTS system, chitobiose-specific IIC component (EC 2.7.1.69) [KO:K02761 ]
CCG30091 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) [KO:K02761 ]
CCG30093 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) [KO:K02761 ]
CCG32102 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) [KO:K02761 ]
CCG31889 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) [KO:K02761 ]
CCG32647 PTS system, cellobiose-specific IIC component (EC 2.7.1.69) [KO:K02761 ]
CCG29482 PTS system, mannose-specific IIA component (EC 2.7.1.69) / PTS system, mannose-specific IIB component (EC 2.7.1.69) [KO:K02794 ] [EC:2.7.1.191 ]
CCG29481 PTS system, mannose-specific IIC component (EC 2.7.1.69) [KO:K02795 ]
CCG29480 PTS system, mannose-specific IID component (EC 2.7.1.69) [KO:K02796 ]
CCG33165 PTS system, N-acetylgalactosamine-and galactosamine-specific IIA component (EC 2.7.1.69) [KO:K02744 ] [EC:2.7.1.-]
CCG33168 PTS system, N-acetylgalactosamine-specific IIB component (EC 2.7.1.69) [KO:K02745 ] [EC:2.7.1.-]
CCG33167 PTS system, N-acetylgalactosamine-specific IIC component (EC 2.7.1.69) [KO:K02746 ]
CCG33166 PTS system, N-acetylgalactosamine-specific IID component (EC 2.7.1.69) [KO:K02747 ]
CCG31962 PTS system, mannose-specific IIA component (EC 2.7.1.69) / PTS system, mannose-specific IIB component (EC 2.7.1.69) [KO:K17465 ] [EC:2.7.1.203 ]
CCG31963 PTS system, mannose-specific IIC component (EC 2.7.1.69) [KO:K17466 ]
CCG31964 PTS system, mannose-specific IID component (EC 2.7.1.69) [KO:K17467 ]
CCG33682 PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components (EC 2.7.1.69) [KO:K02782 ] [EC:2.7.1.198 ]
CCG33683 PTS system, glucitol/sorbitol-specific IIC component (EC 2.7.1.69) [KO:K02783 ]
CCG29071 Fructose-specific phosphocarrier protein HPr (EC 2.7.1.69) / PTS system, fructose-specific IIA component (EC 2.7.1.69) [KO:K11183 ] [EC:2.7.1.202 ]
CCG29073 PTS system, fructose-specific IIB component (EC 2.7.1.69) / PTS system, fructose-specific IIC component (EC 2.7.1.69) [KO:K02770 ] [EC:2.7.1.202 ]
CCG29734 PTS system, fructose-specific IIA component (EC 2.7.1.69) / PTS system, fructose-specific IIB component (EC 2.7.1.69) / PTS system, fructose-specific IIC component (EC 2.7.1.69) [KO:K02769 ] [EC:2.7.1.202 ]
CCG33561 FIG001592: Phosphocarrier protein kinase/phosphorylase, nitrogen regulation associated [KO:K08484 ] [EC:2.7.3.9 ]
CCG33097 Phosphocarrier protein, nitrogen regulation associated [KO:K08485 ]
CCG33099 PTS IIA-like nitrogen-regulatory protein PtsN [KO:K02806 ] [EC:2.7.1.-]
Compound
C00352 D-Glucosamine 6-phosphate
C00354 D-Fructose 1,6-bisphosphate
C00357 N-Acetyl-D-glucosamine 6-phosphate
C00689 alpha,alpha'-Trehalose 6-phosphate
C01113 D-Galactose 6-phosphate
C01132 N-Acetyl-D-galactosamine
C03752 2-Amino-2-deoxy-D-gluconate
C04534 6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
C06376 N-Acetyl-D-galactosamine 6-phosphate
C06377 D-Galactosamine 6-phosphate
C11544 2-O-(alpha-D-Mannosyl)-D-glycerate
C16186 L-Ascorbate 6-phosphate
C16489 Fructoselysine 6-phosphate
C16698 N-Acetylmuramic acid 6-phosphate
C16699 2-O-(6-Phospho-alpha-mannosyl)-D-glycerate
C20589 D-Glucosaminate-6-phosphate
C20979 Glucoselysine-6-phosphate
C21152 N,N'-Diacetylchitobiose 6'-phosphate
Reference
Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
Journal
Reference
Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
Journal
Reference
Authors
Kristich CJ, Glekas GD, Ordal GW.
Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
Journal
Reference
Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
Journal
Reference
Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
Title
EcoCyc: a comprehensive database resource for Escherichia coli.
Journal
Reference
Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
Journal
Reference
Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
Journal
Reference
Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
Title
The complete phosphotranferase system in Escherichia coli.
Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
Authors
Kotrba P, Inui M, Yukawa H.
Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
Journal
Related pathway
ear00051 Fructose and mannose metabolism
KO pathway
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