KEGG   PATHWAY: ecg03060
Entry
ecg03060                    Pathway                                
Name
Protein export - Escherichia coli O127:H6 E2348/69 (EPEC)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ecg03060  Protein export
ecg03060

Other DBs
GO: 0043952 0043953
Organism
Escherichia coli O127:H6 E2348/69 (EPEC) [GN:ecg]
Gene
E2348C_3563  secY; preprotein translocase membrane subunit [KO:K03076]
E2348C_4288  secE; preprotein translocase membrane subunit [KO:K03073]
E2348C_3454  secG; preprotein translocase membrane subunit [KO:K03075]
E2348C_0343  secD; SecYEG protein translocase auxillary subunit SecF [KO:K03072]
E2348C_0344  secF; SecYEG protein translocase auxillary subunit SecD [KO:K03074]
E2348C_0342  yajC; SecYEG protein translocase auxillary subunit [KO:K03210]
E2348C_4016  yidC; cytoplasmic insertase into membrane protein, Sec-system [KO:K03217]
E2348C_0103  secA; preprotein translocase subunit SecA, ATPase [KO:K03070] [EC:7.4.2.8]
E2348C_3858  secB; protein export chaperone SecB [KO:K03071]
E2348C_0102  secM; regulator of SecA translation [KO:K13301]
E2348C_2899  ffh; Signal Recognition Particle (SRP) component with 4.5S RNA (ffs) [KO:K03106] [EC:3.6.5.4]
E2348C_ncR_05  ffs; 4.5S sRNA component of signal recognition particle (SRP); works with the Ffh protein; involved in co-translational protein translocation into and possibly through membranes [KO:K01983]
E2348C_3704  ftsY; fused Signal Recognition Particle (SRP) receptor: membrane binding protein/conserved protein [KO:K03110]
E2348C_4150  tatA; TatABCE protein translocation system subunit [KO:K03116]
E2348C_4151  tatB; TatABCE protein translocation system subunit [KO:K03117]
E2348C_4152  tatC; TatABCE protein translocation system subunit [KO:K03118]
E2348C_0527  tatE; TatABCE protein translocation system subunit TatE [KO:K03425]
E2348C_2845  lepB; leader peptidase (signal peptidase I) [KO:K03100] [EC:3.4.21.89]
E2348C_0027  lspA; prolipoprotein signal peptidase (signal peptidase II) [KO:K03101] [EC:3.4.23.36]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   
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