KEGG   PATHWAY: erj03070
Entry
erj03070                    Pathway                                
Name
Bacterial secretion system - Erwinia sp. Ejp617
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
erj03070  Bacterial secretion system
erj03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Erwinia sp. Ejp617 [GN:erj]
Gene
EJP617_15890  tolC; outer membrane channel protein [KO:K12340]
EJP617_27220  prgI; Type III secretion needle MxiH like protein [KO:K03221]
EJP617_17060  hrcC; hrp/hrc Type III secretion system-Hrp/hrc secretion/translocation pathway-hrcC protein [KO:K03219]
EJP617_16940  hrpJ; hrp/hrc Type III secretion system-Hrp/hrc secretion/translocation pathway-hrpJ protein [KO:K04058]
EJP617_17010  hrcJ; hrp/hrc Type III secretion system-Hrp/hrc secretion/translocation pathway-hrcJ protein [KO:K03222]
EJP617_16870  hrcR; type III secretion system protein [KO:K03226]
EJP617_16860  hrcS; hrp/hrc Type III secretion system-Hrp/hrc secretion/translocation pathway-hrcS protein [KO:K03227]
EJP617_16850  hrcT; HrcT [KO:K03228]
EJP617_16840  hrcU; HrcU [KO:K03229]
EJP617_16930  hrpI; hrp/hrc Type III secretion system-Hrp/hrc secretion/translocation pathway-harpin secretion protein [KO:K03230]
EJP617_27270  invA; Type III secretion apparatus InvA [KO:K03230]
EJP617_16910  hrcN; hrp/hrc Type III secretion system-Hrp/hrc secretion/translocation pathway-hrcN protein [KO:K03224] [EC:7.4.2.8]
EJP617_16880  hrcQ; hrp/hrc Type III secretion system-Hrp/hrc secretion/translocation pathway-hrcQ protein [KO:K03225]
EJP617_27300  spaO; Type III secretion apparatus [KO:K03225]
EJP617_17030  hrpE; type III secretion protein HrpE [KO:K03223]
EJP617_03290  outD; General secretion pathway protein D [KO:K02453]
EJP617_03400  outS; General secretion pathway lipoprotein [KO:K02465]
EJP617_03280  outC; General secretion pathway protein C (Pectic enzymes secretion protein OutC) [KO:K02452]
EJP617_03310  outF; General secretion pathway protein F (Pectic enzymes secretion protein OutF) [KO:K02455]
EJP617_03320  outG; General secretion pathway protein G [KO:K02456]
EJP617_03330  outH; General secretion pathway protein H [KO:K02457]
EJP617_03340  outI; General secretion pathway protein I [KO:K02458]
EJP617_03350  outJ; General secretion pathway protein J [KO:K02459]
EJP617_03360  outK; General secretion pathway protein K [KO:K02460]
EJP617_03370  outL; General secretion pathway protein L [KO:K02461]
EJP617_03300  outE; General secretion pathway protein E (Type II traffic warden ATPase) (Cholera toxin secretion protein EpsE) [KO:K02454] [EC:7.4.2.8]
EJP617_06750  hypothetical protein [KO:K02454] [EC:7.4.2.8]
EJP617_03390  outO; Type IV-A prepilin peptidase PilD [KO:K02464] [EC:3.4.23.43 2.1.1.-]
EJP617_06710  hypothetical protein [KO:K02464] [EC:3.4.23.43 2.1.1.-]
EJP617_20810  secD; preprotein translocase subunit SecD [KO:K03072]
EJP617_20820  secF; preprotein translocase subunit SecF [KO:K03074]
EJP617_13370  secE; hypothetical protein [KO:K03073]
EJP617_15200  secG; protein-export protein [KO:K03075]
EJP617_08470  secY; preprotein translocase SecY subunit [KO:K03076]
EJP617_20800  yajC; preprotein translocase subunit YajC [KO:K03210]
EJP617_11480  oxaA; putative inner membrane protein translocase component YidC [KO:K03217]
EJP617_03420  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
EJP617_03430  secM; SecA regulator SecM [KO:K13301]
EJP617_09700  ftsY; Cell division protein [KO:K03110]
EJP617_12610  secB; preprotein translocase subunit SecB [KO:K03071]
EJP617_19490  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
EJP617_14230  tatA; probable sec-independent twin-arginine translocase subunit TatA [KO:K03116]
EJP617_14240  tatB; sec-independent protein translocase protein TatB [KO:K03117]
EJP617_14250  tatC; twin-arginine protein translocation system subunit TatC [KO:K03118]
EJP617_22340  tatE; twin arginine translocase protein E [KO:K03425]
EJP617_04580  vgrG1; Rhs element Vgr protein [KO:K11904]
EJP617_04500  vgrG2; Rhs element Vgr protein [KO:K11904]
EJP617_04750  hcp; Virulence factor for secretion apparatus (Hemolysin-coregulated protein) [KO:K11903]
EJP617_04840  Type VI secretion system, lipoprotein [KO:K11906]
EJP617_27660  Type VI secretion system, IcmF protein [KO:K11891]
EJP617_04810  Type VI secretion system, IcmF protein [KO:K11891]
EJP617_27670  vasF; OmpA family protein [KO:K11892]
EJP617_04820  vasF; OmpA family protein [KO:K11892]
EJP617_04600  Type VI secretion system family ATPase, ClpV1 [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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